EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)RPH3AL NOC2Q9UNE23
Rab GDP dissociation inhibitorGDI2 HEL-S-46e hCG_24071Q6IAT13
Rab GDP dissociation inhibitor (Fragment)GDI2Q5SX863
Rab-like protein 2ARABL2AQ9UBK73
RAB33B, member RAS oncogene familyRAB33BQ5U6023
RAB6A, member RAS oncogene family isoform a variant (Fragment)0Q53ET83
Radixin (Fragment)RDXE9PNV33
Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1)RANGRF MOG1 RANGNRF HSPC165 HSPC236 MDS5Q9HD473
RANBP2-like and GRIP domain-containing protein 1 (Ran-binding protein 2-like 6) (RanBP2-like 6) (RanBP2L6)RGPD1 RANBP2L6 RGP1P0DJD03
RanBP2-like and GRIP domain-containing protein 4RGPD4 RGP4Q7Z3J33
RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)RGPD8 RANBP2ALPHA RANBP2L1 RANBP2L3O147153
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)RAPGEF5 GFR KIAA0277 MRGEFQ925653
Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)RASSF5 NORE1 RAPLQ8WWW03
Ras association domain-containing protein 6RASSF6Q6ZTQ33
Ras GTPase-activating protein 2RASA2D6RBA93
Ras GTPase-activating-like protein IQGAP2 (Fragment)IQGAP2E7EWC23
Ras-related C3 botulinum toxin substrate 2 (Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_c)RAC2 hCG_1811995B1AH803
Ras-related GTP binding C, isoform CRA_aRRAGC hCG_25149D3DPT83
Ras-related GTP-binding protein RAB39 (Ras-related protein Rab-34, isoform NARR)RAB34Q96PJ73
Ras-related protein Rab-26RAB26Q9ULW53
Ras-related protein Rab-2A (Fragment)RAB2AH7C1253
Ras-related protein Rab-2BRAB2BQ6NZ333
Ras-related protein Rab-34, isoform NARRRAB34A8MYQ93
Ras-related protein Rab-5C (Fragment)RAB5CF8VVK33
Ras-related protein Rap-1b (Fragment)RAP1BF5H8233
Ras-related protein Rap-1b (GTP-binding protein smg p21B)RAP1B OK/SW-cl.11B4DW743
Ras-related protein Rap-2aRAP2AF6U7843
RDX protein (Fragment)RDXQ05CU63
Rearranged Vl3l gene segment (Rearranged Vl3l segment) (Fragment)VL3LQ7Z2E83
Receptor expression-enhancing protein 4REEP4 C8orf20 PP432Q9H6H43
Receptor expression-enhancing protein 5 (cDNA FLJ50528, moderately similar to Receptor expression-enhancing protein 5)REEP5B7Z3323
Receptor of-activated protein C kinase 1RACK1D6RF233
Receptor of-activated protein C kinase 1RACK1D6RAU23
Receptor of-activated protein C kinase 1 (Fragment)RACK1D6RFX43
Receptor of-activated protein C kinase 1 (Fragment)RACK1H0YAM73
Receptor of-activated protein C kinase 1 (Fragment)RACK1H0Y9P03
Receptor protein-tyrosine kinase (EC 2.7.10.1)EGFRQ504U83
Receptor protein-tyrosine kinase (EC 2.7.10.1)EGFRE9PFD73
Receptor protein-tyrosine kinase (EC 2.7.10.1) (Fragment)EPHB2 variant proteinQ4LE533
Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092O433533
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)RIPK4 ANKRD3 DIKP570783
Receptor-type tyrosine-protein phosphatase (EC 3.1.3.48)0A8K2Z93
Receptor-type tyrosine-protein phosphatase (EC 3.1.3.48)0B7Z2A43
Receptor-type tyrosine-protein phosphatase F (Fragment)PTPRFH0Y4H13
Receptor-type tyrosine-protein phosphatase F (Fragment)PTPRFH0Y6Z73
Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)PTPRR ECPTP PTPRQQ152563
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)PTPRU FMI PCP2 PTPROQ927293
RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)RMI2 C16orf75Q96E143
Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP/PAP) (Human proislet peptide) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]REG3A HIP PAP PAP1Q061413
Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV)REG4 GISP RELPQ9BYZ83
Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32)RGCC C13orf15 RGC32Q9H4X13
Regulator of G-protein signaling 4 (RGP4) (RGS4)RGS4P497983
RELA protein (Transcription factor p65)RELAQ2TAM53
Retina-specific copper amine oxidase (RAO) (EC 1.4.3.21) (Amine oxidase [copper-containing]) (Semicarbazide-sensitive amine oxidase) (SSAO)AOC2O751063
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)RBL2 RB2Q089993
Rheumatoid factor C6 light chain (Fragment)V1A0N5G13
Rho GDP-dissociation inhibitor 2 (Fragment)ARHGDIBF5H2R53
Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)ARHGAP23 KIAA1501Q9P2273
Rho GTPase-activating protein 45ARHGAP45K7ES923
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)ARHGEF26 SGEF HMFN1864Q96DR73
Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)ARHGEF9 ARHDH9 KIAA0424O433073
Rho-related GTP-binding protein RhoCRHOCQ5JR053
Rho-related GTP-binding protein RhoC (Fragment)RHOCQ5JR063
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)RHOH ARHH TTFQ156693
Ribonuclease inhibitor (Fragment)RNH1H0YCR73
Ribosomal protein L15 (Fragment)RPL15E7EX533
Ribosomal protein L35, isoform CRA_aRPL35 hCG_2021297A0A024R8663
Ribosomal protein S4, Y-linked 1 Y isoform variant (Fragment)0Q53HI63
Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)RPS6KA4 MSK2O756763
Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)RPS6KA6 RSK4Q9UK323
Ribosyldihydronicotinamide dehydrogenase [quinone]NQO2Q5TD073
RING finger protein 141 (Zinc finger protein 230)RNF141 ZNF230Q8WVD53
RNA binding protein S1 (RNA binding protein S1, serine-rich domain, isoform CRA_a)RNPS1 rnps1 hCG_1989969D3DU923
RNA helicase (EC 3.6.4.13)DDX55F5H5U23
RNA-binding protein 20 (RNA-binding motif protein 20)RBM20Q5T4813
RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3)RALYL HNRPCL3Q86SE53
RPL17-C18orf32 readthroughRPL17-C18orf32A0A0A0MRF83
RPL26 proteinRPL26Q6IBH63
RPLP1 protein (Fragment)RPLP1Q6ICQ43
RPS21 protein (Ribosomal protein S21) (Ribosomal protein S21, isoform CRA_d) (Fragment)RPS21 hCG_41768Q6FGH53
RRBP1 proteinRRBP1A1A5C43
rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)MRM3 RNMTL1 HC90Q9HC363
rRNA-processing protein UTP23 homologUTP23 C8orf53Q9BRU93
RSL1D1 protein (Fragment)RSL1D1A0PJ613
RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca)RUSC1 NESCAQ9BVN23
Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)RUNX1 AML1 CBFA2Q011963
RWD domain-containing protein 2ARWDD2A RWDD2Q9UIY33
S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin)SAGA0FDN63
Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b)CD163L1 CD163B M160 UNQ6434/PRO23202Q9NR163
SCL-interrupting locus protein (TAL-1-interrupting locus protein)STIL SILQ154683
SEC13-like 1 isoform b variant (Fragment)0Q53GB23
Secretoglobin family 1D member 1 (Lipophilin-A)SCGB1D1 LIPHA LPNAO959683
Selenoprotein T (SelT) (Thioredoxin reductase-like enzyme) (EC 1.8.1.9)SELENOT SELT UNQ150/PRO176P623413
Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)SEMA6A KIAA1368 SEMAQQ9H2E63
Septin 6, isoform CRA_b (Septin-6)SEPT6 hCG_23191B1AMS23
Serine hydroxymethyltransferase (EC 2.1.2.1) (Fragment)0Q53ET43
Serine hydroxymethyltransferase (EC 2.1.2.1) (Fragment)0Q53ET73
Serine hydroxymethyltransferase 1 (Soluble), isoform CRA_bSHMT1 hCG_1985219D3DXC93
Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]SPINK5Q9NQ383
Serine--tRNA ligase, mitochondrial (cDNA FLJ58068, highly similar to Seryl-tRNA synthetase, mitochondrial (EC 6.1.1.11))SARS2B4DJM93
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