EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Lymphocyte antigen 6E (Ly-6E) (Retinoic acid-induced gene E protein) (RIG-E) (Stem cell antigen 2) (SCA-2) (Thymic shared antigen 1) (TSA-1)LY6E 9804 RIGE SCA2 TSA1Q165537
Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (Acyl-CoA:lysocardiolipin acyltransferase 1)LCLAT1 AGPAT8 ALCAT1 LYCAT UNQ1849/PRO3579Q6UWP77
Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5)LPCAT3 MBOAT5 OACT5Q6P1A27
Macrosialin (Gp110) (CD antigen CD68)CD68P348107
Male-enhanced antigen 1 (MEA-1)MEA1 MEAQ166267
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)MCAT MTQ8IVS27
MARVEL domain-containing protein 2 (Tricellulin)MARVELD2 TRICQ8N4S97
MHC class I polypeptide-related sequence B (MIC-B)MICB PERB11.2Q299807
MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A)APOOL CXorf33 FAM121A MIC27 UNQ8193/PRO23204Q6UXV47
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)MAPT MAPTL MTBT1 TAUP106367
Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like)MAP1LC3B2A6NCE77
Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1)MTUS1 ATBP ATIP GK1 KIAA1288 MTSG1Q9ULD27
Midnolin (Midbrain nucleolar protein)MIDNQ504T87
Mitochondrial pyruvate carrier 2 (Brain protein 44)MPC2 BRP44O955637
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)MAP4K3 RAB8IPL1Q8IVH87
Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Protein MSL3-1) (Transcription factor-like protein MRG15)MORF4L1 MRG15 FWP006 HSPC008 HSPC061 PP368Q9UBU87
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)SMAD1 BSP1 MADH1 MADR1Q157977
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)SMAD4 DPC4 MADH4Q134857
MSN protein (Fragment)MSNQ6PJT47
MSTP0570Q8IXH27
Mucin-2 (MUC-2) (Intestinal mucin-2)MUC2 SMUCQ028177
Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11)ABCC5 MRP5O154407
Myeloid differentiation primary response protein MyD88MYD88Q998367
MYL6 proteinMYL6Q6IBG57
Myocyte-specific enhancer factor 2DMEF2DQ148147
Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)PDE4DIP CMYA2 KIAA0454 KIAA0477 MMGLQ5VU437
Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1)MYOM1P521797
Myosin IC, isoform CRA_aMYO1C hCG_28722D3DTH77
Myosin light polypeptide 6 (Fragment)MYL6H0YI437
Myosin regulatory light chain MRCL3 variant (Fragment)0Q53HL17
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)MYH10D3DTS17
Myosin-15 (Myosin heavy chain 15)MYH15 KIAA1000Q9Y2K37
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)SLC9A3R1 NHERF NHERF1B3KY217
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7)NDUFA11Q86Y397
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 17.3) (Np17.3) (p17.3)NDUFB11 UNQ111/PRO1064Q9NX147
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit)NDUFB7P175687
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (Complex I-AQDQ) (CI-AQDQ) (NADH-ubiquinone oxidoreductase 18 kDa subunit)NDUFS4O431817
Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like)NACA2 NACALQ9H0097
Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6)NCR3LG1 B7H6Q68D857
Nephrin (Renal glomerulus-specific cell adhesion receptor)NPHS1 NPHNO605007
Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)UNC5C UNC5H3O951857
Neuroligin-2NLGN2 KIAA1366Q8NFZ47
Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3) (Steerin-1) (Unc-53 homolog 1) (unc53H1)NAV1 KIAA1151 KIAA1213 POMFIL3 STEERIN1Q8NEY17
Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2Q8IVL17
Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)DCX DBCN LISXO436027
Neuronal-specific septin-3SEPT3 SEP3Q9UH037
Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)NTSR1 NTRRP309897
Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)NBR1 1A13B KIAA0049 M17S2 MIG19Q145967
NHL repeat-containing protein 3NHLRC3Q5JS377
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1)NMNAT1 NMNATQ9HAN97
Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)NIN KIAA1565Q8N4C67
NME1-NME2 readthroughNME1-NME2J3KPD97
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)TNK1Q134707
Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer)NOSTRINQ8IVI97
Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like)NUP210LQ5VU657
Nucleolar protein 9NOP9 C14orf21 KIAA2021Q86U387
Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1)NUP58 KIAA0410 NUPL1Q9BVL27
Nucleoside diphosphate kinase A (Fragment)NME1C9K0287
Numb-like protein (Numb-related protein) (Numb-R)NUMBLQ9Y6R07
Olfactomedin-like protein 2B (Photomedin-2)OLFML2BQ68BL87
Oral-facial-digital syndrome 1 protein (Protein 71-7A)OFD1 CXorf5O756657
ORF proteinORFQ7KYM97
Ornithine carbamoyltransferase, mitochondrial (EC 2.1.3.3) (Ornithine transcarbamylase) (OTCase)OTCP004807
P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)OCA2 D15S12 PQ046717
p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)PAK1IP1 PIP1 WDR84Q9NWT17
Parvalbumin alphaPVALBP204727
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8)0Q71V997
Peptidyl-prolyl cis-trans isomerase APPIAE5RIZ57
Peroxiredoxin 6 (Fragment)0A4UCS67
Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)ACOX3 BRCOX PRCOXO152547
Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2)PCTP STARD2Q9UKL67
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)PIK3CAP423367
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)PIK3CB PIK3C1P423387
Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)PTDSS1 KIAA0024 PSSAP486517
Platelet-derived growth factor receptor-like protein (PDGFR-like protein) (PDGF receptor beta-like tumor suppressor)PDGFRL PRLTSQ151987
Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1)PLEKHA1 TAPP1Q9HB217
Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)PLEKHG3 KIAA0599A1L3907
PML-RARA-regulated adapter molecule 1 (PRAM) (PRAM-1)PRAM1Q96QH27
Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)POGZ KIAA0461 SUHW5 ZNF280E ZNF635 Nbla00003Q7Z3K37
Poly(rC)-binding protein 2 (Fragment)PCBP2H3BRU67
Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9)NOL9Q5SY167
Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5)GALNT5Q7Z7M97
POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1)POU2F1 OCT1 OTF1P148597
PP38560Q8WY827
PR310 c-K-ras protein (Fragment)0Q140147
Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27)PRPF38BQ5VTL87
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]LMNA LMN1Q5I6Y67
Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]IL16Q140057
PRO22750Q9P1737
Probable ATP-dependent RNA helicase DHX40 (EC 3.6.4.13) (DEAH box protein 40) (Protein PAD)DHX40 DDX40 ARG147Q8IX187
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)HERC1Q157517
Probable ergosterol biosynthetic protein 28C14orf1 AD-011 HSPC288 x0006Q9UKR57
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)PLOD1 LLH PLODB4DR877
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-183); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258); Met-enkephalin-Arg-Phe]PENKP012107
ProfilinPFN1 hCG_32691K7EJ447
Programmed cell death protein 6 (Fragment)PDCD6H0Y9X37
Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)P3H3 LEPREL2Q8IVL67
Prostaglandin E synthase (EC 5.3.99.3) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein)PTGES MGST1L1 MPGES1 PGES PIG12O146847
Proteasome (Prosome, macropain) 26S subunit, ATPase, 4, isoform CRA_b (cDNA FLJ78505, highly similar to Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4), transcript variant 1, mRNA) (cDNA, FLJ93682, Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4(PSMC4), transcript variant 1, mRNA)PSMC4 hCG_43346A8K2M07
Proteasome 26S ATPase subunit 1 variant (Fragment)0Q53HB37
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