EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239)HSD17B2 EDH17B2 SDR9C2P370597
Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)EEF2KO004187
Eukaryotic translation elongation factor 1 epsilon-1 (Fragment)EEF1E1H0YAL77
Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b)EXPH5 KIAA0624 SLAC2BQ8NEV87
FerritinFTH1E9PRK87
FH2 domain-containing protein 1FHDC1 KIAA1727Q9C0D67
Fibroblast growth factor 19 (FGF-19)FGF19 UNQ334/PRO533O957507
Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND)FSD1 GLFND MIR1 VLP27Q9BTV57
Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein)FNDC1 FNDC2 KIAA1866 MEL4B3Q4ZHG47
Filamin A (Filamin-A)FLNAQ60FE57
Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)FILIP1L COL4A3BPIP DOC1 GIP90Q4L1807
FLOT1 protein (Flotillin 1) (Flotillin 1, isoform CRA_b)FLOT1 hCG_2006678Q5ST807
Follistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein)FSTL3 FLRG UNQ674/PRO1308O956337
Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN)]FXN FRDA X25Q165957
Frizzled-6 (Fz-6) (hFz6)FZD6O603537
Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase)FPGT GFPPO147727
FUN14 domain-containing protein 1FUNDC1Q8IVP57
G-protein-coupled receptor family C group 5 member C (Fragment)GPRC5CA8MXZ47
Galactoside 3(4)-L-fucosyltransferase (EC 2.4.1.65) (Blood group Lewis alpha-4-fucosyltransferase) (Lewis FT) (Fucosyltransferase 3) (Fucosyltransferase III) (FucT-III)FUT3 FT3B LEP212177
GEM-interacting protein (GMIP)GMIPQ9P1077
General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)GTF3C2 KIAA0011Q8WUA47
General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)GTF2E1 TF2E1P290837
GGT1 protein (Fragment)GGT1A2VCM77
Glutamine-rich protein 1QRICH1Q2TAL87
Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)QPCTLQ9NXS27
Glutathione S-transferase kappa (EC 2.5.1.18)LOC51064 GSTK1 hCG_20682 tcag7.883Q6FII17
Golgi-associated plant pathogenesis-related protein 1GLIPR2Q5VZR07
GPN-loop GTPase 2 (ATP-binding domain 1 family member B)GPN2 ATPBD1B UNQ5828/PRO19647Q9H9Y47
Granulins (Fragment)GRNK7EKL37
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)GAB1Q134807
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)GAB2 KIAA0571Q9UQC27
Growth arrest-specific protein 1 (GAS-1)GAS1P548267
GTP-binding nuclear protein RanRAN hCG_1744585B5MDF57
GTP-binding nuclear protein Ran (Fragment)RANH0YFC67
GTP-binding nuclear protein Ran (Fragment)RANJ3KQE57
GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4)GIMAP4 IAN1 IMAP4 MSTP062Q9NUV97
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)CLCN5 CLCK2P517957
HCG2001850, isoform CRA_c (Nucleoside diphosphate kinase B)NME2 hCG_2001850F6XY727
HCG2044799 (HNRNPUL2-BSCL2 readthrough (NMD candidate))HNRNPUL2-BSCL2 hCG_2044799H3BQZ77
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)HSH2D ALXQ96JZ27
Hemoglobin subunit beta (Fragment)HBBF8W6P57
Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2)HDGFRP3 HDGF2 CGI-142Q9Y3E17
Heterogeneous nuclear ribonucleoprotein C-like 3HNRNPCL3B7ZW387
Heterogeneous nuclear ribonucleoprotein H3 isoform a variant (Fragment)0Q53F487
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)HMG20A HMGX1 HMGXB1Q9NP667
Histidyl-tRNA synthetaseHRSQ52NV47
Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)ASF1BQ9NVP27
Histone H2AHIST1H2AB HIST1H2AE hCG_1640984 hCG_1787383Q08AJ97
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)NSD2 KIAA1090 MMSET TRX5 WHSC1O960287
Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.43) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1)SMYD3 ZMYND1 ZNFN3A1Q9H7B47
HLA class I histocompatibility antigen, B-39 alpha chain (MHC class I antigen B*39)HLA-B HLABP304757
Homer protein homolog 2 (Homer-2) (Cupidin)HOMER2Q9NSB87
Hormone-sensitive lipase (HSL) (EC 3.1.1.79)LIPEQ054697
Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]IDS SIDSP223047
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)FCGRT FCRNP558997
Immunglobulin heavy chain variable region (Fragment)0Q0ZCJ47
Immunoglobulin heavy variable 2-70 (Ig heavy chain V-II region COR) (Ig heavy chain V-II region DAW) (Ig heavy chain V-II region OU) (Ig heavy chain V-II region SESS)IGHV2-70P044387
Immunoglobulin heavy variable 3-23 (Ig heavy chain V-III region LAY) (Ig heavy chain V-III region POM) (Ig heavy chain V-III region TEI) (Ig heavy chain V-III region TIL) (Ig heavy chain V-III region TUR) (Ig heavy chain V-III region VH26) (Ig heavy chain V-III region WAS) (Ig heavy chain V-III region ZAP)IGHV3-23P017777
Immunoglobulin heavy variable 3-30 (Ig heavy chain V-III region BUR) (Ig heavy chain V-III region CAM) (Ig heavy chain V-III region GA) (Ig heavy chain V-III region NIE)IGHV3-30P017697
Immunoglobulin heavy variable 3-72IGHV3-72A0A0B4J1Y97
Immunoglobulin heavy variable 3/OR16-12 (non-functional) (Fragment)IGHV3OR16-12A0A075B7B87
Immunoglobulin kappa variable 1-6IGKV1-6A0A0C4DH727
Immunoglobulin kappa variable 1D-16 (Ig kappa chain V-I region HK146) (Ig kappa chain V-I region HK189) (Fragment)IGKV1D-16P016017
Immunoglobulin kappa variable 3D-20IGKV3D-20A0A0C4DH257
Immunoglobulin lambda constant 6 (Ig lambda-6 chain C region)IGLC6P0CF747
Immunoglobulin lambda variable 1-51 (Ig lambda chain V-I region BL2) (Ig lambda chain V-I region EPS) (Ig lambda chain V-I region NEW) (Ig lambda chain V-I region NIG-64)IGLV1-51P017027
Immunoglobulin lambda variable 2-8 (Ig lambda chain V-II region BO) (Ig lambda chain V-II region MGC)IGLV2-8P017097
Immunoglobulin lambda variable 3-21 (Ig lambda chain V-III region LOI) (Ig lambda chain V-V region DEL) (Ig lambda chain V-VII region MOT)IGLV3-21P017197
Immunoglobulin superfamily member 1 (IgSF1) (Immunoglobulin-like domain-containing protein 1) (Inhibin-binding protein) (InhBP) (Pituitary gland-specific factor 2) (p120)IGSF1 IGDC1 KIAA0364 PGSF2Q8N6C57
Importin-5 (Fragment)IPO5H0Y3V47
Importin-5 (Fragment)IPO5C9JZ537
Inactive hydroxysteroid dehydrogenase-like protein 1 (Short chain dehydrogenase/reductase family 12C member 3)HSDL1 SDR12C3Q3SXM57
Integrator complex subunit 2 (Int2)INTS2 KIAA1287Q9H0H07
Integrator complex subunit 4 (Int4)INTS4 MSTP093Q96HW77
Integrin alpha-2ITGA2E7ESP47
Integrin alpha-6 (Fragment)ITGA6H7BZ977
Integrin beta-1 (Fragment)ITGB1H7C4N87
Interferon regulatory factor 2-binding protein-like (Enhanced at puberty protein 1)IRF2BPL C14orf4 EAP1 KIAA1865 My039Q9H1B77
Interleukin enhancer-binding factor 2 (cDNA FLJ51660, highly similar to Interleukin enhancer-binding factor 2)ILF2B4DY097
Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)IL1RAPL1 OPHN4Q9NZN17
Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)IL10RB CRFB4 D21S58 D21S66Q083347
Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)IL18BPO959987
Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)EBI3 IL27BQ142137
Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56)IFT80 KIAA1374 WDR56Q9P2H37
Isocitrate dehydrogenase 2 (NADP+), mitochondrial variant (Fragment)0Q53GL57
ITIH4 protein (Inter-alpha-trypsin inhibitor heavy chain H4)ITIH4B7ZKJ87
Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)KATNB1Q9BVA07
Keratin, type II cytoskeletal 5 (Fragment)KRT5H0YI767
Kinesin-like protein KIF26BKIF26BQ2KJY27
L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)SELL LNHR LYAM1P141517
L-xylulose reductase (Fragment)DCXRJ3KS227
Leucine-rich repeat and calponin homology domain-containing protein 2LRCH2 KIAA1495Q5VUJ67
Leucine-rich repeat-containing protein 14LRRC14 KIAA0014Q150487
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)LRIG1 LIG1Q96JA17
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)LDB1 CLIM2Q86U707
Lin-7 homolog C variant (Fragment)0Q53FX57
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)LITAF PIG7 SIMPLEQ997327
Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4)SLC27A4 ACSVL4 FATP4Q6P1M07
Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]FCER2 CD23A CLEC4J FCE2 IGEBFP067347
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)LYVE1 CRSBP1 HAR XLKD1 UNQ230/PRO263Q9Y5Y77
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