EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)SEPT4 ARTS PNUTL2 SEP4 hucep-7O432364
Serine hydroxymethyltransferase (EC 2.1.2.1)0B4E1G24
Serine/arginine repetitive matrix protein 5SRRM5 ZNF576B3KS814
Serine/cysteine proteinase inhibitor clade G member 1 splice variant 2 (Fragment)SERPING1Q5UGI64
Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)STK16 MPSK1 PKL12 TSF1O757164
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)PRKD1 PKD PKD1 PRKCMQ151394
Serine/threonine-protein kinase H1 (EC 2.7.11.1) (Protein serine kinase H1) (PSK-H1)PSKH1P118014
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)LATS2 KPMQ9NRM74
Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase)MAKP207944
Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)NEK10Q6ZWH54
Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)PAK3 OPHN3O759144
Serine/threonine-protein phosphatase (EC 3.1.3.16)0B4DJ754
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (Protein FB19) (p99)PPP1R10 CAT53 FB19 PNUTSQ96QC04
Serum amyloid A proteinSAA1 hCG_15534D3DQX74
Seryl-tRNA synthetase variant (Fragment)0Q53HA44
SET (SET translocation (Myeloid leukemia-associated), isoform CRA_a) (cDNA FLJ51749, highly similar to Protein SET)SET hCG_40357Q5VXV34
SET domain-containing protein 4 (EC 2.1.1.-)SETD4 C21orf18 C21orf27Q9NVD34
SF3B1 protein (Fragment)SF3B1A0PJH54
SH2 domain-containing adapter protein BSHBQ154644
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)SH2B1 KIAA1299 SH2BQ9NRF24
SH3 domain-containing YSC84-like protein 1SH3YL1Q96HL84
SH3-containing Grb-2-like 1 protein0Q9UQD44
Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1)SHARPIN SIPL1 PSEC0216Q9H0F64
Short coiled-coil proteinSCOC SCOCO HRIHFB2072Q9UIL14
Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)SIGLEC10 SLG2 UNQ477/PRO940Q96LC74
Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidase) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3)NEU3Q9UQ494
SID1 transmembrane family member 1SIDT1Q9NXL64
Sideroflexin-2SFXN2Q96NB24
Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)SEC11C SEC11L3 SPC21 SPCS4CQ9BY504
Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1)SCUBE2 CEGP1Q9NQ364
Signal recognition particle 54 kDa proteinSRP54G3V4F74
Signal recognition particle 9 kDa proteinSRP9E9PE204
Signal recognition particle receptor beta subunit (Signal recognition particle receptor, B subunit, isoform CRA_b)SRPRB hCG_2023561Q549N54
Signal recognition particle subunit SRP720Q71V074
Signal transducer and activator of transcriptionSTAT3G8JLH94
Similar to 60S ribosomal protein L7; similar to P18124 (PID:d133021)WUGSC:H_RG054D04.1O950364
Similar to catalase (Fragment)0Q8TAK24
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)SIM2 BHLHE15Q141904
Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)SSBP2 SSDP2P818774
Single-stranded DNA-binding protein, mitochondrial (Fragment)SSBP1C9K0U84
SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)SLAMF6 KALI UNQ6123/PRO20080Q96DU34
SLC5A1 protein (Fragment)SLC5A1A4QPH04
SLIT-ROBO Rho GTPase-activating protein 2SRGAP2A0A075B7B54
Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP)SGSM3 MAP RABGAPLP RUTBC3Q96HU14
Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2)SGTB SGT2Q96EQ04
Small nuclear ribonucleoprotein-associated protein0Q5XPV64
Small nuclear ribonucleoprotein-associated proteinSNRPB hCG_2039421B4DVS04
SNC66 protein0Q8WY244
Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11)SLC4A11 BTR1Q8NBS34
Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3)SLC38A4 ATA3 NAT3 SNAT4Q969I64
Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)SLC5A11 KST1 SLGTX SMIT2Q8WWX84
Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)SLC28A1 CNT1O003374
Sodium/potassium-transporting ATPase subunit alpha (EC 3.6.3.-)ATP1A3M0R1164
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)ATP1A1F5H3A14
Sodium/potassium-transporting ATPase subunit beta (Fragment)ATP1B1Q6LEU24
Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2)ATP1B2P144154
Soluble catechol-O-methyltransferaseCOMTB8XPJ74
Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter)SLC12A1 NKCC2E9PDW44
Solute carrier family 25 member 46SLC25A46 TB1Q96AG34
Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3)SLC28A3 CNT3Q9HAS34
Solute carrier family 43 member 3 (Fragment)SLC43A3E9PS744
Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin)SBSPON C8orf84 RPESPQ8IVN84
Sorting nexin 1 isoform a variant (Fragment)0Q59GU64
Sorting nexin 2 variant (Fragment)0Q53GG34
Sorting nexin 9 variant (Fragment)0Q59ES54
Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3)SPATA7 HSD3Q9P0W84
Spliceosome-associated protein CWC15 homologCWC15 C11orf5 AD-002 HSPC148Q9P0134
SPRY domain-containing protein 4SPRYD4Q8WW594
SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)SRCIN1 KIAA1684 P140Q9C0H94
StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5)STARD5Q9NSY24
Stathmin-3 (SCG10-like protein)STMN3 SCLIPQ9NZ724
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (Fragment)NSDHLC9JDR04
Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)STS ARSC1P088424
Stromal interaction molecule 2STIM2 KIAA1482Q9P2464
Sulfhydryl oxidase (EC 1.8.3.2)0A8K4774
Sulfotransferase (EC 2.8.2.-) (Fragment)SULT1A1H3BRY54
Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)SOD2B3KUK24
SWI/SNF complex subunit SMARCC2SMARCC2F8VXC84
Synapsin-1 (Brain protein 4.1) (Synapsin I)SYN1P176004
Synaptonemal complex protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4)P3H4 LEPREL4 NOL55 SC65Q927914
Synaptophysin (Major synaptic vesicle protein p38)SYPP082474
Synaptophysin-like 1, isoform CRA_a (Synaptophysin-like protein)SYPL SYPL1 hCG_16932 tcag7.98A4D0R14
Synaptotagmin binding, cytoplasmic RNA interacting protein variant (Fragment)0Q59GL14
Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII)SYT17Q9BSW74
Syndecan-1 (Fragment)SDC1H7C1K44
Syntaxin-12 (Fragment)STX12B1AJQ64
Syntaxin-19STX19Q8N4C74
Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)STXBP2 UNC18BE7EQD54
T-cell receptor alpha joining 56 (Fragment)TRAJ56A0A075B6Z24
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)CD2 SRBCP067294
T-lymphoma invasion and metastasis-inducing protein 2 (TIAM-2) (SIF and TIAM1-like exchange factor)TIAM2 KIAA2016 STEFQ8IVF54
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65-alpha) (PAF65-alpha)TAF6L PAF65AQ9Y6J94
Target of Nesh-SH3ABI3BPD3YTG34
TBC1 domain family member 22ATBC1D22A C22orf4Q8WUA74
Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD repeat-containing protein WRAP53) (WD40 repeat-containing protein antisense to TP53 gene)WRAP53 TCAB1 WDR79Q9BUR44
Testisin (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP-1) (Serine protease 21)PRSS21 ESP1 TEST1 UNQ266/PRO303Q9Y6M04
TetraspaninTSPAN4A8MVV64
Tetraspanin (Fragment)TSPAN14A6NEP94
Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence)TSPAN31 SASQ129994
Tetratricopeptide repeat protein 22 (TPR repeat protein 22)TTC22Q5TAA04
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