EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2)Ifih1Q8R5F73
Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (Glucocorticoid-attenuated response gene 39 protein) (GARG-39) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)Ifit2 Garg39 Ifi54 Isg54Q641123
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (Glucocorticoid-attenuated response gene 49 protein) (GARG-49) (P49) (IRG2)Ifit3 Garg49 Ifi49 Isg49Q643453
Interferon-stimulated 20 kDa exonuclease-like 2 (EC 3.1.-.-)Isg20l2Q3U1G53
Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (IL1 inhibitor)Il1rn Il-1raP250853
Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)Il10rb Crfb4Q611903
Intraflagellar transport protein 122 homolog (WD repeat-containing protein 10)Ift122 Wdr10Q6NWV33
Inverted formin-2Inf2Q0GNC13
IQ motif and SEC7 domain-containing protein 1Iqsec1E9PUA33
Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)Ireb2 Irp2Q811J33
Isochorismatase domain-containing protein 2AIsoc2a Isoc2P850943
Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)Idh1Q8C3383
Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)Jam2 VejamQ9JI593
Kallikrein 1-related peptidase b26 (EC 3.4.21.35) (Glandular kallikrein K26) (mGK-26) (Prorenin-converting enzyme 2) (PRECE-2) (Tissue kallikrein 26)Klk1b26 Klk-26 Klk26P363693
Kallikrein 1-related peptidase b27 (EC 3.4.21.-) (Glandular kallikrein K27) (mGK-27) (Tissue kallikrein 27) (mKlk27)Klk1b27 Klk-27 Klk27Q9JM713
Kallikrein 1-related peptidase b9 (EC 3.4.21.35) (Epidermal growth factor-binding protein type C) (EGF-BP C) (Glandular kallikrein K9) (mGK-9) (Tissue kallikrein-9)Klk1b9 Egfbp3 Klk-9 Klk9P159493
Kallikrein j (Kallikrein related-peptidase 10) (Kallikrein-related-peptidase 10)Klk10 KlnjQ99M203
KDEL motif-containing protein 1 (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58)Kdelc1 Ep58Q9JHP73
Keratin, type I cuticular Ha4 (Hair keratin, type I Ha4) (Keratin-34) (K34)Krt34 Ha4 Krt1-4Q9D6463
Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5) (Keratin-35) (K35)Krt35 Krt1-24Q497I43
Keratin, type I cytoskeletal 25 (Cytokeratin-25) (CK-25) (Keratin-25) (K25) (Type I inner root sheath-specific keratin-K25irs1) (mIRSa1)Krt25Q8VCW23
Keratin, type II cuticular 87 (Keratin-87) (K87)Krt87 Kb25 Krt2-25 Krt83Q6IMF03
Keratinocyte-associated transmembrane protein 2Kct2Q8K2013
Kinesin light chain 1 (Kinesin light chain-1)Klc1 Kns2Q5UE593
Kinesin light chain 2Klc2D3YXZ33
Kinesin-like protein KIF18AKif18aQ91WD73
Kinesin-like protein KIF1BKif1bQ605753
Kinesin-like protein KIF21AKif21a Kiaa1708Q9QXL23
Kinesin-like protein KIF22Kif22Q3V3003
Kinesin-like protein KIF7Kif7E9QMU13
Kinetochore protein Spc25Spc25 Spbc25Q3UA163
KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2 homolog) (KRR-R motif-containing protein 1)Krr1 Hrb2Q8BGA53
L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (Protein Fig-1) (mFIG1)Il4i1 Fig1O090463
L1 cell adhesion molecule (Neural cell adhesion molecule L1)L1camQ6PGJ33
La-related protein 4 (La ribonucleoprotein domain family member 4)Larp4Q8BWW43
Laminin subunit alpha-3 (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha)Lama3Q617893
Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin-5 subunit beta) (Nicein subunit beta)Lamb3Q610873
Laminin subunit gamma-2 (Laminin, gamma 2)Lamc2 mCG_22678G5E8743
Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (mLAT2) (Solute carrier family 7 member 8)Slc7a8 Lat2Q9QXW93
Large proline-rich protein BAG6 (Putative uncharacterized protein)Bag6 Bat3Q3UF953
LDLR chaperone MESD (Mesoderm development candidate 2) (Mesoderm development protein)Mesdc2 MesdQ9ERE73
Leucine zipper protein 1 (Leucine zipper motif-containing protein)Luzp1 LuzpQ8R4U73
Leucine-rich repeat-containing protein 47Lrrc47E9PV223
Leucine-rich repeat-containing protein 75A (Leucine-rich repeat-containing protein FAM211A)Lrrc75a Fam211aQ7TSF43
Leucine-rich repeat-containing protein 9Lrrc9Q8CDN93
Leukocyte antigen CD37 (CD antigen CD37)Cd37Q614703
LIM and senescent cell antigen-like-containing domain proteinLims1 mCG_19016A0A0R4J0053
LIM domain only 7Lmo7E9PYF43
LMBR1 domain-containing protein 2Lmbrd2Q8C5613
Long-chain-fatty-acid--CoA ligase 1Acsl1D3Z0413
Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)Fcgr2 Fcgr2b Ly-17P081013
Low-density lipoprotein receptor-related protein 10 (LRP-10)Lrp10 Lrp9Q7TQH73
Low-density lipoprotein receptor-related protein 6Lrp6A0A0R4J0A93
Ly6e protein (Lymphocyte antigen 6 complex, locus E) (Lymphocyte antigen 6 complex, locus E, isoform CRA_a) (Lymphocyte antigen 6E)Ly6e mCG_2785Q99JA53
Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)Ly96 Esop1 Md2Q9JHF93
Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (PDZ-binding kinase) (T-LAK cell-originated protein kinase)Pbk TopkQ9JJ783
Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)Brcc3 Brcc36 C6.1aP467373
Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1)Lpcat2 Aytl1 Aytl1a Lpcat2aQ8BYI63
Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-)Ppt2O354483
Lysosomal-associated transmembrane protein 4ALaptm4aE9QLR33
Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog)Lyst Bg Chs1P974123
Major urinary protein 17 (MUP 17)Mup17 Mup15B5X0G23
Maltase-glucoamylase (EC 3.2.1.20)MgamB5THE23
Manganese-transporting ATPase 13A1 (CATP) (EC 3.6.3.-)Atp13a1 Atp13aQ9EPE93
Mannose-P-dolichol utilization defect 1 (Mannose-P-dolichol utilization defect 1 protein) (Putative uncharacterized protein)Mpdu1Q8R0J23
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB)Man1a2 Man1bP390983
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1)Mark4 Kiaa1860Q8CIP43
Mapk-regulated corepressor-interacting protein 1 (Protein FAM195B)Mcrip1 Fam195bQ3UGS43
Mas-related G-protein coupled receptor member E (Evolutionary breakpoint transcript 3 protein)Mrgpre Ebrt3 MrgeQ91ZB73
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)Kit SlP055323
MAX gene-associated proteinMga Kiaa4252A2AWL73
MCG14935, isoform CRA_a (Putative uncharacterized protein) (WD repeat-containing protein 20)Wdr20 Wdr20a mCG_14935Q3UWE63
MCG4620, isoform CRA_b (Mutated in colorectal cancers)Mcc mCG_4620G3UW403
MCG5982 (Rho GTPase-activating protein SYDE1)Syde1 mCG_5982G3X9603
MCG6895 (RIKEN cDNA 2210016F16 gene)2210016F16Rik mCG_6895G3X8U33
MCG9626, isoform CRA_c (Myotubularin-related protein 3)Mtmr3 mCG_9626M0QW743
Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)Med12 Kiaa0192 Mopa Tnrc11 Trap230A2AGH63
Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (mSur-2)Med23 Crsp3 Kiaa1216 Sur2Q80YQ23
Melanoma-associated antigen D1 (Dlxin-1) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)Maged1 NrageQ9QYH63
Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET)Manf ArmetQ9CXI53
Mesoderm-specific transcript protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein)Mest Peg1 121aQ076463
Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (mACDP2) (Cyclin-M2)Cnnm2 Acdp2Q3TWN33
Metallo-beta-lactamase domain-containing protein 2 (EC 3.-.-.-)Mblac2Q8BL863
Metalloreductase STEAP3Steap3A0A0R4J1G93
Metastasis suppressor protein 1 (Missing in metastasis protein)Mtss1 MimQ8R1S43
Metastasis-associated protein MTA3Mta3Q924K83
Metaxin-1 (Fragment)Mtx1D3Z3F43
Metaxin-1 (Fragment)Mtx1G3XA663
Metaxin-1 (Mitochondrial outer membrane import complex protein 1)Mtx1 Mtx MtxnP478023
Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)Mars2Q499X93
Methylsterol monooxygenase 1 (EC 1.14.13.72) (C-4 methylsterol oxidase)Msmo1 Sc4molQ9CRA43
Methyltransferase-like 26Mettl26Q9DCS23
Mevalonate kinase (MK) (EC 2.7.1.36)MvkQ9R0083
MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13)Micall1 D15Mit260 Kiaa1668 Mirab13Q8BGT63
MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)Micall2 JrabQ3TN343
Microtubule-actin cross-linking factor 1Macf1E9PVY83
Microtubule-associated protein 2 (MAP-2)Map2 Mtap2P203573
Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP)Map6 Mtap6Q7TSJ23
Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1)Mast3 Kiaa0561Q3U2143
Minor histocompatibility antigen H13 (EC 3.4.23.-) (Presenilin-like protein 3) (Signal peptide peptidase)Hm13 H13 Psl3Q9D8V03
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