EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)TBC1D15Q8TC0723
Thymocyte nuclear protein 1 (Thymocyte protein Thy28)THYN1 THY28 HSPC144 MDS012 My0054Q9P01623
Thymosin beta-10TMSB10 PTMB10 THYB10P6331323
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)ATRX RAD54L XH2P4610023
Transmembrane protein 50A (Small membrane protein 1)TMEM50A SMP1 UNQ386/PRO718O9580723
tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase)METTL1 C12orf1Q9UBP623
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)BTK AGMX1 ATK BPKQ0618723
Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]UBE2G1 UBE2GP6225323
Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)VMA21 MEAX XMEAQ3ZAQ723
Visinin-like protein 1 (VILIP) (VLP-1) (Hippocalcin-like protein 3) (HLP3)VSNL1 VISL1P6276023
WD repeat-containing protein 18WDR18Q9BV3823
Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1)SLC39A1 IRT1 ZIP1 ZIRTL CGI-08 CGI-71Q9NY2623
39S ribosomal protein L11, mitochondrial (L11mt) (MRP-L11) (Mitochondrial large ribosomal subunit protein uL11m)MRPL11 CGI-113Q9Y3B722
39S ribosomal protein L13, mitochondrial (L13mt) (MRP-L13) (Mitochondrial large ribosomal subunit protein uL13m)MRPL13Q9BYD122
40S ribosomal protein S4, Y isoform 1 (Small ribosomal subunit protein eS4)RPS4Y1 RPS4Y PRO2646P2209022
Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)NDUFAB1O1456122
ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)ARFGAP1 ARF1GAPQ8N6T322
Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-)AOX1 AOQ0627822
Apoptosis-inducing factor 2 (EC 1.-.-.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (Apoptosis-inducing factor-like mitochondrion-associated inducer of death) (p53-responsive gene 3 protein)AIFM2 AMID PRG3Q9BRQ822
Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein)AGFG1 HRB RAB RIPP5259422
ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338)ABCG2 ABCP BCRP BCRP1 MXRQ9UNQ022
Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)NPR1 ANPRAP1606622
BRI3-binding protein (I3-binding protein) (Cervical cancer 1 proto-oncogene-binding protein KG19) (HCCRBP-1)BRI3BP KG19Q8WY2222
Chloride intracellular channel protein 2 (XAP121)CLIC2O1524722
Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1)CHD1O1464622
Chromogranin-A (CgA) (Pituitary secretory protein I) (SP-I) [Cleaved into: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; Catestatin (SL21); AL-11; GV-19; GR-44; ER-37; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]CHGAP1064522
Claudin-2 (SP82)CLDN2 PSEC0059 SP82 UNQ705/PRO1356P5773922
Claudin-7 (CLDN-7)CLDN7 CEPTRL2 CPETRL2O9547122
Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)CPSF2 CPSF100 KIAA1367Q9P2I022
Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64)CSTF2P3324022
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP)CHCHD2 C7orf17 AAG10Q9Y6H122
COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG)COMMD5 HT002Q9GZQ322
Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)NCAPH BRRN BRRN1 CAPH KIAA0074Q1500322
Crooked neck-like protein 1 (Crooked neck homolog) (hCrn)CRNKL1 CRN CGI-201 MSTP021Q9BZJ022
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)CDKN2A CDKN2 MTS1P4277122
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)ALDH4A1 ALDH4 P5CDHP3003822
Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)DEF6 IBPQ9H4E722
DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD)DFFA DFF1 DFF45 H13O0027322
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)POLR2LP6287522
Dynactin subunit 5 (Dynactin subunit p25)DCTN5Q9BTE122
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (RING-type E3 ubiquitin transferase TRIM21) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)TRIM21 RNF81 RO52 SSA1P1947422
Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1)ELOVL1 SSC1 CGI-88Q9BW6022
EmbiginEMBQ6PCB822
ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)KDELR2 ERD2.2P3394722
Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)EXOC6 SEC15A SEC15L SEC15L1Q8TAG922
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)EXOSC8 OIP2 RRP43Q96B2622
Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP)FABP1 FABPLP0714822
FRAS1-related extracellular matrix protein 2 (ECM3 homolog)FREM2Q5SZK822
Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97)GEMIN4P5767822
Hematological and neurological expressed 1-like protein (HN1-like protein)HN1L C16orf34 L11Q9H91022
High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)FCER1GP3027322
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)HMGA2 HMGICP5292622
HIV Tat-specific factor 1 (Tat-SF1)HTATSF1O4371922
HLA class II histocompatibility antigen, DRB1-15 beta chain (DW2.2/DR2.2) (MHC class II antigen DRB1*15)HLA-DRB1 HLA-DRB2P0191122
Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)HIP1R HIP12 KIAA0655O7514622
Immunoglobulin heavy variable 3-23 (Ig heavy chain V-III region LAY) (Ig heavy chain V-III region POM) (Ig heavy chain V-III region TEI) (Ig heavy chain V-III region TIL) (Ig heavy chain V-III region TUR) (Ig heavy chain V-III region VH26) (Ig heavy chain V-III region WAS) (Ig heavy chain V-III region ZAP)IGHV3-23P0176522
Immunoglobulin heavy variable 3-30 (Ig heavy chain V-III region BUR) (Ig heavy chain V-III region CAM) (Ig heavy chain V-III region GA) (Ig heavy chain V-III region NIE)IGHV3-30P0176822
Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Interferon-inducible protein 1-8D)IFITM2Q0162922
Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)IL18 IGIF IL1F4Q1411622
Keratin, type II cuticular Hb2 (Keratin-82) (K82) (Type II hair keratin Hb2) (Type-II keratin Kb22)KRT82 KRTHB2Q9NSB422
Low-density lipoprotein receptor-related protein 5 (LRP-5)LRP5 LR3 LRP7O7519722
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)LRP8 APOER2Q1411422
Lysyl oxidase homolog 1 (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL)LOXL1 LOXLQ0839722
Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) [Cleaved into: Processed macrophage colony-stimulating factor 1]CSF1P0960322
Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)AOC3 VAP1Q1685322
Methyltransferase-like protein 7A (EC 2.1.1.-) (Protein AAM-B)METTL7A PRO0066 UNQ1902/PRO4348Q9H8H322
Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)MFAP2 MAGP1P5500122
Mimitin, mitochondrial (B17.2-like) (B17.2L) (Myc-induced mitochondrial protein) (MMTN) (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2) (NDUFA12-like protein)NDUFAF2 NDUFA12LQ8N18322
Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)TIMM8A DDP DDP1 TIM8AO6022022
Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)MBNL1 EXP KIAA0428 MBNLQ9NR5622
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit)NDUFV1 UQOR1P4982122
Non-secretory ribonuclease (EC 3.1.27.5) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)RNASE2 EDN RNS2P1015322
Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)NUP107P5774022
Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155)NUP155 KIAA0791O7569422
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)NUCKS1 NUCKS JC7Q9H1E322
O-acetyl-ADP-ribose deacetylase 1 (EC 3.5.1.-)OARD1 C6orf130Q9Y53022
ORM1-like protein 1 (Adoplin-1)ORMDL1 HSPC202Q9P0S322
ParathymosinPTMSP2096222
Peptidyl-prolyl cis-trans isomerase FKBP11 (PPIase FKBP11) (EC 5.2.1.8) (19 kDa FK506-binding protein) (19 kDa FKBP) (FKBP-19) (FK506-binding protein 11) (FKBP-11) (Rotamase)FKBP11 FKBP19 UNQ336/PRO535Q9NYL422
Peripherin (Neurofilament 4)PRPH NEF4 PRPH1P4121922
Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2)YTHDC2Q9H6S022
Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)SETX ALS4 KIAA0625 SCAR1Q7Z33322
Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)KLK3 APSP0728822
Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)KIAA1524 CIP2AQ8TCG122
Protein lunaparkLNP KIAA1715Q9C0E822
Protein POF1B (Premature ovarian failure protein 1B)POF1BQ8WVV422
Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1)PRRC1Q96M2722
Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)PDXDC1 KIAA0251Q6P99622
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)AKT1 PKB RACP3174922
Ras-related protein Rab-3CRAB3CQ96E1722
Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B)RNASEH2B DLEU8Q5TBB122
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)RNPS1 LDC2Q1528722
Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)ROBO1 DUTT1Q9Y6N722
Semaphorin-5A (Semaphorin-F) (Sema F)SEMA5A SEMAFQ1359122
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)PRPF4B KIAA0536 PRP4 PRP4H PRP4KQ1352322
Serum amyloid A-2 protein (SAA2)SAA2P0DJI922
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43P6316522
Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)SLC5A2 SGLT2P3163922
Sorting nexin-4SNX4O9521922
Sorting nexin-8SNX8Q9Y5X222
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