EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Dihydrolipoyl dehydrogenase (EC 1.8.1.4)DLDE9PEX63
Dihydropyrimidinase-like 2 short form (Fragment)DPYSL2A9CQZ23
Dihydropyrimidinase-related protein 1CRMP1E9PD683
Dihydropyrimidinase-related protein 2DPYSL2A0A1C7CYX93
Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)TFB1M CGI-75Q8WVM03
DIS30A8QI983
DIS3-like exonuclease 1 (EC 3.1.13.-)DIS3L DIS3L1 KIAA1955Q8TF463
Discoidin, CUB and LCCL domain-containing protein 1DCBLD1Q8N8Z63
Discs, large homolog 3 (Neuroendocrine-dlg, Drosophila), isoform CRA_b (Disks large homolog 3)DLG3 hCG_15353Q5JUW83
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)DLG4 PSD95P783523
Disrupted in schizophrenia 1 proteinDISC1 KIAA0457Q9NRI53
DLST proteinDLSTQ6IBS53
DMA protein (HLA-DMA protein) (MHC class II antigen) (Major histocompatibility complex, class II, DM alpha) (Major histocompatibility complex, class II, DM alpha, isoform CRA_c) (cDNA FLJ75740, highly similar to Homo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNA)DMA HLA-DMA hCG_2001572Q316043
DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F)APOBEC3FQ8IUX43
DNA excision repair protein ERCC-1ERCC1P079923
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)ERCC6 CSBQ034683
DNA helicase (EC 3.6.4.12) (Fragment)0Q53HJ43
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)LIG4P499173
DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1)ALKBH2 ABH2Q6NS383
DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)POLA1 POLAP098843
DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7) (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta)POLG2 MTPOLBQ9UHN13
DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)REV3L POLZ REV3O606733
DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)RAD51C RAD51L2O435023
DNA topoisomerase 2 (EC 5.99.1.3) (Fragment)TOP2BQ71UH43
DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (Fragment)APEX1G3V3C73
DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2)SATB2 KIAA1034Q9UPW63
DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase)POLM polmuQ9NP873
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (DNA-directed RNA polymerase II subunit M, isoforms 4/5)POLR2M GRINL1AQ6EEV43
DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)CRCPO755753
DNA-directed RNA polymerase subunit (EC 2.7.7.6)POLR1AB9ZVN93
DNA-directed RNA polymerase subunit beta (EC 2.7.7.6)POLR2BC9J2Y93
DNA-directed RNA polymerase subunit beta (EC 2.7.7.6)0B4DHJ33
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15)POLR2F POLRFP612183
DnaJ (Hsp40) homolog, subfamily C, member 7 variant (Fragment)0Q59EH73
DnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)DNAJB6 HSJ2 MRJ MSJ1A8KAG03
DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1)DNAJC1 HTJ1Q96KC83
Docking protein 3 (Downstream of tyrosine kinase 3)DOK3Q7L5913
Docosahexaenoic acid omega-hydroxylase CYP4F3 (EC 1.14.13.199) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (CYPIVF3) (Cytochrome P450 4F3) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.13.30)CYP4F3 LTB4HQ084773
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)DDOST KIAA0115 OST48 OK/SW-cl.45B4DLI23
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Fragment)RPN2Q5JYR43
Dolichyldiphosphatase 1 (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase 1)DOLPP1 LSFR2Q86YN13
Double-strand break repair protein MRE11MRE11F8W7U83
Double-strand break repair protein MRE11 (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)MRE11 HNGS1 MRE11AB3KTC73
Down syndrome cell adhesion molecule (CHD2)DSCAMO604693
Down syndrome cell adhesion molecule-like protein 1 (Down syndrome cell adhesion molecule 2)DSCAML1 DSCAM2 KIAA1132Q8TD843
Drebrin-like protein (Fragment)DBNLH0Y5J43
Drug-sensitive protein 1 (Gastric-associated differentially-expressed protein YA61P)YA61Q9NZ233
DTW domain-containing protein 2DTWD2Q8NBA83
Dual oxidase maturation factor 2 (Dual oxidase activator 2)DUOXA2Q1HG443
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)MAP2K5 MEK5 MKK5 PRKMK5Q131633
Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)DUSP14 MKP6O951473
Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)TESK2Q96S533
Dual-specificity protein phosphatase 3 (Fragment)DUSP3K7ES893
Dynactin subunit 4 (Fragment)DCTN4E5RGG13
Dynamin-like 120 kDa protein, mitochondrial (Mitochondrial dynamin-like 120 kDa protein) (Optic atrophy 1 (Autosomal dominant), isoform CRA_g)OPA1 hCG_17270E5KLJ53
Dynein heavy chain 9, axonemalDNAH9E7EP173
Dynein light chain Tctex-type 1 (Dynein, light chain, Tctex-type 1, isoform CRA_a)DYNLT1 hCG_16821Q5VTU33
Dynein light chain Tctex-type 3DYNLT3A6NGJ03
Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like)DYNLT3 TCTE1L TCTE1XLQ6ICS33
E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4)DTX4 KIAA0937 RNF155Q9Y2E63
E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)HACE1 KIAA1320Q8IYU23
E3 ubiquitin-protein ligase MARCH11 (EC 2.3.2.27) (Membrane-associated RING finger protein 11) (Membrane-associated RING-CH protein XI) (MARCH-XI) (RING-type E3 ubiquitin transferase MARCH11)MARCH11A6NNE93
E3 ubiquitin-protein ligase MGRN1 (cDNA FLJ60814, highly similar to Probable E3 ubiquitin-protein ligase MGRN1(EC 6.3.2.-))MGRN1B4DR123
E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)PDZRN3 KIAA1095 LNX3 SEMCAP3Q9UPQ73
E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)RNF126Q9BV683
E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.-) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein)RNF144B IBRDC2 P53RFPQ7Z4193
E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING-type E3 ubiquitin transferase RNF25)RNF25Q96BH13
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)SHPRH KIAA2023Q149N83
E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4)TRIM4 RNF87Q9C0373
E3 ubiquitin-protein ligase UBR5UBR5E7EMW73
E3 ubiquitin-protein ligase ZNF645 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645)ZNF645Q8N7E23
Early lymphoid activation gene protein (DIAPH2 antisense RNA 1) (DIAPH2 antisense gene protein 1)DIAPH2-AS1 EPAGQ142363
EBNA1 binding protein 2 (EBNA1 binding protein 2 variant) (EBNA1 binding protein 2, isoform CRA_a) (EBNA1BP2 protein)EBNA1BP2 hCG_2031782Q6IB293
Echinoderm microtubule-associated protein-like 4EML4B5MBZ03
Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)EML6 EML5LQ6ZMW33
EEA1 protein (Fragment)EEA1Q05D763
EF-hand calcium-binding domain-containing protein 3EFCAB3Q8N7B93
EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)EDIL3 DEL1Q8N6103
EH domain-containing protein 1 (Fragment)EHD1C9IZH13
Elastin (Tropoelastin)ELNP155023
Ellis-van Creveld syndrome protein (DWF-1)EVCP576793
Elongation factor 1-deltaEEF1DE9PRY83
Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)ELOA TCEB3 MSTP059Q142413
EMILIN-1EMILIN1A0A0C4DFX33
Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)NTHL1 NTH1 OCTS3P785493
Endophilin A1 BAR domainSH3GL2Q3V6393
Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31)ERP29 C12orf8 ERP28C9J1833
Endoplasmin (Fragment)HSP90B1F8W0263
Endosomal/lysomomal potassium channel TMEM175 (Transmembrane protein 175) (hTMEM175)TMEM175Q9BSA93
Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)ECE1Q2Z2K83
ENO3, muscle enolase 3 beta (Fragment)0Q9NPL43
Enoyl-CoA hydratase domain-containing protein 3, mitochondrialECHDC3 PP1494 PP8332Q96DC83
EnvoplakinEVPLK7EKI03
EPH receptor B4, isoform CRA_a (EphB4) (Receptor protein tyrosine kinase EphB4)EPHB4 hCG_20448 tcag7.1248Q541P73
EPHB2 protein (Ephrin type-B receptor 2)EPHB2Q6NVW13
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)NGEFQ8N5V23
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)EPHA4 HEK8 SEK TYRO1B2R6013
Epidermal growth factor receptor kinase substrate 8EPS8A8KA663
Epidermal growth factor receptor substrate 15-like 1EPS15L1M0R1653
Epididymis luminal protein 46 (Golgi phosphoprotein 2, isoform CRA_a) (cDNA FLJ14811 fis, clone NT2RP4001975, highly similar to Golgi phosphoprotein 2) (cDNA PSEC0257 fis, clone NT2RP3003642, highly similar to golgi phosphoprotein 2)GOLPH2 HEL46 hCG_29469B3KNK93
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