EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Paralemmin-1 (Paralemmin)PALM KIAA0270O7578128
Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2)PM20D2 ACY1L2Q8IYS128
Phenazine biosynthesis-like domain-containing protein (EC 5.1.-.-) (MAWD-binding protein) (MAWDBP) (Unknown protein 32 from 2D-page of liver tissue)PBLD MAWBPP3003928
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)INPP5D SHIP SHIP1Q9283528
Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)PPP1R18 HKMT1098 KIAA1949Q6NYC828
Plexin-A4PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003Q9HCM228
Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232)PLXNC1 VESPRO6048628
Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)PNPT1 PNPASEQ8TCS828
Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27)DDX27 cPERP-F RHLP HSPC259 PP3241Q96GQ728
Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4)PGAM4 PGAM3Q8N0Y728
Probable phospholipid-transporting ATPase IH (EC 3.6.3.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A)ATP11A ATPIH ATPIS KIAA1021P9819628
Probable phospholipid-transporting ATPase IIA (EC 3.6.3.1) (ATPase class II type 9A)ATP9A ATPIIA KIAA0611O7511028
Protein CDV3 homologCDV3 H41Q9UKY728
Protein DDI1 homolog 2DDI2Q5TDH028
Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)TMX3 KIAA1830 TXNDC10Q96JJ728
Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)DPY30Q9C00528
Protein Hook homolog 3 (h-hook3) (hHK3)HOOK3Q86VS828
Protein spinster homolog 1 (HSpin1) (Spinster-like protein 1)SPNS1 SPIN1 PP20300Q9H2V728
Protein transport protein Sec16A (SEC16 homolog A)SEC16A KIAA0310 SEC16 SEC16LO1502728
Protein transport protein Sec24B (SEC24-related protein B)SEC24BO9548728
Protein-glutamine gamma-glutamyltransferase 4 (EC 2.3.2.13) (Fibrinoligase) (Prostate transglutaminase) (Prostate-specific transglutaminase) (Transglutaminase P) (TG(P)) (TGP) (TGase P) (Transglutaminase-4) (TGase-4)TGM4P4922128
Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein)TP53I3 PIG3Q53FA728
Ras-related protein Rap-1b-like protein0A6NIZ128
Resistin (Adipose tissue-specific secretory factor) (ADSF) (C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein) (Cysteine-rich secreted protein A12-alpha-like 2) (Cysteine-rich secreted protein FIZZ3)RETN FIZZ3 HXCP1 RSTN UNQ407/PRO1199Q9HD8928
SEC23-interacting protein (p125)SEC23IP MSTP053Q9Y6Y828
Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)SEMA7A CD108 SEMALO7532628
Semenogelin-2 (Semenogelin II) (SGII)SEMG2Q0238328
Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)RIOK1Q9BRS228
Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)PON2Q1516528
Skin-specific protein 32XP32 C1orf68Q5T75028
Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)SLC2A14 GLUT14 GLUT3Q8TDB828
Specifically androgen-regulated gene proteinSARG C1orf116Q9BW0428
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)SRPK1Q96SB428
Stromal cell-derived factor 2-like protein 1 (SDF2-like protein 1) (PWP1-interacting protein 8)SDF2L1 UNQ1941/PRO4424Q9HCN828
Target of Nesh-SH3 (Tarsh) (ABI gene family member 3-binding protein) (Nesh-binding protein) (NeshBP)ABI3BP NESHBP TARSHQ7Z7G028
TELO2-interacting protein 1 homolog (Protein SMG10)TTI1 KIAA0406 SMG10O4315628
Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6)THSD4 UNQ9334/PRO34005Q6ZMP028
Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4)BTF3L4Q96K1728
Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)UCK2 UMPKQ9BZX228
Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)VPS26BQ4G0F528
Zinc finger protein ZPR1 (Zinc finger protein 259)ZPR1 ZNF259O7531228
3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) (Aldo-keto reductase family 1 member D1) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase)AKR1D1 SRD5B1P5185727
Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)AGK MULKQ53H1227
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)MGAT2Q1046927
Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO)AOC1 ABP1 DAO1P1980127
Ankyrin-3 (ANK-3) (Ankyrin-G)ANK3Q1295527
Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4)SLPI WAP4 WFDC4P0397327
Armadillo repeat protein deleted in velo-cardio-facial syndromeARVCFO0019227
AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1O1449727
BystinBYSLQ1389527
Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)CPA4 CPA3 UNQ694/PRO1339Q9UI4227
Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)CSNK1G2 CK1G2P7836827
Chloride intracellular channel protein 5CLIC5Q9NZA127
Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)CIRBP A18HNRNP CIRPQ1401127
Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein)COG2 LDLCQ1474627
Cystatin-M (Cystatin-6) (Cystatin-E)CST6Q1582827
Deoxyhypusine synthase (DHS) (EC 2.5.1.46)DHPS DSP4936627
DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)POLR2J POLR2J1P5243527
DnaJ homolog subfamily C member 8 (Splicing protein spf31)DNAJC8 SPF31 HSPC315 HSPC331O7593727
Endosialin (Tumor endothelial marker 1) (CD antigen CD248)CD248 CD164L1 TEM1Q9HCU027
Exportin-4 (Exp4)XPO4 KIAA1721Q9C0E227
G-rich sequence factor 1 (GRSF-1)GRSF1Q1284927
Gamma-glutamyltransferase 5 (GGT 5) (EC 2.3.2.2) (Gamma-glutamyl transpeptidase-related enzyme) (GGT-rel) (Gamma-glutamyltransferase-like activity 1) (Gamma-glutamyltranspeptidase 5) (Glutathione hydrolase 5) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) [Cleaved into: Gamma-glutamyltransferase 5 heavy chain; Gamma-glutamyltransferase 5 light chain]GGT5 GGTLA1P3626927
Gigaxonin (Kelch-like protein 16)GAN GAN1 KLHL16Q9H2C027
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)CCDC88A APE GRDN KIAA1212Q3V6T227
Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2)GSTA2 GST2P0921027
Hepatocyte growth factor activator (HGF activator) (HGFA) (EC 3.4.21.-) [Cleaved into: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain]HGFACQ0475627
HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a)HIGD1A HIG1 HSPC010Q9Y24127
Histone H3HIST2H3PS2 RP5-998N21.6-001Q5TEC627
HLA class I histocompatibility antigen, A-80 alpha chain (Aw-80) (HLA class I histocompatibility antigen, A-1 alpha chain) (MHC class I antigen A*80)HLA-A HLAAQ0916027
HLA class I histocompatibility antigen, B-13 alpha chain (MHC class I antigen B*13)HLA-B HLABP3046127
HLA class I histocompatibility antigen, B-38 alpha chain (Bw-4) (MHC class I antigen B*38)HLA-B HLABQ9536527
HLA class I histocompatibility antigen, B-48 alpha chain (Bw-48) (MHC class I antigen B*48)HLA-B HLABP3048627
Immunoglobulin heavy variable 1-2 (Ig heavy chain V-I region ND) (Ig heavy chain V-I region V35)IGHV1-2P2308327
Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)ITGAX CD11CP2070227
Intercellular adhesion molecule 2 (ICAM-2) (CD antigen CD102)ICAM2P1359827
Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4)IFT27 RABL4 RAYLQ9BW8327
Keratin, type I cytoskeletal 25 (Cytokeratin-25) (CK-25) (Keratin-25) (K25) (Keratin-25A) (K25A) (Type I inner root sheath-specific keratin-K25irs1)KRT25 KRT25AQ7Z3Z027
Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein)CRYM THBPQ1489427
Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)KIF20A MKLP2 RAB6KIFLO9523527
Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A)KIF3A KIF3Q9Y49627
Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)CES1 CES2 SES1P2314127
Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)MMP7 MPSL1 PUMP1P0923727
Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)TOMM20 KIAA0016Q1538827
Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)MSRAQ9UJ6827
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)MEGF8 C19orf49 EGFL4 KIAA0817Q7Z7M027
N-acetylgalactosaminyltransferase 7 (EC 2.4.1.-) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7)GALNT7Q86SF227
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)NEFL NF68 NFLP0719627
Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)BPTF FAC1 FALZQ1283027
Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)OSBPL9 ORP9 OSBP4Q96SU427
Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)VNN1O9549727
Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)PDCL3 PhLP2A VIAF1Q9H2J427
Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)GPLD1 PIGPLD1P8010827
Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)PIEZO1 FAM38A KIAA0233Q9250827
Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))]PPBP CTAP3 CXCL7 SCYB7 TGB1 THBGB1P0277527
Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Polypeptide GalNAc transferase 3) (GalNAc-T3) (pp-GaNTase 3) (Protein-UDP acetylgalactosaminyltransferase 3) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3)GALNT3Q1443527
Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)ATP4AP2064827
Protein FAM151AFAM151A C1orf179 UNQ3034/PRO9836Q8WW5227
Protein NipSnap homolog 3A (NipSnap3A) (Protein NipSnap homolog 4) (NipSnap4) (Target for Salmonella secreted protein C) (TassC)NIPSNAP3A NIPSNAP4 HSPC299Q9UFN027
Protein transport protein Sec61 subunit gammaSEC61GP6005927
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