EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Protein Red (Cytokine IK) (IK factor) (Protein RER)IK RED RERQ131238
Protein rogdi homologROGDIQ9GZN78
Protein SCO1 homolog, mitochondrialSCO1 SCOD1O758808
Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B)SAMD4B SMAUG2Q5PRF98
Protein SYS1 homologSYS1 C20orf169Q8N2H48
Protein THEMIS2 (Induced by contact to basement membrane 1 protein) (Protein ICB-1) (Thymocyte-expressed molecule involved in selection protein 2)THEMIS2 C1orf38 ICB1Q5TEJ88
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)ROS1 MCF3 ROSP089228
Protocadherin alpha-11 (PCDH-alpha-11)PCDHA11 CNRS7Q9Y5I18
Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh)PCDH7 BHPCDHO602458
PSME1 protein (Fragment)PSME1Q6FHU38
Putative protein FAM10A5 (Suppression of tumorigenicity 13 pseudogene 5)ST13P5 FAM10A5Q8NFI48
Putative uncharacterized protein DKFZp666I134 (Fragment)DKFZp666I134Q658S98
Putative uncharacterized protein DKFZp686K18196 (Fragment)DKFZp686K18196Q6N0928
Putative uncharacterized protein DKFZp686M08189DKFZp686M08189Q6MZX98
RAB13 protein (Fragment)RAB13Q504R68
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)AKT3 PKBGQ9Y2438
RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1)RALBP1 RLIP1 RLIP76Q153118
RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63)RGPD5 RANBP2L1 RGP5 RGP7 RGPD7; RGPD6 RANBP2L2 RGP6Q996668
RAS protein activator like-3RASAL3Q86YV08
Ras-related protein Rab-11B (GTP-binding protein YPT3)RAB11B YPT3Q5U0I18
Ras-related protein Ral-BRALBB4E0408
RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)RB1CC1 KIAA0203 RBICCQ8TDY28
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)PTPRM PTPRL1P288278
Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)RTN2 NSPL1O752988
Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) (Stargardt disease protein)ABCA4 ABCRP783638
Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)RB1P064008
Retinoic acid-induced protein 3 (Fragment)GPRC5AF5GWG38
Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3)RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430Q8NBN78
Rho GDP-dissociation inhibitor 1ARHGDIAJ3QQX28
Ribonucleoprotein PTB-binding 1 (Protein raver-1)RAVER1 KIAA1978Q8IY678
Ribosomal protein S5 variant (Fragment)0Q53G258
Ribosome biogenesis protein NSA2 homolog (Hairy cell leukemia protein 1) (TGF-beta-inducible nuclear protein 1)NSA2 TINP1 HUSSY-29O954788
RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1) [Cleaved into: RNA binding motif protein, X-linked-like-1, N-terminally processed]RBMXL1Q96E398
RNA-binding motif protein, X chromosome (Fragment)RBMXH0Y6E78
RuvB-like helicase (EC 3.6.4.12)RUVBL2 hCG_16214B3KNL28
RuvB-like helicase (EC 3.6.4.12) (Fragment)RUVBL1H7C4G58
Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)RYR3 HBRRQ154138
Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)SLMAP KIAA1601 SLAP UNQ1847/PRO3577Q14BN48
Schlafen family member 5SLFN5Q08AF38
Secretory carrier-associated membrane protein (Secretory carrier membrane protein) (Fragment)SCAMP3Q6FHJ58
Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)]PLA2R1 CLEC13CQ130188
Septin-11SEPT11D6RER58
Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)HTRA3 PRSPP831108
Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK)ICK KIAA0936Q9UPZ98
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)LMTK2 AATYK2 BREK KIAA1079 KPI2 LMR2Q8IWU28
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)PAK6 PAK5Q9NQU58
Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13Q9Y3S18
Serpin B7 (Megsin) (TP55)SERPINB7O756358
Serum albuminALBB7WNR08
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)SH2D1A DSHP SAPO608808
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)SHANK2 CORTBP1 KIAA1022 PROSAP1Q9UPX88
Sialic acid-binding Ig-like lectin 16 (Siglec-16) (Siglec-P16)SIGLEC16 SIGLECP16A6NMB18
Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169)SIGLEC1 SNQ9BZZ28
Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3)SIRPB1Q5TFQ88
Similar to Chain, Heat-Shock Cognate 70kd Protein (44kd Atpase N-Terminal) (E.C.3.6.1.3) Mutant With Asp 206 Replaced By Ser (D206s)LOC401308 tcag7.1163A4D1118
SLIT and NTRK-like protein 6SLITRK6Q9H5Y78
Sodium-dependent phosphate transport protein 4 (Na(+)/PI cotransporter 4) (Sodium/phosphate cotransporter 4) (Solute carrier family 17 member 3)SLC17A3 NPT4O004768
Sorting nexin-15SNX15Q9NRS68
Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Membrane lipid desaturase)DEGS1 DES1 MLD MIG15O151218
Stabilin-1 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1) (FEEL-1) (MS-1 antigen)STAB1 FEEL1 KIAA0246Q9NY158
StathminSTMN1B5BU838
Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)SRA1 PP7684Q9HD158
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)SMC6 SMC6L1Q96SB88
Submaxillary gland androgen-regulated protein 3B (Proline-rich peptide P-B) (Proline-rich protein 3) [Cleaved into: Peptide P-A; Peptide D1A]SMR3B PBII PRL3 PROL3P028148
SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)SUN2 FRIGG KIAA0668 RAB5IP UNC84BQ9UH998
Surfeit locus protein 6SURF6 SURF-6O756838
Sushi domain-containing protein 5SUSD5 KIAA0527O602798
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)SMARCAD1 KIAA1122Q9H4L78
Synaptic vesicle glycoprotein 2ASV2A KIAA0736 PSEC0174Q7L0J38
Synaptosomal-associated protein 23SNAP23H3BNE18
Syntaxin-4 (Fragment)STX4C9JFM58
T-cell surface glycoprotein CD1c (CD antigen CD1c)CD1CP290178
T-complex protein 1 subunit epsilonCCT5E9PCA18
T-complex protein 1 subunit gamma0B3KX118
TBC domain-containing protein kinase-like proteinTBCK TBCKL HSPC302Q8TEA78
TBC1 domain family member 17TBC1D17Q9HA658
TBC1 domain family member 5TBC1D5 KIAA0210Q926098
Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6)ZCCHC6 HS2 KIAA1711 TUT7Q5VYS88
Tetraspanin0B4DEK88
Tetraspanin (Fragment)KAI1Q6LET08
Tetraspanin (Fragment)CD63F8VWK88
Tetraspanin (Fragment)CD9G8JLH68
Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)TMX4 KIAA1162 TXNDC13 PSEC0095 UNQ475/PRO938Q9H1E58
Thy-1 cell surface antigen, isoform CRA_a (Thy-1 membrane glycoprotein variant 2) (cDNA FLJ33325 fis, clone BNGH42008832, highly similar to THY-1 MEMBRANE GLYCOPROTEIN) (cDNA FLJ33677 fis, clone BRAWH2002125, highly similar to THY-1 MEMBRANE GLYCOPROTEIN)THY1 hCG_14965B0YJA48
Tolloid-like protein 2 (EC 3.4.24.-)TLL2 KIAA0932Q9Y6L78
Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains)TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204Q9UIK58
TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)TRAFD1 FLN29O145458
Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein)TRAPPC9 KIAA1882 NIBP T1Q96Q058
Transcription factor E2F8 (E2F-8)E2F8A0AVK68
Transmembrane protein 200ATMEM200A KIAA1913 HBE61Q86VY98
Transmembrane protein 206TMEM206 C1orf75Q9H8138
Transmembrane protein 263TMEM263 C12orf23Q8WUH68
Transmembrane protein 94TMEM94 KIAA0195Q127678
Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)TRIM3 BERP RNF22 RNF97O753828
tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog)TRMT11 C6orf75 MDS024Q7Z4G48
Tubulin alpha-1A chain (Fragment)TUBA1AF8VRZ48
Tubulin beta chain (Fragment)TUBB3G3V2A38
Tubulin beta-8 chain-like protein LOC2603340A6NNZ28
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)MERTK MERQ128668
Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)PTPN14 PEZ PTPD2Q156788
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