EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)SMARCB1 BAF47 INI1 SNF5L1Q1282421
Syntaxin-11STX11O7555821
TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)TMF1 ARA160P8209421
TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)TBC1D4 AS160 KIAA0603O6034321
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)RIF1Q5UIP021
Tetratricopeptide repeat protein 7A (TPR repeat protein 7A)TTC7A KIAA1140 TTC7Q9ULT021
THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)THOC7 NIF3L1BP1Q6I9Y221
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)TRPM4 LTRPC4Q8TD4321
Transmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)TMED1 IL1RL1L IL1RL1LGQ1344521
Transmembrane protein 9 (Dermal papilla-derived protein 4)TMEM9 DERP4 TMEM9A HSPC186 PSEC0012 UNQ631/PRO1248Q9P0T721
Transmembrane protein 97 (Meningioma-associated protein 30)TMEM97 MAC30Q5BJF221
Triosephosphate isomerase (EC 5.3.1.1) (Fragment)0Q53HE221
Tripartite motif-containing protein 16 (Estrogen-responsive B box protein)TRIM16 EBBPO9536121
Type II inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II)INPP4BO1532721
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)UBE3A E6AP EPVE6AP HPVE6AQ0508621
Upstream-binding factor 1-like protein 1UBTFL1 C11orf27P0CB4721
Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)UPK3A UPK3O7563121
Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)VTI1AQ96AJ921
Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C)LRRC8C AD158 FAD158Q8TDW021
WASH complex subunit 2AWASHC2A FAM21A FAM21BQ641Q221
WD repeat-containing protein 91WDR91 HSPC049A4D1P621
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)EBPQ1512520
Absent in melanoma 1 protein (Beta/gamma crystallin domain-containing protein 1)AIM1 CRYBG1Q9Y4K120
Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)ACTR3B ARP11 ARP4Q9P1U120
Adaptin ear-binding coat-associated protein 2 (NECAP endocytosis-associated protein 2) (NECAP-2)NECAP2Q9NVZ320
Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)INA NEF5Q1635220
Ankyrin repeat domain-containing protein 13A (Protein KE03)ANKRD13A ANKRD13Q8IZ0720
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)ASAP1 DDEF1 KIAA1249Q9ULH120
Arylsulfatase F (ASF) (EC 3.1.6.-)ARSFP5479320
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein)BLOC1S2 BLOS2 CEAPQ6QNY120
Biorientation of chromosomes in cell division protein 1-like 1BOD1L1 BOD1L FAM44A KIAA1327Q8NFC620
Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin)CDH17Q1286420
Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6)CHERP DAN26 SCAF6Q8IWX820
Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC)CRTAC1 ASPIC1 CEP68Q9NQ7920
Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V)CTSV CATL2 CTSL2 CTSU UNQ268/PRO305O6091120
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)CDC27 ANAPC3 D0S1430E D17S978EP3026020
Cerebral cavernous malformations 2 protein (Malcavernin)CCM2 C7orf22 PP10187Q9BSQ520
Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)CHD6 CHD5 KIAA1335 RIGBQ8TD2620
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC 2.5.1.17) (Cob(I)alamin adenosyltransferase) (Methylmalonic aciduria type B protein)MMABQ96EY820
CXADR-like membrane protein (Adipocyte adhesion molecule) (Coxsackie- and adenovirus receptor-like membrane protein) (CAR-like membrane protein)CLMP ACAM ASAM UNQ318/PRO363Q9H6B420
Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox)CYBAP1349820
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)NCK2 GRB4O4363920
DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)DCAF1 KIAA0800 RIP VPRBPQ9Y4B620
Dehydrogenase/reductase SDR family member 11 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 24C member 1)DHRS11 SDR24C1 UNQ836/PRO1774Q6UWP220
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3)NUDT3 DIPP DIPP1O9598920
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)POLR3AO1480220
E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) (RING-type E3 ubiquitin transferase RNF13)RNF13 RZFO4356720
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)UBR5 EDD EDD1 HYD KIAA0896O9507120
Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)TSFMP4389720
Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)EVL RNB6Q9UI0820
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)SH3GL2 CNSA2 SH3D2AQ9996220
Epithelial membrane protein 3 (EMP-3) (Hematopoietic neural membrane protein 1) (HNMP-1) (Protein YMP)EMP3 YMPP5485220
Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein)OVCA2Q8WZ8220
Exosome component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)EXOSC10 PMSCL PMSCL2 RRP6Q0178020
F-BAR domain only protein 1FCHO1 KIAA0290O1452620
F-BAR domain only protein 2FCHO2Q0JRZ920
Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)FCN1 FCNMO0060220
Fragile X mental retardation syndrome-related protein 2FXR2 FMR1L2P5111620
GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1)GMPR GMPR1P3695920
Golgin subfamily A member 7BGOLGA7B C10orf132 C10orf133Q2TAP020
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116)CSF2RA CSF2R CSF2RYP1550920
Guanine nucleotide exchange factor VAV2 (VAV-2)VAV2P5273520
Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type)GNALP3840520
Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain)GNAT3A8MTJ320
Haloacid dehalogenase-like hydrolase domain-containing 5 (Cat eye syndrome critical region protein 5)HDHD5 CECR5Q9BXW720
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)HCLS1 HS1P1431720
Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2)HNRNPA1L2 HNRNPA1LQ32P5120
HLA class I histocompatibility antigen, A-74 alpha chain (Aw-19) (Aw-74) (MHC class I antigen A*74)HLA-A HLAAP3045920
HLA class II histocompatibility antigen, DRB1-11 beta chain (DR-5) (DR5) (DRw11) (MHC class II antigen DRB1*11)HLA-DRB1P2003920
HLA class II histocompatibility antigen, DRB1-7 beta chain (MHC class II antigen DRB1*7) (DR-7) (DR7)HLA-DRB1P1376120
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)HMGCLP3591420
Immunoglobulin heavy variable 4-59 (Ig heavy chain V-II region NEWM)IGHV4-59P0182520
Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1)ITGB1BP1 ICAP1O1471320
Inter-alpha-trypsin inhibitor heavy chain H2ITIH2Q5T98520
Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)KALRN DUET DUO HAPIP TRADO6022920
Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein)KIFAP3 KIF3AP SMAPQ9284520
L-lactate dehydrogenase A-like 6B (EC 1.1.1.27)LDHAL6B LDHAL6 LDHLQ9BYZ220
Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (EC 6.2.1.-) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3)SLC27A3 ACSVL3 FATP3 PSEC0067 UNQ367/PRO703Q5K4L620
Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase)LIPAP3857120
MAGUK p55 subfamily member 7MPP7Q5T2T120
Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)MLPH SLAC2AQ9BV3620
MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)NIFK MKI67IP NOPP34Q9BYG320
MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)MOB4 MOB3 MOBKL3 PHOCN PREI3 CGI-95Q9Y3A320
Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)PRTN3 MBNP2415820
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (13 kDa differentiation-associated protein) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2)NDUFA12 DAP13Q9UI0920
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)NDUFS7O7525120
Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)NCOA5 KIAA1637Q9HCD520
OTU domain-containing protein 6B (EC 3.4.19.12) (DUBA-5)OTUD6B DUBA5 CGI-77Q8N6M020
Pantothenate kinase 4 (hPanK4) (EC 2.7.1.33) (Pantothenic acid kinase 4)PANK4Q9NVE720
PDZ domain-containing protein GIPC2GIPC2Q8TF6520
Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4)SLC26A4 PDSO4351120
Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase)FKBP9 FKBP60 FKBP63O9530220
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)PLD1Q1339320
Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)PHKBQ9310020
Plasminogen activator inhibitor 2 (PAI-2) (Monocyte Arg-serpin) (Placental plasminogen activator inhibitor) (Serpin B2) (Urokinase inhibitor)SERPINB2 PAI2 PLANH2P0512020
Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)WTAP KIAA0105Q1500720
Proline-rich protein 4 (Lacrimal proline-rich protein) (Nasopharyngeal carcinoma-associated proline-rich protein 4)PRR4 LPRP PROL4Q1637820
Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)PTGR2 ZADH1Q8N8N720
Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)SEL1L TSA305 UNQ128/PRO1063Q9UBV220
Protein sprouty homolog 4 (Spry-4)SPRY4Q9C00420
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