EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1)HAX1 HS1BP1O001654
HEAT repeat-containing protein 1HEATR1Q5T3Q74
Heat shock 70kDa protein 1A variant (Fragment)0Q59EJ34
Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)HSF1 HSTF1Q006134
Hemoglobin alpha-2 chain variant (Fragment)HBA2E9LUX24
Hemoglobin subunit delta (Fragment)HBDE9PEW84
Hemoglobin subunit epsilon (Fragment)HBE1A8MUF74
Heterogeneous nuclear ribonucleoprotein C-like 4HNRNPCL4P0DMR14
Heterogeneous nuclear ribonucleoprotein Q (Fragment)SYNCRIPF6UXX14
HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b)HIGD2AQ9BW724
Histone 1, H1e (Histone H1e)HIST1H1E hCG_1645742A3R0T84
Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)KAT7 HBO1 HBOa MYST2O952514
Histone cluster 1, H1eHIST1H1EQ4VB244
Histone deacetylase 4 (HD4) (EC 3.5.1.98)HDAC4 KIAA0288P565244
Histone deacetylase complex subunit SAP18 (Fragment)SAP18H7BZW64
Histone H2A0B2R5B34
Histone H2A.V (H2A.F/Z)H2AFV H2AVA6NFA84
Histone H4-like protein type GHIST1H4G H4/L H4FLQ995254
HLA class I histocompatibility antigen, A-3 alpha chainHLA-AQ5SRN74
HLA class I histocompatibility antigen, alpha chain E (HLA-E protein) (MHC class I antigen) (MHC class Ib antigen) (Major histocompatibility complex, class I, E)HLA-EQ6DU444
HLA class I histocompatibility antigen, Cw-6 alpha chainHLA-CF8W9Z84
HLA class II histocompatibility antigen, DM alpha chain (MHC class II antigen DMA) (Really interesting new gene 6 protein)HLA-DMA DMA RING6P280674
Homeobox-containing protein 1HMBOX1Q6NT764
HornerinHRNR S100A18Q5DT204
HPRT1 protein (Fragment)HPRT1Q6LET34
HPX protein (Hemopexin)HPXQ9BS194
Hsp89-alpha-delta-N0O753224
HSPC0270Q9Y6E34
Hyaluronan synthase 3 (EC 2.4.1.212) (Hyaluronate synthase 3) (Hyaluronic acid synthase 3) (HA synthase 3)HAS3O002194
Hydroxyacylglutathione hydrolase, mitochondrial (Fragment)HAGHH3BPK34
ICAM2 protein (Intercellular adhesion molecule 2) (Intercellular adhesion molecule 2 variant) (Intercellular adhesion molecule 2, isoform CRA_a)ICAM2 hCG_41817Q6FHE24
ICOS ligand (Inducible T-cell co-stimulator ligand, isoform CRA_b)ICOSLG hCG_401312K4DIA04
IgGFc-binding proteinFCGBPA0A087WXI24
IGL@ proteinIGL@Q6GMX44
Immunglobulin heavy chain variable region (Fragment)0Q0ZCH64
Immunglobulin heavy chain variable region (Fragment)0Q0ZCJ14
Immunoglobulin heavy chain variant (Fragment)0Q9NPP64
Immunoglobulin heavy variable 1-18IGHV1-18A0A0C4DH314
Immunoglobulin heavy variable 1-45IGHV1-45A0A0A0MS144
Immunoglobulin heavy variable 3-38 (non-functional) (Fragment)IGHV3-38A0A0C4DH364
Immunoglobulin heavy variable 3/OR16-10 (non-functional) (Fragment)IGHV3OR16-10A0A075B7F04
Immunoglobulin J chain (Fragment)JCHAIND6RD174
Immunoglobulin kappa variable 1-39 (Ig kappa chain V-I region DEE) (Ig kappa chain V-I region Hau) (Ig kappa chain V-I region Mev) (Ig kappa chain V-I region OU) (Ig kappa chain V-I region Walker)IGKV1-39P016004
Immunoglobulin kappa variable 1-8IGKV1-8A0A0C4DH674
Immunoglobulin kappa variable 2-28IGKV2-28A0A075B6P54
Immunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)IGKV3-20A0A0B4J1Z64
Immunoglobulin lambda variable 3-27 (Ig lambda chain V-IV region Kern)IGLV3-27P017184
Immunoglobulin lambda variable 9-49IGLV9-49A0A0B4J1Y84
Immunoglobulin mu-chain D-J4-region (Fragment)IGHMA2N7P44
Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)IGSF3 EWI3 KIAA0466A6NJZ64
Immunoglobulin-like domain-containing receptor 2ILDR2 C1orf32Q71H614
Immunogobulin kappa, VJ region (Fragment)0A2NH534
Importin subunit alphaKPNA2Q7Z7264
Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)PLCL2 KIAA1092 PLCE2Q9UPR04
Indian hedgehog protein (IHH) (HHG-2) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]IHHQ146234
Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3)IVNS1ABP ARA3 FLARA3 KIAA0850 NS1 NS1BP HSPC068Q9Y6Y04
Inner nuclear membrane protein Man1 (LEM domain-containing protein 3)LEMD3 MAN1Q9Y2U84
Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)IMPDH1 IMPD1A4D0Z64
Insulin-like growth factor 2 mRNA-binding protein 2IGF2BP2F8W9304
Insulin-like growth factor 2 receptor variant (Fragment)0Q59EZ34
Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68)INTS11 CPSF3L RC68Q5TA454
Integrin alpha-2ITGA2E9PB774
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]ITGA8P537084
Integrin betaITGB2 hCG_401305D3DSM04
Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein)ITGBL1 OSCP TIEDO959654
Integrin-alpha FG-GAP repeat-containing protein 2ITFG2Q969R84
Intelectin-2 (Endothelial lectin HL-2)ITLN2 UNQ2789/PRO7179Q8WWU74
Inter-alpha (Globulin) inhibitor H4 (Plasma Kallikrein-sensitive glycoprotein)ITIH4B2RMS94
Interferon-induced transmembrane protein 3IFITM3E9PS444
Interferon-induced very large GTPase 1 (Interferon-induced very large GTPase pseudogene 1)GVINP1 GVIN1 VLIG1Q7Z2Y84
Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-)ISG20L2 HSD-38 HSD38Q9H9L34
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]IL1R1 IL1R IL1RA IL1RT1P147784
Interleukin-1 receptor-like 1 (Protein ST2)IL1RL1 DER4 ST2 T1Q016384
Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)IL10P223014
Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)IL17RA IL17RQ96F464
Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1)IL36G IL1E IL1F9 IL1H1 IL1RP2 UNQ2456/PRO5737Q9NZH84
Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)IL6 IFNB2P052314
Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)IL7RP168714
Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Ki-1/57 intracellular antigen)HABP4Q5JVS04
Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10) (WD repeat-containing protein 140)IFT122 SPG WDR10 WDR140Q9HBG64
Intraflagellar transport protein 22 homolog (Rab-like protein 5)IFT22 RABL5Q9H7X74
IPO5 protein (Fragment)IPO5Q9BVS94
IQ domain-containing protein GIQCGQ9H0954
Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)ICA1Q050844
Isobutyryl-CoA dehydrogenase, mitochondrial (EC 1.3.99.-) (Activator-recruited cofactor 42 kDa component) (ARC42) (Acyl-CoA dehydrogenase family member 8) (ACAD-8)ACAD8 ARC42 IBDQ9UKU74
IST1 homolog (hIST1) (Putative MAPK-activating protein PM28)IST1 KIAA0174A8KAH54
Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)JOSD1 JSPH1 KIAA0063Q150404
Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2)JOSD2 SBBI54Q8TAC24
Kallikrein-12 (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5)KLK12 KLKL5 UNQ669/PRO1303Q9UKR04
Kallikrein-4 (EC 3.4.21.-) (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (KLK-L1) (Prostase) (Serine protease 17)KLK4 EMSP1 PRSS17 PSTSQ9Y5K24
Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1)KLHDC8AQ8IYD24
Kelch repeat and BTB domain-containing protein 3 (BTB and kelch domain-containing protein 3)KBTBD3 BKLHD3Q8NAB24
Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4)KBTBD4 BKLHD4Q9NVX74
Keratin, type I cytoskeletal 13KRT13K7ERE34
Keratin, type I cytoskeletal 17 (Fragment)KRT17K7EPJ94
Keratin, type I cytoskeletal 26 (Cytokeratin-26) (CK-26) (Keratin-25B) (K25B) (Keratin-26) (K26) (Type I inner root sheath-specific keratin-K25irs2)KRT26 KRT25BQ7Z3Y94
Keratin, type II cytoskeletal 5 (Fragment)KRT5H0YIN94
Keratin, type II cytoskeletal 8 (Fragment)KRT8F8W1U34
Keratin-associated protein 3-2 (High sulfur keratin-associated protein 3.2) (Keratin-associated protein 3.2)KRTAP3-2 KAP3.2 KRTAP3.2Q9BYR74
Keratin-like protein KRT222 (Keratin-222) (Keratin-222 pseudogene)KRT222 KA21 KRT222PQ8N1A04
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