EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
cDNA FLJ782170A8K55614
Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I)CRABP1 RBP5P2976214
Ceroid-lipofuscinosis neuronal protein 5 (Protein CLN5) [Cleaved into: Ceroid-lipofuscinosis neuronal protein 5, secreted form]CLN5O7550314
Cilia- and flagella-associated protein 54CFAP54 C12orf55 C12orf63Q96N2314
CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4)CMTM4 CKLFSF4Q8IZR514
Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56)CES2 ICEO0074814
Collagen type IV alpha-3-binding protein (Ceramide transfer protein) (hCERT) (Goodpasture antigen-binding protein) (GPBP) (START domain-containing protein 11) (StARD11) (StAR-related lipid transfer protein 11)COL4A3BP CERT STARD11Q9Y5P414
Collectin-11 (Collectin kidney protein 1) (CL-K1)COLEC11 UNQ596/PRO1182Q9BWP814
Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB)SPRR1BP2252814
COX assembly mitochondrial protein homolog (Cmc1p)CMC1 C3orf68Q7Z7K014
Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2)CAND2 KIAA0667 TIP120BO7515514
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)CDK12 CRK7 CRKRS KIAA0904Q9NYV414
Cysteine-rich protein 1 (CRP-1) (Cysteine-rich heart protein) (CRHP) (hCRHP) (Cysteine-rich intestinal protein) (CRIP)CRIP1 CRIP CRP1P5023814
Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NRDR) (humNRDR) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (SCAD-SRL) (Short chain dehydrogenase/reductase family 25C member 2) (Short-chain dehydrogenase/reductase family member 4)DHRS4 SDR25C2 UNQ851/PRO1800Q9BTZ214
DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)LIG3P4991614
DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase)MPG AAG ANPG MID1P2937214
DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)POLR2IP3695414
Double-stranded RNA-binding protein Staufen homolog 2STAU2Q9NUL314
Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)DNAH14 C1orf67Q0VDD814
Ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) (EC 3.6.1.5) (CD39 antigen-like 3) (Ecto-ATP diphosphohydrolase 3) (Ecto-ATPDase 3) (Ecto-ATPase 3) (Ecto-apyrase 3) (HB6)ENTPD3 CD39L3O7535514
Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)ECI2 DRS1 HCA88 PECIO7552114
Epididymis secretory protein Li 103 (Heat shock 70kDa protein 1A) (Heat shock 70kDa protein 1B) (cDNA FLJ75127, highly similar to Homo sapiens heat shock 70kDa protein 1A, mRNA)HEL-S-103 HSPA1A HSPA1B hCG_1820593 hCG_43726A8K5I014
Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)ESRP1 RBM35AQ6NXG114
Extracellular glycoprotein lacritinLACRTQ9GZZ814
Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi casein kinase) (Golgi-enriched fraction casein kinase) (GEF-CK)FAM20C DMP4Q8IXL614
F-box only protein 22 (F-box protein FBX22p44)FBXO22 FBX22Q8NEZ514
Fanconi anemia group I protein (Protein FACI)FANCI KIAA1794Q9NVI114
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)FAF1 UBXD12 UBXN3A CGI-03Q9UNN514
Flotillin-2FLOT2E7EMK314
Frizzled-2 (Fz-2) (hFz2) (FzE2)FZD2Q1433214
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)FYCO1 ZFYVE7Q9BQS814
Gastricsin (EC 3.4.23.3) (Pepsinogen C)PGCP2014214
Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)GLRX5 C14orf87Q86SX614
Glutathione S-transferase PGSTP1A8MX9414
Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1)GLMP C1orf85 PSEC0030 UNQ2553/PRO6182Q8WWB714
Golgi phosphoprotein 3-like (GPP34-related protein)GOLPH3L GPP34RQ9H4A514
HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27)HAUS2 C15orf25 CEP27Q9NVX014
HEAT repeat-containing protein 5AHEATR5A C14orf125 KIAA1316Q86XA914
Heat shock cognate 71 kDa proteinHSPA8E9PNE614
Heat shock cognate 71 kDa protein (cDNA FLJ77848)HSPA8A8K7Q214
Heat shock cognate 71 kDa protein (Fragment)HSPA8E9PI6514
Heat shock cognate 71 kDa protein (Fragment)HSPA8E9PN2514
Heat shock cognate 71 kDa protein (Fragment)HSPA8E9PN8914
Heat shock cognate 71 kDa protein (Fragment)HSPA8E9PQQ414
Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.43) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)ASH1L KIAA1420 KMT2HQ9NR4814
HLA class I histocompatibility antigen, A-66 alpha chain (Aw-66) (HLA class I histocompatibility antigen, A-10 alpha chain) (MHC class I antigen A*66)HLA-A HLAAP3045714
HLA class I histocompatibility antigen, B-49 alpha chain (HLA class I histocompatibility antigen, B-21 alpha chain) (MHC class I antigen B*49)HLA-B HLABP3048714
HLA class I histocompatibility antigen, B-52 alpha chain (Bw-52) (HLA class I histocompatibility antigen, B-5 alpha chain) (MHC class I antigen B*52)HLA-B HLABP3049014
HLA class I histocompatibility antigen, B-81 alpha chain (B'DT) (MHC class I antigen B*81)HLA-B HLABQ3161014
HLA class II histocompatibility antigen, DRB1-3 chain (Clone P2-beta-3) (MHC class II antigen DRB1*3)HLA-DRB1P0191214
Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1)HYAL1 LUCA1Q1279414
Immunoglobulin kappa variable 1D-33 (Ig kappa chain V-I region AG) (Ig kappa chain V-I region Bi) (Ig kappa chain V-I region Lay) (Ig kappa chain V-I region Ni) (Ig kappa chain V-I region Rei) (Ig kappa chain V-I region Roy) (Ig kappa chain V-I region Scw) (Ig kappa chain V-I region WAT)IGKV1D-33P0160814
Inosine-5'-monophosphate dehydrogenase 2 (Fragment)IMPDH2H0Y4R114
Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)ITPR1 INSP3R1Q1464314
Inositol monophosphatase 2 (IMP 2) (IMPase 2) (EC 3.1.3.25) (Inositol-1(or 4)-monophosphatase 2) (Myo-inositol monophosphatase A2)IMPA2 IMP.18PO1473214
Integrin beta-7 (Gut homing receptor beta subunit)ITGB7P2601014
Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein)MX2P2059214
Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)IL13RA2 IL13RQ1462714
InvolucrinIVLP0747614
Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)IVDP2644014
Keratin, type I cuticular Ha4 (Hair keratin, type I Ha4) (Keratin-34) (K34)KRT34 HHA4 HKA4 KRTHA4O7601114
Keratin, type I cytoskeletal 17KRT17F5GWP814
Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1)SLC43A1 LAT3 PB39 POV1O7538714
LEM domain-containing protein 2 (hLEM2)LEMD2Q8NC5614
LIX1-like proteinLIX1LQ8IVB514
Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5)ACSL5 ACS5 FACL5 UNQ633/PRO1250Q9ULC514
Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14)PPT2Q9UMR514
Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen)MAGEA4 MAGE4P4335814
Melanoma-associated antigen B2 (Cancer/testis antigen 3.2) (CT3.2) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2 antigen) (MAGE-B2 antigen)MAGEB2O1547914
Metalloreductase STEAP1 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 1)STEAP1 PRSS24 STEAPQ9UHE814
Metaxin-1 (Mitochondrial outer membrane import complex protein 1)MTX1 MTX MTXNQ1350514
Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)MUTP2203314
Methyltransferase-like protein 13 (EC 2.1.1.-)METTL13 KIAA0859 CGI-01Q8N6R014
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)MAD1L1 MAD1 TXBP181Q9Y6D914
MYH14 protein (Myosin-14)MYH14A1L2Z214
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)MPRIP KIAA0864 MRIP RHOIP3Q6WCQ114
N-alpha-acetyltransferase 16, NatA auxiliary subunit (NMDA receptor-regulated 1-like protein) (NARG1-like protein)NAA16 NARG1L NAT2Q6N06914
NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)NLRP2 NALP2 NBS1 PAN1 PYPAF2Q9NX0214
NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)SIRT2 SIR2L SIR2L2Q8IXJ614
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)NDUFB5O4367414
NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2)CYB5R2Q6BCY414
Negative elongation factor C/D (NELF-C/D) (TH1-like protein)NELFCD NELFD TH1 TH1L HSPC130Q8IXH714
Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein)NENF CIR2 SPUFQ9UMX514
Nodal modulator 2 (pM5 protein 2)NOMO2Q5JPE714
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)SP100P2349714
Nuclear export mediator factor NEMF (Antigen NY-CO-1) (Serologically defined colon cancer antigen 1)NEMF SDCCAG1O6052414
Pepsin A-3 (EC 3.4.23.1) (Pepsinogen-3)PGA3P0DJD814
Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP)PLIN2 ADFPQ9954114
Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) (Protein PEX11 homolog beta) (PEX11-beta)PEX11BO9601114
PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3)PSD3 EFA6R HCA67 KIAA0942Q9NYI014
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)PREX1 KIAA1415Q8TCU614
Phosphofurin acidic cluster sorting protein 1 (PACS-1)PACS1 KIAA1175Q6VY0714
Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)PGK1 PGKA MIG10 OK/SW-cl.110A8K4W614
Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)PLXNA3 PLXN4 SEXP5180514
Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia)FIP1L1 FIP1 RHEQ6UN1514
Probable maltase-glucoamylase 2 (Maltase-glucoamylase (alpha-glucosidase) pseudogene) [Includes: Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]MGAM2Q2M2H814
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y)USP9Y DFFRYO0050714
Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)PDCD1LG2 B7DC CD273 PDCD1L2 PDL2Q9BQ5114
Prolargin (Proline-arginine-rich end leucine-rich repeat protein)PRELP SLRR2AP5188814
Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)PCSK5 PC5 PC6Q9282414
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