EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)TLR2 TIL4O6060316
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)TP53BP1Q1288816
Trafficking protein particle complex subunit 8 (Protein TRS85 homolog)TRAPPC8 KIAA1012Q9Y2L516
TransferrinTFQ06AH716
Translocation protein SEC63 homologSEC63 SEC63LQ9UGP816
Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4)TMC6 EVER1 EVIN1Q7Z40316
Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26)TMED3 C15orf22 UNQ5357/PRO1078Q9Y3Q316
Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)TMOD2 NTMODQ9NZR116
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)TNFRSF10D DCR2 TRAILR4 TRUNDD UNQ251/PRO288Q9UBN616
U3 small nucleolar RNA-associated protein 15 homologUTP15Q8TED016
Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1)UBAC2 PHGDHL1 PSEC0110Q8NBM416
Uncharacterized protein C2orf72C2orf72A6NCS616
Uncharacterized protein C6orf132C6orf132Q5T0Z816
UPF0488 protein C8orf33C8orf33Q9H7E916
Uroplakin-3b-like proteinUPK3BL UPLPB0FP4816
Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p)VPS39 KIAA0770 TLP VAM6Q96JC116
Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D)LRRC8D LRRC5 UNQ213/PRO239Q7L1W416
WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)WDFY3 KIAA0993Q8IZQ116
YrdC domain-containing protein, mitochondrial (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)YRDC DRIP3 IRIPQ86U9016
Zinc finger CCCH-type antiviral protein 1-likeZC3HAV1L C7orf39Q96H7916
Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein)ZFYVE16 KIAA0305Q7Z3T816
28S ribosomal protein S22, mitochondrial (MRP-S22) (S22mt) (Mitochondrial small ribosomal subunit protein mS22)MRPS22 C3orf5 RPMS22 GK002P8265015
28S ribosomal protein S34, mitochondrial (MRP-S34) (S34mt) (Mitochondrial small ribosomal subunit protein mS34)MRPS34P8293015
39S ribosomal protein L4, mitochondrial (L4mt) (MRP-L4) (Mitochondrial large ribosomal subunit protein uL4m)MRPL4 CDABP0091 CGI-28Q9BYD315
39S ribosomal protein L41, mitochondrial (L41mt) (MRP-L41) (39S ribosomal protein L27 homolog) (Bcl-2-interacting mitochondrial ribosomal protein L41) (Cell proliferation-inducing gene 3 protein) (MRP-L27 homolog) (Mitochondrial large ribosomal subunit protein mL41)MRPL41 BMRP MRPL27 RPML27 PIG3Q8IXM315
39S ribosomal protein L48, mitochondrial (L48mt) (MRP-L48) (Mitochondrial large ribosomal subunit protein mL48)MRPL48 CGI-118 HSPC290Q96GC515
60S ribosomal protein L30 (Fragment)RPL30E5RI9915
A-kinase anchor protein 2 (AKAP-2) (AKAP-KL) (Protein kinase A-anchoring protein 2) (PRKA2)AKAP2 KIAA0920 PRKA2Q9Y2D515
Actin, cytoplasmic 1 (HCG15971, isoform CRA_b)ACTB hCG_15971G5E9R015
Actin, cytoplasmic 2 (Fragment)ACTG1I3L4N815
Actin, cytoplasmic 2 (Fragment)ACTG1I3L3I015
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)ACVR1 ACVRLK2Q0477115
Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9)ADCY9 KIAA0520O6050315
Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2)ADIRF AFRO APM2 C10orf116Q1584715
Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase subunit beta)ADH1B ADH2P0032515
Alpha-endosulfine (ARPP-19e)ENSAO4376815
Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A)MAOAP2139715
Aminopeptidase (EC 3.4.11.-)NPEPPSE9PLK315
Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2)ANO1 DOG1 ORAOV2 TAOS2 TMEM16AQ5XXA615
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (Centaurin-beta-1) (Cnt-b1)ACAP1 CENTB1 KIAA0050Q1502715
ARP3 actin-related protein 3 homolog variant (Fragment)0Q59FV615
Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1)NAT1 AAC1P1844015
ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal membrane protein) (PMP70)ABCD3 PMP70 PXMP1P2828815
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrialCLPXO7603115
Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein)BCL2L12 BPRQ9HB0915
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT)GCNT3O9539515
Beta-adducin (Erythrocyte adducin subunit beta)ADD2 ADDBP3561215
Casein kinase II subunit alpha 3 (CK II alpha 3) (EC 2.7.11.1) (Casein kinase II alpha 1 polypeptide pseudogene)CSNK2A3 CSNK2A1PQ8NEV115
CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)CD177 NB1 PRV1 UNQ595/PRO1181Q8N6Q315
Claudin-11 (Oligodendrocyte-specific protein)CLDN11 OSP OTMO7550815
Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF)CLDN5 AWAL TMVCFO0050115
Collagen alpha-1(X) chainCOL10A1Q0369215
Collagen alpha-5(IV) chainCOL4A5P2940015
Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin)COLEC12 CLP1 NSR2 SCARA4 SRCLQ5KU2615
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)CDK3 CDKN3Q0052615
Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)COX6B1 COX6BP1485415
Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)DNASE2 DNASE2A DNL2O0011515
Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4)DPYSL4 CRMP3 ULIP4O1453115
Dystrobrevin beta (DTN-B) (Beta-dystrobrevin)DTNBO6094115
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)UBR1Q8IWV715
Echinoderm microtubule-associated protein-like 3 (EMAP-3)EML3Q32P4415
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)EPHA5 BSK EHK1 HEK7 TYRO4P5475615
Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)EIF1AYO1460215
Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)FABP7 BLBP FABPB MRGO1554015
Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1)PKHD1L1Q86WI115
Fibulin-1FBLN1B1AHL215
Fidgetin-like protein 1 (EC 3.6.4.-)FIGNL1Q6PIW415
Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (LCHC1) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)]FTCDO9595415
Galectin-3-binding protein (Fragment)LGALS3BPK7EJY815
Galectin-3-binding protein (Fragment)LGALS3BPK7EP3615
Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase)GKP3218915
GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)RIT1 RIBB RIT ROC1Q9296315
Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]MST1 D3F15S2 DNF15S2 HGFLP2692715
Histidine ammonia-lyase (Histidase) (EC 4.3.1.3)HAL HISP4235715
Histone H2A (Fragment)H2AFJH0YFX915
HLA class I histocompatibility antigen, A-32 alpha chain (MHC class I antigen A*32)HLA-A HLAAP1031415
Immunoglobulin heavy variable 3-11 (Ig heavy chain V-III region TRO)IGHV3-11P0176215
Immunoglobulin kappa variable 1D-33 (Ig kappa chain V-I region AG) (Ig kappa chain V-I region Bi) (Ig kappa chain V-I region Lay) (Ig kappa chain V-I region Ni) (Ig kappa chain V-I region Rei) (Ig kappa chain V-I region Roy) (Ig kappa chain V-I region Scw) (Ig kappa chain V-I region WAT)IGKV1D-33P0160515
Immunoglobulin lambda variable 1-44 (Ig lambda chain V-I region MEM) (Ig lambda chain V-I region VOR)IGLV1-44P0169915
Immunoglobulin lambda variable 2-11 (Ig gamma lambda chain V-II region DOT) (Ig lambda chain V-II region BOH) (Ig lambda chain V-II region BUR) (Ig lambda chain V-II region NIG-58) (Ig lambda chain V-II region TRO) (Ig lambda chain V-II region WIN)IGLV2-11P0170615
Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608)IGSF10 CMF608Q6WRI015
Insulin receptor substrate 2 (IRS-2)IRS2Q9Y4H215
Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)ICAM5 TLCN TLNQ9UMF015
Intraflagellar transport protein 172 homologIFT172 KIAA1179Q9UG0115
Keratin, type I cuticular Ha7 (Hair keratin, type I Ha7) (Keratin-37) (K37)KRT37 HHA7 HKA7 KRTHA7O7601415
Keratin, type II cuticular Hb1 (Hair keratin K2.9) (Keratin, hair, basic, 1) (Keratin-81) (K81) (Metastatic lymph node 137 gene protein) (MLN 137) (Type II hair keratin Hb1) (Type-II keratin Kb21) (ghHKb1) (ghHb1)KRT81 KRTHB1 MLN137Q1453315
Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104)KIF1A ATSV C2orf20Q1275615
Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]KLQ9UEF715
Late secretory pathway protein AVL9 homologAVL9 KIAA0241Q8NBF615
Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2)LRRFIP2Q9Y60815
Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog)SHOC2 KIAA0862Q9UQ1315
Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)LMF2 TMEM112B TMEM153Q9BU2315
Lipase member H (LIPH) (EC 3.1.1.-) (LPD lipase-related protein) (Membrane-associated phosphatidic acid-selective phospholipase A1-alpha) (mPA-PLA1 alpha) (Phospholipase A1 member B)LIPH LPDLR MPAPLA1 PLA1BQ8WWY815
Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)FCGR3A CD16A FCG3 FCGR3 IGFR3P0863715
MARVEL domain-containing protein 3MARVELD3 MRVLDC3Q96A5915
Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS)MTRQ9970715
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)MGMTP1645515
Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)MCMBP C10orf119Q9BTE315
Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)SLC16A2 MCT8 XPCTP3602115
mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]RNGTT CAP1AO6094215
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