EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ribonuclease HII (RNase HII) (EC 3.1.26.4)rnhB SPy_1162 M5005_Spy0883Q99ZM61
Ribonuclease HIII (RNase HIII) (EC 3.1.26.4)rnhC SPy_1841 M5005_Spy1564P666771
Ribonuclease J (RNase J) (EC 3.1.-.-)rnj spr0125Q8DRH71
Ribonuclease J (RNase J) (EC 3.1.-.-)rnj SPy_1876Q99Y421
Ribonuclease J (RNase J) (EC 3.1.-.-)rnj SPy_1020Q99ZY21
Ribonuclease J 1 (RNase J1) (EC 3.1.-.-)rnj1 MW0972Q7A1711
Ribonuclease J 1 (RNase J1) (EC 3.1.-.-)rnj1 SAOUHSC_01035Q2FZG91
Ribonuclease J 2 (RNase J2) (EC 3.1.-.-)rnj2 SAOUHSC_01252Q2FZ191
Ribonuclease P protein component (RNase P protein) (RNaseP protein) (EC 3.1.26.5) (Protein C5)rnpA fasX SPy_0246 M5005_Spy0207Q9A1J41
Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase)rph YPO0044 y0097 YP_0045Q8ZJP81
Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase)rph rphA Rv1340 MTCY02B10.04 MTCY130.25P9WGZ71
Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase)rph OOM_0373I2AXL71
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr FTN_1461A0Q7W41
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr B195_03173M5QMQ31
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr spr0878Q8DQ301
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr YPO0380Q7CKL81
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr SPy_0503Q9A1271
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr OOM_0764I2AYK31
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr SAOUHSC_00803Q2G0241
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr FTT_1553cQ5NER51
Ribonuclease R (RNase R) (EC 3.1.13.1) (Protein VacB)rnr vacB yjeC b4179 JW5741P214991
Ribonuclease Y (RNase Y) (EC 3.1.-.-)rny SPy_1633 M5005_Spy1342P672841
Ribonuclease Y (RNase Y) (EC 3.1.-.-)rny LMRG_00851G2JZ151
Ribonuclease Y (RNase Y) (EC 3.1.-.-) (Conserved virulence factor A)rny cvfA SAOUHSC_01263Q2FZ081
Ribonuclease Z (RNase Z) (EC 3.1.26.11) (tRNA 3 endonuclease) (tRNase Z)rnz elaC SPy_0924 M5005_Spy0725P601991
Ribonuclease Z (RNase Z) (EC 3.1.26.11) (tRNA 3 endonuclease) (tRNase Z)rnz CD630_25390Q182M71
Ribonuclease, T2 familyACIN5021_3490L9M5021
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)Fphi_1619B0TZT11
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)nrdA KPN_02642A6TBT81
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)nrdA FTN_0981A0Q6K41
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)lmo2155Q8Y5B21
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)B195_07020M5QY501
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)nrdE.1 SPy_0427Q9A1751
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)RRM1 Smlt0247B2FI641
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)nrdA SCH_2280Q57M761
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)SAOUHSC_00742Q2G0781
Ribonucleoside-diphosphate reductase (EC 1.17.4.1)LMRG_01677A0A0H3GI401
Ribonucleoside-diphosphate reductase 1 beta chain (EC 1.17.4.1)ftsB YPO1213Q0WHJ11
Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1)nrdA dnaF b2234 JW2228P004521
Ribonucleoside-diphosphate reductase 1, beta subunitnrdB SCH_2281Q57M751
Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1)B195_06645M5QXZ31
Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1)nrdF spr1066Q8DPP81
Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1)nrdF.2 SPy_1378Q99Z621
Ribonucleoside-diphosphate reductase subunit beta nrdF2 (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase nrdF2) (Ribonucleotide reductase R2-2 small subunit)nrdF2 Rv3048cP9WH711
Ribonucleotide monophosphatase NagD (EC 3.1.3.5)nagD b0675 JW0661P0AF241
Ribonucleotide reductase, small chain family proteinHPSD74_2031U4S9X81
Ribonucleotide-disphosphate reductase beta chain, putative (EC 1.17.4.1)SAOUHSC_00743Q2G0771
Ribose ABC transporter permease proteinrbsC VSAK1_16172A6CYV21
Ribose ABC transporter, periplasmic ribose-binding subunitrbsB PP_2454Q88K381
Ribose import ATP-binding protein RbsA (EC 3.6.3.17)rbsA BSU35940P369471
Ribose import binding protein RbsBrbsB rbsP STM3884P0A2C51
Ribose-5-phosphate isomerase A (EC 5.3.1.6) (Phosphoriboisomerase A) (PRI)rpiA ygfC b2914 JW5475P0A7Z01
Ribose-5-phosphate isomerase A (EC 5.3.1.6) (Phosphoriboisomerase A) (PRI)rpiA HPSD74_1241U4SIK61
Ribose-5-phosphate isomerase A (EC 5.3.1.6) (Phosphoriboisomerase A) (PRI)rpiA Smlt3868B2FT301
Ribose-5-phosphate isomerase A (EC 5.3.1.6) (Phosphoriboisomerase A) (PRI)rpiA SPy_0889 M5005_Spy0695P666971
Ribose-5-phosphate isomerase A (EC 5.3.1.6) (Phosphoriboisomerase A) (PRI)rpiA FTT_1208Q5NFM51
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs MW0455P652381
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prsA prs ETAE_1402D0ZGI91
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs B195_04751M5QLA41
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs prsA YPO2013 y2295 YP_1861Q8ZEY21
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs prsA Rv1017c MTCY10G2.32P9WKE31
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs SC1083_1401G4A9911
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prsA prs SFV_1221Q0T5I81
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs CD630_35140Q181B31
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs SAOUHSC_00472Q2G0S21
Ribose-phosphate pyrophosphokinase 1 (RPPK 1) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate 1) (Phosphoribosyl diphosphate synthase 1) (Phosphoribosyl pyrophosphate synthase 1) (P-Rib-PP synthase 1) (PRPP synthase 1) (PRPPase 1)prs1 prsA prsA.1 SPy_0020 M5005_Spy0018P652431
Ribose-phosphate pyrophosphokinase 2 (RPPK 2) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate 2) (Phosphoribosyl diphosphate synthase 2) (Phosphoribosyl pyrophosphate synthase 2) (P-Rib-PP synthase 2) (PRPP synthase 2) (PRPPase 2)prs2 SPy_1123 M5005_Spy0845Q99ZR01
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease componentSPJ_1793C1CGB21
Ribosomal protein L11 methyltransferase (L11 Mtase) (EC 2.1.1.-)prmA SPy_1988 M5005_Spy1695Q99XW81
Ribosomal protein S1 family proteinMXAN_3559Q1D6H11
Ribosomal RNA large subunit methyltransferase H (EC 2.1.1.177) (23S rRNA (pseudouridine1915-N3)-methyltransferase) (23S rRNA m3Psi1915 methyltransferase) (rRNA (pseudouridine-N3-)-methyltransferase RlmH)rlmH spr2044P0A4S41
Ribosomal RNA large subunit methyltransferase H (EC 2.1.1.177) (23S rRNA (pseudouridine1915-N3)-methyltransferase) (23S rRNA m3Psi1915 methyltransferase) (rRNA (pseudouridine-N3-)-methyltransferase RlmH)rlmH SPy_2215 M5005_Spy1864Q99XH01
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m2G2445 methyltransferase (EC 2.1.1.173) (rRNA (guanine-N(2)-)-methyltransferase RlmL); 23S rRNA m7G2069 methyltransferase (EC 2.1.1.264) (rRNA (guanine-N(7)-)-methyltransferase RlmK)]rlmL FTN_0798A0Q6211
Ribosomal RNA large subunit methyltransferase M (EC 2.1.1.186) (Fragment)VSAK1_10603A6D9L51
Ribosomal RNA small subunit methyltransferase A (EC 2.1.1.182) (16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase) (16S rRNA dimethyladenosine transferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein KsgA) (Kasugamycin dimethyltransferase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase)rsmA ksgA b0051 JW0050P069921
Ribosomal RNA small subunit methyltransferase A (EC 2.1.1.182) (16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase) (16S rRNA dimethyladenosine transferase) (16S rRNA dimethylase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase)rsmA ksgA SPy_0262 M5005_Spy0222Q9A1I01
Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193)SPy_1987Q99XW91
Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.-) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase)rsmG SPy_0329 M5005_Spy0278Q9A1D71
Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.170) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase)gidB rsmG VSAK1_24645A6D4261
Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH)rsmH mraW SPy_1666 M5005_Spy1368P654311
Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH)rsmH mraW SAOUHSC_01143P603931
Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI)rsmI VSAK1_05155A6D3541
Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI)rsmI SPy_0406 M5005_Spy0335Q9A1861
Ribosomal S11 family protein (Fragment)HPSD74_1565U4SHH41
Ribosomal silencing factor RsfSrsfS Fphi_1671B0TZY41
Ribosomal silencing factor RsfSrsfS SPy_0310Q9A1F01
Ribosome biogenesis GTPase ASPy_1161Q99ZM71
Ribosome hibernation promoting factor (HPF)hpf SPy_1613Q99YN91
Ribosome hibernation promotion factor (HPF) (Hibernation promoting factor SaHPF)hpf SAOUHSC_00767Q2G0551
Ribosome hibernation promotion factor (HPF) (Ribosome hibernation-promoting factor)hpf LMRG_01737A0A0H3GEZ81
Ribosome maturation factor RimMrimM KPN78578_28760 KPN_02931A6TCL61
Ribosome maturation factor RimMrimM ylqE BSU16020O317401
Ribosome maturation factor RimMrimM SPy_0847 M5005_Spy0655P581831
Ribosome-associated ATPase (Ribosomal bound ATPase)rbbA yhiG yhiH b3486 JW5676P376241
Ribosome-binding ATPase YchFychF B195_04736M5QYJ61
Ribosome-binding ATPase YchFychF PA4673Q9HVC21
Ribosome-binding ATPase YchFychF SPy_0006Q9A2071
Ribosome-binding ATPase YchFychF SAOUHSC_00346Q2G1151
Ribosome-binding factor ArbfA A1S_0338A3M1K41
Ribosome-binding factor ArbfA SF3208 S3425P0A7G51
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