EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)Cnn2Q080936
Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)Cps1Q8C1966
Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase I) (CA-I)Ca1 Car1P136346
Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II)Ca2 Car2P009206
Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)Csnk1a1Q8BK636
Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)Csnk1g2 Ck1g2Q8BVP56
CCR4-NOT transcription complex subunit 11Cnot11 D1Bwg0212eQ9CWN76
CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1) (EPO-induced protein FL10)Cnot9 Rcd1 Rqcd1Q9JKY06
CD166 antigenAlcamE9Q4G86
CDGSH iron-sulfur domain-containing protein 1 (MitoNEET)Cisd1 D10Ertd214e Zcd1Q91WS06
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)Cadm1 Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1Q8R5M86
Cell surface A33 antigen (Glycoprotein A33) (mA33)Gpa33Q9JKA56
Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2)Chpf Css2 D1Bwg1363eQ6IQX76
Chondroitin sulfate synthase 3 (EC 2.4.1.175) (EC 2.4.1.226) (Carbohydrate synthase 2) (Chondroitin glucuronyltransferase 3) (Chondroitin synthase 2) (ChSy-2) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3) (N-acetylgalactosaminyltransferase 3)Chsy3 Chsy2 Css3 Kiaa4168Q5DTK16
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)Cbx5 Hp1aQ616866
Clathrin light chainCltaB1AWD96
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)St3gal1 Siat4 Siat4aP547516
Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)F13a1 F13aQ8BH616
COBW domain-containing protein 1 (Cobalamin synthase W domain-containing protein 1)Cbwd1Q8VEH66
Coiled-coil domain-containing protein 50 (Protein Ymer)Ccdc50Q810U56
Collagen alpha3(VI) (Fragment)Col6a3Q9Z0I96
COMM domain-containing protein 2Commd2Q8BXC66
Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26)C1qtnf3 Cors26 Ctrp3Q9ES306
Complement component C9C9P066836
Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]Cfi IfQ611296
Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (mCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog)Ncaph Brrn Brrn1 CaphQ8C1566
Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein)Cnksr3Q8BMA36
Copine-4 (Copine IV)Cpne4Q8BLR26
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)Cbfb Pebp2b Pebpb2Q080246
Costars family protein ABRACLAbracl 3110003A17RikE9QMV26
CUB domain-containing protein 1 (Membrane glycoprotein gp140) (Transmembrane and associated with src kinases) (CD antigen CD318)Cdcp1Q5U4626
Cullin-4B (CUL-4B)Cul4b mKIAA0695A2A4326
Cullin-5 (CUL-5)Cul5Q9D5V56
Cullin-7 (CUL-7) (p185) (p193)Cul7 Kiaa0076Q8VE736
Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2)Cdk15 Als2cr7 Pftk2Q3V3A16
Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2)Cdk17 Pctaire2 Pctk2Q8K0D06
Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein)Uqcr10Q8R1I16
Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]Pla2g4a Cpla2 Pla2g4P477136
DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1)Dazap1Q9JII56
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, isoform CRA_a (Probable ATP-dependent RNA helicase DDX17) (Putative uncharacterized protein)Ddx17 mCG_13126Q3U7416
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (MCG18410, isoform CRA_a)Ddx23 mCG_18410D3Z0M96
Decorin (Bone proteoglycan II) (PG-S2) (PG40)DcnP286546
Dedicator of cytokinesis protein 10 (Zizimin-3)Dock10 Kiaa0694 Ziz3Q8BZN66
Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]Aldh18a1 P5cs PycsQ9Z1106
Deoxyuridine triphosphatase (Deoxyuridine triphosphatase, isoform CRA_a) (Putative uncharacterized protein)Dut mCG_6136Q9CQ436
Dip2c protein (Disco-interacting protein 2 homolog C)Dip2cB2RQ716
Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (Thymocyte-activating molecule) (THAM) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]Dpp4 Cd26P288436
DNA helicase (EC 3.6.4.12)Mcm5 mCG_14998Q52KC36
DNA repair protein RAD50 (mRad50) (EC 3.6.-.-)Rad50P703886
Double-strand-break repair protein rad21 homolog (Pokeweed agglutinin-binding protein 29) (PW29) (SCC1 homolog)Rad21 Hr21Q615506
Double-stranded RNA-binding protein Staufen homolog 1Stau1 StauQ9Z1086
Dynactin subunit 3 (Dynactin light chain p24)Dctn3Q9Z0Y16
E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING-type E3 ubiquitin transferase MGRN1)Mgrn1 Kiaa0544Q9D0746
E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.27) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) (RING-type E3 ubiquitin transferase MYCBP2)Mycbp2 Pam Phr1Q7TPH66
E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) (RING-type E3 ubiquitin transferase RNF13)Rnf13 RzfO549656
E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (G1-related zinc finger protein) (Goliath homolog) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)Rnf130 G1rpQ8VEM16
E3 ubiquitin-protein ligase SMURF1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)Smurf1Q9CUN66
E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32)Trim32Q8CH726
Early endosome antigen 1Eea1Q8BL666
EF-hand domain-containing protein D2 (Efhd2 protein) (Putative uncharacterized protein)Efhd2Q8C8456
EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1)Efemp2 Fbln4 Mbp1Q9WVJ96
Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (VEGF-induced aminopeptidase)Erap1 Appils Arts1Q9EQH26
Enhancer of mRNA-decapping protein 4Edc4Q3UJB96
Epididymis-specific alpha-mannosidase (EC 3.2.1.24) (Mannosidase alpha class 2B member 2)Man2b2 Kiaa0935O547826
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (Protein-tyrosine kinase MPK-6) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)Ddr1 Cak Eddr1 Mpk6Q031466
ER membrane protein complex subunit 8 (Neighbor of COX4)Emc8 Cox4al Cox4nb Noc4O703786
Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97)Eif4g2 Nat1Q624486
Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2)Exoc6b Sec15b Sec15l2A6H5Z36
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)Dis3 Kiaa1008 Rrp44Q9CSH36
Far upstream element (FUSE)-binding protein 3 (MCG130458)Fubp3 mCG_130458A2AJ726
Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1)Fubp1 D3Ertd330eQ91WJ86
Fatty acid-binding protein, adipocyte (3T3-L1 lipid-binding protein) (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4) (Myelin P2 protein homolog) (P15) (P2 adipocyte protein) (Protein 422)Fabp4 Ap2P041176
Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7)Fabp7 BlbpP518806
Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2)Far1 Mlstd2Q922J96
Fetuin-B (Fetuin-like protein IRL685)FetubQ9QXC16
Fibromodulin (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin)FmodP506086
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1)Fen1 Fen-1P397496
Folate transporter 1 (Intestinal folate carrier 1) (IFC-1) (Reduced folate carrier 1) (RFC-1) (RFC1) (Solute carrier family 19 member 1)Slc19a1P414386
Fragile X mental retardation syndrome-related protein 2Fxr2 Fxr2hQ9WVR46
Fragile X mental retardation syndrome-related protein 2 (Fragile X mental retardation, autosomal homolog 2) (Putative uncharacterized protein)Fxr2 Fxr2hQ6P5B56
Fructose-bisphosphate aldolase (EC 4.1.2.13)Aldoart1A6ZI466
G-protein coupled receptor 84Gpr84Q8CIM56
Galectin-9 (Gal-9)Lgals9O085736
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha)Aph1aQ8BVF76
Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)Gjc1 Cxn-45 Gja7P282296
Gem (Nuclear organelle) associated protein 4 (Gem (nuclear organelle)-associated protein 4) (Putative uncharacterized protein)Gemin4 mCG_50370Q6P6L66
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)RabggtaQ9JHK46
Glutathione S-transferase A4 (EC 2.5.1.18) (GST A4-4) (GSTA4-4) (GST class-alpha member 4) (Glutathione S-transferase 5.7) (GST 5.7)Gsta4 GstaP244726
Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase)GssP518556
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)Gpd1 Gdc-1 Gdc1 Kiaa4010P137076
GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)Gmpr2Q99L276
Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)Gnat2P501496
Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1)Gnl1 Gna-rs1 Mmr1P369166
Guanylate-binding protein 1 (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (mGBP-1) (mGBP1) (Guanine nucleotide-binding protein 1) (Interferon-gamma-inducible protein MAG-1) (Interferon-induced guanylate-binding protein 1)Gbp1 Gbp-1 Mag-1 Mpa1Q015146
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)Clcn5 Clc5Q9WVD46
H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)Nhp2 Nola2Q9CRB26
HEAT repeat-containing protein 3Heatr3Q8BQM46
Heme oxygenase 1 (HO-1) (EC 1.14.14.18) (P32 protein)Hmox1P149016
High affinity copper uptake protein 1 (Copper transporter 1) (CTR1) (Solute carrier family 31 member 1)Slc31a1Q8K2116
Histone H2A type 1-BHist1h2abP227526
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