EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein)KDM6A UTXO155501
LysM and putative peptidoglycan-binding domain-containing protein 2LYSMD2Q8IV501
Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)ACP6 ACPL1 LPAP UNQ205/PRO231Q9NPH01
Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)LPAR5 GPR92 GPR93Q9H1C01
Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor)LPAR6 P2RY5P436571
Lysophospholipid acyltransferase 1 (LPLAT 1) (EC 2.3.1.-) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1)MBOAT1 OACT1Q6ZNC81
Lysosomal acid phosphataseACP2E9PKW91
Lysosomal acid phosphataseACP2E9PQY31
Lysosomal acid phosphatase (cDNA FLJ51107, highly similar to Lysosomal acid phosphatase (EC 3.1.3.2))ACP2B7Z6U31
Lysosomal acid phosphatase (Fragment)ACP2E9PP231
Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)ACP2Q561W51
Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]GAAQ143511
Lysosomal alpha-mannosidase (Fragment)MAN2B1M0R1741
Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP)PRCP PCPB3KRK51
Lysosomal-associated transmembrane protein 4B (Fragment)LAPTM4BH0YBN11
Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)SCARB2 CD36L2 LIMP2 LIMPIIE7EM681
Lysosome-associated membrane glycoprotein 2 (Fragment)LAMP2H0YCG21
Lysozyme-like protein 6 (EC 3.2.1.17)LYZL6 LYC1 UNQ754/PRO1485O759511
LYST-interacting protein LIP5 (Fragment)0Q9C0631
Lysyl oxidase homolog 1 (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL)LOXL1 LOXLQ96BW71
Lysyl oxidase homolog 2 (Fragment)LOXL2H0YAP61
Lysyl oxidase homolog 2 (Fragment)LOXL2E5RI221
Lysyl oxidase homolog 2 (Fragment)LOXL2E5RFY01
Lysyl oxidase homolog 2 (Fragment)LOXL2H0YAR11
Lysyl oxidase homolog 4 (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)LOXL4 LOXCQ96PC01
M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)CDC25AP303041
M-phase inducer phosphatase 2CDC25BG8JLH21
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)CDC25B CDC25HU2P303051
M-phase phosphoprotein 9MPHOSPH9F5H7981
Macoilin (Transmembrane protein 57)TMEM57Q8N5G21
Macrophage colony-stimulating factor 1 (Fragment)CSF1E9PJA21
Macrophage erythroblast attacher, isoform CRA_bMAEA hCG_1646851D3DVP11
Macrophage migration inhibitory factor (Fragment)MIFI4AY871
Macrophage receptor MARCO (Fragment)MARCOC9JKT81
Macrophage-capping protein (Actin regulatory protein CAP-G)CAPG AFCP MCPB8ZZS71
Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1)MPEG1Q2M3851
MAD2L1-binding protein (Caught by MAD2 protein)MAD2L1BP CMT2 KIAA0110Q150131
Maestro heat-like repeat family member 5MROH5Q6ZUA91
Maestro heat-like repeat-containing protein family member 6MROH6 C8orf73A6NGR91
Maestro heat-like repeat-containing protein family member 9MROH9 C1orf129F5GWX61
MAGE-like protein 2 (Necdin-like protein 1) (Protein nM15)MAGEL2 NDNL1Q9UJ551
MAGEL2 protein (Fragment)MAGEL2Q05BN91
Magnesium transporter NIPA3 (NIPA-like protein 1) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 3)NIPAL1 NIPA3 NPAL1Q6NVV31
Magnesium transporter NIPA4 (Ichthyin) (NIPA-like protein 4) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 4)NIPAL4 ICHN NIPA4Q0D2K01
MAGUK p55 subfamily member 2 (cDNA FLJ52373, highly similar to MAGUK p55 subfamily member 2)MPP2B4DZ841
MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)MPP3 DLG3Q133681
MAGUK p55 subfamily member 3 (Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3), isoform CRA_a)MPP3 hCG_28215D3DX461
MAGUK p55 subfamily member 4 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein) (Discs large homolog 6)MPP4 ALS2CR5 DLG6Q96JB81
MAGUK p55 subfamily member 5 (Fragment)MPP5G3V2H11
MAGUK p55 subfamily member 6 (Fragment)MPP6C9J4Q31
MAGUK p55 subfamily member 6 (Fragment)MPP6C9JGI81
Major facilitator superfamily domain-containing protein 1 (Fragment)MFSD1H7C5U31
Major facilitator superfamily domain-containing protein 10MFSD10D6RE791
Major facilitator superfamily domain-containing protein 2BMFSD2BA6NFX11
Major prion proteinPRNPO759421
Male-specific lethal 1 homologMSL1J3KSZ81
Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)MSL1 MSL1L1Q68DK71
Maleylacetoacetate isomeraseGSTZ1A0A0A0MR331
Maleylacetoacetate isomerase (Fragment)GSTZ1H0YJN81
Malic enzyme0A8K1681
Malic enzyme (Fragment)ME3E9PMB91
MAM domain-containing glycosylphosphatidylinositol anchor protein 2MDGA2A0A0A0MSW61
Mammary dihydrolipoamide acetyltransferase, mature sequence (EC 2.3.1.12) (Fragment)0Q167911
Mannan-binding lectin serine protease 1MASP1F8W8761
Mannose-6-phosphate isomeraseMPIH3BMZ91
Mannose-6-phosphate isomerase (EC 5.3.1.8)MPI hCG_2006995H3BPB81
Mannose-6-phosphate isomerase (EC 5.3.1.8) (Fragment)MPIH3BP571
Mannose-6-phosphate isomerase (Fragment)MPIH3BU661
Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)MBL2 COLEC1 MBLQ5SQS31
Mannose-P-dolichol utilization defect 1 proteinMPDU1J3KSI41
Mannosyl (Alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase variant (Fragment)0Q59G701
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)MAN1A1Q6P0521
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)MAN1A1Q9NU441
Mannosyltransferase (EC 2.4.1.-)0A0A087WZ621
MAP kinase-activated protein kinase 5 (Fragment)MAPKAPK5R4GN331
MAP kinase-activating death domain proteinMADDA0A0A0MRB51
MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor)MADD DENN IG20 KIAA0358B5MEE51
MAP kinase-activating death domain protein (Fragment)MADDC9JM971
MAP kinase-interacting serine/threonine-protein kinase 1MKNK1E9PQ261
MAP/microtubule affinity-regulating kinase 3 (Fragment)MARK3H0YKJ31
MAP/microtubule affinity-regulating kinase 3 (Fragment)MARK3A2SY061
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)MARK4 KIAA1860 MARKL1Q96L341
MAP6 domain-containing protein 1 (21 kDa STOP-like protein) (SL21)MAP6D1Q9H9H51
Mapk-regulated corepressor-interacting protein 1MCRIP1I3L2L51
MARVEL domain-containing protein 2 (Tricellulin isoform c)MARVELD2A1BQX21
Mas-related G-protein coupled receptor member X2MRGPRX2 MRGX2Q96LB11
Mast cell carboxypeptidase A (MC-CPA) (EC 3.4.17.1) (Carboxypeptidase A3)CPA3P150881
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)MELK KIAA0175Q146801
Matrilin-2 (Fragment)MATN2H0YBU51
Matrix metalloproteinase (EC 3.4.24.-) (Fragment)MMP10F5GYX71
Matrix metalloproteinase (EC 3.4.24.-) (Fragment)MMP14F8W1B71
Matrix metalloproteinase 1 preproprotein variant (Fragment)0Q53FK31
Matrix metalloproteinase 7 (Fragment)MMP7A5GZ721
Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)MMP17 MT4MMPQ9ULZ91
Matrix metalloproteinase-23 (Fragment)MMP23BH0Y6I41
Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24]MMP24 MT5MMPQ9Y5R21
Matrix metalloproteinase-27 (MMP-27) (EC 3.4.24.-)MMP27 UNQ2503/PRO5992Q9H3061
Matrix remodeling-associated protein 8 (Limitrin)MXRA8B4DE341
Matrix-remodeling-associated protein 7MXRA7K7EQX81
Matrix-remodeling-associated protein 7MXRA7K7EPS41
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