EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Histidine kinase (EC 2.7.13.3)CPC_2172B1BIT81
Histidine kinase (EC 2.7.13.3)CPC_2875B1BHV31
Histidine kinase (EC 2.7.13.3)hk09 spr0579Q8DQN71
Histidine kinase (EC 2.7.13.3)narX PA3878G3XD661
Histidine kinase (EC 2.7.13.3)VSAK1_05090A6D3411
Histidine kinase (EC 2.7.13.3)SPy_1553Q48XM71
Histidine kinase (EC 2.7.13.3)SPy_2026Q99XU61
Histidine kinase (EC 2.7.3.-)hk07 spr0153Q8DRF61
Histidine kinase (EC 2.7.3.-)hk02 spr1106Q8DPL81
Histidine kinase (EC 2.7.3.-)hk08 spr0077Q8DRK01
Histidine kinase-MCP coupling proteincheW jhp_0990Q9ZKE81
Histidine protein kinaseSPy_0895Q9A0801
Histidine protein kinase SaeS (EC 2.7.13.3) (Sensor protein SaeS) (Staphylococcus exoprotein expression protein S)saeS SAOUHSC_00714Q2G2U11
Histidine triad family proteinVSAK1_09023A6D5V71
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS MXAN_3725Q1D6131
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS PA3802Q9HXJ51
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS b2514 JW2498P609061
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS SPy_2157 M5005_Spy1814Q99XK91
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS FSU_3184C9RMG61
Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)hisS SCH_2519Q57LI71
Histidine-binding periplasmic proteinhisJ YPO2774Q0WDB71
Histidine-binding periplasmic protein (HBP)hisJ b2309 JW2306P0AEU01
Histidinol dehydrogenase (HDH) (EC 1.1.1.23)hisD NMB1581Q9JYH81
Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) (HPAT) (HspAT)hisC b2021 JW2003P069861
Histidinol-phosphate aminotransferase 2 (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase 2)hisC2 PA3165Q9HZ681
HIT family hydrolaseVSAK1_03840A6D3V61
HlyD family membrane fusion proteinOOM_0023I2AWQ01
HlyD family secretion proteinPP_0166Q88RG41
HlyD family secretion proteinPP_5175Q88CK51
HlyD family secretion proteinemrA1 FTT_1257Q5NFH71
HlyD family secretion proteinemrA2 FTT_1654Q5NEI01
HMG-CoA synthase, putativeSAOUHSC_02860Q2FV761
HMP-PP phosphatase (EC 3.6.1.-)cof b0446 JW0436P468911
HolinPP_1559Q88ML21
Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12)ruvA SPy_2119 M5005_Spy1802P667511
Holliday junction ATP-dependent DNA helicase RuvA (EC 3.6.4.12)ruvA SAOUHSC_01751Q2FXT31
Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12)ruvB spr0238Q8CWU71
Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12)ruvB PP_1217Q88NJ01
Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12)ruvB PA0967Q514261
Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12)ruvB SFV_1862Q0T3U61
Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12)ruvB SPy_0038 M5005_Spy0035Q9A1Y11
Homocysteine S-methyltransferaseRxyl_0843Q1AXR81
Homocysteine synthasemetY PA5025Q9HUE41
Homocysteine synthaseVSAK1_14570A6D4U91
Homogentisate 1,2-dioxygenase (HGDO) (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)hmgA B195_05216M5QKZ21
Homologous to secreted protein sopDsopD SCH_0926Q57R291
Homoserine dehydrogenase (EC 1.1.1.3)metM NMB1228Q7DDD61
Homoserine dehydrogenase (EC 1.1.1.3)B195_05720M5R1171
Homoserine dehydrogenase (EC 1.1.1.3)hom spr1219Q8DPE11
Homoserine dehydrogenase (HDH) (EC 1.1.1.3)hom tdm BSU32260P195821
Homoserine/threonine efflux family proteinOOM_0858I2AYT91
HopZ proteinhopZQ9S3I71
HPrptsH HPSD74_1457U4SG561
HPr kinase/phosphorylase (HPrK/P) (EC 2.7.11.-) (EC 2.7.4.-) (HPr(Ser) kinase/phosphorylase)hprK spr1270Q8DPA21
HPr kinase/phosphorylase (HPrK/P) (EC 2.7.11.-) (EC 2.7.4.-) (HPr(Ser) kinase/phosphorylase)hprK ptsK SPy_0584 M5005_Spy0484P688981
HTH-type transcriptional regulator IscRiscR yfhP b2531 JW2515P0AGK81
HTH-type transcriptional regulator IscRiscR SSON_2613Q3YZ211
HTH-type transcriptional regulator IscRiscR VSAK1_12120A6D3001
HTH-type transcriptional regulator MalR (Maltose operon transcriptional repressor)malR spr1922P0A4T21
HTH-type transcriptional regulator rot (Repressor of toxins)rot SAOUHSC_01879Q9RFJ61
HTH-type transcriptional regulator SarR (Staphylococcal accessory regulator R)sarR SAOUHSC_02566Q9F0R11
HTH-type transcriptional regulator SarS (Staphylococcal accessory regulator S)sarS sarH1 SAOUHSC_00070Q2G1N71
HTH-type transcriptional regulator SarX (Staphylococcal accessory regulator X)sarX SAOUHSC_00674Q2G0D11
HTH-type transcriptional repressor PurR (Pur regulon repressor) (Purine nucleotide synthesis repressor)purR SSON_1498Q3Z2131
Hyaluronan synthase (EC 2.4.1.212) (Hyaluronate synthase) (Hyaluronic acid synthase) (HA synthase)hasA SPy_2200 M5005_Spy1851P0C0H11
Hydantoin utilization protein A (HyuA)HP_0695O254021
Hydrogenase-4 component F (EC 1.-.-.-)hyfF b2486 JW2471P774371
Hydrolase, alpha/beta fold familyMXAN_0158Q1DFY21
Hydrolase, alpha/beta fold familyCPC_2541B1BK671
Hydrolase, alpha/beta fold family domain proteinSAOUHSC_01279Q2FYZ31
Hydroxyacylglutathione hydrolase (EC 3.1.2.6) (Glyoxalase II) (Glx II)gloB LBL_1390Q051W51
Hydroxyacylglutathione hydrolase (EC 3.1.2.6) (Glyoxalase II) (Glx II)gloB SSON_0226Q3Z5F11
Hydroxydechloroatrazine ethylaminohydrolase (EC 3.5.99.3)VSAK1_24940A6CZ441
Hydroxylamine reductase (EC 1.7.99.1) (Hybrid-cluster protein) (HCP) (Prismane protein)hcp VSAK1_16922A6CUU51
Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34)KU39_726A0A0K2L1681
Hydroxymycolate synthase MmaA4 (EC 2.1.1.-) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT)mmaA4 hma mma4 Rv0642cQ79FX81
Hydroxypyruvate isomerase (EC 5.3.1.22)VSAK1_24905A6CZ371
Hyperosmotically inducible periplasmic protein, RpoS-dependent stationary phase proteinosmY SCH_4409Q57G471
Hypothetical acetolactate synthase, iolDVSAK1_25150A6CZ861
Hypothetical bacteriophage proteinSSON_2180 SSON_2647Q3YYZ21
Hypothetical dipeptidaseVS_II0492B7VRA61
Hypothetical GntR-famly transcriptional regulatorVSAK1_20429A6CY631
Hypothetical lipoproteinFTT_0289cQ5NI031
Hypothetical lipoproteinFTT_0742Q5NGT91
Hypothetical lipoproteinFTT_1122cQ5NFU71
Hypothetical lipoproteinFTT_1170Q5NFQ61
Hypothetical lipoproteinFTT_1206Q5NFM71
Hypothetical lipoproteinFTT_1416cQ5NF331
Hypothetical lipoproteinFTT_1419Q5NF301
Hypothetical lipoproteinFTT_1602Q5NEM41
Hypothetical lytic transglycosylase proteinVS_2563B7VK341
Hypothetical membrane channel protein component of Pn transporterVSAK1_00782A6D1B71
Hypothetical membrane proteinVS_2395B7VJ911
Hypothetical membrane proteinFTT_0083Q5NII51
Hypothetical membrane proteinFTT_0119Q5NIF31
Hypothetical membrane proteinFTT_0243Q5NI461
Hypothetical membrane proteinFTT_0261Q5NI291
Hypothetical membrane proteinFTT_0293Q5NHZ91
Hypothetical membrane proteinFTT_0474Q5NHI01
Hypothetical membrane proteinFTT_0505Q5NHF21
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