EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)LRRC8EQ6NSJ518
WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)WDR75 UTP17Q8IWA018
Xylulose kinase (Xylulokinase) (EC 2.7.1.17)XYLBO7519118
28S ribosomal protein S7, mitochondrial (MRP-S7) (S7mt) (Mitochondrial small ribosomal subunit protein uS7m) (bMRP-27a) (bMRP27a)MRPS7Q9Y2R917
39S ribosomal protein L50, mitochondrial (L50mt) (MRP-L50) (Mitochondrial large ribosomal subunit protein mL50)MRPL50Q8N5N717
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)MTHFSP4991417
Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19)ZFYVE19 ANCHR MPFYVEQ96K2117
Actin, cytoplasmic 1 (Fragment)ACTBC9JUM117
Adhesion G-protein coupled receptor G2 (G-protein coupled receptor 64) (Human epididymis-specific protein 6) (He6)ADGRG2 GPR64 HE6 TM7LN2Q8IZP917
ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) (RbBP-35)ADPGK PSEC0260Q9BRR617
Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)GPT2 AAT2 ALT2Q8TD3017
All-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat) (PPAR-alpha-regulated and starvation-induced gene protein)RETSAT PPSIG UNQ439/PRO872Q6NUM917
Ammonium transporter Rh type C (Rh glycoprotein kidney) (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein) (Tumor-related protein DRC2)RHCG C15orf6 CDRC2 PDRC2 RHGKQ9UBD617
Angiopoietin-related protein 4 (Angiopoietin-like protein 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP)ANGPTL4 ARP4 HFARP PGAR PP1158 PSEC0166 UNQ171/PRO197Q9BY7617
AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad)AP1G2O7584317
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)AAK1 KIAA1048Q2M2I817
Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12)ALOX12 12LO LOG12P1805417
Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (Protein POR1)ARFIP2 POR1P5336517
BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)ZNF207 BUGZO4367017
Cadherin-6 (Kidney cadherin) (K-cadherin)CDH6P5528517
Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH)CDHR5 MUCDHL MUPCDH UNQ2781/PRO7168Q9HBB817
Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_a (F-actin-capping protein subunit beta)CAPZB hCG_41078B1AK8717
Carbonic anhydrase II (Fragment)carbonic anhydrase II/ CA IIQ6LD9917
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)CSNK1EP4967417
Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]CASP6 MCH2P5521217
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]CASP7 MCH3P5521017
Cell surface A33 antigen (Glycoprotein A33)GPA33Q9979517
Centrin-2 (Caltractin isoform 1)CETN2 CALT CEN2P4120817
Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)ITGB3BP CENPR NRIF3Q1335217
Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2)CC2D1B KIAA1836Q5T0F917
Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2)COL26A1 EMID2 EMU2Q96A8317
CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2)CELF1 BRUNOL2 CUGBP CUGBP1 NAB50Q9287917
Cystathionine beta-synthase-like protein (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)CBSLP0DN7917
Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6)DPYSL5 CRMP5 ULIP6Q9BPU617
Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)DPH5 AD-018 CGI-30 HSPC143 NPD015Q9H2P917
Disheveled-associated activator of morphogenesis 2DAAM2 KIAA0381Q86T6517
DnaJ homolog subfamily A member 4DNAJA4Q8WW2217
Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]DBHP0917217
Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3)DCTN6 WS3O0039917
Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)DNAH5 DNAHC5 HL1 KIAA1603Q8TE7317
E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (RING-type E3 ubiquitin transferase TRIM56) (Tripartite motif-containing protein 56)TRIM56 RNF109Q9BRZ217
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)ZNRF2 RNF202Q8NHG817
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]ENPP3 PDNP3O1463817
Ectopic P granules protein 5 homologEPG5 KIAA1632Q9HCE017
Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11)EPHA7 EHK3 HEK11Q1537517
F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)FBXO6 FBG2 FBS2 FBX6Q9NRD117
Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)FABP4P1509017
Gamma-glutamylaminecyclotransferase (GGACT) (EC 2.3.2.4) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase)GGACT A2LD1Q9BVM417
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)APH1A PSF CGI-78 UNQ579/PRO1141Q96BI317
GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1)POFUT1 FUT12 KIAA0180Q9H48817
General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)GTF2F1 RAP74P3526917
Glutathione S-transferase theta-2B (EC 2.5.1.18) (GST class-theta-2) (Glutathione S-transferase theta-2)GSTT2B GSTT2P0CG3017
Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase)GATM AGATP5044017
Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1, BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2)GREM1 CKTSF1B1 DAND2 DRM PIG2O6056517
Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2)PLA2G15 LYPLA3 UNQ341/PRO540Q8NCC317
Growth hormone-regulated TBC protein 1 (TBC1 domain family member 6)GRTP1 TBC1D6Q5TC6317
Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP)GDF10 BMP3BP5510717
Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain)GNAT1 GNATRP1148817
HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]HEATR1 BAP28 UTP10Q9H58317
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) (Stromal RNA-regulating factor)HNRNPLL HNRPLL SRRF BLOCK24Q8WVV917
HLA class I histocompatibility antigen, A-25 alpha chain (HLA class I histocompatibility antigen, A-10 alpha chain) (MHC class I antigen A*25)HLA-A HLAAP1846217
HLA class I histocompatibility antigen, B-14 alpha chain (MHC class I antigen B*14)HLA-B HLABP3046217
HLA class I histocompatibility antigen, B-55 alpha chain (Bw-55) (HLA class I histocompatibility antigen, B-12 alpha chain) (MHC class I antigen B*55)HLA-B HLAB CDABP0067P3049317
HLA class I histocompatibility antigen, Cw-14 alpha chain (MHC class I antigen Cw*14)HLA-C HLACP3051017
HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)HLA-DQA1P0190917
HLA class II histocompatibility antigen, DRB1-12 beta chain (MHC class II antigen DRB1*12) (DR-12) (DR12)HLA-DRB1Q95IE317
ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)ICOSLG B7H2 B7RP1 ICOSL KIAA0653O7514417
Immunoglobulin kappa variable 1-33 (Ig kappa chain V-I region AU) (Ig kappa chain V-I region Ka)IGKV1-33P0159417
Immunoglobulin lambda constant 3 (Ig lambda chain C region DOT) (Ig lambda chain C region NEWM) (Ig lambda-3 chain C regions)IGLC3P0DOY317
Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16)IGBP1 IBP1P7831817
Intelectin-1 (ITLN-1) (Endothelial lectin HL-1) (Galactofuranose-binding lectin) (Intestinal lactoferrin receptor) (Omentin)ITLN1 INTL ITLN LFR UNQ640/PRO1270Q8WWA017
Interferon regulatory factor 3 (IRF-3)IRF3Q1465317
Keratin, type I cytoskeletal 9KRT9K7EQQ317
KIAA0368KIAA0368J3KN1617
L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X)LDHC LDH3 LDHXP0786417
La-related protein 7 (La ribonucleoprotein domain family member 7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)LARP7 HDCMA18PQ4G0J317
Leucine-rich repeat neuronal protein 4 (Neuronal leucine-rich repeat protein 4) (NLRR-4)LRRN4 C20orf75Q8WUT417
Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)LAT2 LAB NTAL WBS15 WBSCR15 WBSCR5 HSPC046Q9GZY617
Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)PPFIBP2Q8ND3017
Low-density lipoprotein receptor-related protein 6 (LRP-6)LRP6O7558117
Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)PBK TOPKQ96KB517
Lysine-specific demethylase 3A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A)KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGAQ9Y4C117
Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)LPAR1 EDG2 LPA1Q9263317
Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)MRC1 CLEC13D CLEC13DL MRC1L1P2289717
Manganese-transporting ATPase 13A1 (EC 3.6.3.-)ATP13A1 ATP13A KIAA1825 CGI-152Q9HD2017
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)MED22 SURF5Q1552817
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)MED24 ARC100 CRSP4 DRIP100 KIAA0130 THRAP4 TRAP100O7544817
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)MED4 ARC36 DRIP36 VDRIP HSPC126Q9NPJ617
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)MED8Q96G2517
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)MAPK13 PRKM13 SAPK4O1526417
Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)SLC47A1 MATE1Q96FL817
Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)MLF2Q1577317
Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)NECTIN3 PRR3 PVRL3Q9NQS317
Neural proliferation differentiation and control protein 1 (NPDC-1)NPDC1Q9NQX517
Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46)GAP43P1767717
Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I)NPTX1Q1581817
Nipped-B-like protein (Delangin) (SCC2 homolog)NIPBL IDN3Q6KC7917
Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)NOC2L NIRQ9Y3T917
Nucleoporin NUP188 homolog (hNup188)NUP188 KIAA0169Q5SRE517
Nucleoside diphosphate kinase (EC 2.7.4.6)NME1-NME2 hCG_2001850Q32Q1217
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