EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Beta-centractin (Actin-related protein 1B) (ARP1B)ACTR1B CTRN2P4202598
Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)ENO3P1392998
Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)CNN2Q9943998
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)PRKACA PKACAP1761298
Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)CHMP1A CHMP1 KIAA0047 PCOLN3 PRSM1Q9HD4298
Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)MT-CO2 COII COXII MTCO2P0040398
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)ECH1Q1301198
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)DLD GCSL LAD PHE3P0962298
ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha)ERO1A ERO1L UNQ434/PRO865Q96HE798
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)GDF15 MIC1 PDF PLAB PTGFBQ9998898
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)TIMP2P1603598
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)MACF1 ABP620 ACF7 KIAA0465 KIAA1251Q9UPN398
NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]SNU13 NHP2L1P5576998
Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)PODXL PCLP PCLP1O0059298
Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP)PARP4 ADPRTL1 KIAA0177 PARPLQ9UKK398
Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]FAT1 CDHF7 FATQ1451798
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]STK24 MST3 STK3Q9Y6E098
Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)STOML2 SLP2 HSPC108Q9UJZ198
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)UCHL3P1537498
Alpha-2-antiplasmin (Alpha-2-AP) (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Serpin F2)SERPINF2 AAP PLIP0869797
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)CAMK2D CAMKDQ1355797
Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1)CHMP4A C14orf123 SHAX2 CDA04 HSPC134Q9BY4397
Copine-8 (Copine VIII)CPNE8Q86YQ897
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)COX4I1 COX4P1307397
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)ITCHQ96J0297
Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)ELOB TCEB2Q1537097
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3)EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5P2932397
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)HNRNPAB ABBP1 HNRPABQ9972997
Myeloid-derived growth factor (MYDGF) (Interleukin-25) (IL-25) (Stromal cell-derived growth factor SF20)MYDGF C19orf10 IL25Q969H897
Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta)PITPNBP4873997
Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)CUTA ACHAP C6orf82O6088897
Signal transducer and activator of transcription 3 (Acute-phase response factor)STAT3 APRFP4076397
ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)NUDT5 NUDIX5 HSPC115Q9UKK996
ATPase ASNA1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I)ASNA1 ARSA TRC40O4368196
Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2)EFNB1 EFL3 EPLG2 LERK2P9817296
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)EIF2S2 EIF2BP2004296
Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)HARS HRSP1208196
Immunoglobulin lambda-like polypeptide 5 (G lambda-1) (Germline immunoglobulin lambda 1)IGLL5B9A06496
Nidogen-2 (NID-2) (Osteonidogen)NID2Q1411296
Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]PIGRP0183396
Ras-related protein Rab-4ARAB4A RAB4P2033896
Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)SNRPF PBSCFP6230696
Ubiquitin-60S ribosomal protein L40 (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (Large ribosomal subunit protein eL40)]UBA52 UBCEP2P6298796
Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)VPS37C PML39A5D8V696
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)ACADVL VLCADP4974896
ATP synthase subunit d, mitochondrial (ATPase subunit d)ATP5H My032O7594795
Desmoglein-2 (Cadherin family member 5) (HDGC)DSG2 CDHF5Q1412695
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)MCM3P2520595
EH domain-containing protein 2 (PAST homolog 2)EHD2 PAST2Q9NZN495
Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)EIF3G EIF3S4O7582195
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)HGS HRSO1496495
Keratinocyte proline-rich protein (hKPRP)KPRP C1orf45Q5T74995
Malignant T-cell-amplified sequence 1 (MCT-1) (Multiple copies T-cell malignancies)MCTS1 MCT1Q9ULC495
NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (YjeF N-terminal domain-containing protein 1) (YjeF_N1)NAXE AIBP APOA1BP YJEFN1Q8NCW595
Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen)NUMA1 NMP22 NUMAQ1498095
Protein S100-A14 (S100 calcium-binding protein A14) (S114)S100A14 S100A15Q9HCY895
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)RRM1 RR1P2392195
SH3 domain-binding glutamic acid-rich-like proteinSH3BGRLO7536895
Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein)SRP72O7609495
Syntaxin-3STX3 STX3AQ1327795
Calumenin (Crocalbin) (IEF SSP 9302)CALUO4385294
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]C1SP0987194
Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase)EPHX1 EPHX EPOXP0709994
FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)SUPT16H FACT140 FACTP140Q9Y5B994
G-protein coupled receptor family C group 5 member C (Retinoic acid-induced gene 3 protein) (RAIG-3)GPRC5C RAIG3 PSEC0087Q9NQ8494
Haptoglobin-related proteinHPRP0073994
Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2)HSPA1B HSP72P0DMV994
Phosphomevalonate kinase (PMKase) (hPMK) (EC 2.7.4.2)PMVK PMKIQ1512694
Plastin-1 (Intestine-specific plastin) (I-plastin)PLS1Q1465194
Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)PCYOX1 KIAA0908 PCL1 UNQ597/PRO1183Q9UHG394
Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)PDCD5 TFAR19O1473794
Protein EFR3 homolog A (Protein EFR3-like)EFR3A KIAA0143Q1415694
Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)RCC2 KIAA1470 TD60Q9P25894
Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')PTPA PPP2R4Q1525794
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Vpu-binding protein) (UBP)SGTA SGT SGT1O4376594
Small VCP/p97-interacting proteinSVIPQ8NHG794
Thyroxine-binding globulin (Serpin A7) (T4-binding globulin)SERPINA7 TBGP0554394
Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)TBCB CG22 CKAP1Q9942694
V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD)ATP6V1H CGI-11Q9UI1294
Actin, alpha skeletal muscle (Alpha-actin-1)ACTA1 ACTAP6813393
Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)AIDA C1orf80Q96BJ393
Collagen alpha-1(V) chainCOL5A1P2090893
Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein)EIF4H KIAA0038 WBSCR1 WSCR1Q1505693
Exocyst complex component 4 (Exocyst complex component Sec8)EXOC4 KIAA1699 SEC8 SEC8L1Q96A6593
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)HADH HAD HADHSC SCHADQ1683693
Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)PRNP ALTPRP PRIP PRPP0415693
Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog)TRMT112 AD-001 HSPC152 HSPC170Q9UI3093
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)NECTIN2 HVEB PRR2 PVRL2Q9269293
Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)SERPING1 C1IN C1NHP0515593
Plexin-A1 (Semaphorin receptor NOV)PLXNA1 NOV PLXN1Q9UIW293
Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein)SEC31A KIAA0905 SEC31L1 HSPC275 HSPC334O9497993
Ras-related protein Rap-2a (RbBP-30)RAP2AP1011493
Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)RTN3 ASYIP NSPL2O9519793
RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]RBMX HNRPG RBMXP1P3815993
Syntaxin-12STX12Q86Y8293
Trafficking protein particle complex subunit 3 (BET3 homolog)TRAPPC3 BET3 CDABP0066O4361793
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)UBE2D3 UBC5C UBCH5CP6107793
Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)HDLBP HBP VGLQ0034193
Alpha-1B-glycoprotein (Alpha-1-B glycoprotein)A1BGP0421792
Attractin (DPPT-L) (Mahogany homolog)ATRN KIAA0548 MGCAO7588292
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