EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Regulation of nuclear pre-mRNA domain-containing protein 1B (Fragment)RPRD1BA2A2M02
Regulator of G-protein signaling 6 (RGS6) (S914)RGS6P497582
Renin receptorATP6AP2A0A1C7CYW42
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adaptor) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit)ATP6AP2 ATP6IP2 CAPER ELDF10 HT028 MSTP009 PSEC0072Q96LB52
Renin receptor (cDNA FLJ59846, highly similar to Renin receptor)ATP6AP2H0Y7502
Renin receptor (cDNA FLJ59846, highly similar to Renin receptor)ATP6AP2B7Z1I92
Replication factor C subunit 2 (Fragment)RFC2H7C5G42
Replication stress response regulator SDE2SDE2 C1orf55Q6IQ492
REST corepressor 2RCOR2Q8IZ402
Reticulon (Fragment)Nbla00271Q3LIF42
Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)RTN3 ASYIP NSPL2B3KQS22
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)RTN4 KIAA0886 NOGO My043 SP1507Q7L7Q62
Reticulophagy regulator 2RETREG2 C2orf17 FAM134A MAG2Q8NC442
Reticulophagy regulator 3RETREG3K7EJ342
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35)PDE6HQ139562
Retinitis pigmentosa 1-like 1 proteinRP1L1Q8IWN72
Retinoic acid-induced protein 1RAI1 KIAA1820Q7Z5J42
Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)GPRC5A GPCR5A RAI3 RAIG1O953572
Retinol dehydrogenase 11RDH11G3V5102
Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82Q0QD402
Retinol-binding protein 1RBP1H0YAK82
Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (IRBP) (Interstitial retinol-binding protein)RBP3P107452
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)ARHGDIA GDIA1B2R5X12
Rho GDP-dissociation inhibitor 2 (Fragment)ARHGDIBH0YGX72
Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma)ARHGDIGQ998192
Rho GTPase-activating protein 17 (Fragment)ARHGAP17I3L4P62
Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20)ARHGAP20 KIAA1391Q9P2F62
Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)ARHGAP31 CDGAP KIAA1204Q2M1Z32
Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)ARHGAP44 KIAA0672 RICH2Q17R892
Rho guanine nucleotide exchange factor 19 (Ephexin-2)ARHGEF19Q8IW932
Rho guanine nucleotide exchange factor 2 (Fragment)ARHGEF2V9GYF02
Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)ROCK1Q2KHM42
Rho-associated protein kinase 2ROCK2E9PF632
Rho-related GTP-binding protein RhoCRHOCE9PLA22
Rho-related GTP-binding protein RhoC (Fragment)RHOCE9PQH62
Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia)RHOF ARHF RIFQ9NXH62
Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase)RFKQ969G62
Ribonuclease inhibitorRNH1E9PMA92
Ribonuclease inhibitorRNH1E9PMN02
Ribonuclease inhibitorRNH1E9PR822
Ribonuclease inhibitor (Fragment)RNH1E9PMJ32
Ribonuclease P protein subunit p20 (Fragment)POP7C9JYM02
Ribonuclease P protein subunit p25 (RNase P protein subunit p25) (EC 3.1.26.5)RPP25Q9BUL92
Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2)RPP30 RNASEP2E9PB022
Ribonucleoprotein PTB-binding 2 (Protein raver-2)RAVER2 KIAA1579Q9HCJ32
Ribonucleoside-diphosphate reductase subunit M2 B (Fragment)RRM2BH0YAV12
Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III)PRPS1L1 PRPS3 PRPSLQ6P5P62
Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)RSL1D1 CATX11 CSIG PBK1 L12Q9Y3Z92
Ribosomal L1 domain-containing protein 1 (Fragment)RSL1D1I3L2342
Ribosomal protein L12 variant (Fragment)0Q59FI92
Ribosomal protein L18a variant (Fragment)0Q53HD32
Ribosomal protein L19 (Fragment)0Q53G492
Ribosomal protein L5 (Ribosomal protein L5, isoform CRA_c) (cDNA, FLJ95579, Homo sapiens ribosomal protein L5 (RPL5), mRNA)RPL5 hCG_2028912A2RUM72
Ribosomal protein S2RPS2Q6IPX52
Ribosomal protein S6 kinase (EC 2.7.11.1)RPS6KA2F2Z2J12
Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)NOP53 GLT GLTSCR2 PICT1Q9NZM52
Ribosome maturation protein SBDSSBDSA0A087X0202
Ribosome maturation protein SBDS (Shwachman-Bodian-Diamond syndrome protein)SBDS CGI-97Q96FX02
Ribosome production factor 2 homolog (Fragment)RPF2Q5VXN02
RING finger and transmembrane domain-containing protein 2 (Transmembrane protein 118)RNFT2 TMEM118Q96EX22
RING finger protein 113A (Zinc finger protein 183)RNF113A RNF113 ZNF183O155412
RING finger protein 145RNF145Q96MT12
RING finger protein 166RNF166Q96A372
RING finger protein 214RNF214Q8ND242
RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)TARBP2 TRBPQ156332
RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1)MOV10L1Q9BXT62
RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)ELL C19orf17P551992
RNA pseudouridylate synthase domain-containing protein 3RPUSD3Q6P0872
RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]RBMX HNRPG RBMXP1Q8N8Y72
RNA-binding motif protein, X-linked-like-3RBMXL3 CXorf55Q8N7X12
RNA-binding motif, single-stranded-interacting protein 3RBMS3Q6XE242
RNA-binding protein 43 (RNA-binding motif protein 43)RBM43 C2orf38Q6ZSC32
RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)RBM6 DEF3P783322
RNA-binding protein 7 (RNA-binding motif protein 7)RBM7Q9Y5802
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)EWSR1 EWSQ926352
RNA-binding protein FUSFUSH3BPE72
RNA-binding protein with multiple splicing (RBP-MS) (Heart and RRM expressed sequence) (Hermes)RBPMS HERMESQ930622
RNF20 protein (Fragment)RNF20A0PJJ62
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)PDE6A PDEAP164992
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)PDE6B PDEBP359132
Roquin-1 (Roquin) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)RC3H1 KIAA2025 RNF198Q5TC822
Roundabout homolog 4 (cDNA FLJ54518, highly similar to Roundabout homolog 4)ROBO4B4DYV82
RPL3 protein (Fragment)RPL3Q9BT632
RPL3 protein (Ribosomal protein L3, isoform CRA_b)RPL3 hCG_2015191Q49AJ92
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)RUBCN KIAA0226Q926222
RUN domain-containing protein 3A (Rap2-interacting protein 8) (RPIP-8)RUNDC3A RAP2IP RPIP8Q59EK92
Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)RUNX2 AML3 CBFA1 OSF2 PEBP2AQ139502
RUS1 family protein C16orf58C16orf58Q96GQ52
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)RUVBL1 INO80H NMP238 TIP49 TIP49AQ53Y272
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)RUVBL2 INO80J TIP48 TIP49B CGI-46Q6FIB92
RuvB-like helicase (EC 3.6.4.12)RUVBL2M0R0Z02
RuvB-like helicase (EC 3.6.4.12) (Fragment)RUVBL2M0QXI62
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)MAT2A AMS2 MATA2Q53SP52
S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)ESDQ5TBU82
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)SKP1 EMC19 OCP2 SKP1A TCEB1LQ8TAY22
S100A10 protein (Fragment)S100A10Q6FGE52
SAA2-SAA4 readthroughSAA2-SAA4A0A096LPE22
Salivary acidic proline-rich phosphoprotein 1/2 (Fragment)PRH1A0A087WYF52
SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog)SASH3 CXorf9 SLYO759952
SAR1a gene homolog 2 variant (Fragment)0Q53F372
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