EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
COX5B proteinCOX5BQ6FHM42
COX7A2 protein (Cytochrome c oxidase subunit VIIa polypeptide 2 (Liver))COX7A2Q496I02
Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)CKMT2P175402
CREB3 regulatory factor (Luman recruitment factor) (LRF)CREBRF C5orf41Q8IUR62
CSNK1A1 protein (Fragment)CSNK1A1Q6PJ062
CSNK2A1 proteinCSNK2A1Q5U5J22
CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog)STN1 OBFC1Q9H6682
CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-)CTDSPL2 HSPC058 HSPC129Q05D322
CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3)CSMD3 KIAA1894Q7Z4072
CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (Transmembrane and associated with src kinases) (CD antigen CD318)CDCP1 TRASK UNQ2486/PRO5773Q6U9Y22
Cullin 4B, isoform CRA_e (Cullin-4B)CUL4B hCG_40765K4DI932
Cullin-2 (CUL-2)CUL2O002002
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)CAND1 KIAA0829 TIP120 TIP120AQ9P0H72
CWF19-like protein 2CWF19L2Q2TBE02
CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF)CXXC5 HSPC195 TCCCIA00297Q7LFL82
Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)ATF1P188462
Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)ATF7 ATFAP175442
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)CDK1 CDC2 CDC28A CDKN1 P34CDC2O607642
Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor)CDK2AP1 CDKAP1 DOC1O145192
Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein)CINPQ9BW662
Cyclin-dependent kinase 4 (Fragment)CDK4F8VYH92
Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)CDKN2B MTS2P427722
Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48)CDKN3G3V2J72
Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)CDKL5 STK9O760392
Cyclin-dependent kinases regulatory subunitCKS1B hCG_1739274Q9BZU32
Cyclin-L1 (Cyclin-L)CCNL1 BM-001 UNQ530/PRO1073Q9UK582
Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X)CCNY C10orf9 CBCP1 CFP1Q8TEX32
CYR61 protein (Cysteine-rich, angiogenic inducer, 61, isoform CRA_a)CYR61 hCG_23652Q6FI182
Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)CST3B2R5J92
Cysteine and glycine-rich protein 2CSRP2F8VW962
Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3)CRIPT HSPC139Q9P0212
Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit)MT-CYB COB CYTB MTCYBP001562
Cytochrome b reductase 1 (EC 1.-.-.-) (Duodenal cytochrome b) (Ferric-chelate reductase 3)CYBRD1 DCYTB FRRS3B4DWD72
Cytochrome b561CYB561J3QS472
Cytochrome c (Fragment)0Q6LER62
Cytochrome c oxidase assembly factor 6 homologCOA6 C1orf31Q5JTJ32
Cytochrome c oxidase assembly factor 7 (Beta-lactamase hcp-like protein) (Respiratory chain assembly factor 1) (Sel1 repeat-containing protein 1)COA7 C1orf163 RESA1 SELRC1Q96BR52
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialCOX16 C14orf112 HSPC203 PTD019Q9P0S22
Cytochrome c oxidase subunit 2 (Fragment)COX2H9E7T72
Cytochrome c oxidase subunit 5A, mitochondrialCOX5AH3BNX82
Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)COX5AQ8TB652
Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa polypeptide 2) (Cytochrome c oxidase subunit VIIa polypeptide 2 (Liver), isoform CRA_a)COX7A2 hCG_17987H0UI062
Cytochrome c oxidase subunit Va (EC 1.9.3.1) (Fragment)COX5AQ71UP12
Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))CYP2A6 CYP2A3P115092
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)CSF2RB IL3RB IL5RBP329272
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)DYNC1I2 DNCI2 DNCIC2Q96NG72
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)DYNC1I2 DNCI2 DNCIC2B7ZA042
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)CYFIP1 KIAA0068Q144672
Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta)PITPNC1Q9UKF72
Cytoplasmic protein NCK1 (Fragment)NCK1C9J0K52
Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1)CTU1 ATPBD3 NCS6Q7Z7A32
Cytosol aminopeptidase (Fragment)LAP3H0Y9832
Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)ACOT7 BACHO437032
Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3)AGBL3 CCP3Q8NEM82
Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)ENGASEQ8NFI32
Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2)NUBP2B2RDN32
Cytosolic phospholipase A2 beta (Fragment)PLA2G4BH3BSX52
Cytosolic purine 5'-nucleotidase (Fragment)NT5C2Q5JUV62
DALR anticodon-binding domain-containing protein 3DALRD3Q5D0E62
DC390Q9H2J92
DCC-interacting protein 13-betaAPPL2F8VR682
DCN1-like protein 3 (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)DCUN1D3 SCCRO3B3KVY42
DCN1-like protein 4 (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)DCUN1D4 KIAA0276Q925642
DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)DCAF10 WDR32Q5QP822
DDB1- and CUL4-associated factor 15DCAF15 C19orf72Q66K642
DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)DCAF6 IQWD1 MSTP055Q58WW22
DDX6 protein (Probable ATP-dependent RNA helicase DDX6)DDX6Q8IV962
Dedicator of cytokinesis 5, isoform CRA_aDOCK5 hCG_15493D3DSS62
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Epididymis tissue protein Li 189m)DHDDS HDSQ86SQ92
Dehydrogenase/reductase SDR family member 7 (Fragment)DHRS7H0YJE42
Dehydrogenase/reductase SDR family member 7B (Fragment)DHRS7BJ3KRS12
Dehydrogenase/reductase SDR family member 7C (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 2)DHRS7C SDR32C2A6NNS22
Delta-aminolevulinic acid dehydratase (EC 4.2.1.24)0B7Z3I92
Delta-hemoglobin (Fragment)0Q144852
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1)DLL1 UNQ146/PRO172O005482
DendrinDDN KIAA0749O948502
DENN domain-containing protein 3DENND3 KIAA0870A2RUS22
Density-regulated proteinDENRF8VVL12
Dentin sialophosphoprotein [Cleaved into: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)]DSPPQ9NZW42
Deoxyguanosine kinase, mitochondrial (dGK) (EC 2.7.1.113)DGUOK DGKQ168542
Deoxyhypusine synthase (Fragment)DHPSM0R0V22
Deoxyribonuclease-1-like 1 (Fragment)DNASE1L1A6QRJ02
Deoxyribose-phosphate aldolaseDERAE9PPM82
Deoxyribose-phosphate aldolase (Fragment)DERAE9PML72
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)DUTQ168602
DEP domain-containing protein 1ADEPDC1 DEPDC1AQ5TB302
Dephospho-CoA kinase domain-containing proteinDCAKDQ8WVC62
Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]DCD AIDD DSEPQ53YJ22
DERP12 (Dermal papilla derived protein 12)derp12Q8TE012
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)DSG1 CDHF4B7Z8452
Destrin (Actin-depolymerizing factor) (ADF)DSTN ACTDP DSNQ5W1662
DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)DDA1 C19orf58 PCIA1Q9BW612
Deubiquitinase DESI2 (EC 3.4.19.12) (Desumoylating isopeptidase 2) (DeSI-2) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A)DESI2 C1orf121 FAM152A PPPDE1 CGI-146 PNAS-4Q9BSY92
Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3)DRG1 NEDD3Q9UGF22
Diamine acetyltransferase 1SAT1E9PD372
Diaphanous homolog 2 (Drosophila), isoform CRA_c (Protein diaphanous homolog 2)DIAPH2 hCG_1811114A6NML82
Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)DKK1 UNQ492/PRO1008B2RC192
Dickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]DKK4Q9UBT32
Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1)DHFR2 DHFRL1 DHFRP4Q86XF02
Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)DLD GCSL LAD PHE3B4DHG02
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