EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
TetraspaninCD9A6NNI424
Tetraspanin-11 (Tspan-11)TSPAN11A1L15724
Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231)TSPAN7 A15 DXS1692E MXS1 TM4SF2P4173224
Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog)ENY2 DC6Q9NPA824
Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)TGFBRAP1Q8WUH224
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)UBQLN1 DA41 PLIC1Q9UMX024
YTH domain-containing family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)YTHDF2 HGRG8Q9Y5A924
28S ribosomal protein S29, mitochondrial (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3) (Ionizing radiation resistance conferring protein) (Mitochondrial small ribosomal subunit protein mS29)DAP3 MRPS29P5139823
39S ribosomal protein L43, mitochondrial (L43mt) (MRP-L43) (Mitochondrial large ribosomal subunit protein mL43) (Mitochondrial ribosomal protein bMRP36a)MRPL43Q8N98323
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]PFKFB2O6082523
7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Putative sterol reductase SR-2) (Sterol Delta(7)-reductase)DHCR7 D7SRQ9UBM723
Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein)FIBPO4342723
Adiponectin (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte, C1q and collagen domain-containing protein) (Adipose most abundant gene transcript 1 protein) (apM-1) (Gelatin-binding protein)ADIPOQ ACDC ACRP30 APM1 GBP28Q1584823
Alkaline phosphatase, placental-like (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like)ALPPL2 ALPPLP1069623
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)SNCA NACP PARK1P3784023
Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)DDC AADCP2071123
ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)ABCA1 ABC1 CERPO9547723
ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)DDX3Y DBYO1552323
Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP) (hHBP)AZU1P2016023
Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Bucelipase) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase)CEL BALP1983523
Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)CDH11P5528723
Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1)CSNK1G1Q9HCP023
CDC42 small effector protein 1 (CDC42-binding protein SCIP1) (Small effector of CDC42 protein 1)CDC42SE1 SPEC1Q9NRR823
Coiled-coil domain-containing protein 124CCDC124Q96CT723
Collagen alpha-1(XVI) chainCOL16A1 FP1572Q0709223
Complement C1q tumor necrosis factor-related protein 1 (G protein-coupled receptor-interacting protein) (GIP)C1QTNF1 CTRP1 UNQ310/PRO353Q9BXJ123
Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8)COG8Q96MW523
CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)CTDSPL C3orf8 NIF1 NIFL SCP3 YA22O1519423
DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1)ZNF326 ZIRDQ5BKZ123
DesminDESP1766123
Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3)CRMP1 DPYSL1 ULIP3Q1419423
DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)POLE3 CHRAC17Q9NRF923
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)MAP2K3 MEK3 MKK3 PRKMK3 SKK2P4673423
Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39)ENTPD1 CD39P4996123
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)MAN1B1 UNQ747/PRO1477Q9UKM723
Endothelial cell-selective adhesion moleculeESAM UNQ220/PRO246Q96AP723
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)EPHB1 ELK EPHT2 HEK6 NETP5476223
Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)EIF4G3O4343223
Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2)EIF5A2Q9GZV423
Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) [Cleaved into: Processed exostosin-like 2]EXTL2 EXTR2Q9UBQ623
Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens (human) (Fragment)0Q86SX123
FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like)FXYD3 MAT8 PLMLQ1480223
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)GABARAP FLC3B HT004O9516623
Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)GCSHP2343423
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4GNG4 GNGT4P5015023
Histone H2A type 3HIST3H2AQ7L7L023
Histone H2B type 1-O (Histone H2B.2) (Histone H2B.n) (H2B/n)HIST1H2BO H2BFH H2BFNP2352723
HLA class I histocompatibility antigen, Cw-15 alpha chain (MHC class I antigen Cw*15)HLA-C HLACQ0700023
HLA class I histocompatibility antigen, Cw-18 alpha chain (MHC class I antigen Cw*18)HLA-C HLACQ2986523
HLA class I histocompatibility antigen, Cw-4 alpha chain (MHC class I antigen Cw*4)HLA-C HLACP3050423
HLA class II histocompatibility antigen, DRB1-1 beta chain (MHC class II antigen DRB1*1) (DR-1) (DR1)HLA-DRB1P0422923
Immunoglobulin kappa variable 1-17 (Ig kappa chain V-I region Gal) (Ig kappa chain V-I region WEA)IGKV1-17P0161023
Immunoglobulin kappa variable 2D-28 (Ig kappa chain V-II region FR) (Ig kappa chain V-II region GM607) (Ig kappa chain V-II region MIL) (Ig kappa chain V-II region TEW)IGKV2D-28P0161723
Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 3.6.4.3) (p60 katanin)KATNA1O7544923
Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62)KIF21A KIAA1708 KIF2Q7Z4S623
L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (Protein Fig-1) (hFIG1)IL4I1 FIG1 UNQ636/PRO1265Q96RQ923
Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)LGMN PRSC1Q9953823
Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)CD53 MOX44 TSPAN25P1939723
Major facilitator superfamily domain-containing protein 1 (Smooth muscle cell-associated protein 4) (SMAP-4)MFSD1 SMAP4 UG0581B09Q9H3U523
Melanoma inhibitory activity protein 3 (C219-reactive peptide) (D320) (Transport and Golgi organization protein 1)MIA3 KIAA0268 TANGO TANGO1 UNQ6077/PRO20088Q5JRA623
Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10)SLC25A10 DICQ9UBX323
MyoglobinMBP0214423
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit)NDUFS5O4392023
NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)NDFIP2 KIAA1165 N4WBP5AQ9NV9223
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)WWP1Q9H0M023
Negative elongation factor B (NELF-B) (Cofactor of BRCA1)NELFB COBRA1 KIAA1182Q8WX9223
Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)NPNT EGFL6L POEM UNQ295/PRO334Q6UXI923
NeurochondrinNCDN KIAA0607Q9UBB623
Neuronal membrane glycoprotein M6-b (M6b)GPM6B M6BQ1349123
Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serpin I1)SERPINI1 PI12Q9957423
Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]DEFA3 DEF3P5966623
Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)NUP214 CAIN CAN KIAA0023P3565823
P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)SELPLGQ1424223
Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S)PGLYRP1 PGLYRP PGRP TNFSF3L SBBI68 UNQ639/PRO1269O7559423
Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase)PAHP0043923
Pleiotropic regulator 1PLRG1O4366023
Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2)PARP14 BAL2 KIAA1268Q460N523
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)XAB2 HCNP KIAA1177 SYF1 PP3898Q9HCS723
Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)DDX58O9578623
Probable Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)XPNPEP3Q9NQH723
Properdin (Complement factor P)CFP PFCP2791823
Protein FAM49AFAM49AQ9H0Q023
Protein unc-119 homolog BUNC119BA6NIH723
Proton-coupled amino acid transporter 2 (Proton/amino acid transporter 2) (Solute carrier family 36 member 2) (Tramdorin-1)SLC36A2 PAT2 TRAMD1Q495M323
Putative phospholipase B-like 2 (EC 3.1.1.-) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form]PLBD2Q8NHP823
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16)DHX16 DBP2 DDX16 KIAA0577O6023123
Putative tubulin-like protein alpha-4B (Alpha-tubulin 4B)TUBA4B TUBA4Q9H85323
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)REPS1Q96D7123
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1Q70E7323
Ras-related protein M-Ras (Ras-related protein R-Ras3)MRAS RRAS3O1480723
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)PTPRO GLEPP1 PTPU2Q1682723
S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III)MAT1A AMS1 MATA1Q0026623
SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)SCYL2 CVAK104 KIAA1360Q6P3W723
Semaphorin-3B (Sema A(V)) (Semaphorin-V) (Sema V)SEMA3B SEMA5 SEMAAQ1321423
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)ATMQ1331523
Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)SLC15A2 PEPT2Q1634823
Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)SLC26A6Q9BXS923
Stimulated by retinoic acid gene 6 protein homologSTRA6 PP14296 UNQ3126/PRO10282/PRO19578Q9BX7923
Survival motor neuron protein (Component of gems 1) (Gemin-1)SMN1 SMN SMNT; SMN2 SMNCQ1663723
Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50)VPS50 CCDC132 KIAA1861Q96JG623
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