EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)EIF2B5 EIF2BEQ1314431
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)USP10 KIAA0190Q1469431
Ubiquitin-associated protein 2-like (Protein NICE-4)UBAP2L KIAA0144 NICE4Q1415731
Unconventional myosin-If (Myosin-Ie)MYO1FO0016031
Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)VPS11 RNF108 PP3476Q9H27031
Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)ELAC2 HPC2Q9BQ5231
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L)ADI1 MTCBP1 HMFT1638Q9BV5730
39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49) (Mitochondrial large ribosomal subunit protein mL49) (Neighbor of FAU) (NOF) (Protein NOF1)MRPL49 C11orf4 NOF1 OK/SW-cl.67Q1340530
Actin-related protein 10 (Actin-related protein 11) (hARP11)ACTR10 ACTR11 ARP11Q9NZ3230
Aldehyde dehydrogenase family 8 member A1 (EC 1.2.1.-) (Aldehyde dehydrogenase 12)ALDH8A1 ALDH12Q9H2A230
Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357)AKR1C2 DDH2P5289530
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1)GIT1Q9Y2X730
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)BCR BCR1 D22S11P1127430
Cadherin-3 (Placental cadherin) (P-cadherin)CDH3 CDHPP2222330
Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 3.6.3.8) (ATP-dependent Ca(2+) pump PMR1)ATP2C1 KIAA1347 PMR1L HUSSY-28P9819430
Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI)CPB2Q96IY430
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)CPT1A CPT1P5041630
Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)CDC23 ANAPC8Q9UJX230
Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)CPSF3 CPSF73Q9UKF630
Coiled-coil domain-containing protein 22CCDC22 CXorf37 JM1O6082630
Coiled-coil domain-containing protein 58CCDC58Q4VC3130
Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone)CCSO1461830
Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)CBSP3552030
Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (LIM domain only protein 5) (LMO-5) (Smooth muscle cell LIM protein) (SmLIM)CSRP2 LMO5 SMLIMQ1652730
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)ERC1 ELKS KIAA1081 RAB6IP2Q8IUD230
Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233Q8NBQ530
FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region]FLAD1 PP591Q8NFF530
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)LGALS8O0021430
Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (Gamma-interferon-inducible protein IP-30) (Legumaturain)IFI30 GILT IP30P1328430
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)GFPT2O9480830
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)GPD1P2169530
GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein)PIGS UNQ1873/PRO4316Q96S5230
Haloacid dehalogenase-like hydrolase domain-containing protein 2HDHD2Q9H0R430
Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1)HNRNPCL1 HNRPCL1O6081230
HLA class I histocompatibility antigen, B-15 alpha chain (MHC class I antigen B*15)HLA-B HLABP3046430
HLA class I histocompatibility antigen, B-18 alpha chain (MHC class I antigen B*18)HLA-B HLABP3046630
HLA class II histocompatibility antigen, DRB1-4 beta chain (MHC class II antigen DRB1*4) (DR-4) (DR4)HLA-DRB1P1376030
Immunoglobulin heavy variable 3-7 (Ig heavy chain V-III region GAL) (Ig heavy chain V-III region GAR) (Ig heavy chain V-III region JON)IGHV3-7P0178130
Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)IPO8 RANBP8O1539730
Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)IKBIP IKIPQ70UQ030
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)PPIP5K1 HISPPD2A IP6K IPS1 KIAA0377 VIP1Q6PFW130
Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5)ITIH5 KIAA1953 PP14776 UNQ311/PRO354Q86UX230
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)IFIT1 G10P1 IFI56 IFNAI1 ISG56P0991430
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)ITSN1 ITSN SH3D1AQ1581130
Kinesin-like protein KIF12KIF12Q96FN530
Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2)ACSL1 FACL1 FACL2 LACS LACS1 LACS2P3312130
MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like)MAPK1IP1L C14orf32Q8NDC030
Metaxin-2 (Mitochondrial outer membrane import complex protein 2)MTX2O7543130
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)MCCC2 MCCBQ9HCC030
Midasin (MIDAS-containing protein)MDN1 KIAA0301Q9NU2230
Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)PMPCB MPPBO7543930
Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2)MAP3K6 ASK2 MAPKKK6 MEKK6O9538230
N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase)SGSH HSSP5168830
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]NOTCH1 TAN1P4653130
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)TYK2P2959730
Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)GTPBP4 CRFG NOG1Q9BZE430
Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX)ACOX1 ACOXQ1506730
PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)PCNPQ8WW1230
Plexin-B1 (Semaphorin receptor SEP)PLXNB1 KIAA0407 PLXN5 SEPO4315730
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)PITRM1 KIAA1104 MP1Q5JRX330
Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P)FAM162A C3orf28 E2IG5 DC16 FWP001Q96A2630
Protein FAM177A1FAM177A1 C14orf24Q8N12830
Protein FAM84B (Breast cancer membrane protein 101) (Protein NSE2)FAM84B BCMP101 NSE2Q96KN130
Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I)RBP1 CRBP1P0945530
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)RND3 ARHE RHO8 RHOEP6158730
Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)ULK3Q6PHR230
Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9)SERPINB9 PI9P5045330
Shootin-1 (Shootin1)SHTN1 KIAA1598A0MZ6630
Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter)SLC17A5Q9NRA230
Solute carrier family 12 member 9 (Cation-chloride cotransporter 6) (hCCC6) (Cation-chloride cotransporter-interacting protein 1) (CCC-interacting protein 1) (hCIP1) (Potassium-chloride transporter 9) (WO3.3)SLC12A9 CCC6 CIP1Q9BXP230
Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3)SAMM50 SAM50 CGI-51 TRG3Q9Y51230
Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase)FDFT1P3726830
Sulfatase-modifying factor 2 (C-alpha-formylglycine-generating enzyme 2)SUMF2 PSEC0171 UNQ1968/PRO4500Q8NBJ730
Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)SULT1A1 STP STP1 OK/SW-cl.88P5022530
Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog)TEP1 TLP1 TP1Q9997330
THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)THOC1 HPR1Q96FV930
Trafficking protein particle complex subunit 4 (Hematopoietic stem/progenitor cell protein 172) (Synbindin) (TRS23 homolog)TRAPPC4 SBDN CGI-104 HSPC172 PTD009Q9Y29630
Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o)TCEA1 GTF2S TFIISP2319330
Tubulin alpha chain-like 3TUBAL3A6NHL230
Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)NUDT16L1 SDOS TIRRQ9BRJ730
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)UCHL5 UCH37 AD-019 CGI-70Q9Y5K530
Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)UBE4A KIAA0126Q1413930
Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)UFD1 UFD1LQ9289030
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)ATG7 APG7LO9535230
UBX domain-containing protein 6 (UBX domain-containing protein 1)UBXN6 UBXD1 UBXDC2Q9BZV130
Uroplakin-2 (UP2) (Uroplakin II) (UPII)UPK2O0052630
60S ribosome subunit biogenesis protein NIP7 homolog (KD93)NIP7 CGI-37 HSPC031 HSPC180 OK/SW-cl.76 OK/SW-cl.78Q9Y22129
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)ACTN3Q0804329
Alpha-taxilinTXLNA TXLNP4022229
BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18)BET1O1515529
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)CTBP1 CTBPQ1336329
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)CXCR4P6107329
Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)CALB1 CAB27P0593729
Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV)CA4P2274829
Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain]CTSL CTSL1P0771129
Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)CSTF1Q0504829
Coagulation factor XIII B chain (Fibrin-stabilizing factor B subunit) (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain)F13BP0516029
Cochlin (COCH-5B2)COCH COCH5B2 UNQ257/PRO294O4340529
Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1)COG5 GOLTC1 GTC90Q9UP8329
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)CDK4P1180229
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