EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)Ppm1a Pppm1aP494435
Protein phosphatase 1G (EC 3.1.3.16) (Fibroblast growth factor-inducible protein 13) (FIN13) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)Ppm1g Fin13 Ppm1cQ610745
Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)Ppme1 Pme1Q8BVQ55
Protein polybromo-1 (BRG1-associated factor 180) (BAF180)Pbrm1 Baf180 Pb1Q8BSQ95
Protein sidekick-1Sdk1Q3UH535
Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)Tanc1Q0VGY85
Protein transport protein Sec31B (SEC31-like protein 2) (SEC31-related protein B)Sec31b Gm341 Sec31l2Q3TZ895
Protein zwilch homologZwilchQ8R0605
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)Ptk2b Fak2 Pyk2 RaftkQ9QVP95
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha]PtmaP263505
Pumilio homolog 2Pum2 Kiaa0235Q80U585
Putative ATP-dependent RNA helicase Pl10 (EC 3.6.4.13)D1Pas1 Pl10P163815
Putative oxidoreductase GLYR1 (EC 1.-.-.-) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60)Glyr1 Np60Q922P95
Putative uncharacterized proteinItga6Q8CC065
Putative uncharacterized protein (Putative uncharacterized protein Tes) (Testin) (Testis derived transcript) (Testis derived transcript, isoform CRA_a)Tes mCG_11251Q921W75
Putative uncharacterized protein (Serine--tRNA ligase, cytoplasmic) (Seryl-aminoacyl-tRNA synthetase, isoform CRA_b)Sars Sars1 mCG_4072Q8C4835
Putative uncharacterized protein (UPF3 regulator of nonsense transcripts homolog B (yeast))Upf3bQ3ULL65
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)Pc PcxQ059205
Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog)Cryzl1Q921W45
Rab-like protein 3Rabl3Q9D4V75
Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)Rab3gap1 Kiaa0066 Rab3gapQ80UJ75
RAP1, GTP-GDP dissociation stimulator 1Rap1gds1E9Q6Q45
Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)Rac3P607645
Ras-related GTP-binding protein B (Rag B) (RagB)RragbQ6NTA45
Ras-related protein M-Ras (Muscle and microspikes Ras) (Ras-related protein R-Ras3) (X-Ras)Mras XrasO089895
Replication factor C subunit 1 (A1-P145) (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (Differentiation-specific element-binding protein) (ISRE-binding protein) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)Rfc1 Ibf-1 Recc1P356015
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)Rpa2 Rpa34Q621935
Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Cell line MC/9.IL4-derived protein 1) (M42C60) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short-chain aldehyde dehydrogenase) (SCALD)Rdh11 Arsdr1 Mdt1 Psdr1Q9QYF15
Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP)Rbp4Q007245
Ribosomal protein S6 kinase alpha-3Rps6ka3B1AXN95
Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)Rrp1 Nnp1P561835
RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10)Nat10 Kiaa1709Q8K2245
RNA polymerase II-associated factor 1 homologPaf1Q8K2T85
RNA-binding protein 26 (Protein expressed in male leptotene and zygotene spermatocytes 393) (MLZ-393) (RNA-binding motif protein 26)Rbm26Q6NZN05
RNA-binding protein NOB1Nob1Q8BW105
RNA-binding protein PNO1Pno1Q9CPS75
Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II)Scarf2 Srec2P592225
Secreted frizzled-related protein 3 (sFRP-3) (Frezzled) (Fritz) (Frizzled-related protein 1) (FrzB-1)Frzb Fiz Fre Frzb1 Sfrp3P974015
Semaphorin-6A (Semaphorin Q) (Sema Q) (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1)Sema6a SemaqO354645
Septin-7Sept7E9Q1G85
Serine protease inhibitor A3G (Serpin A3G) (Serine protease inhibitor 2A) (Serpin 2A)Serpina3g Spi2AQ5I2A05
Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Embryo-derived protein kinase) (Edpk) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase Krct) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2)Stk16 Edpk Krct Mpsk1 Pkl12 Tsf1O886975
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)Dclk1 Dcamkl1 DclkQ9JLM85
Serine/threonine-protein kinase N2Pkn2G3UXH45
Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)Ppp6r1 Kiaa1115 Pp6r1 Saps1Q7TSI35
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3)Ppp6r3 D19Ertd703e Kiaa1558 Pp6r3 Saps3Q922D45
Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5)Pgam5Q8BX105
Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16)Ppef2O353855
Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (Serum aryldialkylphosphatase 1)Pon1 PonP524305
SH3 and PX domain-containing protein 2A (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)Sh3pxd2a Fish Sh3md1 Tks5O890325
SH3 domain-binding protein 4Sh3bp4Q921I65
Signal recognition particle 54 kDa protein (SRP54)Srp54P145765
Signal transducer and activator of transcriptionStat1 mCG_123683Q8C3V45
Signal-regulatory protein alpha (Signal-regulatory protein alpha, isoform CRA_a) (Tyrosine-protein phosphatase non-receptor type substrate 1)Sirpa Ptpns1 mCG_9902Q6P6I85
Sister chromatid cohesion protein PDS5 homolog APds5a Kiaa0648Q6A0265
Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)Slc9a1 Nhe1Q611655
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Scavenger receptor cysteine-rich domain-containing protein LOC284297 homolog)Ssc5d S5D-SRCRBQ8BV575
Sorting and assembly machinery component 50 homologSamm50Q8BGH25
SPARC-like protein 1 (Extracellular matrix protein 2) (Matrix glycoprotein Sc1)Sparcl1 Ecm2 Sc1P706635
Spastin (EC 3.6.4.3)Spast Kiaa1083 Spg4Q9QYY85
Spectrin alpha chain, non-erythrocytic 1Sptan1 Spna2A3KGU55
Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase)SmsP973555
Stathmin (Fragment)Stmn1D3Z1Z85
Stromal cell-derived factor 2-like protein 1 (SDF2-like protein 1)Sdf2l1Q9ESP15
Structural maintenance of chromosomes flexible hinge domain-containing protein 1Smchd1 Kiaa0650Q6P5D85
Synaptic functional regulator FMR1 (Fragile X mental retardation protein 1 homolog) (FMRP) (Protein FMR-1) (mFmr1p)Fmr1 Fmr-1P359225
Synaptogyrin-2 (Cellugyrin)Syngr2O551015
Synaptosomal-associated protein 29 (SNAP-29) (Golgi SNARE of 32 kDa) (Gs32) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)Snap29Q9ERB05
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)Mlst8 Gbl Lst8Q9DCJ15
TBC1 domain family member 8BTbc1d8bA3KGB45
Telomere length regulation protein TEL2 homologTelo2 Kiaa0683Q9DC405
Testis-expressed protein 10Tex10Q3URQ05
TetraspaninTspan6 Tm4sf6 mCG_9501Q99L965
Tetraspanin-15 (Tspan-15) (Transmembrane 4 superfamily member 15)Tspan15F7BWT75
Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (PE31) (TALLA homolog) (Transmembrane 4 superfamily member 2) (CD antigen CD231)Tspan7 Mxs1 Tm4sf2Q622835
Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1)Tmx1 Txndc Txndc1Q8VBT05
THO complex subunit 5 homolog (Fms-interacting protein) (FMIP)Thoc5 Fmip Kiaa0983Q8BKT75
Thymidine kinase, cytosolic (EC 2.7.1.21)Tk1 Tk-1P041845
Thyroid adenoma-associated protein homologThada Kiaa1767A8C7565
Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)Thrap3 Trap150Q569Z65
Tight junction protein ZO-1 (Tjp1 protein)Tjp1B9EHJ35
Torsin-2A (Torsin family 2 member A)Tor2aQ8R1J95
Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2)Tmed5Q9CXE75
Transmembrane protein 176A (Gene signature 188) (Kidney-expressed gene 2 protein)Tmem176a Gs188 Keg2Q9DCS15
Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog)Tmem237 Als2cr4Q3V0J15
Transmembrane protein 33 (Protein DB83)Tmem33 Db83Q9CR675
Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)Tmod1 TmodP498135
Tropomyosin alpha-1 chainTpm1E9Q4525
Tubulin alpha chain-like 3Tubal3Q3UX105
Tubulointerstitial nephritis antigen-likeTinagl1H3BJ975
Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)Nudt16l1 Sdos TirrQ8VHN85
Tyrosine-protein kinase receptor (EC 2.7.10.1)Igf1rE9QNX95
U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50)Utp18 Wdr50Q5SSI65
U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K)Rrp9 Rnu3ip2 U3-55kQ91WM35
U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3)Prpf3Q922U15
U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (U4/U6 snRNP 61 kDa protein) (Protein 61K)Prpf31 Prp31Q8CCF05
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (snRNP core Sm-like protein Sm-x5)Lsm2 G7bO359005
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (Ubiquitin-like product Chap1/Dsk2)Ubqln2 Plic2Q9QZM05
Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)Usp24B1AY135
Ubiquitin carboxyl-terminal hydrolase isozyme L4 (UCH-L4) (EC 3.4.19.12) (Ubiquitin thioesterase L4)Uchl4P583215
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