EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Putative folyl-polyglutamate synthetasefolC.2 SPy_0814Q9A0E11
Putative folyl-polyglutamate synthetasefolC.1 SPy_1096Q99ZT01
Putative formate dehydrogenase SAOUHSC_02582 (EC 1.17.1.9)SAOUHSC_02582Q2FVV91
Putative formate dehydrogenase, alphasubunitVSAK1_02149A6D5X21
Putative fructose-bisphosphate aldolasefba CD196_0388A0A0H3N3R51
Putative fructose-specific enzyme II, PTS system BC componentSPy_0855Q9A0B01
Putative general secretion pathway protein AVSAK1_08151A6D0131
Putative general secretion pathway protein DxpsD Smlt0697B2FNI31
Putative geranyltranstransferase (Farnesyl diphosphate synthase) (EC 2.5.1.10)fps SPy_1498Q99YX51
Putative gluconeogenesis factorSPy_0653 M5005_Spy0540Q9A0R71
Putative glucosyl transferaseSPy_0516Q9A1161
Putative glutamate decarboxylaseVSAK1_06315A6D6Y61
Putative glutamate synthase (EC 1.4.1.13)OOM_0890I2AYW41
Putative glutamine synthetase (EC 6.3.1.2)glnA SPy_1877Q99Y411
Putative glutamine-binding periplasmic proteinglnH YPO2512Q7CJ671
Putative glutamine-binding periplasmic proteinSPy_0277Q9A1H01
Putative glutamyl-aminopeptidasepepA SPy_0115Q9A1S81
Putative glutamyl-aminopeptidase, M42 family (EC 3.4.11.7)CD630_21520Q185U01
Putative glutathione reductase (GR) (EC 1.8.1.7)gor SPy_0813Q9A0E21
Putative glutathione S-transferaseVSAK1_16202A6CYV81
Putative glycerol dehydrogenasegldA SPy_2047Q99XT51
Putative glycerol uptake facilitator proteinglpF.2 SPy_1854Q99Y611
Putative glycerol-3-phosphate cytidyltransferaseVSAK1_09583A6D0F71
Putative glycerophosphodiester phosphodiesteraseSPy_0839Q9A0C21
Putative glycine betaine/proline ABC transporter (ATP-binding protein)opuAA SPy_0183Q9A1N01
Putative glycine-betaine binding permease proteinopuABC SPy_0184Q9A1M91
Putative glycoprotein endopeptidaseSPy_1874Q99Y441
Putative glycoside hydrolasePP_4041Q88FP81
Putative glycosyl transferaseSPy_0794Q9A0F81
Putative glycosyltransferase0Q7BC551
Putative glycosyltransferase-possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharidergpEc SPy_0791Q9A0G11
Putative glycyl-radical enzyme activating enzyme YjjW (GRE activating enzyme YjjW) (EC 1.97.1.-)yjjW b4379 JW4342P394091
Putative GTP pyrophosphokinaseSPy_1125Q99ZQ81
Putative GTP-binding factoryihK SSON_4043Q3YVA21
Putative GTP-binding protein TypA/BipA (Tyrosine phosphorylated protein A)SPy_1527Q99YV11
Putative heat shock-related protease htrA proteinPGN_0637B2RIG11
Putative heavy metal-transporting ATPaseSPy_1434Q99Z271
Putative heme-dependent peroxidase LMRG_01267 (EC 1.11.1.-) (UPF0447 protein LMRG_01267)LMRG_01267A0A0H3GJ151
Putative heme-dependent peroxidase YwfI (EC 1.11.1.-) (UPF0447 protein YwfI)ywfI BSU37670 ipa-87rP396451
Putative hemin-binding lipoproteinSSON_1637Q3Z1N01
Putative hemolysinETAE_0911D0ZE251
Putative hemolysinhlyA1 SPy_1497Q99YX61
Putative hemolysinhlyX SPy_0378Q9A1A41
Putative histidine kinase proteinSPy_1236Q99ZG91
Putative histidine kinase-lantibiotic associatedsrtK SPy_1082Q99ZT61
Putative histidine-binding periplasmic proteinB195_06665M5QM961
Putative hyaluronidaseSPy_1600Q99YP81
Putative hydrogenase, membrane componentompA SCH_1022Q57QT31
Putative hydrolaseCPC_2268B1BIJ71
Putative hydrolaseVSAK1_19414A6CWG31
Putative Immunity proteinPP_1576Q88MJ51
Putative inner membrane lipoproteindcrB SCH_3509Q57IP71
Putative inner membrane proteinKPN_04636A6THF31
Putative inner membrane proteinSTM4261Q8ZKG61
Putative inner membrane proteinyfaZ STM2294Q8ZNF61
Putative inner membrane proteinyqjD STM3229Q7CPR31
Putative inorganic pyrophosphatase, manganese-dependentFSU_0582D9S7581
Putative inositol-1-monophosphatasesuhB HPSD74_0056U4SM851
Putative insulinase family proteaseYPO3991Q7CG151
Putative integral membrane proteinCj1276cQ0P8Y01
Putative integral membrane proteindltB SPy_1311Q99ZA71
Putative integraseETAE_2742D0ZD151
Putative integration host factor MihFmihF Rv1388P716581
Putative internalin (Putative surface protein NetI)netI CP4_3446 pNetB_00079F8UNH61
Putative internalin AinlA SPy_1361Q99Z761
Putative IRON-REGULATED OUTER MEMBRANE PROTEINfrpB_3 jhp_1405Q9ZJA81
Putative IRON-REGULATED OUTER MEMBRANE PROTEINfrpB_1 jhp_0810Q9ZKX41
Putative iron-regulated proteincjrA SSON_2662Q3YYX71
Putative iron-sulfur cofactor synthesis proteinSPy_1122Q99ZR11
Putative iron-sulfur cofactor synthesis proteinSPy_0816Q9A0D91
Putative isocitrate dehydrogenase [NADP] (EC 1.1.1.42)icd Smlt4273B2FJR81
Putative isocitrate/isopropylmalate dehydrogenaseSmlt0982B2FQQ51
Putative K(+)-stimulated pyrophosphate-energized sodium pump (EC 3.6.1.1) (Membrane-bound sodium-translocating pyrophosphatase) (Pyrophosphate-energized inorganic pyrophosphatase) (Na(+)-PPase)hppA MXAN_1671Q1DBQ01
Putative L-asparaginaseasnB SPy_1782Q99YB31
Putative L-lactate dehydrogenase (EC 1.1.-.-)lldD lldD2 Rv1872cP9WND51
Putative L-serine dehydratase alpha subunit (EC 4.3.1.17)sdhA SPy_2190Q99XI51
Putative L-serine dehydratase beta subunitsdhB SPy_2189Q99XI61
Putative LACI-type transcriptional regulatorytfQ SSON_4409Q3YUC31
Putative lactate oxidaselctO SPy_0414Q9A1811
Putative lactonizing lipaseVSAK1_19969A6CWS41
Putative lactose phosphotransferase system repressor proteinlacR.1 SPy_1712Q99YG71
Putative lactose phosphotransferase system repressor proteinlacR.2 SPy_1924Q99Y111
Putative lactoylglutathione lyase (EC 4.4.1.5)gloA SPy_0511Q9A1211
Putative laminin adhesionlmb SPy_2007Q99XV31
Putative large conductance mechanosensitive channelmscL SPy_0780Q9A0H01
Putative leucine aminopeptidaseSmlt0373B2FJ441
Putative Lex2B protein (Lipooligosaccharide 5G8 epitope biosynthesis-associated protein)VSAK1_09658A6D0H21
Putative lipaseVS_II0774B7VS251
Putative lipoproteinMXAN_5495Q1D1351
Putative lipoproteinMXAN_5293Q1D1M81
Putative lipoproteinMXAN_7221Q1CW891
Putative lipoproteinMXAN_7118Q1CWJ21
Putative lipoproteinMXAN_6537Q1CY641
Putative lipoproteinMXAN_6511Q1CY891
Putative lipoproteinMXAN_6421Q1CYH81
Putative lipoproteinMXAN_6045Q1CZJ31
Putative lipoproteinMXAN_5525Q1D1051
Putative lipoproteinMXAN_5390Q1D1D61
Putative lipoproteinMXAN_4984Q1D2I31
Putative lipoproteinMXAN_4844Q1D2W81
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