EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Epiplakin (450 kDa epidermal antigen)EPPK1 EPIPLP5810757
Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) (EC 4.1.1.41)ECHDC1Q9NTX557
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (Testis-specific histone H2B)HIST1H2BA TSH2BQ96A0857
Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)IGKV3-20P0161957
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)IGF2BP1 CRDBP VICKZ1 ZBP1Q9NZI857
Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)IGFBP3 IBP3P1793657
Inverted formin-2 (HBEBP2-binding protein C)INF2 C14orf151 C14orf173Q27J8157
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)ACADMP1131057
Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2)MAPRE2 RP1Q1555557
Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)PLEKHO2 PLEKHQ1 PP9099Q8TD5557
Protein enabled homologENAH MENAQ8N8S757
Protein mago nashi homolog 2MAGOHB MAGOH2Q96A7257
Protein regulator of cytokinesis 1PRC1O4366357
Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)S100P S100EP2581557
Protein transport protein Sec24A (SEC24-related protein A)SEC24AO9548657
Ras-related protein Rab-12RAB12Q6IQ2257
Reticulon-1 (Neuroendocrine-specific protein)RTN1 NSPQ1679957
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)EWSR1 EWSQ0184457
Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)SEC11A SEC11L1 SPC18 SPCS4AP6781257
Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6)SLC6A6P3164157
Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)STMN2 SCG10 SCGN10Q9304557
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3)NSDHL H105E3Q1573857
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)OXCT1 OXCT SCOTP5580957
Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)USP24 KIAA1057Q9UPU557
Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)UFC1 CGI-126 HSPC155Q9Y3C857
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)VAMP5 HSPC191O9518357
Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Thioesterase superfamily member 2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]ACOT13 THEM2 HT012 PNAS-27Q9NPJ356
Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I)APOL1 APOLO1479156
Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)ASLP0442456
Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I)CA1P0091556
Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35)CEMIP KIAA1199Q8WUJ356
Coiled-coil domain-containing protein 50 (Protein Ymer)CCDC50 C3orf6Q8IVM056
Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)COG3 SEC34Q96JB256
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)DST BP230 BP240 BPAG1 DMH DT KIAA0728Q0300156
Epididymal secretory protein E1 (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein)NPC2 HE1P6191656
Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4)GSTM1 GST1P0948856
Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)GYG1 GYGP4697656
Hemicentin-2HMCN2Q8NDA256
Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)HP1BP3Q5SSJ556
Immunoglobulin lambda variable 3-21 (Ig lambda chain V-III region LOI) (Ig lambda chain V-V region DEL) (Ig lambda chain V-VII region MOT)IGLV3-21P8074856
Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)PPA2 HSPC124Q9H2U256
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)KRT76 KRT2B KRT2PQ0154656
Lamina-associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin-related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]TMPO LAP2P4216656
Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)LTBP1Q1476656
Lipopolysaccharide-binding protein (LBP)LBPP1842856
Lysosomal-associated transmembrane protein 4A (Golgi 4-transmembrane-spanning transporter MTP)LAPTM4A KIAA0108 LAPTM4 MBNT MTRP UNQ1846/PRO3574Q1501256
Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B)ABCC4 MRP4O1543956
N-alpha-acetyltransferase 50 (EC 2.3.1.258) (N-acetyltransferase 13) (N-acetyltransferase 5) (hNAT5) (N-acetyltransferase san homolog) (hSAN) (NatE catalytic subunit)NAA50 MAK3 NAT13 NAT5Q9GZZ156
OccludinOCLNQ1662556
Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)CPVL VLP PSEC0124 UNQ197/PRO223Q9H3G556
Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1)P3H1 GROS1 LEPRE1 PSEC0109Q32P2856
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)FNTAP4935456
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)PPP1R12A MBS MYPT1O1497456
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)PYCR1P3232256
Ribonucleases P/MRP protein subunit POP1 (hPOP1) (EC 3.1.26.5)POP1 KIAA0061Q9957556
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)UBE2I UBC9 UBCE9P6327956
Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029)TSPAN8 TM4SF3P1907556
Translation initiation factor eIF-2B subunit beta (S20I15) (S20III15) (eIF-2B GDP-GTP exchange factor subunit beta)EIF2B2 EIF2BBP4977056
Transmembrane glycoprotein NMB (Transmembrane glycoprotein HGFIN)GPNMB HGFIN NMB UNQ1725/PRO9925Q1495656
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)HIBADHP3193755
Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L)ANP32EQ9BTT055
Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)CEACAM1 BGP BGP1P1368855
COMM domain-containing protein 10COMMD10 HSPC305 PTD002Q9Y6G555
COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)COPS7A CSN7A DERP10Q9UBW855
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)CDK2 CDKN2P2494155
Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)DPP9 DPRP2Q86TI255
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC)STT3A ITM1 TMCP4697755
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8-like protein 1) (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-related protein 1)EPS8L1 DRC3 EPS8R1 PP10566Q8TE6855
Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160)GOLGA3Q0837855
Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]GRNP2879955
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)GNG2P5976855
Histone H2A type 1-A (Histone H2A/r)HIST1H2AA H2AFRQ96QV655
Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)LRBA BGL CDC4L LBAP5085155
Lipoprotein lipase (LPL) (EC 3.1.1.34)LPL LIPDP0685855
Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I)MGST1 GST12 MGSTP1062055
Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin LCN2) (p25)LCN2 HNL NGALP8018855
Nuclear autoantigenic sperm protein (NASP)NASPP4932155
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4)PIN4Q9Y23755
Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1)PSMG2 HCCA3 PAC2 TNFSF5IP1Q969U755
Protein C10C12orf57 C10Q9962255
RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)RBM25 RNPC7P4975655
Sideroflexin-3SFXN3Q9BWM755
Solute carrier family 43 member 3 (Protein FOAP-13)SLC43A3 PSEC0252Q8NBI555
Superkiller viralicidic activity 2-like 2 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (TRAMP-like complex helicase)SKIV2L2 DOB1 KIAA0052 Mtr4P4228555
Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15)TSPAN15 NET7 TM4SF15 UNQ677/PRO1311O9585855
Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein)TM9SF3 SMBP UNQ245/PRO282Q9HD4555
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)FAS APT1 FAS1 TNFRSF6P2544555
Ubiquitin-fold modifier 1UFM1 C13orf20 BM-002P6196055
Vacuolar protein sorting-associated protein 13CVPS13C KIAA1421Q709C855
Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (Swelling protein 1)LRRC8A KIAA1437 LRRC8 SWELL1 UNQ221/PRO247Q8IWT655
Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (iGnT) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)B4GAT1 B3GNT1 B3GNT6O4350554
Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase)NTPCR C1orf57Q9BSD754
Cartilage-associated proteinCRTAP CASPO7571854
Complement component C8 alpha chain (Complement component 8 subunit alpha)C8AP0735754
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)H2AFY2 MACROH2A2Q9P0M654
Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1)ALDH1L1 FTHFDO7589154
Dihydrofolate reductase (EC 1.5.1.3)DHFRP0037454
Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)MVD MPDP5360254
Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)ECI1 DCIP4212654
Ester hydrolase C11orf54 (EC 3.1.-.-)C11orf54 LP4947 PTD012Q9H0W954
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