EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3)HAVCR2 TIM3 TIMD3Q8TDQ06
Hereditary hemochromatosis protein (HLA-H)HFE HLAHQ302016
Heterogeneous nuclear ribonucleoprotein A/BHNRNPABD6R9P36
Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)ASF1A CGI-98 HSPC146Q9Y2946
Histone cluster 1, H1tHIST1H1TA1L4076
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (RPD3-2) (SMAP45)HDAC3O153796
Histone H2AHIST1H2AH hCG_1640359A3KPC76
Histone H2AH2AFVC9J3866
Histone PARylation factor 1HPF1 C4orf27Q9NWY46
Histone-binding protein RBBP7RBBP7E9PC526
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7Q9UMN66
HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2)HLA-DQA2 HLA-DXAP019066
Hsp90 co-chaperone Cdc37-like 1 (Hsp90-associating relative of Cdc37)CDC37L1 CDC37B HARCQ7L3B66
HYOU1 proteinHYOU1Q6IN676
IGL@ proteinIGL@Q6GMW46
IGL@ proteinIGL@Q8N5F46
Immunoglobulin heavy variable 3-23 (Ig heavy chain V-III region LAY) (Ig heavy chain V-III region POM) (Ig heavy chain V-III region TEI) (Ig heavy chain V-III region TIL) (Ig heavy chain V-III region TUR) (Ig heavy chain V-III region VH26) (Ig heavy chain V-III region WAS) (Ig heavy chain V-III region ZAP)IGHV3-23P017796
Immunoglobulin heavy variable 3-74IGHV3-74A0A0B4J1X56
Immunoglobulin heavy variable 3-9 (Ig heavy chain V-III region DOB)IGHV3-9P017826
Immunoglobulin heavy variable 3/OR16-9 (non-functional) (Fragment)IGHV3OR16-9A0A0B4J2B56
Immunoglobulin heavy variable 5-51IGHV5-51A0A0C4DH386
Immunoglobulin kappa variable 2-29IGKV2-29A2NJV56
Immunoglobulin kappa variable 4-1 (Ig kappa chain V-IV region B17) (Ig kappa chain V-IV region JI) (Ig kappa chain V-IV region Len) (Ig kappa chain V-IV region STH)IGKV4-1P063136
Immunoglobulin lambda variable 4-3IGLV4-3A0A075B6K66
Immunoglobulin lambda variable 7-46IGLV7-46A0A075B6I96
Immunoglobulin-like domain-containing receptor 1ILDR1Q86SU06
Importin-5IPO5E7EQT56
Importin-5 (Fragment)IPO5C9JXE06
Importin-5 (Fragment)IPO5E7EWK46
Importin-7 (Fragment)IPO7E9PLB26
Inactive caspase-12 (CASP-12)CASP12 UNQ9415/PRO34398Q6UXS96
Inhibin beta C chain (Activin beta-C chain)INHBCP551036
Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159)ITPK1Q135726
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)IRS4O146546
Integral membrane protein 2C (Fragment)ITM2CC9JG416
Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74)INTS9 RC74Q9NV886
Integrin alpha-V (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]ITGAV MSK8 VNRAB7ZLX06
Integrin beta0B4E0R16
Intercellular adhesion molecule 4 (ICAM-4) (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD antigen CD242)ICAM4 LWQ147736
Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)IFIH1 MDA5 RH116Q9BYX46
Interferon-induced transmembrane protein 2IFITM2E9PQN96
Intraflagellar transport protein 46 homologIFT46 C11orf2 C11orf60Q9NQC86
Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26)TTC26 IFT56A0AVF16
Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2)IFT74 CCDC2 CMG1Q96LB36
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)IDH3GP515536
Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)JAM2 C21orf43 VEJAM UNQ219/PRO245P570876
Kelch-like protein 22KLHL22Q53GT16
Kell blood group glycoprotein (EC 3.4.24.-) (CD antigen CD238)KELP232766
Keratin, type I cuticular Ha5KRT35C4AM866
Keratin, type I cytoskeletal 15KRT15A8MT216
Keratin, type I cytoskeletal 16 (Fragment)KRT16K7ENW66
Keratin, type I cytoskeletal 17 (Fragment)KRT17K7ESE16
Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1)KCP CRIM2 KCP1Q6ZWJ86
Kinesin-like protein (Fragment)KIF5BQ2TA906
Kinesin-like protein KIF16B (Sorting nexin-23)KIF16B C20orf23 KIAA1590 SNX23Q96L936
Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)KIF2C KNSL6Q996616
KRT8 protein0Q7L4M36
L-lactate dehydrogenase B chain (Fragment)LDHBC9J7H86
Laminin subunit beta-2 (Fragment)LAMB2F5H5206
Lariat debranching enzyme (EC 3.1.-.-)DBR1Q9UK596
LBP proteinLBPQ8TCF06
Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)LEFTY1 LEFTB LEFTYB UNQ278/PRO317O756106
Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein)LRCH4 LRN LRRN1 LRRN4O754276
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)LRRK1 KIAA1790Q38SD26
LIM and cysteine-rich domains protein 1 (Dyxin)LMCD1Q9NZU56
Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6)ACSL6 ACS2 FACL6 KIAA0837 LACS5Q9UKU06
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)HELLS PASG SMARCA6 Nbla10143Q9NRZ96
LYR motif-containing protein 4LYRM4 C6orf149 ISD11 CGI-203Q9HD346
Lysine-specific demethylase 3B (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA)KDM3B C5orf7 JHDM2B JMJD1B KIAA1082Q7LBC66
Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4)LPAR2 EDG4 LPA2Q9HBW06
Magnesium transporter MRS2 homolog, mitochondrial (MRS2-like protein)MRS2 HPT MRS2LQ9HD236
Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48)MDP1Q86V886
Major centromere autoantigen B (Centromere protein B) (CENP-B)CENPBP071996
Major facilitator superfamily domain-containing protein 12MFSD12 C19orf28Q6NUT36
Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7)MFSD8 CLN7Q8NHS36
Major vault protein (Fragment)MVPH3BUK76
Malate dehydrogenase, cytoplasmic (Fragment)MDH1C9JRL46
Maturin (Maturin neural progenitor differentiation regulator protein homolog) (Protein Ells1)MTURN C7orf41Q8N3F06
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2Q156486
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170O602446
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)MED21 SRB7 SURB7Q135036
Mesencephalic astrocyte-derived neurotrophic factor (cDNA FLJ77177, highly similar to Homo sapiens arginine-rich, mutated in early stage tumors (ARMET), mRNA)MANFA8K8786
Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2)CNNM2 ACDP2Q9H8M56
Methylglutaconyl-CoA hydratase, mitochondrial (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase)AUHQ138256
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)MSMO1 DESP4 ERG25 SC4MOLQ158006
MHC class I polypeptide-related sequence A (MIC-A)MICA PERB11.1Q299836
MICOS complex subunit MIC13 (Protein P117)MIC13 C19orf70 QIL1Q5XKP06
Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)MTCL1 CCDC165 KIAA0802 SOGA2Q9Y4B56
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5MACF1H3BPE16
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)MAP1LC3AQ9H4926
Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)MTUS2 CAZIP KIAA0774 TIP150Q5JR596
Mitochondrial carrier homolog 1 (Presenilin-associated protein)MTCH1 PSAP CGI-64 UNQ1871/PRO4314Q9NZJ76
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)MAP4K5Q9Y4K46
Mitotic checkpoint protein BUB3 (Fragment)BUB3J3QT286
Molybdopterin synthase sulfur carrier subunit (MOCO1-A) (Molybdenum cofactor synthesis protein 2 small subunit) (Molybdenum cofactor synthesis protein 2A) (MOCS2A) (Molybdopterin-synthase small subunit) (Sulfur carrier protein MOCS2A)MOCS2 MOCO1O960336
Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)MORF4L2 KIAA0026 MRGXQ150146
Mucin-12 (MUC-12) (Mucin-11) (MUC-11)MUC12 MUC11Q9UKN16
Mucin-20 (MUC-20)MUC20 KIAA1359 UNQ2782/PRO7170Q8N3076
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)MALT1 MLTQ9UDY86
Multifunctional protein ADE2 (Fragment)PAICSE9PBS16
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