EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)ROR2 NTRKR2Q0197412
U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component)UTP4 CIRH1A cPERP-E KIAA1988Q969X612
U6 snRNA-associated Sm-like protein LSm7LSM7Q9UK4512
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)B3GALNT1 B3GALT3 UNQ531/PRO1074O7575212
UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)UGGT2 UGCGL2 UGT2Q9NYU112
Unconventional myosin-VIIaMYO7A USH1BQ1340212
UPF0687 protein C20orf27C20orf27Q9GZN812
UPF0696 protein C11orf68 (Basophilic leukemia-expressed protein Bles03) (Protein p5326)C11orf68 BLES03Q9H3H312
Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)SLC14A1 HUT11 JK RACH1 UT1 UTEQ1333612
V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2)ATP6V1C2Q8NEY412
Vacuolar protein sorting-associated protein 8 homologVPS8 KIAA0804Q8N3P412
Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)CRYBG3Q68DQ212
Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]PROCP0407012
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)WIPF2 WICH WIRE PP10631Q8TF7412
WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1)WDHD1 AND1O7571712
WD repeat- and FYVE domain-containing protein 4WDFY4 C10orf64 KIAA1607Q6ZS8112
28S ribosomal protein S35, mitochondrial (MRP-S35) (S35mt) (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt) (Mitochondrial small ribosomal subunit protein mS35)MRPS35 MRPS28 HDCMD11P MDS023 PSEC0213P8267311
39S ribosomal protein L15, mitochondrial (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein uL15m)MRPL15 HSPC145Q9P01511
40S ribosomal protein S3RPS3E9PPU111
4F2 cell-surface antigen heavy chain (Fragment)SLC3A2H0YFX411
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)PRKAB1 AMPKQ9Y47811
60S ribosomal protein L14RPL14E7EPB311
60S ribosomal protein L270B2R4D811
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-)ADAMTS12 UNQ1918/PRO4389P5839711
ABI gene family member 3 (New molecule including SH3) (Nesh)ABI3 NESHQ9P2A411
Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)ACVR1B ACVRLK4 ALK4P3689611
Acyl-CoA-binding domain-containing protein 5ACBD5 KIAA1996Q5T8D311
Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3)ADGRB3 BAI3 KIAA0550O6024211
Adhesion G-protein coupled receptor F1 (G-protein coupled receptor 110) (G-protein coupled receptor KPG_012) (G-protein coupled receptor PGR19)ADGRF1 GPR110 PGR19Q5T60111
ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) (HSP-975) (HSVI-binding protein) (SR-15) (SRp25) (SR-25) (Splicing factor SRrp37)ARL6IP4Q66PJ311
ADP-ribosylation factor-related protein 1 (ARF-related protein 1) (ARP)ARFRP1 ARP1Q1379511
Alpha-actinin-4ACTN4F5GXS211
Annexin (Fragment)ANXA2H0YM5011
Annexin (Fragment)ANXA2H0YN5211
Annexin A2 (Fragment)ANXA2H0YNB811
Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)ANO7 NGEP PCANAP5 TMEM16GQ6IWH711
ANXA1 proteinANXA1Q05BR211
APOA1 protein (Apolipoprotein A1) (Fragment)APOA1Q6LEJ811
Apolipoprotein A-IAPOA1F8W69611
Arachidonate 15-lipoxygenase B (15-LOX-B) (EC 1.13.11.33) (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-)ALOX15BO1529611
ATPase family AAA domain-containing protein 2 (EC 3.6.1.3) (AAA nuclear coregulator cancer-associated protein) (ANCCA)ATAD2 L16 PRO2000Q6PL1811
Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B)NPR2 ANPRBP2059411
Autophagy protein 5 (APG5-like) (Apoptosis-specific protein)ATG5 APG5L ASPQ9H1Y011
Autophagy-related protein 16-1 (APG16-like 1)ATG16L1 APG16L UNQ9393/PRO34307Q676U511
Autophagy-related protein 2 homolog BATG2B C14orf103Q96BY711
B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)MS4A1 CD20P1183611
Basigin (Ok blood group), isoform CRA_a (Cervical EMMPRIN) (cDNA FLJ36018 fis, clone TESTI2016337, highly similar to BASIGIN)hEMMPRIN BSG hCG_20562Q54A5111
Beta-1,4-galactosyltransferase 3 (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3) [Includes: N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]B4GALT3O6051211
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)BMPR2 PPH1Q1387311
C-myc promoter-binding protein (DENN domain-containing protein 4A)DENND4A IRLB MYCPBPQ7Z40111
Cadherin EGF LAG seven-pass G-type receptor 1 (Cadherin family member 9) (Flamingo homolog 2) (hFmi2)CELSR1 CDHF9 FMI2Q9NYQ611
Calcium homeostasis modulator protein 2 (Protein FAM26B)CALHM2 FAM26BQ9HA7211
Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) (Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form]CLCA4 CaCC2 UNQ562/PRO1124Q14CN211
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)CAMK2B CAM2 CAMK2 CAMKBQ1355411
Calmodulin-2CALM2 CAM2 CAMBP0DP2411
cAMP-dependent protein kinase type II-alpha regulatory subunitPRKAR2A PKR2 PRKAR2Q9BUB111
Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III)CA3P0745111
Cardiomyopathy-associated protein 5 (Dystrobrevin-binding protein 2) (Genethonin-3) (Myospryn) (SPRY domain-containing protein 2) (Tripartite motif-containing protein 76)CMYA5 C5orf10 DTNBP2 SPRYD2 TRIM76Q8N3K911
Casein kinase II subunit alphaCSNK2A1E7EU9611
cDNA FLJ55895, highly similar to Ras-related protein Rab-70B4DPH911
cDNA FLJ58187, highly similar to Protein-glutamine gamma-glutamyltransferase 2(EC 2.3.2.13)0B4DIT711
cDNA FLJ58275, highly similar to Keratin, type II cytoskeletal 40B4DRS211
cDNA, FLJ93804, highly similar to Homo sapiens gp25L2 protein (HSGP25L2G), mRNA0B2R8A211
Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6)CENPV PRR6Q7Z7K611
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Tumor metastasis-suppressor gene 1 protein)CERS2 LASS2 TMSG1Q96G2311
Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7)CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7Q1311211
ClaudinCLDN3 hCG_1737329Q75L7911
Claudin-6 (Skullin)CLDN6 UNQ757/PRO1488P5674711
Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]F7P0870911
Coiled-coil domain-containing protein 43CCDC43Q96MW111
Collagen alpha-1(IX) chainCOL9A1P2084911
Complement C1q tumor necrosis factor-related protein 6C1QTNF6 CTRP6 UNQ581/PRO1151Q9BXI911
Complement C3 (Fragment)C3M0R0Q911
Complex III assembly factor LYRM7 (LYR motif-containing protein 7)LYRM7 C5orf31 MZM1LQ5U5X011
Copine-6 (Copine VI) (Neuronal-copine) (N-copine)CPNE6O9574111
CPNE3 protein (Fragment)CPNE3Q05DL811
CWF19-like protein 1 (C19L1)CWF19L1Q69YN211
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)CKS1B CKS1 PNAS-143 PNAS-16P6102411
Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]CSTA STF1 STFAQ6IB9011
Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2)CRISPLD2 CRISP11 LCRISP2 UNQ2914/PRO1156/PRO9783Q9H0B811
Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)UQCRHP0791911
Cytochrome b561 (Cytochrome b-561)CYB561P4944711
Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)CRLF3 CREME9 CRLM9 CYTOR4 P48Q8IUI811
Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1)DHRS7B SDR32C1 CGI-93 UNQ212/PRO238Q6IAN011
Diacylglycerol kinase alpha (DAG kinase alpha) (EC 2.7.1.107) (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha)DGKA DAGK DAGK1P2374311
DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)POLR2G RPB7P6248711
DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1)DNAJB9 MDG1 UNQ743/PRO1471Q9UBS311
Down syndrome critical region protein 3 (Down syndrome critical region protein A)DSCR3 DCRA DSCRAO1497211
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)MID1 FXY RNF59 TRIM18 XPRFO1534411
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)RNF114 ZNF228 ZNF313Q9Y50811
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.27) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)RNF31 ZIBRAQ96EP011
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)SMURF1 KIAA1625Q9HCE711
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD)ENPP2 ATX PDNP2Q1382211
EH domain-binding protein 1EHBP1 KIAA0903 NACSINQ8NDI111
ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)ELAVL4 HUD PNEMP2637811
ELMO domain-containing protein 2ELMOD2Q8IZ8111
Endonuclease/exonuclease/phosphatase family domain-containing protein 1EEPD1 KIAA1706Q7L9B911
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK)EPHA8 EEK HEK3 KIAA1459P2932211
Epithelial cell adhesion molecule (Fragment)EPCAMC9JKY311
Eukaryotic translation initiation factor 3 subunit C-like proteinEIF3CLB5ME1911
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