EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Integrin beta-6ITGB6P1856437
Kinesin light chain 2 (KLC 2)KLC2Q9H0B637
Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)KYNUQ1671937
Macrophage erythroblast attacher (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10)MAEA EMP HLC10 PIG5Q7L5Y937
Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4)CNNM4 ACDP4 KIAA1592Q6P4Q737
Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III)MGST3O1488037
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)PDZK1 CAP70 NHERF3 PDZD1Q5T2W137
Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1Q8NF9137
Netrin-4 (Beta-netrin) (Hepar-derived netrin-like protein)NTN4Q9HB6337
Neuronal membrane glycoprotein M6-a (M6a)GPM6A M6AP5167437
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); Antimicrobial peptide VGF[554-577]]VGFO1524037
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)PIP5K1AQ9975537
Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)PLPP2 LPP2 PPAP2CO4368837
Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)LIN7A MALS1 VELI1O1491037
Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613)NDRG2 KIAA1248 SYLDQ9UN3637
Putative annexin A2-like protein (Annexin A2 pseudogene 2) (Lipocortin II pseudogene)ANXA2P2 ANX2L2 ANX2P2 LPC2BA6NMY637
Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)SIGMAR1 OPRS1 SRBP AAG8Q9972037
Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)SUDS3 SAP45 SDS3Q9H7L937
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)SUCLG1P5359737
Thrombospondin-3THBS3 TSP3P4974637
Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B)TOR1B DQ1 FKSG18O1465737
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)TFAM TCF6 TCF6L2Q0005937
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)TRIOO7596237
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)USP15 KIAA0529Q9Y4E837
[F-actin]-methionine sulfoxide oxidase MICAL1 (EC 1.14.13.225) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)MICAL1 MICAL NICALQ8TDZ237
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H)HIBCHQ6NVY136
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease)ADAMTS13 C9orf8 UNQ6102/PRO20085Q76LX836
A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)AKAP9 AKAP350 AKAP450 KIAA0803Q9999636
Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) (ASC-1 complex subunit p200) (ASC1p200) (Helicase, ATP binding 1) (Trip4 complex subunit p200)ASCC3 HELIC1Q8N3C036
ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4)SLC25A4 ANT1P1223536
AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)AP3M1Q9Y2T236
Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)ATXN2L A2D A2LG A2LP A2RPQ8WWM736
Calcyphosin (Calcyphosine)CAPSQ1393836
Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3)CA12O4357036
Collagen triple helix repeat-containing protein 1 (Protein NMTC1)CTHRC1 UNQ762/PRO1550Q96CG836
Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein]CRIM1 S52 UNQ1886/PRO4330Q9NZV136
Double-strand break repair protein MRE11 (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)MRE11 HNGS1 MRE11AP4995936
EmerinEMD EDMD STAP5040236
Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A)ELMO2 CED12A KIAA1834Q96JJ336
ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)EMC2 KIAA0103 TTC35Q1500636
FAS-associated factor 2 (Protein ETEA) (UBX domain-containing protein 3B) (UBX domain-containing protein 8)FAF2 ETEA KIAA0887 UBXD8 UBXN3BQ96CS336
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1)GBF1 KIAA0248Q9253836
GTP-binding protein 1 (G-protein 1) (GP-1) (GP1)GTPBP1O0017836
Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60)HSPA14 HSP60 HSP70L1Q0VDF936
Histone H1.1 (Histone H1a)HIST1H1A H1F1Q0253936
HLA class I histocompatibility antigen, A-68 alpha chain (Aw-68) (HLA class I histocompatibility antigen, A-28 alpha chain) (MHC class I antigen A*68)HLA-A HLAAP0189136
Immunoglobulin heavy variable 3-53 (Ig heavy chain V-III region BUT)IGHV3-53P0176736
Immunoglobulin kappa variable 2-30 (Ig kappa chain V-II region RPMI 6410)IGKV2-30P0631036
Immunoglobulin lambda variable 1-47 (Ig lambda chain V-I region HA) (Ig lambda chain V-I region WAH)IGLV1-47P0170036
Integrin beta-8ITGB8P2601236
Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25)HSPB11 C1orf41 IFT25 HSPC034Q9Y54736
Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)KIDINS220 ARMS KIAA1250Q9ULH036
Lamin-B receptor (Integral nuclear envelope inner membrane protein) (LMN2R)LBRQ1473936
Latent-transforming growth factor beta-binding protein 2 (LTBP-2)LTBP2 C14orf141 LTBP3Q1476736
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)LTBP4Q8N2S136
LDLR chaperone MESD (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61)MESDC2 KIAA0081 MESD UNQ1911/PRO4369Q1469636
LETM1 and EF-hand domain-containing protein 1, mitochondrial (Leucine zipper-EF-hand-containing transmembrane protein 1)LETM1O9520236
Leucine-rich repeat-containing protein 40LRRC40Q9H9A636
Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (EC 2.3.1.n4) (Bladder and breast carcinoma-overexpressed gene 1 protein) (Leukocyte receptor cluster member 4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) (h-mboa-7)MBOAT7 BB1 LENG4 OACT7Q96N6636
Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)MXRA5Q9NR9936
Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]MSLN MPFQ1342136
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)MAP1LC3B MAP1ALC3Q9GZQ836
Migration and invasion enhancer 1 (HBV X-transactivated gene 4 protein) (HBV XAg-transactivated protein 4) (Protein C35)MIEN1 C17orf37 RDX12 XTP4Q9BRT336
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC 3.1.1.93) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10)ABHD10Q9NUJ136
NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein)NIF3L1 ALS2CR1 MDS015 My018Q9GZT836
Ninjurin-1 (Nerve injury-induced protein 1)NINJ1Q9298236
Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30)NOL3 ARC NOPO6093636
Phosphatase and actin regulator 4PHACTR4 PRO2963Q8IZ2136
Protein yippee-like 5YPEL5 CGI-127P6269936
Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part]PRG4 MSF SZPQ9295436
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)PCP1149836
Semenogelin-1 (Cancer/testis antigen 103) (Semenogelin I) (SGI) [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein]SEMG1 SEMGP0427936
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)SPTLC1 LCB1O1526936
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)SHC1 SHC SHCAP2935336
Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]TMSB4X TB4X THYB4 TMSB4P6232836
Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)FUCA1 Nbla10230P0406636
UPF0587 protein C1orf123C1orf123Q9NWV436
V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)ATP6V1B1 ATP6B1 VATB VPP3P1531336
Acetolactate synthase-like protein (EC 2.2.1.-) (IlvB-like protein)ILVBL AHASA1L0T035
Adenylyl cyclase-associated protein 2 (CAP 2)CAP2P4012335
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)ARAP1 CENTD2 KIAA0782Q96P4835
ATP-dependent RNA helicase DHX29 (EC 3.6.4.13) (DEAH box protein 29) (Nucleic acid helicase DDXx)DHX29 DDX29Q7Z47835
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5Q96GD435
Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein)CDC5L KIAA0432 PCDC5RPQ9945935
Chloride intracellular channel protein 3CLIC3O9583335
Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2)STAG2 SA2Q8N3U435
Coiled-coil domain-containing protein 47CCDC47 GK001 MSTP041 PSEC0077Q96A3335
Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]COL2A1P0245835
COMM domain-containing protein 4COMMD4Q9H0A835
Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D)CFD DF PFDP0074635
CSC1-like protein 1 (Transmembrane protein 63A)TMEM63A KIAA0489 KIAA0792O9488635
Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor)CUBN IFCRO6049435
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)DSC3 CDHF3 DSC4Q1457435
Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK)DKK1 UNQ492/PRO1008O9490735
DNA dC->dU-editing enzyme APOBEC-3C (A3C) (EC 3.5.4.-) (APOBEC1-like) (Phorbolin I)APOBEC3C APOBEC1L PBIQ9NRW335
DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)POLR3BQ9NW0835
DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)DNAJC10 ERDJ5 UNQ495/PRO1012Q8IXB135
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)HECTD3Q5T44735
Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20)EIF1BO6073935
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)FBLN5 DANCE UNQ184/PRO210Q9UBX535
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