EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Keratin 77KRT77Q0IIN18
Keratin, type I cuticular Ha8 (Hair keratin, type I Ha8) (Keratin-38) (K38)KRT38 HHA8 HKA8 KRTHA8O760158
Keratin, type II cytoskeletal 5 (Fragment)KRT5F8W0C68
Keratin, type II cytoskeletal 8 (Fragment)KRT8F8VUG28
Kinesin-like protein KIF13A (Kinesin-like protein RBKIN)KIF13A RBKINQ9H1H98
Kinesin-like protein KIF1CKIF1C KIAA0706O438968
Kinesin-like protein KIF26AKIF26A KIAA1236Q9ULI48
Kinetochore-associated protein DSN1 homologDSN1 C20orf172 MIS13Q9H4108
L-lactate dehydrogenase A chain (Fragment)LDHAF5GZQ48
LactadherinMFGE8F5GZN38
LactotransferrinLTFE7ER448
Lambda-chain (AA -20 to 215)0A2NUT28
LAMC1 proteinLAMC1Q6NVY88
Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule)LIME1 LIME LP8067Q9H4008
LoricrinLOR LRNP234908
Ly-6/neurotoxin-like protein 1 (Endogenous prototoxin LYNX1) (Testicular tissue protein Li 112)LYNX1P0DP588
Lysine-specific demethylase 7A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7)KDM7A JHDM1D KDM7 KIAA1718Q6ZMT48
Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog)MFSD6 MMR2Q6ZSS78
MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)MAPKAPK3Q166448
Mapk-regulated corepressor-interacting protein 1 (Granulin-2) (Protein FAM195B)MCRIP1 FAM195B GRAN2C9JLW88
Mast cell-expressed membrane protein 1MCEMP1 C19orf59Q8IX198
Melanoma-derived growth regulatory protein (Melanoma inhibitory activity protein)MIAQ166748
Methionine synthase reductase (MSR) (EC 1.16.1.8)MTRRQ9UBK88
Methylenetetrahydrofolate reductase (EC 1.5.1.20)MTHFRP428988
Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)MAPRE3Q9UPY88
Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)SLC25A22 GC1Q9H9368
Mitochondrial import inner membrane translocase subunit Tim23TIMM23 TIM23O149258
Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B)MZT2B FAM128B MOZART2BQ6NZ678
Mixed lineage kinase domain-like protein (hMLKL)MLKLQ8NB168
MO25-like protein0Q7Z4X08
Monocarboxylate transporter 5 (MCT 5) (Monocarboxylate transporter 4) (MCT 4) (Solute carrier family 16 member 4)SLC16A4 MCT4 MCT5O153748
MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4)MRGBP C20orf20Q9NV568
MYH9 protein (Fragment)MYH9Q86XU58
MYO1E variant protein (Myosin IE) (cDNA FLJ76307, highly similar to Homo sapiens myosin IE (MYO1E), mRNA)MYO1E hCG_38672Q4KMR38
Myosin light polypeptide 6MYL6F8VZU98
Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)MYH4Q9Y6238
Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)MYH7 MYHCBP128838
Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14)MYH7B KIAA1512A7E2Y18
Myotubularin-related protein 13 (SET-binding factor 2)SBF2 CMT4B2 KIAA1766 MTMR13Q86WG58
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1)ACY3 ASPA2Q96HD98
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Fragment)SLC9A3R1J3QRP68
NAD(P)H dehydrogenase [quinone] 1 (cDNA FLJ50573, highly similar to Homo sapiens NAD(P)H dehydrogenase, quinone 1 (NQO1), transcript variant 3, mRNA)NQO1B4DLR88
Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha)NRXN1 KIAA0578Q9ULB18
NeuritinNRN1 NRNQ9NPD78
Neuroblastoma-amplified sequence (Neuroblastoma-amplified gene protein)NBAS NAGA2RRP18
Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)PCSK2 NEC2P165198
Neurotrypsin (EC 3.4.21.-) (Leydin) (Motopsin) (Serine protease 12)PRSS12P567308
Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)SLC1A5 ASCT2 M7V1 RDR RDRCB4DR778
Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)NSMCE3 HCA4 MAGEG1 NDNL2Q96MG78
Nucleolar GTP-binding protein 2 (Autoantigen NGP-1)GNL2 NGP1Q138238
Nucleoside diphosphate kinase ANME1E7ERL08
Nucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15)NUDT15 MTH2Q9NV358
Olfactory receptor 3A3 (Olfactory receptor 17-201) (OR17-201) (Olfactory receptor 3A6) (Olfactory receptor 3A7) (Olfactory receptor 3A8) (Olfactory receptor OR17-22)OR3A3 OR3A6 OR3A7 OR3A8PP478888
ORM1-like protein 3ORMDL3Q8N1388
OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2)OTUD7A C15orf16 CEZANNE2 OTUD7Q8TE498
Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)OSBPL10 ORP10 OSBP9Q9BXB58
p180/ribosome receptorRRBP1A7BI368
p53 and DNA damage-regulated protein 1PDRG1 C20orf126 PDRGQ9NUG68
PA2G4 protein (Fragment)PA2G4Q6PIN58
Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2)PANK2 C20orf48Q9BZ238
PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2]PDZD2 AIPC KIAA0300 PDZK3O150188
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)NGLY1 PNG1Q96IV08
Peroxiredoxin-4 (Fragment)PRDX4H7C3T48
Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]EHHADH ECHDQ084268
PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135)PHF10 BAF45AQ8WUB88
Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 3)ABCB4 MDR3 PGY3P214398
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16) (EC 3.1.3.48)PTPMT1 MOSP PLIP PNAS-129Q8WUK08
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)PIK3C3 VPS34Q8NEB98
Phospholipid phosphatase-related protein type 4 (EC 3.1.3.4) (Brain-specific phosphatidic acid phosphatase-like protein 1) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1)PLPPR4 KIAA0455 LPPR4 PHP1 PRG1Q7Z2D58
Phosphorylated CTD-interacting factor 1PCIF1 C20orf67Q9H4Z38
PIH1 domain-containing protein 1 (Nucleolar protein 17 homolog)PIH1D1 NOP17Q9NWS08
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)GP6Q9HCN68
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)PDGFRA PDGFR2 RHEPDGFRAP162348
Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)PTN HBNF1 NEGF1P212468
PNAS-141 (Fragment)0Q9BXV38
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30)0B2R5W38
Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)PARN DANO954538
Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)PTBP2 NPTB PTB PTBLPQ9UKA98
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)CARS2 OK/SW-cl.10Q9HA778
Probable histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)HARS2 HARSL HARSR HO3P495908
Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1) (ATPase class II type 9B)ATP9B ATPIIB NEO1L HUSSY-20O438618
Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPase class V type 10A) (Aminophospholipid translocase VA) (P4-ATPase flippase complex alpha subunit ATP10A)ATP10A ATP10C ATPVA ATPVC KIAA0566O603128
Proepiregulin [Cleaved into: Epiregulin (EPR)]EREGO149448
Profilin (Fragment)PFN1I3L3D58
Prohibitin-2PHB2F5GY378
Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12)PREB SEC12Q9HCU58
Proteasome endopeptidase complex (EC 3.4.25.1)PSMA4H0YN188
Proteasome subunit alpha type (EC 3.4.25.1)PSMA6G3V2958
Proteasome subunit alpha type (EC 3.4.25.1) (Fragment)PSMA4H0YMI68
Protein amnionlessAMN UNQ513/PRO1028Q9BXJ78
Protein arginine methyltransferase NDUFAF7, mitochondrial (EC 2.1.1.320) (NADH dehydrogenase [ubiquinone] complex I, assembly factor 7) (Protein midA homolog)NDUFAF7 C2orf56 PRO1853Q7L5928
Protein disulfide-isomerase A3 (Fragment)PDIA3H7BZJ38
Protein FAM135AFAM135A KIAA1411Q9P2D68
Protein GREB1 (Gene regulated in breast cancer 1 protein)GREB1 KIAA0575Q4ZG558
Protein Hook homolog 1 (h-hook1) (hHK1)HOOK1Q9UJC38
Protein KHNYN (KH and NYN domain-containing protein)KHNYN KIAA0323O150378
Protein KIAA0196 variant (Fragment)0Q53EL18
Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)PACSIN1 KIAA1379Q9BY118
Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)NEDD1Q8NHV48
Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)PPP1R1B DARPP32Q9UD718
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