EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)CR2 C3DRP200238
Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein)CNKSR3 MAGI1Q6P9H48
COP9 signalosome complex subunit 1 (G protein pathway suppressor 1, isoform CRA_b)GPS1 hCG_1987516C9JFE48
COP9 signalosome complex subunit 6COPS6E7EM648
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)CDK11B CDC2L1 CDK11 PITSLREA PK58P211278
Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase)CSAD CSDQ9Y6008
Cytoglobin (Histoglobin) (HGb) (Stellate cell activation-associated protein)CYGB STAPQ8WWM98
Cytoplasmic dynein heavy chain (Fragment)0Q9NRC38
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) (Short chain dehydrogenase/reductase family 9C member 1)BDH1 BDH SDR9C1Q023388
D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)GLCE KIAA0836O949238
Death-associated protein 1 (DAP-1)DAP DAP1P513978
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)DAPK1 DAPKP533558
Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)DIDO1 C20orf158 DATF1 KIAA0333Q9BTC08
Dedicator of cytokinesis protein 6DOCK6 KIAA1395Q96HP08
Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 19C member 1)DHRS1 SDR19C1Q96LJ78
Delta globin (Delta-globin chain) (Globin A2) (Hemoglobin delta) (Hemoglobin, delta)HBD GLNA2 hCG_1641001A0N0718
DestrinDSTNF6RFD58
Di-N-acetylchitobiase (EC 3.2.1.-)CTBS CTBQ014598
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2)ADAM22 MDC2Q9P0K18
DmX-like protein 2 (Rabconnectin-3)DMXL2 KIAA0856Q8TDJ68
DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)ERCC6L PICHQ2NKX88
DNA helicase (EC 3.6.4.12)0B2RBA68
DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-)POLBP067468
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A)POLE POLE1Q078648
DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)ERCC4 ERCC11 XPFQ928898
DNA replication complex GINS protein PSF1 (GINS complex subunit 1)GINS1 KIAA0186 PSF1Q146918
DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta-1)TOP3B TOP3B1O959858
Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1)DUOX1 DUOX LNOX1 THOX1Q9NRD98
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)MAP2K6 MEK6 MKK6 PRKMK6 SKK3P525648
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)TTK MPS1 MPS1L1P339818
E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.-) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)ARIH1 ARI MOP6 UBCH7BP HUSSY-27Q9Y4X58
E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin)RFFL RNF189 RNF34LQ8WZ738
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)SMURF2Q9HAU48
EH domain-containing protein 1 (Fragment)EHD1C9JDQ88
EH domain-containing protein 1 (Fragment)EHD1C9J2Z48
Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)EEF1G EF1G PRO1608B4DTG28
ENO2 protein (Enolase 2 (Gamma, neuronal), isoform CRA_a) (Epididymis secretory protein Li 279) (cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11)) (cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA)ENO2 HEL-S-279 hCG_25937Q6FHV68
Ensconsin (Epithelial microtubule-associated protein of 115 kDa) (E-MAP-115) (Microtubule-associated protein 7) (MAP-7)MAP7Q142448
Epsin-3 (EPS-15-interacting protein 3)EPN3Q9H2018
ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein)ERI3 PINT1 PRNPIP PRNPIP1O434148
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)EIF4EBP1Q135418
Exportin-6 (Exp6) (Ran-binding protein 20)XPO6 KIAA0370 RANBP20Q96QU88
Extended synaptotagmin-2 (Fragment)ESYT2H7BXI18
Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2)ECM2O947698
F-box only protein 17 (F-box only protein 26)FBXO17 FBG4 FBX17 FBX26 FBXO26Q96EF68
FerritinFTH1Q6NZ448
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)FGFR2 BEK KGFR KSAMP218028
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)FGFR4 JTK2 TKFP224558
Filamin-BFLNBE7EN958
Flotillin-2 (Fragment)FLOT2K7EKW98
Forkhead box protein K2 (Cellular transcription factor ILF-1) (FOXK1) (Interleukin enhancer-binding factor 1)FOXK2 ILF ILF1Q011678
Fructose-bisphosphate aldolase A (Fragment)ALDOAH3BMQ88
Fructose-bisphosphate aldolase A (Fragment)ALDOAH3BR688
G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75)GPATCH11 CCDC75 CENP-YQ8N9548
Galactokinase (EC 2.7.1.6) (Galactose kinase)GALK1 GALKB4E1G68
Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase)GAL3ST1 CSTQ999998
Galectin-3-binding proteinLGALS3BPK7EQT98
Gamma-glutamyltransferase 6 (GGT 6) (EC 2.3.2.2) (Gamma-glutamyltranspeptidase 6) (Glutathione hydrolase 6) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltransferase 6 heavy chain; Gamma-glutamyltransferase 6 light chain]GGT6Q6P5318
Gamma-glutamyltransferase 7 (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltransferase-like 5) (Gamma-glutamyltranspeptidase 7) (Glutathione hydrolase 7) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltransferase 7 heavy chain; Gamma-glutamyltransferase 7 light chain]GGT7 GGTL3 GGTL5Q9UJ148
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)PSENEN PEN2 MDS033Q9NZ428
Ganglioside-induced differentiation-associated protein 1 (GDAP1)GDAP1Q8TB368
Gap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDa liver protein)GJB1 CX32P080348
Glucosamine-6-phosphate isomerase (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase)0A8K3S18
Glucosidase 2 subunit betaPRKCSHK7ELL78
Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)GYPA GPAP027248
GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein)PIGT CGI-06 PSEC0163 UNQ716/PRO1379Q969N28
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)GRAP2 GADS GRB2L GRIDO757918
Growth factor receptor-bound protein 2 (Growth factor receptor-bound protein 2, isoform CRA_a) (cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA)GRB2 hCG_27179B0LPF38
GTP-binding protein 2GTPBP2Q9BX108
GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2)DIRAS2Q96HU88
Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (DGCRK3) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF)GNB1L GY2 KIAA1645 WDR14 FKSG1Q9BYB48
Hamartin (Tuberous sclerosis 1 protein)TSC1 KIAA0243 TSCQ925748
HCG1999854, isoform CRA_ahCG_1999854D3DX338
Heat shock 70kDa protein 8 isoform 1 variant (Fragment)0Q53GZ68
Heat shock cognate 71 kDa protein (Fragment)HSPA8E9PPY68
Heat shock protein beta-1HSPB1F8WE048
Hemoglobin alpha-2 (Fragment)HBA2Q86YQ18
Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]HGF HPTAP142108
Hepatocyte growth factor activatorHGFACD6RAR48
Heterogeneous nuclear ribonucleoprotein HHNRNPH1G8JLB68
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)PDE8B PIG22O952638
HIRA-interacting protein 3HIRIP3Q9BW718
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.43) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)KMT2D ALR MLL2 MLL4O146868
HLA class I histocompatibility antigen, B-46 alpha chain (Bw-46) (MHC class I antigen B*46)HLA-B HLABP304848
HSP90AB1 protein (Fragment)HSP90AB1Q6PK508
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)HMGCS2P548688
Immunoglobulin kappa variable 1-5 (Ig kappa chain V-I region CAR) (Ig kappa chain V-I region EU) (Ig kappa chain V-I region HK102) (Ig kappa chain V-I region Kue)IGKV1-5P015968
Immunoglobulin kappa variable 2D-24 (non-functional) (Fragment)IGKV2D-24A0A075B6R98
Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)IGKV3-20P181368
Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)IPO13 KIAA0724 RANBP13O948298
Inactive carboxypeptidase-like protein X2CPXM2 CPX2 UNQ676/PRO1310Q8N4368
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)CHUK IKKA TCF16O151118
Integrator complex subunit 1 (Int1)INTS1 KIAA1440 UNQ1821/PRO3434Q8N2018
Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1)INTS6 DBI1 DDX26 DDX26AQ9UL038
Interferon regulatory factor 6 (IRF-6)IRF6O148968
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)IRAK1 IRAKP516178
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]CXCL8 IL8P101458
Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1)IFT81 CDV1Q8WYA08
JmjC domain-containing protein 7 (Jumonji domain-containing protein 7)JMJD7P0C8708
Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2]KLK11 PRSS20 TLSP UNQ649/PRO1279Q9UBX78
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