EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)PARD6B PAR6BQ9BYG517
Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)PYM1 PYM WIBGQ9BRP817
PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein)PDLIM4 RILP5047917
PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein)PDZD11 AIPP1 PDZK11 PISP HSPC227 UNQ6486/PRO21335Q5EBL817
Pericentriolar material 1 protein (PCM-1) (hPCM-1)PCM1Q1515417
Pescadillo homologPES1O0054117
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)PLEKHA5 KIAA1686 PEPP2Q9HAU017
Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein)PLXDC2 TEM7R UNQ2514/PRO6003Q6UX7117
Poly(rC)-binding protein 3 (Alpha-CP3)PCBP3P5772117
Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]GALNT1Q1047217
Pre-mRNA-splicing factor 38APRPF38AQ8NAV117
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)SMARCA1 SNF2L SNF2L1P2837017
Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase)THG1L ICF45Q9NWX617
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)PCCAP0516517
Protein crumbs homolog 2 (Crumbs-like protein 2)CRB2Q5IJ4817
Protein FAM26EFAM26E C6orf188Q8N5C117
Protein kinase C delta-binding protein (Cavin-3) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC)PRKCDBP SRBCQ969G517
Protein NOV homolog (NovH) (CCN family member 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephroblastoma-overexpressed gene protein homolog)NOV CCN3 IGFBP9 NOVHP4874517
Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)PRRC2A BAT2 G2P4863417
Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)TANC1 KIAA1728Q9C0D517
Protein unc-80 homologUNC80 C2orf21 KIAA1843Q8N2C717
Protein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein)UXT HSPC024Q9UBK917
Pyruvate kinase (EC 2.7.1.40) (Fragment)PKMH3BTN517
Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17)RABEP1 RAB5EP RABPT5 RABPT5AQ1527617
Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1)RABL6 C9orf86 PARFQ3YEC717
Ras-related protein Rab-17RAB17Q9H0T717
Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1)RAB38P5772917
RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)PPP1R13L IASPP NKIP1 PPP1R13BL RAIQ8WUF517
Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)RCN3 UNQ239/PRO272Q96D1517
Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)ARHGAP5 RHOGAP5Q1301717
Rho guanine nucleotide exchange factor 16 (Ephexin-4)ARHGEF16 EPHEXIN4 NBRQ5VV4117
Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)RRP1 D21S2056E NNP1 NOP52 RRP1AP5618217
RNA-binding protein Musashi homolog 2 (Musashi-2)MSI2Q96DH617
Semaphorin-3A (Semaphorin III) (Sema III)SEMA3A SEMADQ1456317
Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)LACTB MRPL56 UNQ843/PRO1781P8311117
Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]HPN TMPRSS1P0598117
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1)ATR FRP1Q1353517
Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)NEK7Q8TDX717
SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)SNW1 SKIIP SKIPQ1357317
Spermatid perinuclear RNA-binding proteinSTRBP SPNRQ96SI917
Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)RBM17 SPF45Q96I2517
Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4) (SR-related and CTD-associated factor 4)SCAF4 KIAA1172 SFRS15O9510417
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]SRPK2P7836217
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)SUCLA2Q9P2R717
Syntaxin-5STX5 STX5AQ1319017
Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)ZCCHC11 KIAA0191 TUT4Q5TAX317
Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)SLC19A2 THT1 TRMAO6077917
Transmembrane channel-like protein 5TMC5 UNQ8238/PRO33604Q6UXY817
Transmembrane protein 119 (Osteoblast induction factor) (OBIF)TMEM119 PSEC0199 UNQ731/PRO1415Q4V9L617
Transmembrane protein 126ATMEM126AQ9H06117
Transmembrane protein 176B (Protein LR8)TMEM176B LR8Q3YBM217
Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein)TMEM237 ALS2CR4Q96Q4517
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)TMEM55B C14orf9Q86T0317
U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1)SART1O4329017
Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9)USP19 KIAA0891 ZMYND9O9496617
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)OTULIN FAM105BQ96BN817
Uncharacterized protein C7orf50C7orf50 FP15621Q9BRJ617
Uncharacterized protein KIAA2013KIAA2013Q8IYS217
UPF0600 protein C5orf51C5orf51A6NDU817
UPF0764 protein C16orf89C16orf89 UNQ904/PRO1925Q6UX7317
V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)ATP6V0D2Q8N8Y217
Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)VPS52 SACM2LQ8N1B417
WD repeat-containing protein 81WDR81Q562E717
WD repeat-containing protein 92 (WD repeat-containing protein Monad)WDR92Q96MX617
Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1)WASF1 KIAA0269 SCAR1 WAVE1Q9255817
Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)DPF2 BAF45D REQ UBID4Q9278517
39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19) (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein bL19m)MRPL19 KIAA0104 MRPL15P4940616
40S ribosomal protein S4, Y isoform 2 (Small ribosomal subunit protein eS4)RPS4Y2 RPS4Y2PQ8TD4716
60S ribosomal protein L7-like 1 (Large ribosomal subunit protein uL30-like 1)RPL7L1Q6DKI116
Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)ASPM MCPH5Q8IZT616
Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)]ACACB ACC2 ACCBO0076316
Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.3) (YisK-like protein)FAHD1 C16orf36 YISKLQ6P58716
ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289)ARFGAP2 ZNF289 Nbla10535Q8N6H716
Annexin (Fragment)ANXA4 PIG28 hCG_39482Q6LES216
Apolipoprotein C-III (Apolipoprotein C-III variant 1)APOC3B0YIW216
Apolipoprotein F (Apo-F) (Lipid transfer inhibitor protein) (LTIP)APOFQ1379016
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)GIT2 KIAA0148Q1416116
Arginine and glutamate-rich protein 1ARGLU1Q9NWB616
Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C)NPR3 ANPRC C5orf23 NPRCP1734216
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)BIRC5 API4 IAP4O1539216
Bridging integrator 2 (Breast cancer-associated protein 1)BIN2 BRAP1Q9UBW516
Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1)CHST11Q9NPF216
CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)TRNT1 CGI-47Q96Q1116
CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)CNOT2 CDC36 NOT2 HSPC131 MSTP046Q9NZN816
CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320)CD320 8D6A UNQ198/PRO224Q9NPF016
CD59 glycoproteinCD59E9PNW416
cDNA FLJ56154, highly similar to Gelsolin0B7Z6N216
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)CDIPT PIS PIS1O1473516
Complement factor H-related protein 5 (FHR-5)CFHR5 CFHL5 FHR5Q9BXR616
Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3)NCAPD3 CAPD3 KIAA0056P4269516
Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)SGCDQ9262916
DENN domain-containing protein 2DDENND2DQ9H6A016
Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6)DSG3 CDHF6P3292616
Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase)DPYSQ1411716
DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)DNAJA3 HCA57 TID1Q96EY116
E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)RNF149 DNAPTP2Q8NC4216
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)UHRF1 ICBP90 NP95 RNF106Q96T8816
Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)ELOVL5 ELOVL2 PRO0530Q9NYP716
Epsilon-sarcoglycan (Epsilon-SG)SGCE ESG UNQ433/PRO840O4355616
ER lumen protein-retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23)KDELR1 ERD2.1P2439016
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