EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Small subunit processome component 20 homolog (Down-regulated in metastasis protein)Utp20 DrimQ5XG714
Sodium-dependent phosphate transporter 2 (Phosphate transporter 2) (PiT-2) (Solute carrier family 20 member 2) (Type III sodium-dependent phosphate transporter)Slc20a2 Pit2Q80UP84
Sodium/potassium-transporting ATPase subunit alpha (EC 3.6.3.-)Atp4aQ91WH74
Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5)Slc24a5 Nckx5Q8C2614
Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog)Cant1Q8VCF14
Solute carrier family 2, facilitated glucose transporter member 4 (GT2) (Glucose transporter type 4, insulin-responsive) (GLUT-4)Slc2a4 Glut-4 Glut4P141424
Solute carrier family 35 member F1Slc35f1Q8BGK54
Sorbin and SH3 domain-containing protein 1Sorbs1E9Q6A34
Sorting nexin-12 (SDP8 protein)Snx12O704934
Sorting nexin-8Snx8Q8CFD44
SpartinSpg20 Kiaa0610Q8R1X64
Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)Spta1 Spna1 SptaP080324
Spectrin beta chainSptbn2 Spnb3 mCG_8401Q68FG24
Spectrin beta chainSptb Spnb1E9Q3974
Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr)Spats2 Scr59Q8K1N44
Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)Vipas39 Spe39 ViparQ8BGQ14
Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)Sf3a2 Sap62Q622034
Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)Rbm17 Spf45Q8JZX44
Stathmin (Leukemia-associated gene protein) (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)Stmn1 Lag Lap18 Pr22P542274
Striatin-3 (Strn3 protein)Strn3B2RQS14
Structural maintenance of chromosomes proteinSmc4E9Q2X64
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)Suclg1Q9WUM54
Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog)Ppan Ssf1Q91YU84
Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Epithin) (Serine protease 14)St14 Prss14P566774
Suppressor of Ty 16 (Suppressor of Ty 16 homolog (S. cerevisiae))Supt16 Supt16h mCG_18713G3X9564
Surfeit locus protein 6Surf6 Surf-6P702794
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B)Smarcd2 Baf60bQ99JR84
SymplekinSympkQ80X824
Synaptic functional regulator FMR1Fmr1E9QAS94
Synaptosomal-associated proteinSnap23Q9D3L34
Syndetin (Bcl2-like protein blm) (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50)Vps50 Ccdc132 Kiaa1861Q8CI714
Synembryn-A (Protein Ric-8A)Ric8a Ric8Q3TIR34
T-complex protein 1 subunit gammaCct3E9Q1334
Talin-2Tln2E9PUM44
Target of EGR1 protein 1Toe1Q9D2E24
TATA-box-binding protein-associated factor 15 (Fragment)Taf15F6QCI04
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) (mRif1)Rif1Q6PR544
TetraspaninTspan7Q3UHG54
Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence homolog)Tspan31 SasQ9CQ884
Tetratricopeptide repeat protein 27 (TPR repeat protein 27)Ttc27Q8CD924
Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19)Txndc12 Tlp19Q9CQU04
Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1)Txnip Vdup1Q8BG604
Thioredoxin-related transmembrane protein 1 (Fragment)Tmx1F6V0844
THO complex subunit 1 (Tho1) (Nuclear matrix protein p84)Thoc1 Hpr1Q8R3N64
Thrombospondin type-1 domain-containing protein 7AThsd7a Gm837 Kiaa0960Q69ZU64
THUMP domain-containing protein 1Thumpd1Q99J364
Thymosin beta-4 (T beta 4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]Tmsb4x Ptmb4 Tmsb4P200654
Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)TfpiO548194
TitinTtnE9Q8N14
Toll-like receptor 4 (CD antigen CD284)Tlr4 LpsQ9QUK64
TOM1-like protein 2Tom1l2Q5SXA54
TRAF2 and NCK interacting kinase (Traf2 and NCK-interacting protein kinase)TnikB9EKN84
Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15)Trappc12 Ttc15Q8K2L84
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)Yap1 Yap Yap65P469384
Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)Gatad2bQ8VHR54
Transformation/transcription domain-associated protein (Tra1 homolog)TrrapQ80YV34
Transformer-2 protein homolog alphaTra2aE9QP004
Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)]Tgfb1P042024
Transmembrane channel-like proteinTmc6 mCG_19294B1ATB34
Transmembrane emp24 domain-containing protein 4 (Fragment)Tmed4Q5SVW94
Transmembrane p24-trafficking protein 7Tmed7D3YZZ54
Transmembrane protease serine 11B-like protein (EC 3.4.21.-) (Airway trypsin-like protease 5) (Transmembrane protease serine 11B)Tmprss11b Hatl5 Tmprss11bnlQ14C594
Transmembrane protein 104Tmem104A2A6S14
Transmembrane protein 106B (Fragment)Tmem106bD3Z1914
Transmembrane protein 109 (Mitsugumin-23) (Mg23)Tmem109Q3UBX04
Transmembrane protein 132A (HSPA5-binding protein 1)Tmem132a Kiaa1583Q922P84
Transmembrane protein 14CTmem14cQ9CQN64
Transmembrane protein 192Tmem192Q9CXT74
Transmembrane protein 198bTmem198b 1110012D08Rik mCG_18665Q8CFU04
Transmembrane protein 79 (Mattrin)Tmem79 MattQ9D7094
Transmembrane protein 9Tmem9Q9CR234
Transmembrane protein C16orf54 homolog0Q8C7084
TransporterSlc6a8E9Q1514
Transportin-2Tnpo2E9PV584
Transportin-2 (Karyopherin beta-2b)Tnpo2Q99LG24
Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)Slc25a1Q8JZU24
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)Trmt6 Kiaa1153 Trm6Q8CE964
tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.-) (HpaII tiny fragments locus 9c protein)Trmt2a Htf9-c Htf9cQ8BNV14
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like)Dus3lQ91XI14
Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)Tmod2Q9JKK74
Tropomyosin 1, alpha, isoform CRA_i (Tropomyosin alpha-1 chain)Tpm1 mCG_1234G5E8R04
Tropomyosin 3, gammaTpm3Q8K0Z54
Tropomyosin alpha-3 chainTpm3E9Q7Q34
Tubulin polymerization-promoting protein family member 3Tppp3Q9CRB64
Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA)TbcaP484284
Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) (Tuftelin-interacting protein 39)Tfip11 Stip Tip39Q9ERA64
Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein)Tnfaip2Q613334
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphataseTmem55bF8WHW34
Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (Inositol polyphosphate-5-phosphatase B) (Phosphoinositide 5-phosphatase) (5PTase)Inpp5bQ8K3374
Tyrosinase (EC 1.14.18.1) (Albino locus protein) (Monophenol monooxygenase)TyrP113444
Tyrosine-protein kinase (EC 2.7.10.2)Tyk2E9QJS14
Tyrosine-protein phosphatase non-receptor type 2 (Protein-tyrosine phosphatase PTP-2) (EC 3.1.3.48) (MPTP)Ptpn2 PtptQ061804
Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP)Ptpn7Q8BUM34
U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)Snrpc Snrp1cQ622414
U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3)Imp3Q921Y24
U6 snRNA-associated Sm-like protein LSm4Lsm4Q9QXA54
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)Cyld Cyld1 Kiaa0849Q80TQ24
Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)Ube4b Ufd2 Ufd2aQ9ES004
Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Galactosyl transferase-associated protein) (GTAP) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1)Ube2q1 Ube2qQ7TSS24
Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Uba6-specific E2 conjugating enzyme 1) (Use1) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z)Ube2z D11Moh35Q3UE374
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