EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
DNA gyrase subunit A (EC 5.99.1.3)gyrA Fphi_1194B0TXG11
DNA gyrase subunit A (EC 5.99.1.3)gyrA YPO1216Q7CH961
DNA gyrase subunit A (EC 5.99.1.3)gyrA SF2311 S2444P0AES51
DNA gyrase subunit A (EC 5.99.1.3)gyrA KPR_2073R4Y7H51
DNA gyrase subunit A (EC 5.99.1.3)gyrA hisW nalA parD b2231 JW2225P0AES41
DNA gyrase subunit A (EC 5.99.1.3)gyrA VSAK1_01242A6D2D41
DNA gyrase subunit A (EC 5.99.1.3)gyrA SPy_1152 M5005_Spy0874Q9L7Q51
DNA gyrase subunit A (EC 5.99.1.3)gyrA CD630_00060Q18C901
DNA gyrase subunit A (EC 5.99.1.3)gyrA SAOUHSC_00006Q2G2Q01
DNA gyrase subunit A (EC 5.99.1.3)gyrA KU39_2235A0A0K2L5G71
DNA gyrase subunit B (EC 5.99.1.3)gyrB spr0715P0A4M01
DNA gyrase subunit B (EC 5.99.1.3)gyrB SC1083_1450G4A9E01
DNA gyrase subunit B (EC 5.99.1.3)gyrB KPR_0004R4Y6T51
DNA gyrase subunit B (EC 5.99.1.3)gyrB SPy_0727 M5005_Spy0553Q9A0L01
DNA gyrase subunit B (EC 5.99.1.3)gyrB Smlt0005B2FT831
DNA helicase (EC 3.6.4.12)pcrA spr0995Q8DPU81
DNA helicase (EC 3.6.4.12)uvrD VSAK1_24239A6D6J61
DNA helicase (EC 3.6.4.12)uvrD KW89_1150A0A0K2DWB91
DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)])ligA spr1024Q8DPS91
DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)])ligA SPy_0751 M5005_Spy0573Q9A0J51
DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)])ligA SAOUHSC_02122Q2G1Y01
DNA mismatch repair protein HexAhexA spr1888P0A3R41
DNA mismatch repair protein MutLmutL PA4946Q9HUL81
DNA mismatch repair protein MutLmutL SPy_2121 M5005_Spy1804Q99XN71
DNA mismatch repair protein MutSmutS SPy_2148 M5005_Spy1805Q99XL81
DNA polymerase (EC 2.7.7.7)Fphi_1013B0TWX91
DNA polymerase (EC 2.7.7.7)polA FTN_1604A0Q8991
DNA polymerase IVSAK1_13215A6D2D21
DNA polymerase I (EC 2.7.7.7)polA SFV_3637Q0SZ481
DNA polymerase I (EC 2.7.7.7)polA SPy_0185Q9A1M81
DNA polymerase I (EC 2.7.7.7)polA SAOUHSC_01797Q2FXN91
DNA polymerase I (POL I) (EC 2.7.7.7)polA spr0032P592001
DNA polymerase I (POL I) (EC 2.7.7.7)polA PA5493Q9HT801
DNA polymerase I (POL I) (EC 2.7.7.7)polA resA b3863 JW3835P005821
DNA polymerase III delta subunitholA SPy_1407Q7DAL51
DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7)polC spr0251Q8DRA51
DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7)polC dnaF mutI BSU16580P132671
DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7)polC SPy_1961 M5005_Spy1672P0C0B81
DNA polymerase III subunit alpha (EC 2.7.7.7)dnaE SPy_1284 M5005_Spy0990P0C0F31
DNA polymerase III subunit beta (EC 2.7.7.7)dnaN FTN_0002A0Q3U81
DNA polymerase III subunit beta (EC 2.7.7.7)B195_01000M5R5821
DNA polymerase III subunit beta (EC 2.7.7.7)dnaN spr0002P596511
DNA polymerase III subunit beta (EC 2.7.7.7)dnaN MXAN_0236Q1DFQ61
DNA polymerase III subunit beta (EC 2.7.7.7)dnaN Rv0002 MTCY10H4.0 MTV029.02P9WNU11
DNA polymerase III subunit beta (EC 2.7.7.7)SC1083_1784G4AAB11
DNA polymerase III subunit beta (EC 2.7.7.7)dnaN SPy_0003Q9A2091
DNA polymerase III subunit beta (EC 2.7.7.7) (Fragment)VSAK1_12622A6D7Y21
DNA polymerase III subunit deltaholB KPN_01097A6T7F91
DNA polymerase III subunit epsilonVSAK1_13548A6D4K11
DNA polymerase III subunit epsilon (Fragment)VSAK1_07324A6D3E21
DNA polymerase III subunit gamma/tau (EC 2.7.7.7)dnaX SAOUHSC_00442Q2G0T51
DNA polymerase III subunits gamma and tau (EC 2.7.7.7)VSAK1_10083A6D0M41
DNA polymerase III, delta subunitholA spr0673Q8DQG81
DNA polymerase IV (Pol IV) (EC 2.7.7.7)dinB CPR_1538Q0SSQ21
DNA polymerase subunits gamma and taudnaX PA1532Q9I3I11
DNA primase (EC 2.7.7.-)dnaG SPy_0781Q9A0G91
DNA protection during starvation protein (EC 1.16.-.-)dps STM0831Q7CQV91
DNA protection during starvation protein (EC 1.16.-.-)dps YPO2510 y1677 YP_2325Q7CJ651
DNA protection during starvation protein (EC 1.16.-.-)dps SF0763 S0805P0ABT41
DNA protection during starvation protein (EC 1.16.-.-)dps PGN_2037B2RMG01
DNA protection during starvation protein (EC 1.16.-.-)dps PG_0090P0C9351
DNA protection during starvation protein (EC 1.16.-.-)dps SSON_0792Q3Z3X31
DNA protection during starvation protein (EC 1.16.-.-)dps SCH_0826Q57RC91
DNA protection during starvation protein (EC 1.16.-.-) (Bacterioferritin) (HP-NAP) (Neutrophil-activating protein A) (NAP A)dps napA HP_0243P433131
DNA recombination protein RmuC family proteinFTT_0659Q5NH161
DNA repair family proteinKW89_1149A0A0K2DVT51
DNA repair protein RadA (EC 3.6.4.-) (Branch migration protein RadA)radA sms SPy_0236 M5005_Spy0200Q9A1K11
DNA repair protein RecN (Recombination protein N)recN spr1084Q8DPN31
DNA repair protein RecN (Recombination protein N)NSU_3848G6EHM71
DNA repair protein RecO (Recombination protein O)recO SPy_0021 M5005_Spy0019P659871
DNA replication and repair protein RecFrecF SPy_2204 M5005_Spy1855P0C0D11
DNA replication terminus site-binding protein (Ter-binding protein)tus SSON_1550Q3Z1W31
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)topA Fphi_0406B0TZZ51
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)topA FTN_0432A0Q5201
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)topA FTT_0906cQ5NGD91
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)topA SAOUHSC_01222Q2FZ321
DNA topoisomerase 3 (EC 5.99.1.2) (DNA topoisomerase III)topB BSU04260P965831
DNA topoisomerase 4 subunit A (EC 5.99.1.3) (Topoisomerase IV subunit A)parC Fphi_0357B0TZL51
DNA topoisomerase 4 subunit A (EC 5.99.1.3) (Topoisomerase IV subunit A)parC FTN_0492A0Q5731
DNA topoisomerase 4 subunit A (EC 5.99.1.3) (Topoisomerase IV subunit A)parC SPy_0910 M5005_Spy0712Q9L7Q41
DNA topoisomerase 4 subunit A (EC 5.99.1.3) (Topoisomerase IV subunit A)parC grlA SAOUHSC_01352Q2FYS41
DNA topoisomerase 4 subunit B (EC 5.99.1.3) (Topoisomerase IV subunit B)parE PA4967Q9HUJ81
DNA topoisomerase 4 subunit B (EC 5.99.1.3) (Topoisomerase IV subunit B)parE SPy_0909Q9A0691
DNA topoisomerase 4 subunit B (EC 5.99.1.3) (Topoisomerase IV subunit B)parE grlB SAOUHSC_01351Q2FYS51
DNA topoisomerase I (EC 5.99.1.2)VSAK1_04027A6D7J01
DNA topoisomerase I (EC 5.99.1.2)VSAK1_04032A6D7J11
DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family (EC 3.6.1.-) (EC 5.99.1.2)topB MXAN_0535Q1DEW91
DNA topoisomerase IV subunit BVSAK1_04795A6D6C21
DNA translocase FtsKftsK AC3_2155B1BWW51
DNA translocase FtsKftsK SPy_0458 M5005_Spy0372Q9A1551
DNA translocase FtsKftsK b0890 JW0873P468891
DNA-binding proteinbglY YPO2175Q0WEY91
DNA-binding protein H-NS (Heat-stable nucleoid-structuring protein) (Histone-like protein HLP-II) (Protein B1) (Protein H1)hns bglY cur drdX hnsA msyA osmZ pilG topS b1237 JW1225P0ACF81
DNA-binding protein H-NS (Histone-like protein HLP-II) (Protein B1) (Protein H1)hns hnsA osmZ STM1751P0A1S21
DNA-binding protein H-NS (Pathogenesis protein KcpA)hns hnsA kcpA virR SF1237 S1323P091201
DNA-binding protein HUSC1083_2157G4ABC21
DNA-binding protein HUhup hlpA SPy_1489 M5005_Spy1223P0C0H31
DNA-binding protein HUhup_3 FSU_1282C9RNK11
DNA-binding protein HU homolog (21 kDa laminin-2-binding protein) (28 kDa iron-regulated protein) (Irep-28) (Histone-like protein) (Hlp)hup hlp hupB lbp21 Rv2986c MTCY349.01P9WMK71
DNA-binding protein HU, beta subunitB195_07530M5R2231
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