EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Microsomal triglyceride transfer protein large subunitMTTP MTPP5515712
Microtubule-associated proteinMAP4E7EVA012
Mitochondrial fission factorMFF C2orf33 AD030 AD033 GL004Q9GZY812
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)MAPK9 JNK2 PRKM9 SAPK1AP4598412
Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156)MYEF2 KIAA1341Q9P2K512
Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)CD33 SIGLEC3P2013812
Myosin light polypeptide 6 (Fragment)MYL6F8VPF312
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)MYL2 MLC2P1091612
Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)MTMR2 KIAA1073Q1361412
N-acetylated-alpha-linked acidic dipeptidase-like protein (NAALADase L) (EC 3.4.17.21) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase)NAALADL1 NAALADASEL NAALADLQ9UQQ112
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)NDUFS6O7538012
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)PPP1R9B PPP1R6Q96SB312
Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein]CHL1 CALLO0053312
Nexilin (F-actin-binding protein) (Nelin)NEXNQ0ZGT212
NF-kappa-B-repressing factor (NFkB-repressing factor) (Protein ITBA4) (Transcription factor NRF)NKRF ITBA4 NRFO1522612
Non-histone chromosomal protein HMG-14 (High mobility group nucleosome-binding domain-containing protein 1)HMGN1 HMG14P0511412
Nuclear factor 1 B-type (NF1-B) (Nuclear factor 1/B) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/B) (NF-I/B) (NFI-B) (TGGCA-binding protein)NFIBO0071212
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]NFKB1P1983812
Nucleolar protein 11NOL11 L14Q9H8H012
NudC domain-containing protein 3NUDCD3 KIAA1068Q8IVD912
OX-2 membrane glycoprotein (CD antigen CD200)CD200 MOX1 MOX2 My033P4121712
Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4)PPIL4Q8WUA212
Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Digestion substraction 1) (DS-1) (Immature colon carcinoma transcript 1 protein) (Mitochondrial large ribosomal subunit protein mL62)MRPL58 DS1 ICT1Q1419712
Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502)PWP1Q1361012
Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)CDS2O9567412
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)PIK3R2O0045912
Platelet glycoprotein V (GPV) (Glycoprotein 5) (CD antigen CD42d)GP5P4019712
Pre-mRNA-splicing factor ISY1 homologISY1 KIAA1160Q9ULR012
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1Q9NZQ712
Proline and serine-rich protein 2PROSER2 C10orf47Q86WR712
Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)AKT1S1 PRAS40Q96B3612
Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)PCSK6 PACE4P2912212
Protein AAR2 homolog (AAR2 splicing factor homolog)AAR2 C20orf4 CGI-23 PRO0225Q9Y31212
Protein angel homolog 2ANGEL2 KIAA0759LQ5VTE612
Protein archease (Protein ZBTB8OS) (Zinc finger and BTB domain-containing opposite strand protein 8)ZBTB8OS ARCHQ8IWT012
Protein DPCDDPCDQ9BVM212
Protein FAM114A2FAM114A2 C5orf3Q9NRY512
Protein FAM136AFAM136AQ96C0112
Protein FAM171BFAM171B KIAA1946 NPD019Q6P99512
Protein GPR107 (Lung seven transmembrane receptor 1)GPR107 KIAA1624 LUSTR1Q5VW3812
Protein IWS1 homolog (IWS1-like protein)IWS1 IWS1LQ96ST212
Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)PPP1R16A MYPT3Q96I3412
Protein phosphatase inhibitor 2 (IPP-2)PPP1R2 IPP2P4123612
Protein sidekick-1SDK1Q7Z5N412
Protein SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog)SMG8 ABC2 C17orf71Q8ND0412
Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III]YIPF3 C6orf109 KLIP1Q9GZM512
Protein YIPF4 (YIP1 family member 4)YIPF4 Nbla11189Q9BSR812
Protein ZGRF1 (GRF-type zinc finger domain-containing protein 1)ZGRF1 C4orf21Q86YA312
Protein zwilch homolog (hZwilch)ZWILCHQ9H90012
Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3)FAT3 CDHF15 KIAA1989Q8TDW712
Putative heat shock protein HSP 90-alpha A5 (Heat shock protein 90-alpha E) (Heat shock protein 90Ae)HSP90AA5P HSP90AEQ58FG012
Putative WAS protein family homolog 3 (Protein FAM39DP)WASH3P FAM39DPC4AMC712
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)PDHX PDX1O0033012
Pyruvate kinase PKM (Fragment)PKMH3BT2512
Pyruvate kinase PKM (Fragment)PKMH3BU1312
Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)RAPGEF3 CGEF1 EPAC EPAC1O9539812
Ras-related protein Rab-7aRAB7AC9J8S312
RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)RASAL1 RASALO9529412
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP)RIPK1 RIP RIP1Q1354612
Regulation of nuclear pre-mRNA domain-containing protein 2RPRD2 KIAA0460 HSPC099Q5VT5212
Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)ARHGAP29 PARG1Q52LW312
Ribonuclease P protein subunit p14 (EC 3.1.26.5)RPP14O9505912
Ribosomal protein S3 variant (Fragment)0Q53G8312
RNA-binding protein NOB1 (Phosphorylation regulatory protein HP-10) (Protein ART-4)NOB1 ART4 NOB1P PSMD8BP1 MSTP158Q9ULX312
RNA-binding protein PNO1PNO1Q9NRX112
RotatinRTTNQ86VV812
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)ATP2A1O1498312
Secretoglobin family 1D member 2 (Lipophilin-B)SCGB1D2 LIPHB LPNBO9596912
Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)SARS2 SARSMQ9NP8112
Serum albumin (Fragment)ALBH7C01312
Signal transducer and activator of transcription 6 (IL-4 Stat)STAT6P4222612
Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)SIGIRR UNQ301/PRO342Q6IA1712
Single-stranded DNA-binding proteinSSBP1Q567R612
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)SUMO3 SMT3A SMT3H1P5585412
Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11)SLC26A11Q86WA912
Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)SLC15A4 PHT1 PTR4 FP12591Q8N69712
Solute carrier family 2, facilitated glucose transporter member 6 (Glucose transporter type 6) (GLUT-6) (Glucose transporter type 9) (GLUT-9)SLC2A6 GLUT9Q9UGQ312
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)SORBS1 KIAA0894 KIAA1296 SH3D5Q9BX6612
Sorting nexin-24SNX24 SBBI31 UNQ654/PRO1284Q9Y34312
Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STATP3561012
Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)SYNJ1 KIAA0910O4342612
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)CD4P0173012
Target of EGR1 protein 1TOE1Q96GM812
Tetraspanin-10 (Tspan-10) (Oculospanin)TSPAN10 OCSPQ9H1Z912
Thioredoxin domain-containing protein 16TXNDC16 ERP90 KIAA1344Q9P2K212
THUMP domain-containing protein 1THUMPD1Q9NXG212
Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)TJP3 ZO3O9504912
Transferrin receptor (P90, CD71), isoform CRA_c (Transferrin receptor protein 1)TFRC hCG_22086G3V0E512
TranslinTSNE9PGT112
Translocating chain-associated membrane protein 1TRAM1 TRAMQ1562912
Transmembrane protein 41BTMEM41B KIAA0033Q5BJD512
Transmembrane protein C16orf54C16orf54 UNQ9389/PRO34280Q6UWD812
Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)TREH TREAO4328012
Tripartite motif-containing protein 26 (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173)TRIM26 RNF95 ZNF173Q1289912
Tubulin alpha-1B chain (Fragment)TUBA1BF8VRK012
Tubulin beta chainTUBBQ5JP5312
Tubulin polymerization-promoting protein family member 3 (TPPP/p20)TPPP3 CGI-38Q9BW3012
Tumor protein D53 (hD53) (Tumor protein D52-like 1)TPD52L1Q1689012
Tumor susceptibility gene 101 proteinTSG101F5H44212
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)TYROBP DAP12 KARAPO4391412
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