EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2)Sephs2 Sps2P973643
Semaphorin-3BSema3bM9MMK03
Semaphorin-3B (Semaphorin-A) (Sema A)Sema3b Sema SemaaQ621773
Semaphorin-3C (Semaphorin-E) (Sema E)Sema3c Semae SemEQ621813
Semaphorin-3DSema3dQ8BH343
Semaphorin-3E (Semaphorin-H) (Sema H)Sema3e Semah SemhP702753
Semaphorin-6DSema6d Kiaa1479Q76KF03
Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)Espl1 Esp1 Kiaa0165P603303
Sepiapterin reductaseSprG3UXX33
Septin-8Sept8B1AQZ03
Serine peptidase inhibitor, Kazal type 5Spink5Q148R43
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T mutated homolog)AtmQ623883
Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2)Stk38l Ndr2Q7TSE63
Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein)Atr Kiaa4069Q9JKK83
Serine/threonine-protein kinase B-raf (Fragment)BrafF6SZ473
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Brain-enriched kinase) (Lemur tyrosine kinase 2)Lmtk2 Brek Kiaa1079Q3TYD63
Serine/threonine-protein kinase MRCK alphaCdc42bpaH7BX443
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha)Cdc42bpa Kiaa0451Q3UU963
Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)Nek7Q9ES743
Serine/threonine-protein phosphatase (EC 3.1.3.16) (Fragment)Ppp5cF7BX263
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPpp2r1bH3BLQ03
Serine/threonine-protein phosphatase 4 regulatory subunit 2Ppp4r2Q0VGB73
Serine/threonine-protein phosphatase 4 regulatory subunit 3APpp4r3a Smek1E9Q4813
Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)Ppp4r3a Kiaa2010 Pp4r3a Smek1Q6P2K63
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)Ankrd28Q505D13
Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)Serpinb5 Pi5 Spi5 Spi7P701243
Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)Pon2Q620863
SH3 domain-containing protein 21Sh3d21Q7TSG53
Shootin-1 (Shootin1)Shtn1 Kiaa1598Q8K2Q93
SID1 transmembrane family member 2Sidt2Q8CIF63
Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R)Sigmar1 Oprs1O552423
Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)Sec11c Sec11l3 Spc21Q9D8V73
Signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit)Spcs2 Spc25Q9CYN23
Signal peptidase complex subunit 3 (EC 3.4.-.-) (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)Spcs3Q6ZWQ73
Signal recognition particle subunit SRP72Srp72F8VQC13
Signal transducer and activator of transcription 5BStat5bP422323
Slit homolog 3 protein (Slit-3) (Slit3)Slit3Q9WVB43
Small ubiquitin-related modifier 3 (Fragment)Sumo3G3UZX63
Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator)Dagla Kiaa0659 NsddrQ6WQJ13
SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein)Snapin Bloc1s7 Snap25bp SnapapQ9Z2663
Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)Slc6a1 Gabt1 Gat-1 Gat1P316483
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Colonic system B0+ amino acid transporter CATB0+) (Solute carrier family 6 member 14)Slc6a14Q9JMA93
Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (mNAT) (System N amino acid transporter 1)Slc38a3 Sn1 Snat3Q9DCP23
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)Slc34a2 Npt2bQ9DBP03
Sodium/potassium-transporting ATPase subunit alpha (EC 3.6.3.-)Atp1a2D3YYN73
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)Slc12a6 Kcc3Q924N43
Solute carrier family 15 member 3 (Peptide transporter 3) (Peptide/histidine transporter 2) (cAMP-inducible gene 1 protein)Slc15a3 Ci1 Pht2Q8BPX93
Solute carrier family 45 member 4Slc45a4 Kiaa1126Q0P5V93
Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 2 homolog) (PERV-A receptor 2 homolog) (Protein GPR172B) (Riboflavin transporter 1) (mRFT1)Slc52a2 Gpr172b Rft1Q9D8F33
Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (Crl-1) (Disrupter of silencing SAS10) (UTP3 homolog)Utp3 Crl1 Crlz1 Sas10Q9JI133
Son of sevenless homolog 1 (SOS-1) (mSOS-1)Sos1Q622453
SPARCSparcQ5NCU43
Spectrin alpha chain, non-erythrocytic 1Sptan1 Spna2A3KGU73
Spectrin alpha chain, non-erythrocytic 1Sptan1 Spna2A3KGU93
Spermatid perinuclear RNA-binding proteinStrbp SpnrQ91WM13
Spermatogenesis-associated protein 5Spata5A0A0A0MQ803
Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Lysophospholipid receptor B2) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)S1pr2 Edg5 Gpcr13 Lpb2P525923
Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4)U2af1l4 U2af26Q8BGJ93
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12)Srek1 Sfrs12 Srrp86Q8BZX43
Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)Spred2Q924S73
SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein homolog) (CLL deletion region gene 6 protein homolog)Spryd7 Clld6Q3TFQ13
SRSF protein kinase 2 (Serine/arginine-rich protein specific kinase 2, isoform CRA_a)Srpk2 mCG_4527A0A0R4J1243
Striated muscle-specific serine/threonine-protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)Speg Apeg1 Kiaa1297Q624073
Stromal cell-derived factor 1 (SDF-1) (12-O-tetradecanoylphorbol 13-acetate repressed protein 1) (TPAR1) (C-X-C motif chemokine 12) (Pre-B cell growth-stimulating factor) (PBSF) (Thymic lymphoma cell-stimulating factor) (TLSF)Cxcl12 Sdf1P402243
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)Sucla2Q9Z2I93
Succinyl-CoA:3-ketoacid-coenzyme A transferase (EC 2.8.3.5)Oxct1Q3UJQ93
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (mUBC9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)Ube2i Ubc9 Ubce2i Ubce9P632803
Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B)St5 Dennd2bQ924W73
Survival motor neuron proteinSmn1 SmnP978013
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (Protein D15KZ1) (SWI/SNF complex 60 kDa subunit)Smarcd1 Baf60a D15Kz1Q614663
Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)Synj2 Kiaa0348Q9D2G53
Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein)Snap47Q8R5703
Syntaxin-16Stx16Q8BVI53
Syntaxin-17Stx17Q9D0I43
Syntaxin-2 (Epimorphin)Stx2 EpimQ002623
Syntenin-2 (Syndecan-binding protein 2)Sdcbp2Q99JZ03
T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)Ly9 Ly-9Q019653
TaperinTprnA2AI083
TBC1 domain family member 10ATbc1d10aQ5SPX83
TBC1 domain family member 5Tbc1d5Q80XQ23
Terminal uridylyltransferase 7Zcchc6E9PUA23
Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6)Zcchc6 Kiaa1711 Tut7Q5BLK43
Testin (TES1/TES2)TesP472263
Testis-expressed protein 30Tex30Q3TUU53
TetraspaninTspan10 mCG_2164Q3UGA53
TetraspaninTspan5D3Z6413
Tetratricopeptide repeat domain 37Ttc37F8VPK03
Tetratricopeptide repeat protein 1Ttc1A2AJK83
Tetratricopeptide repeat protein 1 (TPR repeat protein 1)Ttc1Q91Z383
Tetratricopeptide repeat protein 21BTtc21bE9PVK43
Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300)Ttc5 StrapQ99LG43
Tetratricopeptide repeat protein 7A (TPR repeat protein 7A)Ttc7a Ttc7Q8BGB23
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)Tgfbr1Q647293
Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Thioredoxin reductase TR3)Txnrd2 Trxr2Q9JLT43
Thioredoxin-related transmembrane protein 2 (Thioredoxin domain-containing protein 14)Tmx2 Txndc14Q9D7103
Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1)Trex1Q91XB03
Thrombospondin type-1 domain-containing protein 7AThsd7aE9QNR53
Tissue factor (TF)F3 mCG_4679A0A0R4J0883
Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B)Tor1bQ9ER413
Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A)Tor3a AdirQ9ER383
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