EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Selenoprotein S (SelS) (Minor histocompatibility antigen H47)Selenos H47 VimpQ9BCZ41
Selenoprotein T (SelT) (Thioredoxin reductase-like enzyme) (EC 1.8.1.9)Selenot SeltP623421
Semaphorin-3A (Semaphorin III) (Sema III) (Semaphorin-D) (Sema D)Sema3a Semad SemDO086651
Semaphorin-3F (Semaphorin IV) (Sema IV)Sema3fO886321
Semaphorin-6ASema6aD3YWM81
Semaphorin-6ASema6aK3W4S51
Semaphorin-6B (Semaphorin VIB) (Sema VIB) (Semaphorin-N) (Sema N)Sema6b SemanO549511
Semaphorin-6DSema6dA2AW731
Sentrin-specific protease 1 (EC 3.4.22.68) (SUMO-1 protease 2) (SuPr-2) (Sentrin/SUMO-specific protease SENP1)Senp1 Supr2P591101
Septin-1 (Differentiation protein 6) (Protein Diff6) (Peanut-like protein 3)Sept1 Diff6 Pnutl3P422091
Septin-11Sept11A0A0J9YTY01
Septin-4 (Fragment)Sept4Q5ND181
Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1)Sept5 Pnutl1Q9Z2Q61
Septin-8Sept8B1AQY91
Septin-8Sept8B7ZC461
Sequestosome-1Sqstm1D3YZJ11
Serine (or cysteine) peptidase inhibitor, clade A, member 3ISerpina3iD3Z4501
Serine (Or cysteine) peptidase inhibitor, clade A, member 3N, isoform CRA_a (Serine protease inhibitor A3N)Serpina3n mCG_3346G3X8T91
Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment)Serpinb6aE9PYY01
Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment)Serpinb6aE9Q0P91
Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment)Serpinb6aE9Q1081
Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment)Serpinb6aE9Q3Y11
Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment)Serpinb6aE9Q6X21
Serine (or cysteine) peptidase inhibitor, clade B, member 6a (Fragment)Serpinb6aK7E6F11
Serine dehydratase-like (EC 4.3.1.17) (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (SDH)Sdsl SdsQ8R2381
Serine hydrolase-like protein (SHL) (EC 3.1.-.-)SerhlQ9EPB51
Serine hydroxymethyltransferase (EC 2.1.2.1) (Fragment)Shmt1G3UYY11
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)Sptlc1 Lcb1O357041
Serine protease hepsin (EC 3.4.21.106) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]HpnO354531
Serine protease HTRA2, mitochondrialHtra2D3YX271
Serine protease HTRA2, mitochondrialHtra2D3YX281
Serine protease HTRA2, mitochondrial (Fragment)Htra2F6TCV01
Serine--pyruvate aminotransferase, mitochondrial (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)Agxt Agxt1O354231
Serine--tRNA ligase, cytoplasmic (Fragment)SarsA2AFS11
Serine/arginine repetitive matrix protein 1Srrm1A2A8V81
Serine/arginine repetitive matrix protein 1Srrm1A2A8V91
Serine/arginine repetitive matrix protein 1Srrm1E9PUK61
Serine/arginine repetitive matrix protein 1Srrm1E9QKA41
Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1)Rsrc1 Srrp53Q9DBU61
Serine/arginine-rich-splicing factor 1Srsf1H7BX951
Serine/arginine-rich-splicing factor 11Srsf11D6RE221
Serine/arginine-rich-splicing factor 11Srsf11E9Q6E51
Serine/arginine-rich-splicing factor 11 (Fragment)Srsf11F6TN801
Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1)Stk11ip Lip1 Lkb1ipQ3TAA71
Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)Stk17b Drak2Q8BG481
Serine/threonine-protein kinase 25 (Fragment)Stk25D3Z3591
Serine/threonine-protein kinase 33 (EC 2.7.11.1)Stk33Q924X71
Serine/threonine-protein kinase ATRAtrE9QPK41
Serine/threonine-protein kinase Chk1Chek1G3UYC51
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Checkpoint kinase-1)Chek1 Chk1O352801
Serine/threonine-protein kinase D3Prkd3D3Z6I01
Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L)Mastl Gw GwlQ8C0P01
Serine/threonine-protein kinase MARK2 (Fragment)Mark2E9Q2J61
Serine/threonine-protein kinase MRCK alphaCdc42bpaD3YYN81
Serine/threonine-protein kinase MRCK alphaCdc42bpaE9PVY01
Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha)Cdc42bpgQ80UW51
Serine/threonine-protein kinase N2Pkn2G3UZM91
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)Pkn2 Prk2 Prkcl2Q8BWW91
Serine/threonine-protein kinase Nek6Nek6A2ATN91
Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) (p21-activated kinase 3) (PAK-3)Pak3 Pak-3 Pakb Stk4Q610361
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)Pink1Q99MQ31
Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3)Riok3Q9DBU31
Serine/threonine-protein kinase SIK3Sik3E9PU871
Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)Sik3 Kiaa0999 QskQ6P4S61
Serine/threonine-protein kinase SIK3 (Fragment)Sik3F6S7W61
Serine/threonine-protein kinase SIK3 (Fragment)Sik3F6U6U51
Serine/threonine-protein kinase SMG1 (Fragment)Smg1J3QQ221
Serine/threonine-protein kinase STK11Stk11E9Q8111
Serine/threonine-protein kinase tousled-like 2Tlk2B1ASU91
Serine/threonine-protein kinase tousled-like 2Tlk2B7ZC851
Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (PKU-alpha) (Tousled-like kinase 2)Tlk2 TlkO550471
Serine/threonine-protein kinase WNK4Wnk4E9PZ381
Serine/threonine-protein kinase WNK4Wnk4E9Q4701
Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)Wnk4 Prkwnk4Q80UE61
Serine/threonine-protein phosphatase (EC 3.1.3.16)Ppp3cbE9Q6P21
Serine/threonine-protein phosphatase (EC 3.1.3.16)Ppp3cb mCG_5935G3X8U71
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53)Ppp1r10 Cat53 PnutsQ80W001
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform (Fragment)Ppp2r2dG3UXS91
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Fragment)Ppp2r1aG3UWL21
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPpp2r1bH3BIV71
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPpp2r1bH3BLE71
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit deltaPpp2r3dJ3QNX11
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta (Fragment)Ppp2r3dJ3QPX41
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)Ppp3cc CalncP484551
Serine/threonine-protein phosphatase 4 regulatory subunit 1Ppp4r1E9PX531
Serine/threonine-protein phosphatase 4 regulatory subunit 1Ppp4r1E9QPR51
Serine/threonine-protein phosphatase 4 regulatory subunit 1Ppp4r1E0CXK81
Serine/threonine-protein phosphatase 4 regulatory subunit 1 (Fragment)Ppp4r1E0CYV21
Serine/threonine-protein phosphatase 4 regulatory subunit 1 (Fragment)Ppp4r1F6TLH31
Serine/threonine-protein phosphatase CPPED1 (Fragment)Cpped1D3Z7F71
Serpin B8Serpinb8O088001
Serum amyloid A-2 protein [Cleaved into: Amyloid protein A (Amyloid fibril protein AA)]Saa2P053671
Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)Pon3Q620871
SET domain-containing 1ASetd1aE9PYH61
SET-binding factor 2Sbf2E9PXF81
SET-binding factor 2Sbf2E9Q3051
SET-binding factor 2Sbf2E9Q3721
SH2 domain-containing protein 1A (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)Sh2d1a XlpO888901
SH3 and multiple ankyrin repeat domains protein 1 (Shank1)Shank1D3YZU11
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)Shank3 Kiaa1650 Prosap2Q4ACU61
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