EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)MCFD2 SDNSFQ8NI226
Multiple myeloma tumor-associated protein 2 (hMMTAG2)MMTAG2 C1orf35Q9BU766
Myeloid-associated differentiation marker (Fragment)MYADMC9JJV66
MYO1B variant protein (Myosin IB, isoform CRA_a)MYO1B hCG_25797B0I1S96
Myosin light polypeptide 6 (Myosin, light polypeptide 6, alkali, smooth muscle and non-muscle, isoform CRA_d)MYL6 hCG_2039617G3V1Y76
Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)MYH13Q9UKX36
Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)MYH8P135356
Myosin-reactive immunoglobulin heavy chain variable region (Fragment)0Q9UL886
Myosin-reactive immunoglobulin light chain variable region (Fragment)0Q9UL836
Myotubularin-related protein 9MTMR9 C8orf9 MTMR8Q96QG76
N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase)NAGKB4DLZ56
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (EC 2.4.1.149) (Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) (EC 2.4.1.146) (Beta-1,3-galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (Beta3GalT8) (b3Gal-T8) (Beta-3-Gx-T8) (Core 1 extending beta-1,3-N-acetylglucosaminyltransferase) (Core1-beta3GlcNAcT) (Transmembrane protein 3) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3) (BGnT-3) (Beta-1,3-Gn-T3) (Beta-1,3-N-acetylglucosaminyltransferase 3) (Beta3Gn-T3) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8)B3GNT3 B3GALT8 TMEM3 UNQ637/PRO1266Q9Y2A96
N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit)NAA20 NAT5P615996
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.43) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)SMYD2 KMT3CQ9NRG46
N6-adenosine-methyltransferase 70 kDa subunit (MT-A70) (EC 2.1.1.62) (Methyltransferase-like protein 3) (hMETTL3)METTL3 MTA70Q86U446
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit)NDUFB3O436766
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4)NDUFV3P561816
NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3) (NADH dehydrogenase subunit 4)MT-ND4 MTND4 NADH4 ND4P039056
Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein)NHSQ6T4R56
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)NCKIPSD AF3P21 SPIN90Q9NZQ36
Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)NELFA WHSC2 P/OKcl.15Q9H3P26
Neprilysin (Fragment)MMEC9JR966
Nesprin-2SYNE2G3V5X46
Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)PPP1R9A KIAA1222Q9ULJ86
Neurexin-2 (Neurexin II-alpha) (Neurexin-2-alpha)NRXN2 KIAA0921Q9P2S26
Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha)NRXN3 C14orf60 KIAA0743Q9Y4C06
Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein)NBEAL1 ALS2CR16 ALS2CR17Q6ZS306
Neuroligin-4, X-linked (Neuroligin X) (HNLX)NLGN4X KIAA1260 NLGN4 UNQ365/PRO701Q8N0W46
Neuronal pentraxin receptorNPTXRO955026
Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)]NPW PPL8 PPNPWQ8N7296
Neuropeptide-like protein C4orf48C4orf48 Chr4_55Q5BLP86
NeuropilinNRP1Q5JWQ66
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)NCF1 NOXO2 SH3PXD1AP145986
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)NFKBIE IKBEO002216
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)NKIRAS2 KBRAS2Q9NYR96
NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)NFATC2IP NIP45Q8NCF56
NHS-like protein 1NHSL1 C6orf63 KIAA1357Q5SYE76
NicastrinNCSTN KIAA0253 UNQ1874/PRO4317Q5T2086
Nidogen-2 (Fragment)NID2H0YJV36
Ninjurin-2 (Nerve injury-induced protein 2)NINJ2Q9NZG76
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)NISCH IRAS KIAA0975Q9Y2I16
Nitric oxide-associated protein 1NOA1 C4orf14Q8NC606
Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1)OLFM1 NOE1 NOEL1Q997846
Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein)NFIA KIAA1439Q128576
Nuclear pore complex protein Nup930A8K8976
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)NCOR2 CTG26Q9Y6186
Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)NRBP2 PP9320 TRG16Q9NSY06
Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2)NFYCQ139526
Nucleophosmin (Fragment)NPM1E5RI986
Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48)NDC1 TMEM48Q9BTX16
Nucleoporin NUP53 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin Nup35)NUP35 MP44 NUP53Q8NFH56
Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)NME4 NM23DO007466
Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)OBSCN KIAA1556 KIAA1639Q5VST96
Obscurin-like protein 1OBSL1 KIAA0657O751476
Oligophrenin-1OPHN1O608906
Origin recognition complex subunit 2ORC2 ORC2LQ134166
Origin recognition complex subunit 5ORC5 ORC5LO439136
OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1)OTUD4 HIN1 KIAA1046Q018046
Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)OSBPL2 KIAA0772 ORP2Q9H1P36
p120 (Fragment)0Q9UEL26
Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)PILRAQ9UKJ16
Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1)PPT1 CLN1 PPTQ6FGQ46
PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein)PDLIM3 ALPQ53GG56
Pepsin A-4 (EC 3.4.23.1) (Pepsinogen-4)PGA4P0DJD76
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8)0A8K4866
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (PPIase CWC27) (EC 5.2.1.8) (Antigen NY-CO-10) (Serologically defined colon cancer antigen 10)CWC27 SDCCAG10 UNQ438/PRO871Q6UX046
Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase)FKBP14 FKBP22 UNQ322/PRO381Q9NWM86
Peptidyl-prolyl cis-trans isomerase FKBP7 (PPIase FKBP7) (EC 5.2.1.8) (23 kDa FK506-binding protein) (23 kDa FKBP) (FKBP-23) (FK506-binding protein 7) (FKBP-7) (Rotamase)FKBP7 FKBP23 UNQ670/PRO1304Q9Y6806
PeriaxinPRX KIAA1620Q9BXM06
PeriplakinPPLK7EKI86
Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)PEX14O753816
Phosphate carrier protein, mitochondrialSLC25A3F8VVM26
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)PIK3CDO003296
Phosphoglycerate mutase (EC 5.4.2.11) (EC 5.4.2.4)PGAM1Q6FHK86
Phosphoribosylformylglycinamidine synthase (FGAR amidotransferase), isoform CRA_b (cDNA FLJ77779, highly similar to Homo sapiens phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) (PFAS), mRNA)PFAS hCG_31283A8K8N76
Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)PHKA2 PHKLA PYKP460196
Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B)PIEZO2 C18orf30 C18orf58 FAM38BQ9H5I56
Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)EGFLAM AGRINL AGRNLQ63HQ26
Placenta-specific gene 8 protein (Protein C15)PLAC8 BM-004Q9NZF16
Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)SERPING1 C1IN C1NHB4E1H26
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)PLEKHA2 TAPP2Q9HB196
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)PLEKHA4 PEPP1Q9H4M76
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)PLEKHA7Q6IQ236
Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B)PLEKHG4B KIAA1909Q96PX96
Plexin-B2 (Fragment)PLXNB2A6QRG96
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)EEDO755306
Polypeptide N-acetylgalactosaminyltransferase 12 (EC 2.4.1.41) (Polypeptide GalNAc transferase 12) (GalNAc-T12) (pp-GaNTase 12) (Protein-UDP acetylgalactosaminyltransferase 12) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12)GALNT12Q8IXK26
Polypeptide N-acetylgalactosaminyltransferase 18 (EC 2.4.1.41) (Polypeptide GalNAc transferase 18) (GalNAc-T18) (Polypeptide GalNAc transferase-like protein 4) (GalNAc-T-like protein 4) (pp-GaNTase-like protein 4) (Polypeptide N-acetylgalactosaminyltransferase-like protein 4) (Protein-UDP acetylgalactosaminyltransferase-like protein 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4)GALNT18 GALNTL4Q6P9A26
Polyubiquitin-C (Fragment)UBCF5H2656
Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29)SYF2 CBPIN GCIPIPO959266
Pregnancy-specific beta-1-glycoprotein 4 (PS-beta-G-4) (PSBG-4) (Pregnancy-specific glycoprotein 4) (Pregnancy-specific beta-1-glycoprotein 9) (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9)PSG4 CGM4 PSG9Q008886
Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)NSUN5 NSUN5A WBSCR20 WBSCR20AQ96P116
Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10)DDX10Q132066
Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) (Helicain)DDX31Q9H8H26
Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog)DDX41 ABSQ9UJV96
Probable cation-transporting ATPase 13A4 (EC 3.6.3.-) (P5-ATPase isoform 4)ATP13A4 UNQ3052/PRO9871Q4VNC16
Probable E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)MKRN2 RNF62 HSPC070Q9H0006
Probable RNA-binding protein 19 (RNA-binding motif protein 19)RBM19 KIAA0682Q9Y4C86
Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)PIBF1 C13orf24 PIBFQ8WXW36
Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog)OGFOD1 KIAA1612 TPA1Q8N5436
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