EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6)THEM6 C8orf55 PSEC0098Q8WUY120
Protein Wnt-5aWNT5AP4122120
Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4)ST13P4 FAM10A4Q8IZP220
Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1)QTRT2 QTRTD1Q9H97420
Rab GDP dissociation inhibitor (Fragment)GDI2Q5SX9020
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)PTPRB PTPBP2346720
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)PTPREP2346920
Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)RGS20 RGSZ1 ZGAP1O7608120
Retinol-binding protein 5 (Cellular retinol-binding protein III) (CRBP-III) (HRBPiso)RBP5P8298020
Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)]ARHGAP45 HMHA1 KIAA0223Q9261920
RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)PAF1 PD2Q8N7H520
S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2)BHMT2Q9H2M320
SAFB-like transcription modulator (Modulator of estrogen-induced transcription)SLTM METQ9NWH920
Secernin-2SCRN2Q96FV220
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)SRSF4 SFRS4 SRP75Q0817020
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)PPP2R5AQ1517220
Signal transducer and activator of transcription 5BSTAT5BP5169220
Sjoegren syndrome/scleroderma autoantigen 1 (Autoantigen p27)SSSCA1O6023220
Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)SLC5A12 SMCT2Q1EHB420
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)SLC12A6 KCC3Q9UHW920
Sorting nexin-33 (SH3 and PX domain-containing protein 3)SNX33 SH3PX3 SH3PXD3C SNX30Q8WV4120
Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)SPG20 KIAA0610 TAHCCP1Q8N0X720
Supervillin (Archvillin) (p205/p250)SVILO9542520
Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)SYT7 PCANAP7O4358120
T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin)ITFG1 LNKN-1 TIP CDA08Q8TB9620
TBC1 domain family member 9BTBC1D9B KIAA0676Q66K1420
Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)TSPAN5 TM4SF9P6207920
Tetratricopeptide repeat protein 27 (TPR repeat protein 27)TTC27Q6P3X320
Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase)TRHDE UNQ2507/PRO5995Q9UKU620
Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5)TFPI2P4830720
Transforming growth factor beta-1-induced transcript 1 protein (Androgen receptor coactivator 55 kDa protein) (Androgen receptor-associated protein of 55 kDa) (Hydrogen peroxide-inducible clone 5 protein) (Hic-5)TGFB1I1 ARA55O4329420
Transmembrane protein 8A (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8)TMEM8A TMEM6 TMEM8Q9HCN320
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)TMEM55AQ8N4L220
U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)SNRPCP0923420
Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)USP34 KIAA0570 KIAA0729Q70CQ220
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)USP8 KIAA0055 UBPYP4081820
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)UBASH3B KIAA1959 STS1Q8TF4220
Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)UBE2S E2EPF OK/SW-cl.73Q1676320
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)UBL4A DXS254E GDX UBL4P1144120
Unconventional myosin-VbMYO5B KIAA1119Q9ULV020
V-type proton ATPase 116 kDa subunit a isoform 4 (V-ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)ATP6V0A4 ATP6N1B ATP6N2Q9HBG420
Vesicle transport protein SFT2B (SFT2 domain-containing protein 2)SFT2D2 UNQ512/PRO1027O9556220
Vitelline membrane outer layer protein 1 homologVMO1 UNQ6350/PRO21055Q7Z5L020
Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]CACNA2D2 KIAA0558Q9NY4720
60S ribosomal protein L10-like (Large ribosomal subunit protein uL16-like)RPL10LQ96L2119
Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog)AACS ACSF1Q86V2119
Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)ADCY3 KIAA0511O6026619
ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1)ARL13B ARL2L1Q3SXY819
Amphoterin-induced protein 2 (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA)AMIGO2 ALI1Q86SJ219
Angiopoietin-1 (ANG-1)ANGPT1 KIAA0003Q1538919
Antigen peptide transporter 1 (APT1) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein)TAP1 ABCB2 PSF1 RING4 Y3Q0351819
Apolipoprotein C-IV (Apo-CIV) (ApoC-IV) (Apolipoprotein C4)APOC4P5505619
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)ACAP2 CENTB2 KIAA0041Q1505719
Armadillo repeat-containing protein 6ARMC6Q6NXE619
Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4) [Includes: N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Lactotriaosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.275) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase)]B4GALT4 UNQ552/PRO1109O6051319
Cadherin-23 (Otocadherin)CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340Q9H25119
Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)CAMK1Q1401219
Calretinin (CR) (29 kDa calbindin)CALB2 CAB29P2267619
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95)CMTR1 FTSJD2 KIAA0082 MTR1Q8N1G219
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]CASP8 MCH5Q1479019
Catenin beta-1 (cDNA FLJ57878, highly similar to Beta-catenin)CTNNB1B4DGU419
CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor)CEBPZ CBF2Q0370119
CCR4-NOT transcription complex subunit 10CNOT10Q9H9A519
cDNA FLJ14473 fis, clone MAMMA1001080, highly similar to Homo sapiens SNC73 protein (SNC73) mRNA0Q96K6819
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)CDC16 ANAPC6Q1304219
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)CBX1 CBXP8391619
CKLF-like MARVEL transmembrane domain-containing protein 7 (Chemokine-like factor superfamily member 7)CMTM7 CKLFSF7Q96FZ519
Clarin-3 (Transmembrane protein 12) (Usher syndrome type-3A-like protein 1)CLRN3 TMEM12 USH3AL1Q8NCR919
Complement factor H-related protein 2 (FHR-2) (DDESK59) (H factor-like 3) (H factor-like protein 2)CFHR2 CFHL2 FHR2 HFL3P3698019
Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6)COG6 KIAA1134Q9Y2V719
Cordon-bleu protein-like 1COBLL1 KIAA0977Q53SF719
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)CDK9 CDC2L4 TAKP5075019
DnaJ homolog subfamily C member 11DNAJC11Q9NVH119
Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2) (EC 3.6.1.-) (CD39 antigen-like 1) (Ecto-ATP diphosphohydrolase 2) (Ecto-ATPDase 2) (Ecto-ATPase 2)ENTPD2 CD39L1Q9Y5L319
Enolase 1 (Fragment)0A4UCS819
Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3)EPS8L3 EPS8R3Q8TE6719
ER membrane protein complex subunit 7EMC7 C11orf3 C15orf24 HT022 UNQ905/PRO1926Q9NPA019
Erythrocyte membrane protein band 4.2 (Erythrocyte protein 4.2) (P4.2)EPB42 E42PP1645219
F-box only protein 7FBXO7 FBX7Q9Y3I119
Fibulin-7 (FIBL-7)FBLN7 TM14Q53RD919
Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)FNBP1L C1orf39 TOCA1Q5T0N519
Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)]GAL GAL1 GALN GLNNP2246619
Gasdermin-A (Gasdermin-1)GSDMA GSDM GSDM1 FKSG9Q96QA519
Glutathione S-transferase pi (Fragment)GSTP1C7DJS119
Glycerophosphodiester phosphodiesterase domain-containing protein 3 (EC 3.1.-.-)GDPD3Q7L5L319
Guanine nucleotide-binding protein subunit alpha-15 (G alpha-15) (G-protein subunit alpha-15) (Epididymis tissue protein Li 17E) (Guanine nucleotide-binding protein subunit alpha-16) (G alpha-16) (G-protein subunit alpha-16)GNA15 GNA16P3067919
Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene)HSP90AA2P HSP90AA2 HSPCAL3Q1456819
Heme oxygenase 1 (HO-1) (EC 1.14.14.18)HMOX1 HO HO1P0960119
HLA class II histocompatibility antigen, DRB1-13 beta chain (MHC class II antigen DRB1*13) (DR-13) (DR13)HLA-DRB1Q5Y7A719
Hyaluronan and proteoglycan link protein 3HAPLN3 EXLD1 UNQ238/PRO271Q96S8619
Immunoglobulin heavy variable 4-39 (Ig heavy chain V-II region WAH)IGHV4-39P0182419
Immunoglobulin kappa variable 1-17 (Ig kappa chain V-I region Gal) (Ig kappa chain V-I region WEA)IGKV1-17P0159919
Immunoglobulin lambda variable 1-51 (Ig lambda chain V-I region BL2) (Ig lambda chain V-I region EPS) (Ig lambda chain V-I region NEW) (Ig lambda chain V-I region NIG-64)IGLV1-51P0170119
Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)IFNGR1P1526019
Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)KCNN4 IK1 IKCA1 KCA4 SK4O1555419
Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase)KHKP5005319
Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1)KIF20B KRMP1 MPHOSPH1Q96Q8919
Leucine zipper protein 1LUZP1Q86V4819
Leucine-rich repeat and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1) (Neuronal protein 81) (NP81)LRCH1 CHDC1 KIAA1016Q9Y2L919
LisH domain and HEAT repeat-containing protein KIAA1468KIAA1468Q9P26019
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