EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC)TBCCQ1581425
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)CD40 TNFRSF5P2594225
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)FGR SRC2P0976925
Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)UBE4B HDNB1 KIAA0684 UFD2O9515525
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)UBE2D2 PUBC1 UBC4 UBC5B UBCH4 UBCH5BP6283725
Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (D8) (Ubiquitin-activating enzyme E1 homolog)UBA7 UBE1L UBE2P4122625
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)UBE2L6 UBCH8O1493325
Uncharacterized protein KIAA1109 (Fragile site-associated protein)KIAA1109 FSA KIAA1371Q2LD3725
UPF0505 protein C16orf62 (Esophageal cancer-associated protein)C16orf62 101F10.2Q7Z3J225
WD repeat and FYVE domain-containing protein 1 (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)WDFY1 KIAA1435 WDF1 ZFYVE17Q8IWB725
Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4)ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730Q8WU9025
Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)ZC3H18 NHN1Q86VM925
40S ribosomal protein S8RPS8Q5JR9524
Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.2) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase)ACOT1 CTE1Q86TX224
Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)ADCY7 KIAA0037P5182824
AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)AFG3L2Q9Y4W624
Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)LRPAP1 A2MRAPP3053324
Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B)NAGAP1705024
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1)APBB1IP PREL1 RARP1 RIAMQ7Z5R624
Apolipoprotein L2 (Apolipoprotein L-II) (ApoL-II)APOL2Q9BQE524
Armadillo repeat-containing protein 10 (Splicing variant involved in hepatocarcinogenesis protein)ARMC10 SVH PSEC0198Q8N2F624
Bcl-2-associated transcription factor 1 (Btf)BCLAF1 BTF KIAA0164Q9NYF824
BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)BABAM1 C19orf62 MERIT40 NBA1 HSPC142Q9NWV824
C-reactive protein [Cleaved into: C-reactive protein(1-205)]CRP PTX1P0274124
Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)SLC25A12 ARALAR1O7574624
cAMP-dependent protein kinase type II-beta regulatory subunitPRKAR2BP3132324
Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2)ABCC2 CMOAT CMOAT1 CMRP MRP2Q9288724
Cathepsin F (CATSF) (EC 3.4.22.41)CTSFQ9UBX124
CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)CLASP2 KIAA0627O7512224
Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34)COLEC10 CLL1 UNQ366/PRO702Q9Y6Z724
Copper transport protein ATOX1 (Metal transport protein ATX1)ATOX1 HAH1O0024424
Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Menkes disease-associated protein)ATP7A MC1 MNKQ0465624
Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (M-CK) [Cleaved into: Creatine kinase M-type, N-terminally processed]CKM CKMMP0673224
Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)NCK1 NCKP1633324
DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)APPL2 DIP13BQ8NEU824
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)DSC2 CDHF2 DSC3Q0248724
Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)DLG3 KIAA1232Q9279624
DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125)POLD1 POLDP2834024
DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)DNAJB2 HSJ1 HSPF3P2568624
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1)HECTD1 KIAA1131Q9ULT824
E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)MGRN1 KIAA0544 RNF156O6029124
Engulfment and cell motility protein 1 (Protein ced-12 homolog)ELMO1 KIAA0281Q9255624
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)PTK2 FAK FAK1Q0539724
Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)LGALS4P5647024
Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1)PGM2L1 BM32AQ6PCE324
Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)GNAZP1908624
HLA class I histocompatibility antigen, B-37 alpha chain (MHC class I antigen B*37)HLA-B HLABP1846324
HLA class I histocompatibility antigen, Cw-16 alpha chain (MHC class I antigen Cw*16)HLA-C HLACQ2996024
Immunoglobulin heavy variable 4-34 (Ig heavy chain V-II region ARH-77)IGHV4-34P0633124
Immunoglobulin kappa variable 3-15 (Ig kappa chain V-III region CLL) (Ig kappa chain V-III region POM)IGKV3-15P0162424
Immunoglobulin lambda constant 1 (Ig lambda chain C region MGC) (Ig lambda-1 chain C region)IGLC1P0CG0424
Immunoglobulin lambda variable 7-43 (Ig lambda chain V region 4A)IGLV7-43P0421124
Inner centromere proteinINCENPQ9NQS724
Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)IGFBP6 IBP6P2459224
Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)ILKAPQ9H0C824
Intraflagellar transport protein 20 homolog (hIFT20)IFT20Q8IY3124
Keratin, type II cytoskeletal 71 (Cytokeratin-71) (CK-71) (Keratin-71) (K71) (Type II inner root sheath-specific keratin-K6irs1) (Keratin 6 irs) (hK6irs) (hK6irs1) (Type-II keratin Kb34)KRT71 K6IRS1 KB34 KRT6IRS1Q3SY8424
Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III)KYAT3 CCBL2 KAT3Q6YP2124
Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]TMPO LAP2P4216724
Lymphocyte antigen 75 (Ly-75) (C-type lectin domain family 13 member B) (DEC-205) (gp200-MR6) (CD antigen CD205)LY75 CD205 CLEC13BO6044924
Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15)MPDU1O7535224
Microtubule-associated protein 1S (MAP-1S) (BPY2-interacting protein 1) (Microtubule-associated protein 8) (Variable charge Y chromosome 2-interacting protein 1) (VCY2-interacting protein 1) (VCY2IP-1) [Cleaved into: MAP1S heavy chain; MAP1S light chain]MAP1S BPY2IP1 C19orf5 MAP8 VCY2IP1Q66K7424
N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)RENBPP5160624
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit)NDUFA8P5197024
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (TYKY subunit)NDUFS8O0021724
Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2)NCAM2 NCAM21O1539424
NeurofascinNFASC KIAA0756O9485624
Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)SLC3A1 RBATQ0783724
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)IKBKG FIP3 NEMOQ9Y6K924
Notchless protein homolog 1NLE1 HUSSY-07Q9NVX224
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)OPTN FIP2 GLC1E HIP7 HYPL NRPQ96CV924
Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)GP2P5525924
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)PAPPAQ1321924
Periodic tryptophan protein 2 homologPWP2 PWP2HQ1526924
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)INPPL1 SHIP2O1535724
Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (Antigen CD42b-alpha) (CD antigen CD42b) [Cleaved into: Glycocalicin]GP1BAP0735924
Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1)PTBP3 ROD1O9575824
Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein)PBXIP1 HPIPQ96AQ624
Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)OSGEP GCPL1Q9NPF424
Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)DIAPH2 DIAO6087924
Protein FAM127A (Mammalian retrotransposon derived protein 8C)FAM127A CXX1 MAR8 MAR8C MART8A6ZKI324
RAP1A, member of RAS oncogene family (Ras-related protein Rap-1A) (cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA)RAP1A hCG_1818872A8KAH924
Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)RICTOR KIAA1999Q6R32724
Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))ALDH1A2 RALDH2O9478824
Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein)RARRES2 TIG2Q9996924
Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)BOP1 KIAA0124Q1413724
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (EC 2.1.1.-) (Protein-glutamine methyltransferase)FBLL1A6NHQ224
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)PKN1 PAK1 PKN PRK1 PRKCL1Q1651224
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)WNK1 HSN2 KDP KIAA0344 PRKWNK1Q9H4A324
Smoothened homolog (SMO) (Protein Gx)SMO SMOHQ9983524
Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)SLC9A1 APNH1 NHE1P1963424
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D)SSC5DA1L4H124
Solute carrier family 22 member 13 (Organic cation transporter-like 3) (ORCTL-3)SLC22A13 OCTL1 ORCTL3Q9Y22624
SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1)SMOC1Q9H4F824
Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9)SAMD9 C7orf5 DRIF1 KIAA2004 OEF1Q5K65124
Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]SIP1441024
Synaptic functional regulator FMR1 (Fragile X mental retardation protein 1) (FMRP) (Protein FMR-1)FMR1Q0678724
Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25)SYNJ2BP OMP25P5710524
Syntaxin-10 (Syn10)STX10 SYN10O6049924
TBC1 domain family member 24TBC1D24 KIAA1171Q9ULP924
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