EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)Arpc5Q9CPW422
Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)Adsl AdlP5482222
Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)Got1P0520122
Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G)Epb41l2 Epb4.1l2O7031822
Barrier-to-autointegration factor (Breakpoint cluster region protein 1) (LAP2-binding protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]Banf1 Baf Bcrp1 L2bp1O5496222
Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)HexaP2941622
Calpain-2 catalytic subunit (EC 3.4.22.53) (80 kDa M-calpain subunit) (CALP80) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)Capn2O0852922
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)Csnk2a1 CkiiaQ6073722
CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (CD antigen CD151)Cd151 Peta3O3556622
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)Cdk1 Cdc2 Cdc2a Cdkn1P1144022
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)DlstQ9D2G222
E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Zinc finger UBR1-type protein 1) (p600)Ubr4 Kiaa0462 Zubr1A2AN0822
Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)EtfaQ99LC522
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (PCI domain-containing protein 1)Eif3m Pcid1Q99JX422
F-actin-capping protein subunit alpha-1 (CapZ alpha-1)Capza1 Cappa1P4775322
Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Keratinocyte lipid-binding protein) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)Fabp5 Fabpe Klbp Mal1Q0581622
Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2)Fermt3 Kind3 Urp2Q8K1B822
Flotillin-1Flot1O0891722
GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]Kras Kras2P3288322
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)Hnrnpa3 Hnrpa3Q8BG0522
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)Hnrnpd Auf1 HnrpdQ6066822
Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (pp68)Syncrip Hnrpq Nsap1 Nsap1lQ7TMK922
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)Hnrnpc HnrpcQ9Z20422
High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor) (Ecotropic retrovirus receptor) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)Slc7a1 Atrc1 Rec-1Q0914322
Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)Hint1 Hint Pkci Pkci1 Prkcnh1P7034922
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Embryonic type II keratin-1) (Keratin-77) (K77) (Type-II keratin Kb39)Krt77 Krt1bQ6IFZ622
Lamin-B1Lmnb1P1473322
Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)KarsQ99MN122
Myb-binding protein 1A (Myb-binding protein of 160 kDa)Mybbp1a P160Q7TPV422
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)Slc9a3r1 Nherf Nherf1P7044122
Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)Nrp2O3537522
Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)Nptn Sdfr1 Sdr1P9730022
Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (SATT) (Solute carrier family 1 member 4)Slc1a4 Asct1O3587422
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)Ybx1 Msy-1 Msy1 Nsep1 Yb1P6296022
Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein)Nap1l1 NrpP2865622
Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C)Ppic CypcP3041222
Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Rotamase D)PpidQ9CR1622
Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)Pafah1b1 Lis-1 Lis1 PafahaP6300522
Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8)Prpf8 Prp8Q99PV022
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (DEAH box protein 15)Dhx15 Ddx15 Deah9O3528622
Procollagen C-endopeptidase enhancer 1 (P14) (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer)Pcolce Pcpe1Q6139822
Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)Prep PepQ9QUR622
Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)Npepps PsaQ1101122
Ras-related protein Rab-21 (Rab-12)Rab21P3528222
Rho-related GTP-binding protein RhoC (Silica-induced gene 61 protein) (SIG-61)Rhoc ArhcQ6215922
S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)MtapQ9CQ6522
Septin-7 (CDC10 protein homolog)Sept7 Cdc10O5513122
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (Serine protease 11)Htra1 Htra Prss11Q9R11822
Syntaxin-4Stx4 Stx4aP7045222
Tetraspanin-4 (Tspan-4) (Transmembrane 4 superfamily member 7)Tspan4 Tm4sf7Q9DCK322
Toll-interacting proteinTollipQ9QZ0622
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)PuraP4266922
Transportin-1 (Importin beta-2) (Karyopherin beta-2)Tnpo1 Kpnb2Q8BFY922
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]GartQ6473722
Tubulin beta-2B chainTubb2bQ9CWF222
Tubulin beta-3 chainTubb3Q9ERD722
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC 2.7.7.-)Uap1l1Q3TW9622
60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20)Rpl26P6125521
Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta]Asah1 AsahQ9WV5421
Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (Single-stranded DNA-binding protein p9) (p14)Sub1 Pc4 Rpo2tc1P1103121
Alcohol dehydrogenase [NADP(+)] (EC 1.1.1.2) (Aldehyde reductase) (Aldo-keto reductase family 1 member A1)Akr1a1 Akr1a4Q9JII621
Alpha-2-macroglobulin-P (Alpha-2-macroglobulin)A2m A2mpQ6GQT121
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)Ap1b1 Adtb1O3564321
Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)Got2 Got-2P0520221
Aspartyl aminopeptidase (EC 3.4.11.21)DnpepQ9Z2W021
ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)Abce1 RliP6122221
Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase)BlvraQ9CY6421
BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein)BroxQ8K2Q721
CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)Cd44 Ly-24P1537921
Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2)Chmp5 Snf7dc2Q9D7S921
Clusterin (Apolipoprotein J) (Apo-J) (Clustrin) (Sulfated glycoprotein 2) (SGP-2) [Cleaved into: Clusterin beta chain; Clusterin alpha chain]Clu Apoj Msgp-2Q0689021
Collagen alpha-1(VI) chainCol6a1Q0485721
Complement C4-B [Cleaved into: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4 gamma chain]C4b C4P0102921
Coronin-1B (Coronin-2)Coro1bQ9WUM321
DNA damage-binding protein 1 (DDB p127 subunit) (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor)Ddb1Q3U1J421
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)Rpn1Q91YQ521
EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)Emilin1Q99K4121
Glycogen [starch] synthase, muscle (EC 2.4.1.11)Gys1 Gys Gys3Q9Z1E421
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)Gnas Gnas1Q6R0H721
Heat shock protein 105 kDa (42 degrees C-HSP) (Heat shock 110 kDa protein) (Heat shock-related 100 kDa protein E7I) (HSP-E7I)Hsph1 Hsp105 Hsp110 Kiaa0201Q6169921
Hemoglobin subunit beta-2 (Beta-2-globin) (Hemoglobin beta-2 chain) (Hemoglobin beta-minor chain)Hbb-b2P0208921
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A)Hnrnpab Cbf-a Cgbfa HnrpabQ9902021
Heterogeneous nuclear ribonucleoprotein M (hnRNP M)Hnrnpm HnrpmQ9D0E121
Histone H2B type 1-B (h2B-143)Hist1h2bbQ6447521
Histone H3.3H3f3a H3.3a; H3f3b H3.3bP8424421
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II)Impdh2P2454721
Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)Ilf2 Nf45Q9CXY621
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)Idh3aQ9D6R221
Junction plakoglobin (Desmoplakin III) (Desmoplakin-3)JupQ0225721
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)Krt2 K2e Krt2-17 Krt2aQ3TTY521
Keratin, type II cytoskeletal 2 oral (Keratin-76) (K76) (Type-II keratin Kb9)Krt76Q3UV1721
MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)Marcksl1 Mlp MrpP2866721
Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)MarsQ68FL621
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)Mapk3 Erk1 Prkm3Q6384421
Peroxiredoxin-4 (EC 1.11.1.15) (Antioxidant enzyme AOE372) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372)Prdx4O0880721
Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 2D-0014IV) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)Prdx5 Prdx6P9902921
Plastin-3 (T-plastin)Pls3Q99K5121
Polyubiquitin-B [Cleaved into: Ubiquitin]UbbP0CG4921
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)Prpf19 Prp19 SnevQ99KP621
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1)Plod1 PlodQ9R0E221
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