EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Spermatogenesis-associated protein 5 (ATPase family protein 2 homolog) (Spermatogenesis-associated factor protein)SPATA5 AFG2 SPAFQ8NB9022
THUMP domain-containing protein 3THUMPD3Q9BV4422
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)RELA NFKB3Q0420622
Tubulin beta chain0Q8IWP622
Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2)TUSC2 C3orf11 FUS1 LGCC PDAP2O7589622
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)LSM1 CASMO1511622
Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47)USP47Q96K7622
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)UBE2HP6225622
USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)USP6NL KIAA0019Q9273822
V-type proton ATPase 116 kDa subunit a isoform 2 (V-ATPase 116 kDa isoform a2) (Lysosomal H(+)-transporting ATPase V0 subunit a2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)ATP6V0A2Q9Y48722
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)FLT1 FLT FRT VEGFR1P1794822
WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP)WDR36Q8NI3622
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)WDR5 BIG3P6196422
WD repeat-containing protein 6WDR6Q9NNW522
Zinc finger protein 185 (LIM domain protein ZNF185) (P1-A)ZNF185O1523122
28S ribosomal protein S28, mitochondrial (MRP-S28) (S28mt) (28S ribosomal protein S35, mitochondrial) (MRP-S35) (S35mt) (Mitochondrial small ribosomal subunit protein bS1m)MRPS28 MRPS35 HSPC007Q9Y2Q921
28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt)MRPS36 DC47P8290921
4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase)HPD PPDP3275421
Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)AARSD1Q9BTE621
Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.-) (Fat mass and obesity-associated protein)FTO KIAA1752Q9C0B121
Annexin A8 (Annexin VIII) (Annexin-8) (Vascular anticoagulant-beta) (VAC-beta)ANXA8 ANX8P1392821
Apoptotic chromatin condensation inducer in the nucleus (Acinus)ACIN1 ACINUS KIAA0670Q9UKV321
Autophagy-related protein 9A (APG9-like 1) (mATG9)ATG9A APG9L1Q7Z3C621
Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase)CNDP1 CN1 CPGL2 UNQ1915/PRO4380Q96KN221
BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl)BPIFA1 LUNX NASG PLUNC SPLUNC1 SPURT UNQ787/PRO1606Q9NP5521
Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)CPS1P3132721
Cartilage intermediate layer protein 2 (CILP-2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2]CILP2Q8IUL821
Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)SLC7A2 ATRC2 CAT2P5256921
CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)CD48 BCM1 BLAST1P0932621
cDNA FLJ75422, highly similar to Homo sapiens capping protein (actin filament) muscle Z-line, alpha 1, mRNA0A8K0T921
cDNA FLJ75881, highly similar to Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA0A8K6Q821
Coiled-coil domain-containing protein 25CCDC25Q86WR021
Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1)CST4P0103621
Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagin-1) (Autophagy-related cysteine endopeptidase 1) (Autophagy-related protein 4 homolog B) (hAPG4B)ATG4B APG4B AUTL1 KIAA0943Q9Y4P121
Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa)DNASE1 DNL1 DRNIP2485521
Disrupted in renal carcinoma protein 2 (Disrupted in renal cancer protein 2)DIRC2Q96SL121
DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]DNAJC2 MPHOSPH11 MPP11 ZRF1Q9954321
Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)DRAP1Q1491921
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)DTX3L BBAPQ8TDB621
E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294)LTN1 C21orf10 C21orf98 KIAA0714 RNF160 ZNF294 HSPC087O9482221
Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP)ERAP2 LRAPQ6P17921
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)EIF3F EIF3S5 hCG_1784554B3KSH121
Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactocerebroside beta-galactosidase) (Galactosylceramidase) (Galactosylceramide beta-galactosidase)GALCP5480321
Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1)GLIPR1 GLIPR RTVP1P4806021
GRIP1-associated protein 1 (GRASP-1)GRIPAP1 KIAA1167Q4V32821
Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)GNAT2 GNATCP1908721
Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III)HK3P5279021
Histone H4HIST1H4L HIST1H4H HIST1H4J hCG_1640981B2R4R021
HLA class I histocompatibility antigen, A-36 alpha chain (Aw-36) (MHC class I antigen A*36)HLA-A HLAAP3045521
HLA class I histocompatibility antigen, B-42 alpha chain (MHC class I antigen B*42)HLA-B HLABP3048021
HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74)CD74 DHLAGP0423321
HLA class II histocompatibility antigen, DRB1-8 beta chain (MHC class II antigen DRB1*8) (DR-8) (DR8) (DRw8)HLA-DRB1Q3013421
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)HIP1O0029121
Immunoglobulin kappa variable 1-5 (Ig kappa chain V-I region CAR) (Ig kappa chain V-I region EU) (Ig kappa chain V-I region HK102) (Ig kappa chain V-I region Kue)IGKV1-5P0159821
Immunoglobulin kappa variable 1D-33 (Ig kappa chain V-I region AG) (Ig kappa chain V-I region Bi) (Ig kappa chain V-I region Lay) (Ig kappa chain V-I region Ni) (Ig kappa chain V-I region Rei) (Ig kappa chain V-I region Roy) (Ig kappa chain V-I region Scw) (Ig kappa chain V-I region WAT)IGKV1D-33P0161321
Immunoglobulin superfamily containing leucine-rich repeat proteinISLR UNQ189/PRO215O1449821
Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)RHBDF2 IRHOM2 RHBDL5 RHBDL6Q6PJF521
Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)INHBAP0847621
Integrin alpha-11ITGA11 MSTP018Q9UKX521
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)IFIT2 CIG-42 G10P2 IFI54 ISG54P0991321
Keratin, type II cuticular Hb3 (Hair keratin K2.10) (Keratin-83) (K83) (Type II hair keratin Hb3) (Type-II keratin Kb23)KRT83 KRTHB3P7838521
Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)SLC7A8 LAT2Q9UHI521
Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)FLRT3 KIAA1469 UNQ856/PRO1865Q9NZU021
Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib)LRRC15 LIBQ8TF6621
Lymphocyte-specific protein 1 (47 kDa actin-binding protein) (52 kDa phosphoprotein) (pp52) (Lymphocyte-specific antigen WP34)LSP1 WP34P3324121
Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin)MBL2 COLEC1 MBLP1122621
Meteorin-like protein (Subfatin)METRNLQ641Q321
Mevalonate kinase (MK) (EC 2.7.1.36)MVKQ0342621
MLN64 N-terminal domain homolog (STARD3 N-terminal-like protein)STARD3NL MENTHO UNQ855/PRO1864O9577221
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)NDUFA9 NDUFS2LQ1679521
Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1)NUP85 NUP75 PCNT1Q9BW2721
P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor)P2RX4Q9957121
PaladinPALD1 KIAA1274 PALDQ9ULE621
PapilinPAPLN UNQ2420/PRO4977O9542821
Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32)PCK1 PEPCK1P3555821
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)PAG1 CBP PAGQ9NWQ821
PodocinNPHS2Q9NP8521
Poly(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) (ADP-ribosylhydrolase 3) ([Protein ADP-ribosylarginine] hydrolase-like protein 2)ADPRHL2 ARH3Q9NX4621
Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4)HERC4 KIAA1593Q5GLZ821
Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9)GPX8 UNQ847/PRO1785Q8TED121
Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40)EBNA1BP2 EBP2Q9984821
Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1)PTGS1 COX1P2321921
Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog)BUD31 EDG2P4122321
Protein TSSC1 (EARP-interacting protein) (Endosome-associated recycling protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein)EIPR1 TSSC1Q53HC921
Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase)PUDP DXF68S1E FAM16AX GS1 HDHD1 HDHD1AQ0862321
Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc)HSP90AB3P HSP90BCQ58FF721
Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)PTPRDP2346821
Rho guanine nucleotide exchange factor 39ARHGEF39 C9orf100Q8N4T421
RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)CTR9 KIAA0155 SH2BP1Q6PD6221
RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)RBM12 KIAA0765 HRIHFB2091Q9NTZ621
RNA-binding protein 28 (RNA-binding motif protein 28)RBM28Q9NW1321
RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)RBM4 RBM4AQ9BWF321
Roundabout homolog 4 (Magic roundabout)ROBO4 UNQ421/PRO3674Q8WZ7521
Scaffold attachment factor B2 (SAF-B2)SAFB2 KIAA0138Q1415121
SHC SH2 domain-binding protein 1SHCBP1Q8NEM221
Ski-like protein (Ski-related oncogene) (Ski-related protein)SKIL SNOP1275721
Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin)SPRR3 SPRCQ9UBC921
Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)SLC5A1 NAGT SGLT1P1386621
Stromal cell-derived factor 2 (SDF-2)SDF2Q9947021
Sulfiredoxin-1 (EC 1.8.98.2)SRXN1 C20orf139 SRXQ9BYN021
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