EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
DBF4-type zinc finger-containing protein 2ZDBF2 KIAA1571Q9HCK19
Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1)DHRS2 SDR25C1Q132689
Dihydropyrimidinase-like 2 variant (Fragment)0Q59GB49
DmX-like protein 1 (X-like 1 protein)DMXL1 XL1Q9Y4859
DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2)IGHMBP2 SMBP2 SMUBP2P389359
Dystrobrevin alpha (DTN-A) (Alpha-dystrobrevin) (Dystrophin-related protein 3)DTNA DRP3Q9Y4J89
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)EP400 CAGH32 KIAA1498 KIAA1818 TNRC12Q96L919
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)PELI1 PRISMQ96FA39
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)RBBP6 P2PR PACT RBQ1 My038Q7Z6E99
E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) (RING-type E3 ubiquitin transferase RNF167) (RING105)RNF167 LP2254Q9H6Y79
EH domain-containing protein 1 (Fragment)EHD1C9JIJ39
Endothelin B receptor (ET-B) (ET-BR) (Endothelin receptor non-selective type)EDNRB ETRBP245309
EPH receptor B4, isoform CRA_b (Ephrin type-B receptor 4) (Receptor protein tyrosine kinase variant EphB4v1)EPHB4 hCG_20448Q96L359
Epididymis luminal protein 112 (Ribosomal protein S27a, isoform CRA_c) (cDNA, FLJ96793, Homo sapiens ribosomal protein S27a (RPS27A), mRNA)RPS27A HEL112 hCG_1987923B2RDW19
Epididymis secretory protein Li 85 (Poly(RC) binding protein 1) (Putative uncharacterized protein PCBP1) (cDNA, FLJ94964, highly similar to Homo sapiens poly(rC) binding protein 1 (PCBP1), mRNA)PCBP1 HEL-S-85 hCG_1776997Q53SS89
EPM2A-interacting protein 1 (Laforin-interacting protein)EPM2AIP1 KIAA0766 My007Q7L7759
ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1)EMC10 C19orf63 HSM1 INM02 UNQ764/PRO1556Q5UCC49
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta)EIF3S9 EIF3B hCG_1998988 tcag7.544A4D2109
Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48)EIF3E EIF3S6 INT6B2R8069
F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)FBXL20 FBL2Q96IG29
F11 receptor (F11 receptor protein) (F11 receptor, isoform CRA_c) (F11R protein) (JAM1) (cDNA FLJ90671 fis, clone PLACE1005544, highly similar to Junctional adhesion molecule 1)F11R hCG_20857Q6FIB49
FerritinFTH1 hCG_1776129G3V1D19
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)FRS2Q8WU209
Fibrous sheath-interacting protein 2FSIP2Q5CZC09
FLJ00385 protein (Fragment)FLJ00385Q8NF179
Flotillin-2 (HCG1998851, isoform CRA_h)FLOT2 hCG_1998851J3QLD99
Formin-2FMN2Q9NZ569
Fructose-bisphosphate aldolase (EC 4.1.2.13) (Fragment)ALDOAH3BU789
Fructose-bisphosphate aldolase A (Fragment)ALDOAH3BUH79
G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1)GPR98 KIAA0686 KIAA1943 MASS1 VLGR1Q8WXG99
G-protein-coupled receptor family C group 5 member CGPRC5CJ9JIE09
G-protein-signaling modulator 1 (Activator of G-protein signaling 3)GPSM1 AGS3Q86YR59
Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta)GABRQQ9UN889
GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)POFUT2 C21orf80 FUT13 KIAA0958Q9Y2G59
Glutamate-rich protein 5ERICH5 C8orf47Q6P6B19
Glutathione peroxidase 2 (GPx-2) (GSHPx-2) (EC 1.11.1.9) (Gastrointestinal glutathione peroxidase) (Glutathione peroxidase-gastrointestinal) (GPx-GI) (GSHPx-GI) (Glutathione peroxidase-related protein 2) (GPRP-2)GPX2P182839
Glutathione S-transferase (EC 2.5.1.18)GSTM3 hCG_40244Q6FGJ99
Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2)GSTT2P0CG299
Glycine N-methyltransferase (EC 2.1.1.20)GNMTQ147499
Glypican-1GPC1H7C4109
GNB2 protein (Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a) (cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA)GNB2 hCG_20449Q6FHM29
GPN-loop GTPase 3 (ATP-binding domain 1 family member C)GPN3 ATPBD1C AD-009 UNQ1876/PRO4319Q9UHW59
Haloacid dehalogenase-like hydrolase domain-containing protein 3HDHD3 C9orf158Q9BSH59
HCG1995540, isoform CRA_b (HCG2044074, isoform CRA_d) (RAB4B protein) (Ras-related protein Rab-4B)RAB4B hCG_1995540 hCG_2044074Q6PIK39
Heat shock cognate 71 kDa protein (Fragment)HSPA8E9PK549
Hedgehog-interacting protein (HHIP) (HIP)HHIP HIP UNQ5825/PRO19644Q96QV19
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)SRCAP KIAA0309Q6ZRS29
Hemoglobin alpha-1 globin chain variant (Fragment)HBA1E1B2D19
Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-)HS2ST1 HS2ST KIAA0448Q7LGA39
Hephaestin (EC 1.-.-.-)HEPH KIAA0698 UNQ2562/PRO6242Q9BQS79
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)FCGR1A FCG1 FCGR1 IGFR1P123149
HLA class I histocompatibility antigen, B-51 alpha chain (MHC class I antigen B*51)HLA-B HLABP184649
HLA class II histocompatibility antigen, DRB1-14 beta chain (MHC class II antigen DRB1*14) (DR-14) (DR14)HLA-DRB1Q9GIY39
Homer protein homolog 1 (Homer-1)HOMER1 SYN47Q86YM79
HRV Fab 027-VL (Fragment)0A2IPI69
Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1)HAS1 HASQ928399
IGH@ proteinIGH@Q6GMX69
IGK@ proteinIGK@Q6PJF29
Immunoglobulin heavy variable 3-15IGHV3-15A0A0B4J1V09
Immunoglobulin heavy variable 3-33 (Ig heavy chain V-III region HIL) (Ig heavy chain V-III region KOL)IGHV3-33P017719
Immunoglobulin kappa variable 1-39 (Ig kappa chain V-I region DEE) (Ig kappa chain V-I region Hau) (Ig kappa chain V-I region Mev) (Ig kappa chain V-I region OU) (Ig kappa chain V-I region Walker)IGKV1-39P016129
Immunoglobulin kappa variable 2D-28 (Ig kappa chain V-II region FR) (Ig kappa chain V-II region GM607) (Ig kappa chain V-II region MIL) (Ig kappa chain V-II region TEW)IGKV2D-28P016169
Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)IGKV3-20P063119
Immunoglobulin lambda variable 1-40 (Ig lambda chain V-I region NEWM)IGLV1-40P017039
Immunoglobulin lambda variable 6-57 (Ig lambda chain V-VI region AR) (Ig lambda chain V-VI region EB4) (Ig lambda chain V-VI region NIG-48) (Ig lambda chain V-VI region SUT) (Ig lambda chain V-VI region WLT)IGLV6-57P017219
Importin subunit alpha-6 (Karyopherin subunit alpha-5)KPNA5O151319
Importin-5 (Fragment)IPO5H0Y8C69
Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein)OCRL INPP5F OCRL1Q019689
Integral membrane protein 2A (Protein E25)ITM2A UNQ603/PRO1189O437369
Integrin beta-1 (Fragment)ITGB1C9JPK59
IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2)IQSEC1 ARFGEP100 BRAG2 KIAA0763Q6DN909
ITGAV proteinITGAVA5YM539
Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)KLK5 SCTE UNQ570/PRO1132Q9Y3379
Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)KLK7 PRSS6 SCCEP498629
KDEL motif-containing protein 2KDELC2 UNQ1904/PRO4350Q7Z4H89
Keratin (Fragment)keratinQ161959
Keratin, type I cytoskeletal 19 (Fragment)KRT19K7EMS39
Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)KRT23Q9C0759
Keratin, type II cytoskeletal 5 (Fragment)KRT5F8VV579
Keratinocyte-associated protein 2 (KCP-2)KRTCAP2 KCP2Q8N6L19
Kinesin-like protein KIF3CKIF3CO147829
KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)KANK1 ANKRD15 KANK KIAA0172Q146789
L-fucose kinase (Fucokinase) (EC 2.7.1.52)FUKQ8N0W39
L-lactate dehydrogenase A chainLDHAF5H8H69
L-lactate dehydrogenase B chain (Fragment)LDHBF5H7939
Lactotransferrin (Fragment)LTFE7EQB29
Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2)SLC43A2 LAT4 PP7664Q8N3709
Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-)LSG1Q9H0899
Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP)LEPROT LEPR OBRO152439
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)LZTS1 FEZ1Q9Y2509
Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)FLRT2 KIAA0405 UNQ232/PRO265O431559
Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)LGR4 GPR48Q9BXB19
Leucine-rich repeat-containing protein 57 (Fragment)LRRC57H3BSW09
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)LILRB1 ILT2 LIR1 MIR7Q8NHL69
Leukocyte immunoglobulin-like receptor subfamily B member 4 (CD85 antigen-like family member K) (Immunoglobulin-like transcript 3) (ILT-3) (Leukocyte immunoglobulin-like receptor 5) (LIR-5) (Monocyte inhibitory receptor HM18) (CD antigen CD85k)LILRB4 ILT3 LIR5Q8NHJ69
LIM domain-containing protein 2LIMD2 SB143Q9BT239
Lipase member M (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 3)LIPM LIPL3Q5VYY29
Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)PPFIA2O753349
Lithostathine-1-alpha (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) (Regenerating islet-derived protein 1-alpha) (REG-1-alpha) (Regenerating protein I alpha)REG1A PSPS PSPS1 REGP054519
Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)LYPD3 C4.4A UNQ491/PRO1007O952749
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