EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Rab GTPase-activating protein 1-likeRABGAP1L HHL KIAA0471Q5R37210
RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2)REPS2 POB1Q8NFH810
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.27) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)RBCK1 C20orf18 RNF54 UBCE7IP3 XAP3 XAP4Q9BYM810
Ras-related protein Rab-7aRAB7AC9J7D110
Ras-related protein Rab-8B (Fragment)RAB8BH0YNE910
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)ERBB3 HER3P2186010
Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51)RMDN3 FAM82A2 FAM82C PTPIP51 hucep-10 UNQ3122/PRO10274Q96TC710
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)RBBP5 RBQ3Q1529110
Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)ARHGAP12Q8IWW610
Rho guanine nucleotide exchange factor 10ARHGEF10 KIAA0294O1501310
Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)ARHGEF17 KIAA0337 TEM4Q96PE210
Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C)RNASEH2C AYP1Q8TDP110
Ribonuclease pancreatic (EC 3.1.27.5) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A)RNASE1 RIB1 RNS1P0799810
Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III)PRPS1L1 PRPS3 PRPSLP2110810
Ribosomal protein S19 (Fragment)0Q8WVX710
Ribosome-releasing factor 2, mitochondrial (RRF2mt) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2) (Elongation factor G2) (hEFG2)GFM2 EFG2 MSTP027Q969S910
RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)LEO1 RDLQ8WVC010
RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)RBM4B RBM30Q9BQ0410
S-phase kinase-associated protein 1SKP1E5RJR510
Septin 11, isoform CRA_b (Septin-11)SEPT11 hCG_24410D6RGI310
Septin-7SEPT7G3V1Q410
Septin-7SEPT7E7ES3310
Serum albuminALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341Q8IUK710
SET and MYND domain-containing protein 5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15)SMYD5 RAI15Q6GMV210
SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)SH3PXD2B FAD49 KIAA1295 TKS4A1X28310
Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)SPCS1 SPC12 HSPC033Q9Y6A910
Signal peptide, CUB and EGF-like domain-containing protein 3SCUBE3 CEGF3Q8IX3010
Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1)SIPA1 SPA1Q96FS410
SLIT and NTRK-like protein 5 (Leucine-rich repeat-containing protein 11)SLITRK5 KIAA0918 LRRC11O9499110
Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein)SMAGPQ0VAQ410
Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II)SPRR2EP2253110
Snurportin-1 (RNA U transporter 1)SNUPN RNUT1 SPN1O9514910
Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13)SLC6A13 GAT2Q9NSD510
Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)SLC2A12 GLUT12 GLUT8Q8TD2010
Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2)SLC2A2 GLUT2P1116810
Spectrin, beta, erythrocytic (Includes spherocytosis, clinical type I) variant (Fragment)0Q59FP510
Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)SAMD9L C7orf6 DRIF2 KIAA2005 UEFQ8IVG510
Stomatin-like protein 3 (SLP-3)STOML3Q8TAV410
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1)SDHAD6RFM510
Surfeit locus protein 1SURF1 SURF-1Q1552610
T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1) (CD antigen CD5)CD5 LEU1P0612710
T-complex protein 1 subunit delta0A8K3C310
T-complex protein 1 subunit gammaCCT3B4DUR810
Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)ACP5P1368610
TBC1 domain family member 13TBC1D13Q9NVG810
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)TERF2IP DRIP5 RAP1 PP8000Q9NYB010
Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)SPOCK3 TICN3 UNQ409/PRO771Q9BQ1610
TetraspaninTSPAN4J3KQ4210
Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230)TRIP11 CEV14Q1564310
TOG array regulator of axonemal microtubules protein 1 (Crescerin-1) (Protein FAM179B)TOGARAM1 FAM179B KIAA0423Q9Y4F410
Torsin-2A (Torsin family 2 member A) (Torsin-related protein 1)TOR2A TORP1 UNQ6408/PRO21181Q5JU6910
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)TANK ITRAF TRAF2Q9284410
Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis)TRAPPC12 TRAMM TTC15 CGI-87Q8WVT310
Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)GTF2E2 TF2E2P2908410
Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)YY1 INO80SP2549010
Transgelin-2 (Fragment)TAGLN2X6RJP610
Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)TRPV5 ECAC1Q9NQA510
Transitional endoplasmic reticulum ATPase (Fragment)VCPC9IZA510
Translation machinery-associated protein 7 (Coiled-coil domain-containing protein 72)TMA7 CCDC72 HSPC016 HSPC330Q9Y2S610
Transmembrane protein 214TMEM214 PP446Q6NUQ410
Transmembrane protein 222TMEM222 C1orf160Q9H0R310
Transport and Golgi organization protein 2 homologTANGO2 C22orf25Q6ICL310
tRNA pseudouridine synthase A, mitochondrial (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)PUS1 PP8985Q9Y60610
Tubulin alpha-4A chain (Fragment)TUBA4AC9JDS910
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)ZAP70 SRKP4340310
Ubiquitin-associated protein 2 (UBAP-2)UBAP2 KIAA1491Q5T6F210
UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6)UGT1A6 GNT1 UGT1P1922410
Uncharacterized protein C1orf109C1orf109Q9NX0410
Unconventional myosin-VIIbMYO7BQ6PIF610
Unconventional myosin-XVIIIbMYO18BQ8IUG510
UPF0577 protein KIAA1324 (Estrogen-induced gene 121 protein)KIAA1324 EIG121 UNQ2426/PRO4985Q6UXG210
Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase)UROC1Q96N7610
UV radiation resistance-associated gene protein (p63)UVRAGQ9P2Y510
Vacuolar fusion protein CCZ1 homologCCZ1 C7orf28A CGI-43P8679110
Vacuolar protein sorting 28 (Yeast), isoform CRA_a (Vacuolar protein sorting 28-like protein isoform 1) (Vacuolar sorting protein 28)VPS28 hCG_24005Q548N110
Vacuolar protein sorting-associated protein 28 homolog (Fragment)VPS28E9PQR710
Vesicle-associated membrane protein 4 (VAMP-4)VAMP4O7537910
VH3 protein (Fragment)VH3Q9Y50910
Villin-like proteinVILLO1519510
VIP36-like protein (Lectin mannose-binding 2-like) (LMAN2-like protein)LMAN2L VIPL PSEC0028 UNQ368/PRO704Q9H0V910
Vitamin D-binding proteinGCD6RF3510
Voltage-dependent calcium channel beta subunit-associated regulatory proteinCBARP C19orf26Q8N35010
WASH complex subunit 3 (Coiled-coil domain-containing protein 53)WASHC3 AD-016 CCDC53 CGI-116 x0009Q9Y3C010
WD repeat-containing protein 87 (Testis development protein NYD-SP11)WDR87Q6ZQQ610
WD repeat-containing protein mioMIOSQ9NXC510
Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3)WASF3 KIAA0900 SCAR3 WAVE3Q9UPY610
Xaa-Pro aminopeptidase 1XPNPEP1Q5T6H710
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]XDH XDHAP4798910
Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin)XIRP2 CMYA3A4UGR910
Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37)ZC3H14Q6PJT710
[Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme)ADPRH ARH1P5492210
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2)PLCB2Q007229
28S ribosomal protein S11, mitochondrial (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) (Mitochondrial small ribosomal subunit protein uS11m)MRPS11 RPMS11 HCC2P829129
28S ribosomal protein S21, mitochondrial (MRP-S21) (S21mt) (Mitochondrial small ribosomal subunit protein bS21m)MRPS21 RPMS21 MDS016P829219
28S ribosomal protein S6, mitochondrial (MRP-S6) (S6mt) (Mitochondrial small ribosomal subunit protein bS6m)MRPS6 C21orf101 RPMS6P829329
39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18) (Mitochondrial large ribosomal subunit protein uL18m)MRPL18 HSPC071Q9H0U69
39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28) (Melanoma antigen p15) (Melanoma-associated antigen recognized by T-lymphocytes) (Mitochondrial large ribosomal subunit protein bL28m)MRPL28 MAAT1Q130849
39S ribosomal protein L37, mitochondrial (L37mt) (MRP-L37) (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) (Mitochondrial large ribosomal subunit protein mL37)MRPL37 MRPL2 RPML2 HSPC235Q9BZE19
39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53) (Mitochondrial large ribosomal subunit protein mL53)MRPL53Q96EL39
40S ribosomal protein S3RPS3E9PQ969
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