EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)Lig3P973863
DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) (MAT1-mediated transcriptional repressor)Dmap1 MmtrQ9JI443
DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)Pola1 PolaP336093
DNA segment, Chr 6, Wayne State University 176, expressed, isoform CRA_f (Protein FAM3C)Fam3c D6Wsu176e mCG_9383G5E9113
DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta-1)Top3b Top3b1Q9Z3213
DNA-binding protein RFX2 (Regulatory factor X 2)Rfx2P483793
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)Polr1a Rpa1 Rpo1-4O351343
DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)Polr1b Rpa2 Rpo1-2P707003
DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein)TwistnbQ78WZ73
DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C)Polr3cQ9D4833
Dolichol-phosphate mannosyltransferase subunit 3 (Dolichol-phosphate mannose synthase subunit 3) (DPM synthase subunit 3) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 3) (Mannose-P-dolichol synthase subunit 3) (MPD synthase subunit 3)Dpm3Q9D1Q43
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (B6dom1 antigen) (Source of immunodominant MHC-associated peptides)Stt3b SimpQ3TDQ13
Double-strand break repair protein MRE11 (Double-strand break repair protein MRE11A) (MmMRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)Mre11 Mre11aQ612163
Double-stranded RNA-binding protein Staufen homolog 1Stau1A2A5R83
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)Map2k2 Mek2 Mkk2 Prkmk2Q639323
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)Map2k7 Mkk7Q8CE903
Dynactin-associated protein (MCG9249) (Putative uncharacterized protein)Dynap mCG_9249Q9D7M53
Dynamin-2Dnm2F8WIV53
Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)Dnah2 Dnahc2P0C6F13
Dynein intermediate chain 2, axonemal (Axonemal dynein intermediate chain 2)Dnai2 Dnaic2A2AC933
Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR)Kiaa0319l AavrQ8K1353
DystoninDstS4R1P53
DystrophinDmdP115313
E3 ISG15--protein ligase Herc6 (EC 2.3.2.-)Herc6F2Z4613
E3 ubiquitin-protein ligase (EC 2.3.2.26)Nedd4l mCG_131856G3X9H83
E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)Rnf40 Bre1b Kiaa0661Q3U3193
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)CblP226823
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L)Dtx3l BbapQ3UIR33
E3 ubiquitin-protein ligase HECTD1Hectd1F8WIE53
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)Ring1 Ring1A Rnf1O357303
E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)Rnf126Q91YL23
E3 ubiquitin-protein ligase RNF130Rnf130Q5SVR53
E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.-) (Double ring-finger protein) (Dorfin) (Gametogenesis-expressed protein GEG-154) (RING finger protein 19A) (UBCM4-interacting protein 117) (UIP117) (XY body protein) (XYbp)Rnf19a Geg-154 Rnf19 XybpP506363
E3 ubiquitin-protein ligase SMURF1Smurf1E9Q4K93
E3 ubiquitin-protein ligase TRAF7Traf7F8WJF73
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)Trim23 Arfd1Q8BGX03
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (mUhrf1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)Uhrf1 Np95Q8VDF23
EF-hand calcium-binding domain-containing protein 3Efcab3Q80X603
EH domain-binding protein 1-like protein 1Ehbp1l1E9QP493
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (CAZ-associated structural protein 2) (CAST2) (Rab6-interacting protein 2)Erc1 Cast2 Kiaa1081 Rab6ip2Q99MI13
ELKS/Rab6-interacting/CAST family member 1 (Rab6 interacting protein 2, isoform CRA_b)Erc1 Rab6ip2 mCG_131716V9GXP83
Elongation factor 1-delta (Fragment)Eef1dF6ZFU03
Elongation factor 1-delta (Putative uncharacterized protein)Eef1dQ80T063
EndoglinEngF7A1B43
Endoglin (Putative uncharacterized protein)EngQ3UAM93
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1)Man1b1A2AJ153
Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina)Ermp1 D19Wsu12e Fxna Kiaa1815Q3UVK03
Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI)Eci2 PeciQ9WUR23
Env polypeptide (Fragment)0Q619753
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (mEK4) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1)Epha3 Etk1 Mek4 Tyro4P293193
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (CEK-7) (EPH homology kinase 1) (EHK-1)Epha5 Bsk Ehk1Q606293
Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2)Epha6 Ehk-2 Ehk2Q624133
Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (Tyrosine-protein kinase receptor EEK)Epha8 EekO091273
Epidermal growth factor receptor pathway substrate 15 isoform B (Epidermal growth factor receptor substrate 15)Eps15Q5JC283
Epsilon-sarcoglycanSgceF6R6P23
ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)Edem3Q2HXL63
Erythrocyte membrane protein band 4.2 (Erythrocyte protein 4.2) (P4.2)Epb42 Epb4.2P492223
Ester hydrolase C11orf54 homolog (EC 3.1.-.-)0Q91V763
Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase)Pcyt2Q922E43
Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)Eef2kO087963
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta)Eif3b EIF3B EIF3S9 Eif3s9Q8CIJ33
Eukaryotic translation initiation factor 3 subunit J-B (eIF3j-B) (Eukaryotic translation initiation factor 3 subunit 1-B) (eIF-3-alpha-B) (eIF3 p35)Eif3j2 Eif3s1-2 Gm9781Q66JS63
Eukaryotic translation initiation factor 4 gamma 2Eif4g2F7CBP13
Eukaryotic translation initiation factor 5A (eIF-5A) (Fragment)Eif5aA0A0A0MQM03
Exocyst complex component 1Exoc1 Sec3l1Q5PPR23
Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)Exosc2 Rrp4Q8VBV33
Exosome complex component RRP40 (EC 3.1.13.-) (Exosome component 3) (Ribosomal RNA-processing protein 40)Exosc3 Rrp40Q7TQK43
Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)Exosc9 Pmscl1Q9JHI73
Expressed sequence AU040320AU040320Z4YK563
Extracellular sulfatase Sulf-1 (mSulf-1) (EC 3.1.6.-)Sulf1 Kiaa1077Q8K0073
F-box only protein 22Fbxo22 Fbx22Q78JE53
FACT complex subunit SSRP1 (Fragment)Ssrp1A2AW053
Fanconi anemia group I protein homolog (Protein FACI)FanciQ8K3683
Fc fragment of IgG-binding proteinFcgbpE9Q0B53
FERM domain-containing protein 4AFrmd4a Frmd4 Kiaa1294Q8BIE63
FERM domain-containing protein 6Frmd6Q8C0V93
Ferric-chelate reductase 1Frrs1A0A0G2JFP43
Fibroleukin (Cytotoxic T-lymphocyte-specific protein) (Fibrinogen-like protein 2) (Prothrombinase)Fgl2 FiblpP128043
Filamin-binding LIM protein 1 (FBLP-1) (CSX-associated LIM)Fblim1 CalQ71FD73
FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP and FKBP-like) (WAFL)Fkbp15 Fkbp133 Kiaa0674Q6P9Q63
FocadhesinFocad Kiaa1797A2AKG83
Forkhead box protein K1 (Myocyte nuclear factor) (MNF)Foxk1 MnfP421283
Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM-protein 3) (SLIM-3)Fhl2O704333
Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2)Fhl3Q9R0593
Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]Cx3cl1 Cx3c Fkn Scyd1O351883
Fukutin-related protein (EC 2.-.-.-)FkrpQ8CG643
FXYD domain-containing ion transport regulator 6 (PLM-like protein) (Phosphohippolin)Fxyd6 PlpQ9D1643
FYN-binding protein (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)FybO356013
G-protein-signaling modulator 1 (Activator of G-protein signaling 3)Gpsm1 Ags3 C10aQ6IR343
GA-binding protein alpha chain (GABP subunit alpha)Gabpa E4tf1aQ004223
Gag-Pol polyproteinMela gag-polP703553
Gag-pro-pol polyprotein0Q1KYM23
GalectinPick1E9QAC63
Gamma-aminobutyric acid receptor-associated proteinGabarapB1AR503
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein)GabarapQ9DCD63
Gamma-parvinParvgQ9ERD83
Ganglioside-induced differentiation-associated protein 1 (GDAP1)Gdap1O887413
Gap junction beta-2 protein (Connexin-26) (Cx26)Gjb2 Cxn-26Q009773
Gap junction beta-3 protein (Connexin-31) (Cx31)Gjb3 Cxn-31P282313
GAS2-like protein 3Gas2l3A0A0R4J1A63
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