EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)Ptpro GLEPP1 Ptpn15 PTPU2E9Q6122
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48)Ptprz1B9EKR12
Refilin-B (Regulator of filamin protein B) (RefilinB)Rflnb Cfm1 Fam101bQ5SVD02
Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)Rprd1b CreptQ9CSU02
Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2-interacting protein) (RPIP1)Rgs14P974922
Regulator of G-protein signaling 18 (RGS18)Rgs18Q99PG42
Regulator of G-protein-signaling 19Rgs19B7ZCT02
Replication protein A 70 kDa DNA-binding subunitRpa1Q5SWN22
Reticulocalbin-2 (Taipoxin-associated calcium-binding protein 49) (TCBP-49)Rcn2Q8BP922
Reticulon-1 (Neuroendocrine-specific protein)Rtn1 NspQ8K0T02
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)Rxra Nr2b1P287002
Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3) (MyEF-3) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein)Peg10 Edr Mar2 Mart2 Mef3l1 Rgag3Q7TN752
Retroviral-like aspartic protease 1 (EC 3.4.23.-) (Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein)Asprv1 Sasp TapsQ09PK22
Reversion-inducing cysteine-rich protein with Kazal motifs (mRECK)ReckQ9Z0J12
Rho GTPase-activating protein 1Arhgap1A2AH252
Rho GTPase-activating protein 12Arhgap12S4R2032
Rho GTPase-activating protein 23Arhgap23B1AQY22
Rho GTPase-activating protein 45Arhgap45 Hmha1D3Z7R72
Rho GTPase-activating protein 5Arhgap5E9PYT02
Rho guanine nucleotide exchange factor 2Arhgef2H3BJU72
Rhomboid-related protein 2 (RRP2) (EC 3.4.21.105) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment (NTF); Rhomboid-related protein 2, C-terminal fragment (CTF)]Rhbdl2A2AGA42
Ribonuclease P protein subunit p29 (EC 3.1.26.5)Pop4 Rpp29Q9CR082
Ribosomal proteinRpl10aQ3U5612
Ribosomal protein L15Gm10020E9QAZ22
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Protein-tyrosine kinase Mpk-9) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)Rps6ka2 Mapkapk1c Rsk3Q9WUT32
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RLSK)Rps6ka5 Msk1Q8C0502
Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)Rrp1bQ91YK22
Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1 homolog)Rrp8Q9DB852
Ribosome assembly factor mrt4Mrto4 2610012O22Rik mCG_122343A2AMV12
Ribulose-phosphate 3-epimeraseRpeM0QWJ22
RIKEN cDNA 1110037F02 gene1110037F02RikE9PZY82
RIKEN cDNA 1300017J02 gene (Fragment)1300017J02RikF6W4D32
RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669)Rnf11 N4wbp2 Sid1669Q9QYK72
RNA binding motif protein 15 (RNA-binding motif protein 15)Rbm15Q0VBL32
RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog)Rexo4 Gm111 Pmc2 Xpmc2hQ6PAQ42
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)Ssu72Q9CY972
RNA polymerase II-associated protein 1Rpap1 Kiaa1403Q80TE02
RNA-binding motif protein, X-linked 2Rbmx2Q8R0F52
RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1)Rbms1 Mssp Mssp1Q91W592
RNA-binding motif, single-stranded-interacting protein 2Rbms2Q8VC702
RNA-binding protein 10 (RNA-binding motif protein 10)Rbm10 Kiaa0122Q99KG32
RNA-binding protein 14 (RNA-binding motif protein 14)Rbm14Q8C2Q32
RNA-binding protein 27 (Peri-implantation stem cell protein 1) (RNA-binding motif protein 27)Rbm27 Kiaa1311Q5SFM82
RNA-binding protein 40 (RNA-binding motif protein 40) (RNA-binding region-containing protein 3)Rnpc3 Kiaa1839 Rbm40Q3UZ012
RNA-binding protein 47 (RNA-binding motif protein 47)Rbm47Q91WT82
RNA-binding protein 7 (RNA-binding motif protein 7)Rbm7Q9CQT22
RNA-binding protein Musashi homolog 2 (Musashi-2)Msi2 Msi2hQ920Q62
RNA-binding protein Raly (Fragment)RalyA2AU612
Rps19 protein (Fragment)Rps19Q5M9P32
rRNA-processing protein UTP23 homologUtp23Q9CX112
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 (EC 2.1.1.-) (Protein-glutamine methyltransferase)Fbll1Q80WS32
RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE)Rufy2 Kiaa1537Q8R4C22
RWD domain-containing protein 1 (DRG family-regulatory protein 2) (IH1)Rwdd1 Dfrp2Q9CQK72
Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)Ryr3A2AGL32
Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)SccpdhQ8R1272
SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes)Sash3 SlyQ8K3522
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)Atp2a1Q8R4292
Schlafen 1 (Schlafen family member 1) (Schlafen1)Slfn1 OTTMUSPWKG00059398 mCG_18884Q9Z0I72
SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)Scyl2 Cvak104 D10Ertd802eQ8CFE42
SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein)Sestd1Q80UK02
SEC14-like protein 1Sec14l1 Kiaa4251A8Y5H72
Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2)Spp2 Spp24Q8K1I32
Secretory carrier-associated membrane protein (Secretory carrier membrane protein)Scamp1Q3TSA82
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)Dvl2Q608382
Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate synthase 1)Sephs1 Sps1Q8BH692
Semaphorin-4A (Semaphorin-B) (Sema B)Sema4a Semab SemBQ621782
Semaphorin-4B (Semaphorin-C) (Sema C)Sema4b Kiaa1745 Semac SemCQ621792
Semaphorin-4C (M-Sema F) (Semaphorin-C-like 1) (Sema I) (Semaphorin I)Sema4c S4c Semacl1 SemaiQ641512
Semaphorin-4D (M-Sema G) (Semaphorin-C-like 2) (Semaphorin-J) (Sema J) (CD antigen CD100)Sema4d Semacl2 SemajO091262
Semaphorin-5A (Semaphorin-F) (Sema F)Sema5a Semaf SemFQ622172
Septin-10Sept10A0A0R4J2332
Septin-2Sept2E9Q3V62
Serglycin (Mastocytoma proteoglycan core protein) (Secretory granule proteoglycan core protein) (gp600)Srgn Prg Prg1P136092
Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)Lactb Lact1Q9EP892
Serine hydroxymethyltransferase (EC 2.1.2.1)Shmt2Q99K872
Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)Sptlc2 Lcb2P973632
Serine/arginine repetitive matrix protein 1 (Fragment)Srrm1F6T4M42
Serine/arginine-rich-splicing factor 11 (Fragment)Srsf11D3Z4B02
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif serine/threonine-protein kinase 3) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (mPar-1c)Mark1 Emk3 Kiaa1477Q8VHJ52
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1)Nek1P519542
Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10)Nek10 Gm282Q3UGM22
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2)Nek2O359422
Serine/threonine-protein kinase SIK3 (Fragment)Sik3F6U8X42
Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1 homolog) (LKB1) (mLKB1)Stk11 Lkb1Q9WTK72
Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled-like kinase 1)Tlk1Q8C0V02
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1)Wnk1 Hsn2 Prkwnk1P837412
Serine/threonine-protein phosphatase (EC 3.1.3.16)Ppp3cbE0CZ782
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPpp2r1bG3UWS42
Serine/threonine-protein phosphatase CPPED1 (EC 3.1.3.16) (Calcineurin-like phosphoesterase domain-containing protein 1)Cpped1 Cstp1Q8BFS62
Serologically defined colon cancer antigen 3 homologSdccag3A2AIW02
Serpin A11 (Fragment)Serpina11D3Z0P32
Serpin B10Serpinb10Q8K1K62
Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP)Srfbp1Q9CZ912
SET-binding factor 2Sbf2E9Q0D42
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)Sh2b1 Sh2bpsm1Q91ZM22
SH3 domain and tetratricopeptide repeat-containing protein 2Sh3tc2 Kiaa1985Q80VA52
SH3 domain-binding protein 1Sh3bp1A2A5V32
Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1) (mTrp1) (Trp-related protein 1)Trpc1 Trp1 Trrp1Q610562
Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (Rabex-5/Rin2-interacting protein) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)Trpc4ap Trrp4apQ9JLV22
Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter)Slc17a5Q8BN822
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