EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Mitochondrial amidoxime reducing component 2 (mARC2) (EC 1.-.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2) (MOSC domain-containing protein 2) (Moco sulfurase C-terminal domain-containing protein 2)Marc2 Mg87 Mosc2Q922Q13
Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10)Slc25a10 DicQ9QZD83
Mitochondrial import inner membrane translocase subunit Tim13Timm13 Tim13a Timm13aP620753
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)Tomm70 D16Wsu109e Tomm70aQ9CZW53
Mitochondrial pyruvate carrier 2 (Brain protein 44)Mpc2 Brp44Q9D0233
Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1)Mtg1 Gm169 Gtpbp7Q8R2R63
Mitofusin-2 (EC 3.6.5.-) (Hypertension-related protein 1) (Mitochondrial assembly regulatory factor) (HSG protein) (Transmembrane GTPase MFN2)Mfn2 Kiaa0214 MarfQ80U633
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7)Mapk15 Erk7Q80Y863
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)Mapk8 Jnk1 Prkm8Q91Y863
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif kinase ZAK) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)Map3k20 Mltk ZakQ9ESL43
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)Map3k5 Ask1 Mekk5O350993
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (HPK) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)Map4k1 Hpk1P702183
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)Map4k3Q99JP03
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (BubR1) (Mitotic checkpoint kinase MAD3L)Bub1b Mad3lQ9Z1S03
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)Smad1 Madh1 Madr1P703403
Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (SMAD family member 9) (SMAD 9) (Smad9) (Smad8)Smad9 Madh8 Madh9 Smad8Q9JIW53
mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase)Rnmt Kiaa0398Q9D0L83
Mucin-1 (MUC-1) (Episialin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]Muc1 Muc-1Q024963
Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)]Muc4Q8JZM83
Mucolipin-2Mcoln2Q8K5953
Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10)Megf10Q6DIB53
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)Megf8 Egfl4P608823
Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)Minpp1 Mipp MNCb-1572Q9Z2L63
Muscleblind-like 1 (Drosophila), isoform CRA_a (Muscleblind-like protein 1)Mbnl1 mCG_19416G3X9Q03
Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)Mbnl1 Exp MbnlQ9JKP53
Myeloid cell nuclear differentiation antigen-like proteinMndalD0QMC33
Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK)Mylk3Q3UIZ83
Myosin phosphatase Rho-interacting protein (Fragment)MpripF6S5I03
Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4)Myh4Q5SX393
Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)Myh6 MyhcaQ025663
Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)Myh8 MyhspP135423
Myotubularin-related protein 10Mtmr10Q7TPM93
Myotubularin-related protein 3 (EC 3.1.3.48) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)Mtmr3Q8K2963
N-acetylgalactosaminyltransferase 7 (EC 2.4.1.-) (Polypeptide GalNAc transferase 7) (GalNAc-T7) (pp-GaNTase 7) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7)Galnt7Q80VA03
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase)NagpaQ8BJ483
N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae), isoform CRA_a (N-alpha-acetyltransferase 20) (Putative uncharacterized protein)Naa20 Nat5 mCG_10160Q9DB823
N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit)Naa20 Nat5P616003
N-alpha-acetyltransferase 30 (EC 2.3.1.256) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit)Naa30 Mak3 Nat12Q8CES03
N-alpha-acetyltransferase 35, NatC auxiliary subunit (Embryonic growth-associated protein) (Protein MAK10 homolog)Naa35 Egap Mak10Q6PHQ83
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (Histone methyltransferase SMYD2) (EC 2.1.1.43) (SET and MYND domain-containing protein 2)Smyd2Q8R5A03
N6-adenosine-methyltransferase subunit METTL3 (EC 2.1.1.62) (Methyltransferase-like protein 3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)Mettl3 Mta70Q8C3P73
Na(+)/H(+) exchange regulatory cofactor NHE-RFSlc9a3r2A0A0R4IZX23
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit)Ndufa5Q9CPP63
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit)Ndufb3Q9CQZ63
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)Ndufb5Q9CQH33
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit)Ndufb6 Gm137Q3UIU23
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit)Ndufb9Q9CQJ83
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit) [Cleaved into: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5, N-terminally processed]Ndufs5Q99LY93
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)Ndufs6 Ip13P525033
NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2)Cyb5r1 Nqo3a2Q9DB733
NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)FdxrQ615783
Nardilysin, N-arginine dibasic convertase, NRD convertase 1Nrd1A6PWC33
Nectin-3 (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)Nectin3 Pvrl3Q9JLB93
NEDD4-binding protein 1 (N4BP1)N4bp1 Kiaa0615Q6A0373
NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Protein BS4)Nub1 Nyren18P547293
NEDD8-activating enzyme E1 catalytic subunit (Putative uncharacterized protein)Uba3 Ube1cQ3TL723
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)Ppp1r9bQ6R8913
Neurobeachin (Lysosomal-trafficking regulator 2)Nbea Lyst2Q9EPN13
Neuroblastoma-amplified sequenceNbasE9Q4113
Neurocalcin-deltaNcald D15Ertd412eQ91X973
Neurochondrin (M-Sema F-associating protein of 75 kDa) (Norbin)Ncdn Kiaa0607 Sfap75Q9Z0E03
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)Nefl Nf68 NflP085513
Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)Nefm Nef3 NfmP085533
Neuron navigator 1 (Pore membrane and/or filament-interacting-like protein 3)Nav1 Kiaa1151 Pomfil3Q8CH773
Nexilin (F-actin-binding protein)NexnQ7TPW13
Next to BRCA1 gene 1 protein (Fragment)Nbr1F6S3973
NF-kappa-B essential modulator (Fragment)IkbkgA3KG443
NF-kappa-B-repressing factor (NFkB-repressing factor) (Transcription factor NRF)Nkrf NrfQ8BY023
Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (Nicotinate phosphoribosyltransferase domain-containing protein 1)Naprt Naprt1Q8CC863
NineinNin Kiaa1565Q610433
Nipped-B-like protein (Delangin homolog) (SCC2 homolog)NipblQ6KCD53
NmrA-like family domain-containing protein 1Nmral1D3YU123
Non-histone chromosomal protein HMG-17 (Fragment)Hmgn2F6W6873
Non-specific serine/threonine protein kinase (EC 2.7.11.1)Mark2E9QMP63
Non-specific serine/threonine protein kinase (EC 2.7.11.1)Mark2A0A0R4J2273
Nuclear distribution protein nudE homolog 1 (NudE) (mNudE)Nde1 NudeQ9CZA63
Nuclear distribution protein nudE-like 1 (Protein mNudE-like) (Protein Nudel) (mNudE-L)Ndel1 NudelQ9ERR13
Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)Nup107Q8BH743
Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155)Nup155Q99P883
Nuclear pore complex protein Nup54 (54 kDa nucleoporin) (Nucleoporin Nup54)Nup54Q8BTS43
Nuclear receptor-binding protein (HLS7-interacting protein kinase) (MLF1 adapter molecule)Nrbp1 Madm NrbpQ99J453
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (JC7)Nucks1 NucksQ80XU33
Nucleobindin-2 (DNA-binding protein NEFA) (Prepronesfatin) [Cleaved into: Nesfatin-1]Nucb2 NefaP811173
Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein)Noc3l Ad24 Fad24Q8VI843
Nucleolar protein 10Nol10 Gm67Q5RJG13
Nucleolar protein 14 (Nucleolar complex protein 14)Nop14 Nol14Q8R3N13
Nucleolar transcription factor 1 (Upstream binding transcription factor, RNA polymerase I, isoform CRA_a)Ubtf mCG_140722A2AWT63
Nucleolysin TIA-1 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1)Tia1 TiaP529123
NucleophosminNpm1Q5SQB03
Nucleoporin Nup37 (Nup107-160 subcomplex subunit Nup37)Nup37Q9CWU93
Nucleoporin NUP53 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin Nup35)Nup35 Mp44 Nup53Q8R4R63
Nucleosome assembly protein 1-like 1Nap1l1E9PW663
NudC domain-containing protein 2Nudcd2E0CYQ23
Oligoribonuclease, mitochondrial (EC 3.1.-.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)Rexo2 SmfnQ9D8S43
Oligosaccharyltransferase complex subunit OSTCOstcQ78XF53
Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2)Nit2 D16Ertd502eQ9JHW23
Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) (Grey-lethal protein)Ostm1 GlQ8BGT03
Ovostatin homologOvosQ3UU353
Oxidoreductase HTATIP2 (EC 1.1.1.-)Htatip2 Cc3 Tip30Q9Z2G93
Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)Osbpl11Q8CI953
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