EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (SAPKK3)Map2k6 Prkmk6 Sapkk3P702362
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)Clk3O354922
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (MP86) (Protein kinase minibrain homolog) (MNBH)Dyrk1a DyrkQ612142
Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1a protein)Dyrk1aA1L3412
Dynactin subunit 5 (Dynactin subunit p25)Dctn5Q9QZB92
Dynamin-1-like proteinDnm1lE9PUD22
Dynein assembly factor 5, axonemal (HEAT repeat-containing protein 2)Dnaaf5 Heatr2B9EJR82
Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)Dnah3 Dnahc3Q8BW942
Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1)Dysf Fer1l1Q9ESD72
Dystrobrevin beta (DTN-B) (mDTN-B) (Beta-dystrobrevin)DtnbO705852
E1A-binding protein p400 (EC 3.6.4.-) (Domino homolog) (mDomino) (p400 kDa SWI2/SNF2-related protein)Ep400 Kiaa1498Q8CHI82
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.-) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein) (UbcM4-interacting protein 48)Arih2 Ari2 Triad1 Uip48Q9Z1K62
E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)Hecw2 Kiaa1301 Nedl2Q6I6G82
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)Herc2 Jdf2 Kiaa0393 RjsQ4U2R12
E3 ubiquitin-protein ligase HUWE1Huwe1A2AFQ02
E3 ubiquitin-protein ligase makorin-1 (Putative uncharacterized protein)Mkrn1Q8C5V42
E3 ubiquitin-protein ligase MARCH7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING-type E3 ubiquitin transferase MARCH7)March7 AxotQ9WV662
E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)Pdzrn3 Kiaa1095 Semcap3Q69ZS02
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)Rbbp6 P2pr PactP978682
E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (RING finger and FYVE-like domain-containing protein 1) (Fring) (RING-type E3 ubiquitin transferase rififylin)RfflQ6ZQM02
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)Rnf2 DinG Ring1bQ9CQJ42
E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) (RING-type E3 ubiquitin transferase RNF123)Rnf123 Kpc1Q5XPI32
E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Phafin-1) (RING finger protein 34) (RING-type E3 ubiquitin transferase RNF34)Rnf34Q99KR62
E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)Znf598 Zfp598Q80YR42
E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)Znrf3Q5SSZ72
Ear6 protein (Eosinophil-associated ribonuclease 6) (Eosinophil-associated, ribonuclease A family, member 6)Ear6Q923L72
Echinoderm microtubule-associated protein-like 2Eml2E9QK482
Echinoderm microtubule-associated protein-like 3 (EMAP-3)Eml3Q8VC032
Ectopic P granules protein 5 homologEpg5 Kiaa1632Q80TA92
EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase)Eogt Aer61 Eogt1Q8BYW92
EGF-containing fibulin-like extracellular matrix protein 1 (Fragment)Efemp1F6ZFS02
EGF-containing fibulin-like extracellular matrix protein 2 (Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_c)Efemp2 mCG_11764G5E8D62
EH domain-binding protein 1Ehbp1 Kiaa0903Q69ZW32
Elastin (Tropoelastin)ElnP543202
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4)Slc4a4 Nbc1 Nbce1O883432
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (Etfdh protein)EtfdhQ6PF962
ELKS/Rab6-interacting/CAST family member 1Erc1F8VPM72
Elongation factor 1-delta (MCG22130, isoform CRA_a)Eef1d mCG_22130A0A0R4J1L22
Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)Tsfm TSFMQ9CX332
Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)EvlP704292
Endonuclease/exonuclease/phosphatase family domain-containing protein 1Eepd1 Kiaa1706Q3TGW22
Endophilin-B2Sh3glb2A2AWI72
Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65)P3h4 Leprel4 Sc65Q8K2B02
Enoyl-CoA hydratase domain-containing protein 2, mitochondrialEchdc2 D4Ertd765eQ3TLP52
Envelope proteinMela envP703562
Envoplakin (210 kDa cornified envelope precursor protein) (p210)EvplQ9D9522
Eosinophil cationic protein 1 (ECP 1) (EC 3.1.27.-) (Eosinophil secondary granule ribonuclease 1) (EAR-1) (Ribonuclease 3-1) (RNase 3-1)Ear1P974262
Eosinophil cationic protein 2 (ECP 2) (EC 3.1.27.-) (Eosinophil secondary granule ribonuclease 2) (EAR-2) (Ribonuclease 3-2) (RNase 3-2)Ear2 Rnase2P974252
Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]Epx EperP492902
Epb4.1l2 protein (Erythrocyte membrane protein band 4.1-like 2 retinal variant) (Protein 4.1G)Epb41l2 EBP4.1L2 Epb4.1l2 EPB41L2Q811B22
Ephrin type-B receptor 4Ephb4E9PWK72
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) [Cleaved into: Ephrin-A1, secreted form]Efna1 Epgl1 Epl1 Lerk1P527932
Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)Efnb2 Elf2 Epl5 Eplg5 Htkl Lerk5P528002
EpiplakinEppk1 EPPKQ8R0W02
Epsin-2Epn2J3QNT72
Epsin-2Epn2Q5NCM62
ER lumen protein-retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)Kdelr2Q9CQM22
ER membrane protein complex subunit 4 (Transmembrane protein 85)Emc4 Tmem85Q9CZX92
ER membrane protein complex subunit 6 (Transmembrane protein 93)Emc6 Tmem93Q9CQW02
ER membrane protein complex subunit 7Emc7 Orf3Q9EP722
Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04 homolog) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1)Erlin1 Keo4 Spfh1Q91X782
ES1 protein homolog, mitochondrialD10Jhu81eQ9D1722
Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8)Hsd17b11 Dhrs8 Pan1bQ9EQ062
Ethanolamine-phosphate cytidylyltransferase (Phosphate cytidylyltransferase 2, ethanolamine, isoform CRA_b)Pcyt2 mCG_2151A2ABY32
Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) (EC 4.1.1.41)Echdc1Q9D9V32
Eukaryotic initiation factor 4A-II (Putative uncharacterized protein)Eif4a2Q8BTU62
Eukaryotic translation initiation factor 1b (eIF1b)Eif1bQ9CXU92
Eukaryotic translation initiation factor 2B, subunit 3Eif2b3B1AUN32
Eukaryotic translation initiation factor 2B, subunit 3 (Putative uncharacterized protein)Eif2b3Q3UKV02
Eukaryotic translation initiation factor 2D (eIF2D) (Ligatin)Eif2d LgtnQ612112
Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)Exoc6 Sec15a Sec15l1Q8R3132
Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (PRUNEM1)Prune1 PruneQ8BIW12
Exportin-4 (Exp4)Xpo4 Kiaa1721Q9ESJ02
Exportin-6 (Exp6) (Ran-binding protein 20)Xpo6 Ranbp20Q924Z62
Exportin-TXpotA0A1W2P7Q62
Expressed sequence AU018091AU018091E9PWS42
Expressed sequence C77080 (Fragment)C77080D3Z0K52
Extracellular matrix protein 1Ecm1F8WI142
Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi-enriched fraction casein kinase) (GEF-CK)Fam20c Dmp4 Kiaa4081Q5MJS32
Eyes absent homolog 3 (EC 3.1.3.48)Eya3P974802
F-actin-uncapping protein LRRC16ACarmil1 Lrrc16aD3Z0302
F-actin-uncapping protein LRRC16A (Fragment)Carmil1 Lrrc16aF7AI272
F-box only protein 2Fbxo2 Fbs1 Fbx2Q80UW22
F-box only protein 30 (Muscle ubiquitin ligase of SCF complex in atrophy-1) (MUSA1)Fbxo30Q8BJL12
F-box only protein 38 (Modulator of KLF7 activity) (MoKA)Fbxo38Q8BMI02
FAD-dependent oxidoreductase domain-containing protein 2Foxred2 D15Bwg0759eQ3USW52
Family with sequence similarity 171, member A1Fam171a1A2ATK92
FANCD2 opposite strand protein (Fanconi anemia group D2 protein opposite strand transcript protein)Fancd2osQ9D4K42
Fatty acid desaturase 2 (EC 1.14.19.-) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase)Fads2 Fadsd2Q9Z0R92
FERM, RhoGEF and pleckstrin domain-containing protein 1Farp1C4IXU22
Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2)FRRS1 Sdfr2 Sdr2Q8K3852
Fibrillin-1 [Cleaved into: Asprosin]Fbn1 Fbn-1Q615542
Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide]Fbn2 Fbn-2Q615552
Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)Fgf2 Fgf-2P156552
Fibroblast growth factor receptor (EC 2.7.10.1)Fgfr3 FR3 mCG_16331Q615632
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)Fgfr1 FlgP160922
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Protein-tyrosine kinase receptor MPK-11) (CD antigen CD334)Fgfr4 Fgfr-4 Mpk-11Q031422
Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-5)Fgfrl1 Fgfr5Q91V872
Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1)Fgfbp1O705142
Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86)Pkhd1l1Q80ZA42
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