EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Prosaposin (Sulfated glycoprotein 1) (SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D]Psap Sgp1Q6120721
Prostaglandin F2 receptor negative regulator (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315)Ptgfrn FprpQ9WV9121
Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z)Psmb7 Mmc14P7019521
Protein FAM49BFam49bQ921M721
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]F2 Cf2P1922121
Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1)Gdi1 RabgdiaP5039621
Ras-related protein Rab-5BRab5bP6102121
Rho guanine nucleotide exchange factor 1 (Lbc's second cousin) (Lymphoid blast crisis-like 2)Arhgef1 Lbcl2 LscQ6121021
Septin-11Sept11 D5Ertd606eQ8C1B721
Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)Srsf7 Sfrs7Q8BL9721
Serpin H1 (47 kDa heat shock protein) (Collagen-binding protein) (Colligin) (Serine protease inhibitor J6)Serpinh1 Cbp1 Hsp47P1932421
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain)Sptan1 Spna2 Spta2P1654621
Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)Tspan9 Net5Q8BJU221
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-A-interacting protein) (KRIP-1) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)Trim28 Kap1 Krip1 Tif1bQ6231821
Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) (Testis/brain RNA-binding protein) (TB-RBP)TsnQ6234821
Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a]Rps27a Uba80 Ubcep1P6298321
V-type proton ATPase subunit H (V-ATPase subunit H) (Vacuolar proton pump subunit H)Atp6v1hQ8BVE321
40S ribosomal protein S27Rps27Q6ZWU920
60S ribosomal protein L31Rpl31P6290020
60S ribosomal protein L34Rpl34Q9D1R920
Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2)Adss Adss2P4666420
Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase B2) (ADH-B2) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284)Adh5 Adh-2 Adh2P2847420
Aldehyde dehydrogenase family 16 member A1Aldh16a1Q571I920
Amyloid beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloidogenic glycoprotein) (AG) (Beta-amyloid precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]AppP1202320
Angiopoietin-related protein 2 (Angiopoietin-like protein 2)Angptl2 Arp2Q9R04520
ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1)Ddx1Q91VR520
ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39)Ddx39a Ddx39Q8VDW020
Basic leucine zipper and W2 domain-containing protein 1Bzw1Q9CQC620
Beta-centractin (Actin-related protein 1B) (ARP1B)Actr1bQ8R5C520
cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]Prkar1aQ9DBC720
Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)Csnk2a2O5483320
Cathepsin Z (EC 3.4.18.1)CtszQ9WUU720
Coactosin-like proteinCotl1 ClpQ9CQI620
Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)Aco1 Ireb1 IrebpP2827120
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)Cyfip2 Kiaa1168 Pir121Q5SQX620
Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1)Cndp2 Cn2Q9D1A220
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)DlatQ8BMF420
DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)Top2bQ6451120
DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p)Dnajb11Q99KV120
Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (Growth cone membrane protein 23-48K) (GMP23-48K) (p50 dynamitin)Dctn2Q99KJ820
Extracellular matrix protein 1 (Secretory component p85)Ecm1Q6150820
Fascin (Singed-like protein)Fscn1 Fan1 SnlQ6155320
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]FgbQ8K0E820
Formin-like protein 1 (Formin-related protein)Fmnl1 Frl Frl1Q9JL2620
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)Gfpt1 GfptP4785620
Guanine nucleotide-binding protein G(o) subunit alphaGnao1 Gna0 GnaoP1887220
Heat shock 70 kDa protein 4 (Heat shock protein 4, isoform CRA_a) (Putative uncharacterized protein)Hspa4 mCG_113604Q3U2G220
High mobility group protein B2 (High mobility group protein 2) (HMG-2)Hmgb2 Hmg2P3068120
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)Ppa1 Pp PypQ9D81920
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)Itgb2P1183520
Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha)Lama5Q6100120
Lipoprotein lipase (LPL) (EC 3.1.1.34)LplP1115220
Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4) (mACS4)Acsl4 Acs4 Facl4Q9QUJ720
Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2)Scarb2O3511420
Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)Abcc1 Abcc1a Abcc1b Mdrap MrpO3537920
Murinoglobulin-1 (MuG1)Mug1 Mug-1P2866520
Myoferlin (Fer-1-like protein 3)Myof Fer1l3 Kiaa1207Q69ZN720
Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)Myh14Q6URW620
Myotrophin (Granule cell differentiation protein) (Protein V-1)Mtpn GcdpP6277420
Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (P18) (nm23-M2)Nme2Q0176820
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]Fkbp4 Fkpb52P3041620
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)Farsa FarslaQ8C0C720
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)Farsb Farsl Farslb FrsbQ9WUA220
Plasma membrane calcium-transporting ATPase 1 (PMCA1) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 1) (Plasma membrane calcium pump isoform 1)Atp2b1G5E82920
Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]PlgP2091820
Prelamin-A/C [Cleaved into: Lamin-A/C]Lmna Lmn1P4867820
Protein RCC2Rcc2 Kiaa1470Q8BK6720
Ras-related C3 botulinum toxin substrate 2 (Protein EN-7) (p21-Rac2)Rac2Q0514420
Ras-related protein R-Ras (p23)RrasP1083320
Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (mUpf1)Upf1 Rent1Q9EPU020
Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (D4) (Rho-GDI beta)Arhgdib Gdid4Q6159920
Serine/arginine-rich splicing factor 1 (ASF/SF2) (Pre-mRNA-splicing factor SRp30a) (Splicing factor, arginine/serine-rich 1)Srsf1 Sfrs1Q6PDM220
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 35 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]Stk24 Mst3 Stk3Q99KH820
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (p21-activated kinase 2) (PAK-2) [Cleaved into: PAK-2p27; PAK-2p34]Pak2Q8CIN420
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)Ppp2r2aQ6P1F620
Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)SrmQ6467420
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)Snrnp200 Kiaa0788Q6P4T220
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1)Ube2v1 Croc1Q9CZY320
Vacuolar protein sorting-associated protein 28 homolog (Caspase-activated DNase inhibitor that interacts with ASK1) (CIIA) (ESCRT-I complex subunit VPS28)Vps28Q9D1C820
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (mVDAC2) (Outer mitochondrial membrane protein porin 2) (Voltage-dependent anion-selective channel protein 6) (VDAC-6) (mVDAC6)Vdac2 Vdac6Q6093020
Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)Xpnpep1Q6P1B120
26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Protein MSS1)Psmc2 Mss1P4647119
26S protease regulatory subunit 7 (Putative uncharacterized protein)Psmc2Q8BVQ919
40S ribosomal protein S21Rps21Q9CQR219
40S ribosomal protein S27-likeRps27lQ6ZWY319
60S ribosomal protein L28Rpl28P4110519
Beta-glucuronidase (EC 3.2.1.31)Gusb Gus Gus-sP1226519
Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40)BlmhQ8R01619
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]CadB2RQC619
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)Camk2d Kiaa4163Q6PHZ219
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)Prkacb PkacbP6818119
Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)Cbr1 CbrP4875819
Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))Ctnnd1 Catns Kiaa0384P3099919
Centrosomal protein of 55 kDa (Cep55)Cep55Q8BT0719
Choline transporter-like protein 1 (Solute carrier family 44 member 1) (CD antigen CD92)Slc44a1 Cd92 Cdw92 Ctl1Q6X89319
Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)Copg2Q9QXK319
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)Cops3 Csn3O8854319
Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)CarsQ9ER7219
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3)Mcm3 Mcmd Mcmd3P2520619
Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM)Dnm2 Dyn2P3905419
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