EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B)Mindy2 Fam63b Kiaa1164Q6PDI65
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C)Ube3c Kiaa0010 Kiaa10Q80U955
Uncharacterized proteinGm8994 Gm5576E9PV045
Uncharacterized protein C10orf88 homolog0Q9D2Q35
Unconventional myosin-Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC)Myo1a Bbmi MyhlO883295
Unconventional myosin-IgMyo1gQ5SUA55
Unconventional myosin-VaMyo5aD3YZ625
Vacuolar fusion protein CCZ1 homologCcz1Q8C1Y85
Vacuolar protein sorting 16 (Yeast) (Vacuolar protein sorting-associated protein 16 homolog)Vps16 mCG_9913G3X8X75
Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29) (Fragment)Vps29D3YYD55
Vacuolar protein sorting-associated protein 33AVps33a Bf BuffQ9D2N95
Vacuolar protein-sorting-associated protein 25Vps25A2A4J85
Vesicle transport through interaction with t-SNAREs 1B homolog (Vesicle transport through interaction with t-SNAREs 1B homolog, isoform CRA_c) (Vesicle transport through interaction with t-SNAREs homolog 1B)Vti1b mCG_5809Q91XH65
Vesicle-associated membrane protein-associated protein B (VAMP-B) (VAMP-associated protein B) (VAP-B) (VAMP-associated protein 33b)VapbQ9QY765
Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]Cacna2d1 Cacna2O085325
Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C)Lrrc8c Ad158 Fad158Q8R5025
von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]VwfQ8CIZ85
WD repeat-containing protein 3Wdr3Q8BHB45
WD repeat-containing protein 35Wdr35Q8BND35
Zinc finger CCCH domain-containing protein 10Zc3h10Q8R2055
Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Epo-immediate response gene protein FM22)Zc3h15 Dfrp1Q3TIV55
Zinc finger protein 622Znf622 D15Ertd806e Zfp622Q91VY95
Zinc transporter ZIP14 (Factor for adipocyte differentiation 123) (FAD-123) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)Slc39a14 Fad123 Kiaa0062 Zip14Q75N735
14-3-3 protein theta (Fragment)YwhaqF6VW304
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) (c-Myc-responsive protein Rcl)Dnph1 RclQ80VJ34
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin)Psmd10Q9Z2X24
26S proteasome non-ATPase regulatory subunit 8 (Putative uncharacterized protein)Psmd8Q9CPS54
28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1)Pdap1Q3UHX24
28S ribosomal protein S22, mitochondrial (MRP-S22) (S22mt)Mrps22 Rpms22Q9CXW24
28S ribosomal protein S9, mitochondrial (MRP-S9) (S9mt)Mrps9Q9D7N34
3-hydroxyacyl-CoA dehydrogenase type-2Hsd17b10A2AFQ24
39S ribosomal protein L15, mitochondrial (L15mt) (MRP-L15)Mrpl15Q9CPR54
39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21)Mrpl21 D9Wsu149Q9D1N94
4-trimethylaminobutyraldehyde dehydrogenase (Putative uncharacterized protein)Aldh9a1Q3U3674
40S ribosomal protein S5 (Putative uncharacterized protein) (Ribosomal protein S5) (Ribosomal protein S5, isoform CRA_a)Rps5 mCG_22552Q91V554
5'-3' exoribonuclease 1 (mXRN1) (EC 3.1.13.-) (Protein Dhm2) (Strand-exchange protein 1 homolog)Xrn1 Dhm2 Exo Sep1P977894
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]Pfkfb4Q6DTY74
60S ribosomal protein L10-likeRpl10lP860484
60S ribosomal protein L26 (Fragment)Rpl26B1ARA34
60S ribosomal protein L7-like 1Rpl7l1Q9D8M44
60S ribosome subunit biogenesis protein NIP7 homolog (PEachy) (kDa93)Nip7Q9CXK84
7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase)Nt5c3b Nt5c3lQ3UFY74
A disintegrin and metalloproteinase with thrombospondin motifs 4Adamts4E9PV914
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (Aggrecanase-1)Adamts4Q8BNJ24
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)Akap8 Akap95Q9DBR04
Abl interactor 1Abi1J3QNK84
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit)Arpc3D3Z2F74
Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl coenzyme A thioester hydrolase) (MTE-I) (Very-long-chain acyl-CoA thioesterase)Acot2 Mte1Q9QYR94
Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.94) (Multiple substrate lipid kinase) (MuLK) (Multi-substrate lipid kinase)Agk MulkQ9ESW44
ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)Adamtsl4 Tsrc1Q80T214
Adenosylhomocysteinase (EC 3.3.1.1)Ahcyl2F8WGT14
Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)Adcy7P518294
Adhesion G protein-coupled receptor E5Adgre5 Cd97Q9DC424
Adhesion G protein-coupled receptor L2Adgrl2A0A0G2JDE34
Adiponectin receptor protein 1Adipor1Q91VH14
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (I-19) (NIM-R5 antigen) (CD antigen CD38)Cd38P565284
ADP-ribosylation factor-like protein 15 (ADP-ribosylation factor-related protein 2) (ARF-related protein 2)Arl15 Arfrp2Q8BGR64
ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like 7)Arl4c Arl7P612084
ADP-ribosylation factor-like protein 8A (Fragment)Arl8aF6QKK24
AfadinAfdnE9Q9C34
Aldehyde dehydrogenase family 16 member A1Aldh16a1D3Z0B94
Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (Aldehyde dehydrogenase 4) (Aldehyde dehydrogenase family 3 member A1) (Dioxin-inducible aldehyde dehydrogenase 3)Aldh3a1 Ahd-4 Ahd4 Aldh3 Aldh4P477394
Aldo-keto reductase family 1, member B10 (aldose reductase) (MCG142264, isoform CRA_a)Akr1b10 mCG_142264D3Z4944
Aldo-keto reductase family 1, member B10 (aldose reductase) (MCG142264, isoform CRA_b)Akr1b10 mCG_142264G5E8954
Aldose reductase-related protein 1 (EC 1.1.1.21) (Aldehyde reductase) (AR) (Aldo-keto reductase family 1 member B7) (MVDP) (Vas deferens androgen-dependent protein)Akr1b7 AvdpP213004
Alpha actinin 1a (Alpha-actinin-1)Actn1 Actn1aA1BN544
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)Mgat2Q921V54
Alpha-4 integrin (Integrin alpha 4) (Integrin alpha-4) (Integrin alpha-4 subunit)Itga4 mCG_20065Q792F94
Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A)MaoaQ641334
Amyloid-like protein 2 (Amyloid-like protein 2, isoform 751)Aplp2 APLP2Q607094
Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein) (B3RP) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2)Slc4a2 Ae2P138084
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14) (p125)Rai14 Kiaa1334 NorpegQ9EP714
Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.-)Ankib1 Kiaa1386Q6ZPS64
Ankyrin repeat and SOCS box protein 15 (ASB-15)Asb15Q8VHS64
Ankyrin repeat domain 50 (Fragment)Ankrd50F7BE844
Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein)Ankrd17 Foe Gtar Kiaa0697Q99NH04
Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin)Ank2Q8C8R34
Antileukoproteinase (ALP) (Secretory leukocyte protease inhibitor)SlpiP974304
AP-1 complex subunit beta-1Ap1b1Q5SVG54
AP-2 complex subunit mu (Adaptor protein complex AP-2, mu1, isoform CRA_a) (Putative uncharacterized protein)Ap2m1 mCG_128452Q3TWV44
AP-3 complex subunit mu-1Ap3m1H7BWY24
Apolipoprotein C-IV (Apo-CIV) (ApoC-IV) (Apolipoprotein C2-linked) (ACL) (Apolipoprotein C4)Apoc4 AclQ612684
Apolipoprotein L domain-containing 1Apold1E9Q0X24
Apolipoprotein M (Apo-M) (ApoM)Apom Ng20Q9Z1R34
Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12) (P-12LO)Alox12 Alox12pP396554
ARF GTPase-activating protein GIT1Git1Q5F2584
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)Arap1 Centd2 Kiaa0782Q4LDD44
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)Arg1Q611764
Arginine-rich, mutated in early stage tumors, isoform CRA_b (Mesencephalic astrocyte-derived neurotrophic factor) (Putative uncharacterized protein)Manf Armet mCG_19507Q3TMX54
Armadillo repeat-containing protein 6Armc6Q8BNU04
Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)Arsb As1 As1-sP504294
Ataxin-2-like protein (Fragment)Atxn2lE9Q5Q04
ATP synthase subunit d, mitochondrialGm10250 mCG_55033G3X9L64
ATP synthase subunit g, mitochondrial (ATPase subunit g)Atp5lQ9CPQ84
ATP-binding cassette sub-family G member 2Abcg2S4R2E14
ATP-binding cassette, sub-family C (CFTR/MRP), member 4Abcc4B9EKC24
ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase)PfkpQ8C6054
ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)Ddx24Q9ESV04
Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N)Epb41l1 Epb4 Epb4.1l1 Kiaa0338Q9Z2H54
Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]Epb41l3 Dal1 Epb4.1l3 Kiaa0987Q9WV924
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